Mercury-induced cognitive impairment in metallothionein-1/2 null mice

Neurotoxicology and Teratology

Volumn 30, Issue 2, 2008, Pages 88-95

  Eddins, Donnie ^a   Petro, Ann ^a   Pollard, Ninitia ^a   Freedman, Jonathan H ^b,c   Levin, Edward D ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Dopamine; Learning; Mercury; Metallothionein; Radial arm maze; Serotonin

Indexed keywords

DOPAMINE; MERCURY; METALLOTHIONEIN I; METALLOTHIONEIN II; MONOAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENVIRONMENTAL EXPOSURE; FEMALE; GENE DELETION; HYPOTHESIS; LEARNING; MALE; MAZE TEST; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; BRAIN CHEMISTRY; COGNITION DISORDERS; GENOTYPE; MAZE LEARNING; MERCURY POISONING, NERVOUS SYSTEM; METALLOTHIONEIN; MICE; MICE, KNOCKOUT; SEROTONIN;

MURINAE; MUS;

EID: 39249085151     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ntt.2007.12.005     Document Type: Article

References (49)

1. Abedi-Valugerdi M., Nilsson C., Zargari A., Gharibdoost F., DePierre J.W., and Hassan M. Bacterial lipopolysaccharide both renders resistant mice susceptible to mercury-induced autoimmunity and exacerbates such autoimmunity in susceptible mice. Clin. Exp. Immunol. 141 (2005) 238-247
2. Bernard S., Enayati A., Redwood L., Roger H., and Binstock T. Autism: a novel form of mercury poisoning. Med. Hypotheses 56 (2001) 462-471
3. Bernard S., Enayati A., Roger H., Binstock T., and Redwood L. The role of mercury in the pathogenesis of autism. Mol. Psychiatry 7 Suppl 2 (2002) S42-S43
4. Carrasco J., Penkowa M., Hadberg H., Molinero A., and Hidalgo J. Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice. Eur. J. Neurosci. 12 (2000) 2311-2322
5. Chen W.Q., Cheng Y.Y., Zhao X.L., Li S.T., Hou Y., and Hong Y. Effects of zinc on the induction of metallothionein isoforms in hippocampus in stress rats. Exp. Biol. Med. (Maywood) 231 (2006) 1564-1568
6. De Souza E.B., and Van Loon G.R. Brain serotonin and catecholamine responses to repeated stress in rats. Brain Res. 367 (1986) 77-86
7. Faro L.R., do Nascimento J.L., Alfonso M., and Duran R. In vivo effects of inorganic mercury (HgCl(2)) on striatal dopaminergic system. Ecotoxicol. Environ. Saf. 48 (2001) 263-267
8. Faro L.R., do Nascimento J.L., San Jose J.M., Alfonso M., and Duran R. Intrastriatal administration of methylmercury increases in vivo dopamine release. Neurochem. Res. 25 (2000) 225-229
9. Faro L.R., Duran R., do Nascimento J.L., Alfonso M., and Picanco-Diniz C.W. Effects of methyl mercury on the in vivo release of dopamine and its acidic metabolites DOPAC and HVA from striatum of rats. Ecotoxicol. Environ. Saf. 38 (1997) 95-98
10. Giralt M., Penkowa M., Lago N., Molinero A., and Hidalgo J. Metallothionein-1 + 2 protect the CNS after a focal brain injury. Exp. Neurol. 173 (2002) 114-128
11. Goldman-Rakic P.S. Working memory and the mind. Sci. Am. 267 (1992) 110-117
12. Goldman-Rakic P.S. Cellular basis of working memory. Neuron 14 (1995) 477-485
13. Goldman-Rakic P.S. Regional and cellular fractionation of working memory. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 13473-13480
14. Goulet S., Dore F.Y., and Mirault M.E. Neurobehavioral changes in mice chronically exposed to methylmercury during fetal and early postnatal development. Neurotoxicol. Teratol. 25 (2003) 335-347
15. Griebel G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol. Ther. 65 (1995) 319-395
16. Hamer D.H. Metallothionein. Ann. Rev. Biochem. 55 (1986) 913-951
17. Havarinasab S., Lambertsson L., Qvarnstrom J., and Hultman P. Dose-response study of thimerosal-induced murine systemic autoimmunity. Toxicol. Appl. Pharmacol. 194 (2004) 169-179
18. Hornig M., Chian D., and Lipkin W.I. Neurotoxic effects of postnatal thimerosal are mouse strain dependent. Mol. Psychiatry 9 (2004) 833-845
19. Hritcu L., Clicinschi M., and Nabeshima T. Brain serotonin depletion impairs short-term memory, but not long-term memory in rats. Physiol. Behav. 91 (2007) 652-657
20. Hultman P., and Enestrom S. Dose-response studies in murine mercury-induced autoimmunity and immune-complex disease. Toxicol. Appl. Pharmacol. 113 (1992) 199-208
21. Hultman P., and Hansson-Georgiadis H. Methyl mercury-induced autoimmunity in mice. Toxicol. Appl. Pharmacol. 154 (1999) 203-211
22. Jakab R.L., and Goldman-Rakic P.S. Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex. J. Comp. Neurol. 417 (2000) 337-348
23. Kagi J.H., and Schaffer A. Biochemistry of metallothionein. Biochemistry 27 (1988) 8509-8515
24. Kelly E.J., Quaife C.J., Froelick G.J., and Palmiter R.D. Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J. Nutr. 126 (1996) 1782-1790
25. Lazo J.S., Kondo Y., Dellapiazza D., Michalska A.E., Choo K.H., and Pitt B.R. Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem. 270 (1995) 5506-5510
26. Levin E.D., Perraut C., Pollard N., and Freedman J.H. Metallothione in expression and neurocognitive function in mice. Physiol. Behav. 87 (2006) 513-518
27. Liu J., Corton C., Dix D.J., Liu Y., Waalkes M.P., and Klaassen C.D. Genetic background but not metallothionein phenotype dictates sensitivity to cadmium-induced testicular injury in mice. Toxicol. Appl. Pharmacol. 176 (2001) 1-9
28. Masters B.A., Kelly E.J., Quaife C.J., Brinster R.L., and Palmiter R.D. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 584-588
29. Matsuo M., Kataoka Y., Mataki S., Kato Y., and Oi K. Conflict situation increases serotonin release in rat dorsal hippocampus: in vivo study with microdialysis and Vogel test. Neurosci. Lett. 215 (1996) 197-200
30. Nielson K.B., Atkin C.L., and Winge D.R. Distinct metal-binding configurations in metallothionein. J. Biol. Chem. 260 (1985) 5342-5350
31. Park J.D., Liu Y., and Klaassen C.D. Protective effect of metallothionein against the toxicity of cadmium and other metals(1). Toxicology 163 (2001) 93-100
32. Peixoto N.C., Roza T., Morsch V.M., and Pereira M.E. Behavioral alterations induced by HgCl2 depend on the postnatal period of exposure. Int. J. Dev. Neurosci. 25 (2007) 39-46
33. Penkowa M., Giralt M., Camats J., and Hidalgo J. Metallothionein 1 + 2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide. J. Comp. Neurol. 444 (2002) 174-189
34. Phillips A.G., Ahn S., and Floresco S.B. Magnitude of dopamine release in medial prefrontal cortex predicts accuracy of memory on a delayed response task. J. Neurosci. 24 (2004) 547-553
35. Pratt W.E., and Mizumori S.J. Neurons in rat medial prefrontal cortex show anticipatory rate changes to predictable differential rewards in a spatial memory task. Behav. Brain Res. 123 (2001) 165-183
36. Rex A., Marsden C.A., and Fink H. Effect of diazepam on cortical 5-HT release and behaviour in the guinea-pig on exposure to the elevated plus maze. Psychopharmacology (Berl.) 110 (1993) 490-496
37. Rofe A.M., Philcox J.C., and Coyle P. Trace metal, acute phase and metabolic response to endotoxin in metallothionein-null mice. Biochem. J. 314 Pt 3 (1996) 793-797
38. Rossetti Z.L., and Carboni S. Noradrenaline and dopamine elevations in the rat prefrontal cortex in spatial working memory. J. Neurosci. 25 (2005) 2322-2329
39. Rueter L.E., and Jacobs B.L. A microdialysis examination of serotonin release in the rat forebrain induced by behavioral/environmental manipulations. Brain Res. 739 (1996) 57-69
40. Satoh M. Analysis of toxicity using metallothionein knockout mice. Yakugaku Zasshi 127 (2007) 709-717
41. Snedecor G.W., and Cochran W.G. Statistical Methods (1967), Iowa State University Press, Ames, Iowa
42. Stennard F.A., Holloway A.F., Hamilton J., and West A.K. Characterisation of six additional human metallothionein genes. Biochim. Biophys. Acta 1218 (1994) 357-365
43. Storey J.D., Robertson D.A., Beattie J.E., Reid I.C., Mitchell S.N., and Balfour D.J. Behavioural and neurochemical responses evoked by repeated exposure to an elevated open platform. Behav. Brain Res. 166 (2006) 220-229
44. Verkes R.J., Gijsman H.J., Pieters M.S., Schoemaker R.C., de Visser S., Kuijpers M., Pennings E.J., de Bruin D., Van de Wijngaart G., Van Gerven J.M., and Cohen A.F. Cognitive performance and serotonergic function in users of ecstasy. Psychopharmacology (Berl.) 153 (2001) 196-202
45. Warfvinge K., Hansson H., and Hultman P. Systemic autoimmunity due to mercury vapor exposure in genetically susceptible mice: dose-response studies. Toxicol. Appl. Pharmacol. 132 (1995) 299-309
46. Watanabe M., Kodama T., and Hikosaka K. Increase of extracellular dopamine in primate prefrontal cortex during a working memory task. J. Neurophysiol. 78 (1997) 2795-2798
47. Wright I.K., Upton N., and Marsden C.A. Effect of established and putative anxiolytics on extracellular 5-HT and 5-HIAA in the ventral hippocampus of rats during behaviour on the elevated X-maze. Psychopharmacology (Berl.) 109 (1992) 338-346
48. Yoshida M., Watanabe C., Horie K., Satoh M., Sawada M., and Shimada A. Neurobehavioral changes in metallothionein-null mice prenatally exposed to mercury vapor. Toxicol. Lett. 155 (2005) 361-368
49. Yoshida M., Watanabe C., Kishimoto M., Yasutake A., Satoh M., Sawada M., and Akama Y. Behavioral changes in metallothionein-null mice after the cessation of long-term, low-level exposure to mercury vapor. Toxicol. Lett. 161 (2006) 210-218