Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3

Breast Cancer Research and Treatment

Volumn 161, Issue 1, 2017, Pages 117-134

  Hamdi, Yosr ^a   Soucy, Penny ^a   Kuchenbaeker, Karoline B ^b,c   Pastinen, Tomi ^d   Droit, Arnaud ^a   Lemaçon, Audrey ^a   Adlard, Julian ^e   Aittomäki, Kristiina ^f   Andrulis, Irene L ^g,h   Arason, Adalgeir ^i,j   Arnold, Norbert ^k   Arun, Banu K ^l   Azzollini, Jacopo ^m   Bane, Anita ⁿ   Barjhoux, Laure ^o   Barrowdale, Daniel ^b   Benitez, Javier ^p,q   Berthet, Pascaline ^r   Blok, Marinus J ^s   Bobolis, Kristie ^t   Bonadona, Valérie ^o   Bonanni, Bernardo ^u   Bradbury, Angela R ^v   Brewer, Carole ^w   Buecher, Bruno ^x   Buys, Saundra S ^y   Caligo, Maria A ^z   Chiquette, Jocelyne ^aa   Chung, Wendy K ^ab   Claes, Kathleen B M ^ac   Daly, Mary B ^ad   Damiola, Francesca ^o   Davidson, Rosemarie ^ae   De la Hoya, Miguel ^af   De Leeneer, Kim ^ac   Diez, Orland ^ag   Ding, Yuan Chun ^t   Dolcetti, Riccardo ^ah,ai   Domchek, Susan M ^v   Dorfling, Cecilia M ^aj   Eccles, Diana ^ak   Eeles, Ros ^al   Einbeigi, Zakaria ^am   Ejlertsen, Bent ^an   Engel, Christoph ^ao   Gareth Evans, D ^ap   Feliubadalo, Lidia ^aq   Foretova, Lenka ^ar   Fostira, Florentia ^as   Foulkes, William D ^d   Fountzilas, George ^at   Friedman, Eitan ^au,av   Frost, Debra ^b   Ganschow, Pamela ^t   Ganz, Patricia A ^aw   Garber, Judy ^ax   Gayther, Simon A ^ay   Gerdes, Anne Marie ^an   Glendon, Gord ^g   Godwin, Andrew K ^az   Goldgar, David E ^ba   Greene, Mark H ^bb   Gronwald, Jacek ^bc   Hahnen, Eric ^bd   Hamann, Ute ^be   Hansen, Thomas V O ^an   Hart, Steven ^bf   Hays, John L ^bg,bh   Hogervorst, Frans B L ^bi   Hulick, Peter J ^bj   Imyanitov, Evgeny N ^bk   Isaacs, Claudine ^bl   Izatt, Louise ^bm   Jakubowska, Anna ^bc   James, Paul ^bn,bo   Janavicius, Ramunas ^bp,bq   Jensen, Uffe Birk ^br   John, Esther M ^bs,bt   Joseph, Vijai ^bu   Just, Walter ^bv   Kaczmarek, Katarzyna ^bc   Karlan, Beth Y ^bw   Kets, Carolien M ^bx   Kirk, Judy ^by   Kriege, Mieke ^bz   Laitman, Yael ^au   Laurent, Maïté ^x   Lazaro, Conxi ^aq   Leslie, Goska ^b   Lester, Jenny ^bw   Lesueur, Fabienne ^ca   Liljegren, Annelie ^cb   Loman, Niklas ^cc   Loud, Jennifer T ^bb   Manoukian, Siranoush ^m   Mariani, Milena ^m   Mazoyer, Sylvie ^cd   McGuffog, Lesley ^b   Meijers Heijboer, Hanne E J ^ce   Meindl, Alfons ^k   Miller, Austin ^cf   Montagna, Marco ^cg   Mulligan, Anna Marie ^h,ch   Nathanson, Katherine L ^v   Neuhausen, Susan L ^t   Nevanlinna, Heli ^ci   Nussbaum, Robert L ^cj   Olah, Edith ^ck   Olopade, Olufunmilayo I ^cl   Ong, Kai ren ^cm   Oosterwijk, Jan C ^cn   Osorio, Ana ^p,q   Papi, Laura ^co   Park, Sue Kyung ^cp   Pedersen, Inge Sokilde ^cq   Peissel, Bernard ^m   Segura, Pedro Perez ^af   Peterlongo, Paolo ^cr   Phelan, Catherine M ^cs   Radice, Paolo ^m   Rantala, Johanna ^cb   Rappaport Fuerhauser, Christine ^ct   Rennert, Gad ^cu   Richardson, Andrea ^cv   Robson, Mark ^bu   Rodriguez, Gustavo C ^bj   Rookus, Matti A ^bi   Schmutzler, Rita Katharina ^bd   Sevenet, Nicolas ^cw   Shah, Payal D ^v   Singer, Christian F ^ct   Slavin, Thomas P ^t   Snape, Katie ^cx   Sokolowska, Johanna ^cy   Sønderstrup, Ida Marie Heeholm ^cz   Southey, Melissa ^bo   Spurdle, Amanda B ^da   Stadler, Zsofia ^bu   Stoppa Lyonnet, Dominique ^x   Sukiennicki, Grzegorz ^bc   Sutter, Christian ^db   Tan, Yen ^ct   Tea, Muy Kheng ^ct   Teixeira, Manuel R ^dc,dd   Teulé, Alex ^aq   Teo, Soo Hwang ^de,df   Terry, Mary Beth ^ab   Thomassen, Mads ^dg   Tihomirova, Laima ^dh   Tischkowitz, Marc ^d,di   Tognazzo, Silvia ^cg   Toland, Amanda Ewart ^bh   Tung, Nadine ^dj   van den Ouweland, Ans M W ^bz   van der Luijt, Rob B ^dk   van Engelen, Klaartje ^dl   van Rensburg, Elizabeth J ^aj   Varon Mateeva, Raymonda ^dm   Wappenschmidt, Barbara ^bd   Wijnen, Juul T ^dn   Rebbeck, Timothy ^v,do   Chenevix Trench, Georgia ^da   Offit, Kenneth ^bu   Couch, Fergus J ^bf   Nord, Silje ^dp   Easton, Douglas F ^b   Antoniou, Antonis C ^b   Simard, Jacques ^a   more..

^a University Laval   (Canada)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d MCGILL UNIVERSITY   (Canada)

^e CHAPEL ALLERTON HOSPITAL   (United Kingdom)

^f HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^g MOUNT SINAI HOSPITAL   (Canada)

^h UNIVERSITY OF TORONTO   (Canada)

ⁱ University of Toronto ^*  (Iceland)

^j UNIVERSITY OF ICELAND   (Iceland)

^k UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^l UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^m NATIONAL CANCER INSTITUTE   (Italy)

ⁿ MCMASTER UNIVERSITY   (Canada)

^o CENTRE LÉON BÉRARD   (France)

^p Structural Biology and Biocomputing Programme   (Spain)

^q CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^r CENTRE FRANÇOIS BACLESSE   (France)

^s MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^t CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^u EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^v UNIVERSITY OF PENNSYLVANIA   (United States)

^w ROYAL DEVON AND EXETER HOSPITAL   (United Kingdom)

^x INSTITUT CURIE   (France)

^y UNIVERSITY OF UTAH   (United States)

^z UNIVERSITY HOSPITAL OF PISA   (Italy)

^aa LAVAL UNIVERSITY   (Canada)

^ab University and University Hospital of Pisa ^*  (United States)

^ac GHENT UNIVERSITY   (Belgium)

^ad FOX CHASE CANCER CENTER   (United States)

^ae QUEEN ELIZABETH UNIVERSITY HOSPITAL   (United Kingdom)

^af HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^ag HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^ah CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^ai UNIVERSITY OF QUEENSLAND   (Australia)

^aj UNIVERSITY OF PRETORIA   (South Africa)

^ak UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^al INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^am SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^an Rigshospitalet   (Denmark)

^ao UNIVERSITY OF LEIPZIG   (Germany)

^ap UNIVERSITY OF MANCHESTER   (United Kingdom)

^aq CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^ar MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

^as INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^at ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^au SHEBA MEDICAL CENTER   (Israel)

^av TEL AVIV UNIVERSITY   (Israel)

^aw UNIVERSITY OF CALIFORNIA   (United States)

^ax DANA FARBER CANCER INSTITUTE   (United States)

^ay UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^az UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^ba UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^bb NATIONAL CANCER INSTITUTE   (United States)

^bc POMERANIAN MEDICAL UNIVERSITY   (Poland)

^bd UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^be GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^bf MAYO CLINIC   (United States)

^bg OHIO STATE UNIVERSITY   (United States)

^bh OHIO STATE UNIVERSITY   (United States)

^bi NETHERLANDS CANCER INSTITUTE   (Netherlands)

^bj NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^bk N N PETROV RESEARCH INSTITUTE OF ONCOLOGY   (Russian Federation)

^bl GEORGETOWN UNIVERSITY   (United States)

^bm GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^bn PETER MACCALLUM CANCER CENTRE   (Australia)

^bo UNIVERSITY OF MELBOURNE   (Australia)

^bp VILNIUS UNIVERSITY   (Lithuania)

^bq State Research Institute Centre for Innovative Medicine   (Lithuania)

^br AARHUS UNIVERSITY HOSPITAL   (Denmark)

^bs CANCER PREVENTION INSTITUTE OF CALIFORNIA   (United States)

^bt STANFORD CANCER INSTITUTE   (United States)

^bu MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^bv UNIVERSITY OF ULM   (Germany)

^bw CEDARS SINAI MEDICAL CENTER   (United States)

^bx RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^by WESTMEAD HOSPITAL   (Australia)

^bz ERASMUS MEDICAL CENTER   (Netherlands)

^ca INSERM U900   (France)

^cb KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^cc LUND UNIVERSITY HOSPITAL   (Sweden)

^cd UNIVERSITÉ DE LYON   (France)

^ce VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^cf ROSWELL PARK CANCER INSTITUTE   (United States)

^cg VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^ch ST MICHAEL'S HOSPITAL   (Canada)

^ci UNIVERSITY OF HELSINKI   (Finland)

^cj UNIVERSITY OF CALIFORNIA   (United States)

^ck NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^cl UNIVERSITY OF CHICAGO   (United States)

^cm BIRMINGHAM CHILDREN S HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^cn UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^co UNIVERSITY OF FLORENCE   (Italy)

^cp Seoul National University College of Medicine   (South Korea)

^cq AALBORG UNIVERSITY HOSPITAL   (Denmark)

^cr FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^cs H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^ct MEDICAL UNIVERSITY OF VIENNA   (Austria)

^cu CLALIT HEALTH SERVICES   (Israel)

^cv JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^cw INSTITUT BERGONIÉ   (France)

^cx ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^cy UNIVERSITÉ DE LORRAINE   (France)

^cz SLAGELSE HOSPITAL   (Denmark)

^da QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^db UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^dc PORTUGUESE ONCOLOGY INSTITUTE   (Portugal)

^dd UNIVERSITY OF PORTO   (Portugal)

^de CANCER RESEARCH INITIATIVES FOUNDATION   (Malaysia)

^df UNIVERSITY OF MALAYA   (Malaysia)

^dg ODENSE UNIVERSITY HOSPITAL   (Denmark)

^dh LATVIAN BIOMEDICAL RESEARCH AND STUDY CENTRE   (Latvia)

^di ADDENBROOKE S HOSPITAL   (United Kingdom)

^dj BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^dk UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^dl ACADEMIC MEDICAL CENTER   (Netherlands)

^dm CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^dn LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^do UNIVERSITY OF PENNSYLVANIA   (United States)

^dp OSLO UNIVERSITY HOSPITAL   (Norway)

more..

Author keywords

BRCA1 and BRCA2 mutation carriers; Breast cancer; Cis regulatory variants; Differential allelic expression; Genetic modifiers; Genetic susceptibility

Indexed keywords

ACAT1 GENE; ADULT; ARTICLE; ATM GENE; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CHROMOSOME 11Q; COMPUTER MODEL; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; NPAT GENE; ONCOGENE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR SUPPRESSOR GENE; ALLELE; BREAST TUMOR; CHROMOSOME 11; GENETIC PREDISPOSITION; GENETIC VARIATION; MUTATION; RISK;

TUMOR MARKER;

ALLELES; BIOMARKERS, TUMOR; BREAST NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 11; FEMALE; GENE EXPRESSION; GENES, BRCA1; GENES, BRCA2; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HETEROZYGOTE; HUMANS; MUTATION; QUANTITATIVE TRAIT LOCI; RISK;

EID: 84992735226     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-016-4018-2     Document Type: Article

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