Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial

The Lancet

Volumn 388, Issue 10055, 2016, Pages 1985-1994

  Mumme, Marcus ^a   Barbero, Andrea ^a   Miot, Sylvie ^a   Wixmerten, Anke ^a   Feliciano, Sandra ^a   Wolf, Francine ^a   Asnaghi, Adelaide M ^a   Baumhoer, Daniel ^a   Bieri, Oliver ^a   Kretzschmar, Martin ^a   Pagenstert, Geert ^a   Haug, Martin ^a   Schaefer, Dirk J ^a   Martin, Ivan ^a   Jakob, Marcel ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 10; COLLAGEN TYPE 2; GLYCOSAMINOGLYCAN;

ADULT; ARTHROTOMY; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE BIOPSY; CARTILAGE CELL; CARTILAGE GRAFT; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN TISSUE; KNEE FUNCTION; KNEE MENISCUS; KNEE MENISCUS RUPTURE; KNEE PAIN; MALE; MENISCAL TRANSPLANTATION; MIDDLE AGED; NOSE CARTILAGE; OBSERVATIONAL STUDY; PATIENT SAFETY; PRIORITY JOURNAL; QUALITY OF LIFE; TISSUE REPAIR; TISSUE SCAFFOLD; YOUNG ADULT; AUTOTRANSPLANTATION; CHONDROCYTE; CLINICAL TRIAL; CONVALESCENCE; CYTOLOGY; DIAGNOSTIC IMAGING; EVIDENCE BASED MEDICINE; FEASIBILITY STUDY; FOLLOW UP; INJURIES; KNEE; MINIMALLY INVASIVE SURGERY; NOSE SEPTUM; PAIN; PATHOLOGY; PATHOPHYSIOLOGY; SELF REPORT; SURGERY; SWITZERLAND; TISSUE ENGINEERING; TRANSPLANTATION; TREATMENT OUTCOME;

ADULT; CARTILAGE, ARTICULAR; CHONDROCYTES; EVIDENCE-BASED MEDICINE; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; KNEE JOINT; MALE; MIDDLE AGED; MINIMALLY INVASIVE SURGICAL PROCEDURES; NASAL SEPTUM; PAIN; QUALITY OF LIFE; RECOVERY OF FUNCTION; SELF REPORT; SWITZERLAND; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTS; TREATMENT OUTCOME;

EID: 84992579418     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(16)31658-0     Document Type: Article

References (33)

1. 1 Hambly, K, Knee articular cartilage repair for athletes. SportEx Medicine 39 (2009), 17–21.
2. 2 Buckwalter, JA, Martin, JA, Osteoarthritis. Adv Drug Deliv Rev 58 (2006), 150–167.
3. 3 Minas, T, A primer in cartilage repair. J Bone Joint Surg Br 94:11 suppl A (2012), 141–146.
4. 4 Dewan, AK, Gibson, MA, Elisseeff, JH, Trice, ME, Evolution of autologous chondrocyte repair and comparison to other cartilage repair techniques. Biomed Res Int, 2014, 2014, 272481.
5. 5 Kafienah, W, Jakob, M, Demarteau, O, et al. Three-dimensional tissue engineering of hyaline cartilage: comparison of adult nasal and articular chondrocytes. Tissue Eng 8 (2002), 817–826.
6. 6 Rotter, N, Bonassar, LJ, Tobias, G, et al. Age dependence of biochemical and biomechanical properties of tissue-engineered human septal cartilage. Biomaterials 23 (2002), 3087–3094.
7. 7 Wolf, F, Haug, M, Farhadi, J, et al. A low percentage of autologous serum can replace bovine serum to engineer human nasal cartilage. Eur Cell Mater 5 (2008), 1–10.
8. 8 Farhadi, J, Fulco, I, Miot, S, et al. Precultivation of engineered human nasal cartilage enhances the mechanical properties relevant for use in facial reconstructive surgery. Ann Surg 244 (2006), 978–985.
9. 9 Fulco, I, Miot, S, Haug, MD, et al. Engineered autologous cartilage tissue for nasal reconstruction after tumour resection: an observational first-in-human trial. Lancet 384 (2014), 337–346.
10. 10 Candrian, C, Vonwil, D, Barbero, A, et al. Engineered cartilage generated by nasal chondrocytes is responsive to physical forces resembling joint loading. Arthritis Rheum 58 (2008), 197–208.
11. 11 Scotti, C, Osmokrovic, A, Wolf, F, et al. Response of human engineered cartilage based on articular or nasal chondrocytes to interleukin-1beta and low oxygen. Tissue Eng Part A 18 (2012), 362–372.
12. 12 Vinatier, C, Gauthier, O, Masson, M, et al. Nasal chondrocytes and fibrin sealant for cartilage tissue engineering. J Biomed Mater Res A 89 (2009), 178–185.
13. 13 Pelttari, K, Pippenger, B, Mumme, et al. Adult human neural crest-derived cells for articular cartilage repair. Sci Transl Med, 27, 2014, 251ra119.
14. 14 Shafiee, A, Kabiri, M, Ahmadbeigi, N, et al. Nasal septum-derived multipotent progenitors: a potent source for stem cell-based regenerative medicine. Stem Cells Dev 20 (2011), 2077–2091.
15. 15 Zscharnack, M, Krause, C, Aust, G, et al. Preclinical good laboratory practice-compliant safety study to evaluate biodistribution and tumorigenicity of a cartilage advanced therapy medicinal product (ATMP). J Transl Med, 13, 2015, 160.
16. 16 Saris, DB, Vanlauwe, J, Victor, J, et al. Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med 36 (2008), 235–246.
17. 17 Wiewiorski, M, Miska, M, Kretzschmar, M, et al. Delayed gadolinium-enhanced MRI of cartilage of the ankle joint: results after autologous matrix-induced chondrogenesis (AMIC)-aided reconstruction of osteochondral lesions of the talus. Clin Radiol 68 (2013), 1031–1038.
18. 18 Marlovits, S, Singer, P, Zeller, P, et al. Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years. Eur J Radiol 57 (2006), 16–23.
19. 19 Endo, J, Watanabe, A, Sasho, T, et al. Utility of T2 mapping and dGEMRIC for evaluation of cartilage repair after allograft chondrocyte implantation in a rabbit model. Osteoarthritis Cartilage 23 (2015), 280–288.
20. 20 Watanabe, A, Wada, Y, Obata, T, et al. Delayed gadolinium-enhanced MR to determine glycosaminoglycan concentration in reparative cartilage after autologous chondrocyte implantation: preliminary results. Radiology 239 (2006), 201–208.
21. 21 Heule, R, Ganter, C, Bieri, O, Rapid estimation of cartilage T2 with reduced T1 sensitivity using double echo steady state imaging. Magn Reson Med 71 (2014), 1137–1143.
22. 22 European Medicines Agency. ICH topic E 2 A: note for guidance on clinical safety data management—definitions and standards for expedited reporting (CPMP/ICH/377/95). http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500002749.pdf (accessed Sept 2, 2016).
23. 23 Bornes, TD, Adesida, AB, Jomha, NM, Mesenchymal stem cells in the treatment of traumatic articular cartilage defects: a comprehensive review. Arthritis Res Ther, 16, 2014, 432.
24. 24 Marcacci, M, Berruto, M, Brocchetta, D, et al. Articular cartilage engineering with Hyalograft C: 3-year clinical results. Clin Orthop Relat Res 435 (2005), 96–105.
25. 25 Albrecht, C, Tichy, B, Nurnberger, S, et al. Gene expression and cell differentiation in matrix-associated chondrocyte transplantation grafts: a comparative study. Osteoarthritis Cartilage 19 (2011), 1219–1227.
26. 26 Jin, CZ, Cho, JH, Choi, BH, et al. The maturity of tissue-engineered cartilage in vitro affects the repairability for osteochondral defect. Tissue Eng Part A 17 (2011), 3057–3065.
27. 27 Miot, S, Brehm, W, Dickinson, S, et al. Influence of in vitro maturation of engineered cartilage on the outcome of osteochondral repair in a goat model. Eur Cell Mater 23 (2012), 222–236.
28. 28 Makris, EA, Gomoll, AH, Malizos, KN, et al. Repair and tissue engineering techniques for articular cartilage. Nat Rev Rheumatol 11 (2015), 21–34.
29. 29 Niethammer, TR, Safi, E, Ficklscherer, A, et al. Graft maturation of autologous chondrocyte implantation: magnetic resonance investigation with T2 mapping. Am J Sports Med 42 (2014), 2199–2204.
30. 30 Trattnig, S, Mamisch, TC, Pinker, K, et al. Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3 Tesla. Eur Radiol 18 (2008), 1251–1259.
31. 31 Mumme, M, Steinitz, A, Nuss, K, et al. Regenerative potential of tissue engineered nasal chondrocytes in goat articular cartilage defects. Tissue Eng Part A, 2016, 10.1089/ten.TEA.2016.0159 published online Sept 15.
32. 32 Johnstone, B, Alini, M, Cucchiarini, M, et al. Tissue engineering for articular cartilage repair: the state of the art. Eur Cell Mater 25 (2013), 248–267.
33. 33 Martin, I, Simmons, PJ, Williams, DF, Manufacturing challenges in regenerative medicine. Sci Transl Med, 6, 2014, 232fs16.