Higher Plasma Concentration of Food-Specific Antibodies in Persons With Autistic Disorder in Comparison to Their Siblings

Focus on Autism and Other Developmental Disabilities

Volumn 23, Issue 3, 2008, Pages 176-185

  Trajkovski, Vladimir ^a   Petlichkovski, Aleksandar ^a   Efinska Mladenovska, Olivija ^a   Trajkov, Dejan ^a   Arsov, Todor ^a   Strezova, Ana ^a   Ajdinski, Ljubomir ^a   Spiroski, Mirko ^a  

^a SS CYRIL AND METHODIUS UNIVERSITY OF SKOPJE   (Macedonia)

Author keywords

autistic disorder; diet; family

Indexed keywords

EID: 84993767921     PISSN: 10883576     EISSN: None     Source Type: Journal    
DOI: 10.1177/1088357608320413     Document Type: Article

References (56)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
2. Ashwood, P., Wills, S., & Van De Water, J. (2006). The immune response in autism: A new frontier for autism research. Journal of Leukocyte Biology, 80, 1-15.
3. Black, C., Kaye, J.A., & Jick, H. (2002). Relation of childhood gastrointestinal disorders to autism: Nested case-control study using data from the UK General Practice Research Database. British Medical Journal, 325(7361), 419-421.
4. Connolly, A.M., Chez, M.G., Pestronk, A., Arnold, S.T., Mehta, S., & Deuel, R.K. (1999). Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders. Journal of Pediatrics, 134, 607-613.
5. Correa, S.G., Maccioni, M., Rivero, V.E., Iribarren, P., Sotomayor, C.E., & Riera, C.M. (2007). Cytokines and the immuneneuroendocrine network: What did we learn from infection and autoimmunity? Cytokine and Growth Factor Reviews, 18(1/2), 125-134.
6. Croonenberghs, J., Wauters, A., Devreese, K., Verkerk, R., Scharpe, S., Bosmans, E., et al. (2002). Increased serum albumin, gamaglobulin, immunoglobulin IgG, and IgG2 and IgG4 in autism. Psychological Medicine, 32, 1457-1463.
7. Egger, J., Stolla, A., & McEwen, L.M. (1992). Controlled trial of hyposensitization in children with food-induced hyperkinetic syndrome. Lancet, 339, 1150-1153.
8. Engstrom, A.H., Ohlson, S., Stubbs, E.G., Maciulus, A., Caldwell, V., Odell, J.D., et al. (2003). Decreased expression of CD95 (FAS/APO-1) on CD4+ T-lymphocytes from participants with autism. Journal of Developmental and Physical Disabilities, 15, 155-163.
9. Ermisch, A., Ruhle, H.J., Neubert, K., Hartrodt, B., & Landgraf, R. (1983). On the blood-brain barrier to peptides: [3H]beta-casomorphin-5 uptake by eighteen brain regions in vivo. Journal of Neurochemistry, 41, 1229-1233.
10. Gupta, S., Aggarwal, S., Rashanravan, B., & Lee, T. (1998). Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism. Journal of Neuroimmunology, 85, 106-109.
11. Hole, K., Bergslien, H., Jorgensen, H.A., Berge, O.G., Reichelt, K.L., & Trygstad, O.E. (1979). A peptide-containing fraction in the urine of schizophrenic patients which stimulates opiate receptors and inhibits dopamine uptake. Neuroscience, 4, 1883-1893.
12. Horvath, K., Papadimitriou, J.C., Rabsztyn, A., Drachenberg, C., & Tildon, J.T. (1999). Gastrointestinal abnormalities in children with autistic disorder. Journal of Pediatrics, 135, 559-563.
13. Horvath, K., & Perman, J.A. (2002). Autism and gastrointestinal symptoms. Current Gastroenterology Reports, 4, 251-258.
14. Jyonouchi, H., Geng, L., Ruby, A., & Zimmerman-Bier, B. (2005). Dysregulated innate immune responses in young children with autistic disorders: their relationship to gastrointestinal symptoms and dietary intervention. Neuropsychobiology, 51, 77-85.
15. Jyonouchi, H., Sun, S., & Itokazu, N. (2002). Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autistic disorder. Neuropsychobiology, 46, 76-84.
16. Jyonouchi, H., Sun, S., & Le, H. (2001). Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autistic disorders and developmental regression. Journal of Neuroimmunology, 120, 170-179.
17. Kalyoncu, A.F., & Stalenheim, G. (1992). Serum IgE levels and allergic spectra in immigrants to Sweden. Allergy, 47(4, Part 1), 277-280.
18. Kidd, P.M. (2002). Autism, an extreme challenge to integrative medicine: Part 2. Medical management. Alternative Medicine Review, 7, 472-499.
19. Knivsberg, A.M., Reichelt, K.L., Hoien, T., & Nodland, M. (2002). A randomized controlled study of dietary intervention in autistic syndromes. Nutritional Neuroscience, 5, 251-261.
20. Knivsberg, A.M., Reichelt, K.L., & Nodland, M. (2001). Reports on dietary intervention in autistic disorders. Nutritional Neuroscience, 4, 5-37.
21. Lucarelli, S., Frediani, T., Zingoni, A.M., Ferruzzi, F., Giardini, O., Quintieri, F., et al. (1995). Food allergy and infantile autism. Panminerva Medica, 37, 137-141.
22. Martin, C.M., Uhlmann, N.V., Killalea, A., Sheils, O., & O'Leary, J.J. (2002). Detection of measles virus in children with ileocolonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder. Molecular Psychiatry, 7(Suppl. 2), S47-S48.
23. Murch, S. (2005). Diet, immunity, and autistic spectrum disorders. Journal of Pediatrics, 146, 582-584.
24. Nyberg, F., Lieberman, H., Lindstrom, L.H., Lyrenas, S., Koch, G., & Terenius, L. (1989). Immunoreactive beta-casomorphin-8 in cerebrospinal fluid from pregnant and lactating women: Correlation with plasma levels. Journal of Clinical Endocrinology and Metabolism, 68, 283-289.
25. Odell, D., Maciulis, A., Cutler, A., Warren, L., McMahon, W.M., Coon, H., et al. (2005). Confirmation of the association of the C4B null allelle in autism. Human Immunology, 66, 140-145.
26. Pasare, C., & Medzhitov, R. (2003). Toll like receptors: Balancing host resistance with immune tolerance. Current Opinion in Immunology, 15, 677-682.
27. Peova, S. (1993). Serumski IgE vo fizioloshki imun odgovor i patologija na deteto [Serum IgE in physiological immune response and pathology of the child]. Unpublished doctoral thesis, University Ss. Kiril and Metodij, Skopje, Republic of Macedonia.
28. Pereira Vega, A., Sanchez Ramos, J.L., Maldonado Perez, J.A., Ayerbe Garcia, R., Gomez Entrena, M., & Gravalos Guzman, J. (1997). Relación entre asma y atopia marcadores en niños y adultos jóvenes [Relation between asthma and atopy markers in children and young adults]. Archivos de Bronconeumologia, 33, 272-277.
29. Plioplys, A.V., Greaves, A., Kazemi, K., & Silverman, E. (1994). Lymphocyte function in autism and Rett syndrome. Neuropsychobiology, 29, 12-16.
30. Reichelt, K.L., & Knivsberg, A.M. (2003). Can the pathophysiology of autism be explained by the nature of discovered urine peptides? Nutritional Neuroscience, 6, 19-28.
31. Sapigni, T., Biavati, P., Simoni, M., Viegi, G., Baldacci, S., Carrozzi, L., et al. (1998). The Po River Delta Respiratory Epidemiological Survey: An analysis of factors related to level of total serum IgE. European Respiratory Journal, 11, 278-283.
32. Silva, S.C., Correia, C., Fesel, C., Barreto, M., Coutinho, A.M., Marques, C., et al. (2004). Autoantibody repertoires to brain tissue in autism nuclear families. Journal of Neuroimmunology, 152, 176-182.
33. Singh, V.K. (1996). Plasma increase of interleukin-12 and interferon-gama. Pathological significance in autism. Journal of Neuroimmunology, 66, 143-145.
34. Singh, V.K., Warren, R., Averett, R., & Ghaziuddin, M. (1997). Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatric Neurology, 17, 88-90.
35. Singh, V.K., Warren, R.P., Odell, J.D., Warren, W.L., & Cole, P. (1993). Antibodies to myelin basic protein in children with autistic behavior. Brain, Behavior, and Immunity, 7, 97-103.
36. Stubbs, E.G., & Crawford, M.L. (1977). Depressed lymphocyte responsiveness in autistic children. Journal of Autism and Childhood Schizophrenia, 7, 49-55.
37. Sweeten, T.L., Bowyer, S.L., Posey, D.J., Halberstadt, G.M., & McDougle, C.J. (2003). Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics, 112, e420.
38. Todd, R.D., Hickok, J.M., Anderson, G.M., & Cohen, D.J. (1988). Antibrain antibodies in infantile autism. Biological Psychiatry, 23, 644-647.
39. Torrente, F., Ashwood, P., Day, R., Machado, N., Furlano, R.I., Anthony, A., et al. (2002). Small intestinal enteropathy with epitelial IgA and complement deposition in children with regressive autism. Molecular Psychiatry, 7, 375-382.
40. Torres, A.R., Maciulis, A., & Odell, D. (2001). The association of MHC genes with autism. Frontiers in Bioscience, 6, D936-D943.
41. Trajkovski, V., Ajdinski, L., & Spiroski, M. (2004). Plasma concentration of immunoglobulin classes and subclasses in children with autism in the Republic of Macedonia: Retrospective study. Croatian Medical Journal, 45, 746-749.
42. Tryphonas, H., & Trites, R. (1979). Food allergy in children with hyperactivity, learning disabilities and/or minimal brain dysfunction. Annals of Allergy, Asthma, and Immunology, 42, 22-27.
43. Uhlmann, V., Martin, C.M., Sheils, O., Pilkington, L., Silva, I., Killalea, A., et al. (2002). Potential viral pathogenic mechanism for new variants in inflammatory bowel disease. Journal of Clinical Pathology, 55, 84-90.
44. Vojdani, A., Bazargan, M., Vojdani, E., Samadi, J., Nourian, A.A., Eghbalieh, N., et al. (2004). Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease. Clinical and Diagnostic Laboratory Immunology, 11(3), 15-24.
45. Vojdani, A., Campbell, A.W., Anyanwu, E., Kashanian, A., Bock, K., & Vojdani, E. (2002). Antibodies to neuron-specific antigens in children with autism: Possible cross-reaction with encephalitogenic proteins from milk, Chlamydia Pneumoniae and Streptococcus group A. Journal of Neuroimmunology, 129(1/2), 168-177.
46. Vojdani, A., Campbell, A.W., Anyanwu, E., Kashanian, A., Bock, K., & Vojdani, E. Erratum in Journal of Neuroimmunology, 130(1/2), 248.
47. Vojdani, A., O'Bryan, T., Green, J.A., McCandless, J., Woeller, K.D., Vojdani, E., et al. (2004). Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutritional Neuroscience, 7, 151-161.
48. Vojdani, A., Pangborn, J.B., Vojdani, E., & Cooper, E.L. (2003). Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism. International Journal of Immunopathology and Pharmacology, 16, 189-199.
49. Wakefield, A.J. (1999). MMR vaccination and autism. Lancet, 11, 949-950.
50. Wakefield, A.J., Anthony, A., Murch, S.H., Thomson, M., Montgomery, S.M., Davies, S., et al. (2000). Enterocolitis in children with developmental disorders. American Journal of Gastroenterology, 95, 2285-2295.
51. Warren, R.P., Margaretten, N.C., Pace, N.C., & Foster, A. (1986). Immune abnormalities in patients with autism. Journal of Autism and Developmental Disorders, 16, 189-197.
52. Warren, R.P., Yonk, L.J., Burger, R.A., Cole, P., Odell, J.D., Warren, W.L., et al. (1990). Deficiency of suppressor-inducer (CD4+CD45RA+) T cells in autism. Immunological Investigations, 19, 245-251.
53. White, J.F. (2003). Intestinal pathophysiology in autism. Experimental Biology and Medicine, 228, 639-649.
54. World Health Organization. (1992). The ICD-10 Classification of Mental and Behavioral Health. Geneva, Switzerland: Author.
55. Woof, J., & Burton, D. (2004). Human antibody-Fc receptor interactions illuminated by crystal structures. Nature Reviews Immunology, 4, 89-99.
56. Yonk, L.J., Warren, R.P., Burger, R.A., Cole, P., Odell, J.D., Warren, W.L., et al. (1990). CD4+ helper T cell depression in autism. Immunology Letters, 25, 341-345.