Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-α receptor

Biochemical and Biophysical Research Communications

Volumn 478, Issue 3, 2016, Pages 1436-1441

  Zhang, Yao ^a   Yang, Lihua ^a   Wang, Hao ^a   Zhang, Guocheng ^a   Sun, Xin ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Interferon receptor; miR 29a; Non structural protein 1; Replication; Respiratory syncytial virus

Indexed keywords

ALPHA INTERFERON RECEPTOR; MICRORNA 29A; NONSTRUCTURAL PROTEIN 1; ALPHA BETA INTERFERON RECEPTOR; MICRORNA; MIRN29 MICRORNA, HUMAN; VIRAL PROTEIN;

3' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN RESPIRATORY SYNCYTIAL VIRUS; LUCIFERASE ASSAY; PLAQUE ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VECTOR CONTROL; VIRUS REPLICATION; VIRUS TITRATION; WESTERN BLOTTING; A-549 CELL LINE; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; RESPIRATORY SYNCYTIAL VIRUS INFECTION;

A549 CELLS; HUMANS; MICRORNAS; RECEPTOR, INTERFERON ALPHA-BETA; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; TRANSFECTION; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84992755478     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.08.142     Document Type: Article

References (30)

1. [1] Collins, P.L., Respiratory syncytial virus and metapneumovirus. Fields, B.N., Knipe, D.M., Howley, P.M., (eds.) Fields Virology, 2007, Lippincott Williams & Wilkins, Philadelphia, 1601–1646.
2. [2] Foronjy, R.F., Dabo, A.J., Taggart, C.C., Weldon, S., Geraghty, P., Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice. PloS One, 9, 2014, e90567.
3. [3] Moore, E.C., Barber, J., Tripp, R.A., Respiratory syncytial virus (RSV) attachment and nonstructural proteins modify the type I interferon response associated with suppressor of cytokine signaling (SOCS) proteins and IFN-stimulated gene-15 (ISG15). Virol. J., 5, 2008, 116.
4. [4] Spann, K.M., Tran, K.C., Chi, B., Rabin, R.L., Collins, P.L., Suppression of the induction of alpha, beta, and gamma interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages. J. Virol. 78 (2004), 4363–4369.
5. [5] McNab, F., Mayer-Barber, K., Sher, A., Wack, A., O'Garra, A., Type I interferons in infectious disease. Nat. Rev. Immunol. 15 (2015), 87–103.
6. [6] Platanias, L.C., Mechanisms of type-I-and type-II-interferon-mediated signalling. Nat. Rev. Immunol. 5 (2005), 375–386.
7. [7] Dill, M.T., Makowska, Z., Trincucci, G., Gruber, A.J., Vogt, J.E., Filipowicz, M., Calabrese, D., Krol, I., Lau, D.T., Terracciano, L., Pegylated IFN-α regulates hepatic gene expression through transient Jak/STAT activation. J. Clin. Investig. 124 (2014), 1568–1581.
8. [8] Prestwood, T.R., Morar, M.M., Zellweger, R.M., Miller, R., May, M.M., Yauch, L.E., Lada, S.M., Shresta, S., Gamma interferon (IFN-γ) receptor restricts systemic dengue virus replication and prevents paralysis in IFN-α/β receptor-deficient mice. J. Virol. 86 (2012), 12561–12570.
9. [9] Colpitts, S.L., Stoklasek, T.A., Plumlee, C.R., Obar, J.J., Guo, C., Lefrançois, L., Cutting edge: the role of IFN-α receptor and MyD88 signaling in induction of IL-15 expression in vivo. J. Immunol. 188 (2012), 2483–2487.
10. [10] Metidji, A., Rieder, S.A., Glass, D.D., Cremer, I., Punkosdy, G.A., Shevach, E.M., IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions. J. Immunol. 194 (2015), 4265–4276.
11. [11] Lim, L.P., Lau, N.C., Garrett-Engele, P., Grimson, A., Schelter, J.M., Castle, J., Bartel, D.P., Linsley, P.S., Johnson, J.M., Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433 (2005), 769–773.
12. [12] Zhang, G.L., Li, Y.X., Zheng, S.Q., Liu, M., Li, X., Tang, H., Suppression of hepatitis B virus replication by microRNA-199a-3p and microRNA-210. Antivir. Res. 88 (2010), 169–175.
13. [13] Othumpangat, S., Walton, C., Piedimonte, G., MicroRNA-221 modulates RSV replication in human bronchial epithelium by targeting NGF expression. PLoS One, 7, 2012, e30030.
14. [14] Bakre, A., Wu, W., Hiscox, J., Spann, K., Teng, M.N., Tripp, R.A., Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-β. J. Gen. Virol. 96 (2015), 3179–3191.
15. [15] Bakre, A., Mitchell, P., Coleman, J.K., Jones, L.P., Saavedra, G., Teng, M., Tompkins, S.M., Tripp, R.A., Respiratory syncytial virus modifies microRNAs regulating host genes that affect virus replication. J. Gen. Virol. 93 (2012), 2346–2356.
16. [16] Al-Afif, A., Alyazidi, R., Oldford, S.A., Huang, Y.Y., King, C.A., Marr, N., Haidl, I.D., Anderson, R., Marshall, J.S., Respiratory syncytial virus infection of primary human mast cells induces the selective production of type I interferons, CXCL10, and CCL4. J. Allergy Clin. Immunol. 136 (2015), 1346–1354.
17. [17] LaBarre, D.D., Lowy, R.J., Improvements in methods for calculating virus titer estimates from TCID 50 and plaque assays. J. Virol. Methods 96 (2001), 107–126.
18. [18] Betel, D., Wilson, M., Gabow, A., Marks, D.S., Sander, C., The microRNA. org resource: targets and expression. Nucleic Acids Res. 36 (2008), D149–D153.
19. [19] Bergmann, M., Garcia-Sastre, A., Carnero, E., Pehamberger, H., Wolff, K., Palese, P., Muster, T., Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication. J. Virol. 74 (2000), 6203–6206.
20. [20] Zitvogel, L., Galluzzi, L., Kepp, O., Smyth, M.J., Kroemer, G., Type I interferons in anticancer immunity. Nat. Rev. Immunol. 15 (2015), 405–414.
21. [21] Lo, M.S., Brazas, R.M., Holtzman, M.J., Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness. J. Virol. 79 (2005), 9315–9319.
22. [22] Boyapalle, S., Wong, T., Garay, J., Teng, M., San Juan-Vergara, H., Mohapatra, S., Mohapatra, S., Respiratory syncytial virus NS1 protein colocalizes with mitochondrial antiviral signaling protein MAVS following infection. PLoS One, 7, 2012, e29386.
23. [23] Spann, K.M., Tran, K.C., Collins, P.L., Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-κB, and proinflammatory cytokines. J. Virol. 79 (2005), 5353–5362.
24. [24] Subramaniam, S., Kwon, B., Beura, L.K., Kuszynski, C.A., Pattnaik, A.K., Osorio, F.A., Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-κB and Sp1. Virology 406 (2010), 270–279.
25. [25] Bossert, B., Marozin, S., Conzelmann, K.K., Nonstructural proteins NS1 and NS2 of bovine respiratory syncytial virus block activation of interferon regulatory factor 3. J. Virol. 77 (2003), 8661–8668.
26. [26] Jia, D., Rahbar, R., Chan, R.W., Lee, S.M., Chan, M.C., Wang, B.X., Baker, D.P., Sun, B., Peiris, J.M., Nicholls, J.M., Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling. PLoS One, 5, 2010, e13927.
27. [27] Ding, S.W., Voinnet, O., Antiviral immunity directed by small RNAs. Cell 130 (2007), 413–426.
28. [28] Gebeshuber, C.A., Zatloukal, K., Martinez, J., miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. EMBO Rep. 10 (2009), 400–405.
29. [29] Ahluwalia, J.K., Khan, S.Z., Soni, K., Rawat, P., Gupta, A., Hariharan, M., Scaria, V., Lalwani, M., Pillai, B., Mitra, D., Human cellular microRNA hsa-miR-29a interferes with viral nef protein expression and HIV-1 replication. Retrovirology, 5, 2008, 117.
30. [30] Papadopoulou, A.S., Dooley, J., Linterman, M.A., Pierson, W., Ucar, O., Kyewski, B., Zuklys, S., Hollander, G.A., Matthys, P., Gray, D.H., The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-[alpha] receptor. Nat. Immunol. 13 (2012), 181–187.