Cross-Sectional Associations of Flow Reversal, Vascular Function, and Arterial Stiffness in the Framingham Heart Study

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 12, 2016, Pages 2452-2459

  Bretón Romero, Rosa ^b   Wang, Na ^a   Palmisano, Joseph ^a   Larson, Martin G ^a   Vasan, Ramachandran S ^a,b   Mitchell, Gary F ^c   Benjamin, Emelia J ^a,b   Vita, Joseph A ^a,b   Hamburg, Naomi M ^a,b  

^a BOSTON UNIVERSITY   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CARDIOVASCULAR ENGINEERING INC   (United States)

Author keywords

arterial stiffness; endothelium; epidemiology; hyperemia; vascular function

Indexed keywords

ADULT; ARTERIAL STIFFNESS; ARTERY BLOOD FLOW; ARTICLE; BRACHIAL ARTERY; CAROTID ARTERY PULSE; CONTROLLED STUDY; DIASTOLE; ENDOTHELIUM; FEMALE; FLOW RATE; FOREARM; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PERIPHERAL ARTERY FLOW REVERSAL; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; PULSE WAVE; VASCULAR RESISTANCE; VASODILATATION; AGED; AORTA; BLOOD FLOW; BLOOD FLOW VELOCITY; CARDIOVASCULAR DISEASES; CROSS-SECTIONAL STUDY; DIAGNOSTIC IMAGING; HYPEREMIA; MANOMETRY; MASSACHUSETTS; MULTIVARIATE ANALYSIS; NONLINEAR SYSTEM; ODDS RATIO; PATHOPHYSIOLOGY; PULSATILE FLOW; PULSED DOPPLER ULTRASONOGRAPHY; RISK FACTOR; STATISTICAL MODEL; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ADULT; AGED; AORTA; BLOOD FLOW VELOCITY; BRACHIAL ARTERY; CARDIOVASCULAR DISEASES; CROSS-SECTIONAL STUDIES; ENDOTHELIUM, VASCULAR; FEMALE; FOREARM; HUMANS; HYPEREMIA; LINEAR MODELS; MALE; MANOMETRY; MASSACHUSETTS; MIDDLE AGED; MULTIVARIATE ANALYSIS; NONLINEAR DYNAMICS; ODDS RATIO; PULSATILE FLOW; REGIONAL BLOOD FLOW; RISK FACTORS; ULTRASONOGRAPHY, DOPPLER, PULSED; VASCULAR RESISTANCE; VASCULAR STIFFNESS; VASODILATION;

EID: 84992688687     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.116.307948     Document Type: Article

References (42)

1. Silver AE, Vita JA. Shear-stress-mediated arterial remodeling in atherosclerosis: too much of a good thing? Circulation. 2006;113:2787-2789. doi: 10.1161/CIRCULATIONAHA.106.634378.
2. Chiu JJ, Chien S. Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev. 2011;91:327-387. doi: 10.1152/physrev.00047.2009.
3. Conway DE, Williams MR, Eskin SG, McIntire LV. Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal. Am J Physiol Heart Circ Physiol. 2010;298:H367-H374. doi: 10.1152/ajpheart.00565.2009.
4. Dai G, Kaazempur-Mofrad MR, Natarajan S, Zhang Y, Vaughn S, Blackman BR, Kamm RD, García-Cardeña G, Gimbrone MA Jr. Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosissusceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A. 2004;101:14871-14876. doi: 10.1073/pnas.0406073101.
5. Gambillara V, Chambaz C, Montorzi G, Roy S, Stergiopulos N, Silacci P. Plaque-prone hemodynamics impair endothelial function in pig carotid arteries. Am J Physiol Heart Circ Physiol. 2006;290:H2320-H2328. doi: 10.1152/ajpheart.00486.2005.
6. Hastings NE, Simmers MB, McDonald OG, Wamhoff BR, Blackman BR. Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming. Am J Physiol Cell Physiol. 2007;293:C1824-C1833. doi: 10.1152/ajpcell.00385.2007.
7. Sorescu GP, Sykes M, Weiss D, Platt MO, Saha A, Hwang J, Boyd N, Boo YC, Vega JD, Taylor WR, Jo H. Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response. J Biol Chem. 2003;278:31128-31135. doi: 10.1074/jbc. M300703200.
8. Hwang J, Saha A, Boo YC, Sorescu GP, McNally JS, Holland SM, Dikalov S, Giddens DP, Griendling KK, Harrison DG, Jo H. Oscillatory shear stress stimulates endothelial production of O2- from p47phoxdependent NAD(P)H oxidases, leading to monocyte adhesion. J Biol Chem. 2003;278:47291-47298. doi: 10.1074/jbc.M305150200.
9. Hahn C, Schwartz MA. Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol. 2009;10:53-62. doi: 10.1038/nrm2596.
10. Lu X, Kassab GS. Nitric oxide is significantly reduced in ex vivo porcine arteries during reverse flow because of increased superoxide production. J Physiol. 2004;561(pt 2):575-582. doi: 10.1113/jphysiol.2004.075218.
11. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol. 2007;49:2379-2393. doi: 10.1016/j. jacc.2007.02.059.
12. Zhou J, Li YS, Chien S. Shear stress-initiated signaling and its regulation of endothelial function. Arterioscler Thromb Vasc Biol. 2014;34:2191-2198. doi: 10.1161/ATVBAHA.114.303422.
13. Credeur DP, Dobrosielski DA, Arce-Esquivel AA, Welsch MA. Brachial artery retrograde flow increases with age: relationship to physical function. Eur J Appl Physiol. 2009;107:219-225. doi: 10.1007/s00421-009-1117-3.
14. Padilla J, Simmons GH, Fadel PJ, Laughlin MH, Joyner MJ, Casey DP. Impact of aging on conduit artery retrograde and oscillatory shear at rest and during exercise: role of nitric oxide. Hypertension. 2011;57:484-489. doi: 10.1161/HYPERTENSIONAHA.110.165365.
15. Young CN, Deo SH, Padilla J, Laughlin MH, Fadel PJ. Pro-atherogenic shear rate patterns in the femoral artery of healthy older adults. Atherosclerosis. 2010;211:390-392. doi: 10.1016/j.atherosclerosis.2010.03.017.
16. Baccelli G, Pignoli P, Corbellini E, Pizzolati PL, Bassini M, Longo T, Zanchetti A. Hemodynamic factors changing blood flow velocity waveform and profile in normal human brachial artery. Angiology. 1985;36:1-8.
17. Mitchell GF, Vita JA, Larson MG, Parise H, Keyes MJ, Warner E, Vasan RS, Levy D, Benjamin EJ. Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study. Circulation. 2005;112:3722-3728. doi: 10.1161/CIRCULATIONAHA.105.551168.
18. Hashimoto J, Ito S. Aortic stiffness determines diastolic blood flow reversal in the descending thoracic aorta: potential implication for retrograde embolic stroke in hypertension. Hypertension. 2013;62:542-549. doi: 10.1161/HYPERTENSIONAHA.113.01318.
19. Mitchell GF. Arterial stiffness and wave reflection: biomarkers of cardiovascular risk. Artery Res. 2009;3:56-64. doi: 10.1016/j.artres.2009.02.002.
20. Vita JA, Mitchell GF. Effects of shear stress and flow pulsatility on endothelial function: insights gleaned from external counterpulsation therapy. J Am Coll Cardiol. 2003;42:2096-2098.
21. Thijssen DH, Schreuder TH, Newcomer SW, Laughlin MH, Hopman MT, Green DJ. Impact of 2-weeks continuous increase in retrograde shear stress on brachial artery vasomotor function in young and older men. J Am Heart Assoc. 2015;4:e001968. doi: 10.1161/JAHA.115.001968.
22. Schreuder TH, Green DJ, Hopman MT, Thijssen DH. Acute impact of retrograde shear rate on brachial and superficial femoral artery flowmediated dilation in humans. Physiol Rep. 2014;2:e00193. doi: 10.1002/phy2.193.
23. Thijssen DH, Dawson EA, Tinken TM, Cable NT, Green DJ. Retrograde flow and shear rate acutely impair endothelial function in humans. Hypertension. 2009;53:986-992. doi: 10.1161/HYPERTENSIONAHA.109.131508.
24. Tinken TM, Thijssen DH, Hopkins N, Black MA, Dawson EA, Minson CT, Newcomer SC, Laughlin MH, Cable NT, Green DJ. Impact of shear rate modulation on vascular function in humans. Hypertension. 2009;54:278-285. doi: 10.1161/HYPERTENSIONAHA.109.134361.
25. Cheng C, van Haperen R, de Waard M, van Damme LC, Tempel D, Hanemaaijer L, van Cappellen GW, Bos J, Slager CJ, Duncker DJ, van der Steen AF, de Crom R, Krams R. Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique. Blood. 2005;106:3691-3698. doi: 10.1182/blood-2005-06-2326.
26. De Keulenaer GW, Chappell DC, Ishizaka N, Nerem RM, Alexander RW, Griendling KK. Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: role of a superoxide-producing NADH oxidase. Circ Res. 1998;82:1094-1101.
27. Silacci P, Desgeorges A, Mazzolai L, Chambaz C, Hayoz D. Flow pulsatility is a critical determinant of oxidative stress in endothelial cells. Hypertension. 2001;38:1162-1166.
28. Choy JS, Lu X, Yang J, Zhang ZD, Kassab GS. Endothelial actin depolymerization mediates NADPH oxidase-superoxide production during flow reversal. Am J Physiol Heart Circ Physiol. 2014;306:H69-H77. doi: 10.1152/ajpheart.00402.2013.
29. McLenachan JM, Vita J, Fish DR, Treasure CB, Cox DA, Ganz P, Selwyn AP. Early evidence of endothelial vasodilator dysfunction at coronary branch points. Circulation. 1990;82:1169-1173.
30. Tinken TM, Thijssen DH, Hopkins N, Dawson EA, Cable NT, Green DJ. Shear stress mediates endothelial adaptations to exercise training in humans. Hypertension. 2010;55:312-318. doi: 10.1161/HYPERTENSIONAHA.109.146282.
31. Simmons GH, Padilla J, Young CN, Wong BJ, Lang JA, Davis MJ, Laughlin MH, Fadel PJ. Increased brachial artery retrograde shear rate at exercise onset is abolished during prolonged cycling: role of thermoregulatory vasodilation. J Appl Physiol (1985). 2011;110:389-397. doi: 10.1152/japplphysiol.00936.2010.
32. Ganz P, Vita JA. Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. Circulation. 2003;108:2049-2053. doi: 10.1161/01. CIR.0000089507.19675.F9.
33. Philpott A, Anderson TJ. Reactive hyperemia and cardiovascular risk. Arterioscler Thromb Vasc Biol. 2007;27:2065-2067. doi: 10.1161/ATVBAHA.107.149740.
34. Anderson TJ, Charbonneau F, Title LM, Buithieu J, Rose MS, Conradson H, Hildebrand K, Fung M, Verma S, Lonn EM. Microvascular function predicts cardiovascular events in primary prevention: long-term results from the Firefighters and Their Endothelium (FATE) study. Circulation. 2011;123:163-169. doi: 10.1161/CIRCULATIONAHA.110.953653.
35. Mitchell GF, Parise H, Vita JA, Larson MG, Warner E, Keaney JF Jr, Keyes MJ, Levy D, Vasan RS, Benjamin EJ. Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study. Hypertension. 2004;44:134-139. doi: 10.1161/01.HYP.0000137305.77635.68.
36. Chung WB, Hamburg NM, Holbrook M, Shenouda SM, Dohadwala MM, Terry DF, Gokce N, Vita JA. The brachial artery remodels to maintain local shear stress despite the presence of cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2009;29:606-612. doi: 10.1161/ATVBAHA.108.181495.
37. Hamburg NM, Mott MM, Bigornia SJ, Duess MA, Kluge MA, Hess DT, Apovian CM, Vita JA, Gokce N. Maladaptive enlargement of the brachial artery in severe obesity is reversed with weight loss. Vasc Med. 2010;15:215-222. doi: 10.1177/1358863X10362831.
38. Mitchell GF, Wang N, Palmisano JN, Larson MG, Hamburg NM, Vita JA, Levy D, Benjamin EJ, Vasan RS. Hemodynamic correlates of blood pressure across the adult age spectrum: noninvasive evaluation in the Framingham Heart Study. Circulation. 2010;122:1379-1386. doi: 10.1161/CIRCULATIONAHA.109.914507.
39. Wilkinson IB, MacCallum H, Cockcroft JR, Webb DJ. Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo. Br J Clin Pharmacol. 2002;53:189-192.
40. Wilkinson IB, Franklin SS, Cockcroft JR. Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology. Hypertension. 2004;44:112-116. doi: 10.1161/01.HYP.0000138068.03893.40.
41. Peng X, Haldar S, Deshpande S, Irani K, Kass DA. Wall stiffness suppresses Akt/eNOS and cytoprotection in pulse-perfused endothelium. Hypertension. 2003;41:378-381.
42. Halliwill JR, Minson CT. Retrograde shear: backwards into the future? Am J Physiol Heart Circ Physiol. 2010;298:H1126-H1127. doi: 10.1152/ajpheart.00174.2010.