-
2
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
-
Burris HA 3rd, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403–2413.
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris, H.A.1
Moore, M.J.2
Andersen, J.3
-
3
-
-
0036682041
-
Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
-
Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG, Benson AB 3rd. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol. 2002;20:3270–3275.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3270-3275
-
-
Berlin, J.D.1
Catalano, P.2
Thomas, J.P.3
Kugler, J.W.4
Haller, D.G.5
Benson, A.B.6
-
4
-
-
4644327989
-
Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
-
Rocha Lima CM, Green MR, Rotche R, et al. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol. 2004;22:3776–3783.
-
(2004)
J Clin Oncol
, vol.22
, pp. 3776-3783
-
-
Rocha Lima, C.M.1
Green, M.R.2
Rotche, R.3
-
5
-
-
20644464360
-
Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial
-
Louvet C, Labianca R, Hammel P, et al; GERCOR; GISCAD. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol. 2005;23:3509–3516.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3509-3516
-
-
Louvet, C.1
Labianca, R.2
Hammel, P.3
-
6
-
-
19944409357
-
Gemcitabine versus cisplatin, epirubicin, fluorouracil, and gemcitabine in advanced pancreatic cancer: a randomised controlled multicentre phase III trial
-
Reni M, Cordio S, Milandri C, et al. Gemcitabine versus cisplatin, epirubicin, fluorouracil, and gemcitabine in advanced pancreatic cancer: a randomised controlled multicentre phase III trial. Lancet Oncol. 2005;6:369–376.
-
(2005)
Lancet Oncol
, vol.6
, pp. 369-376
-
-
Reni, M.1
Cordio, S.2
Milandri, C.3
-
7
-
-
33748297529
-
A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer
-
Stathopoulos GP, Syrigos K, Aravantinos G, et al. A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer. Br J Cancer. 2006;95:587–592.
-
(2006)
Br J Cancer
, vol.95
, pp. 587-592
-
-
Stathopoulos, G.P.1
Syrigos, K.2
Aravantinos, G.3
-
8
-
-
33748445708
-
Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer
-
Heinemann V, Quietzsch D, Gieseler F, et al. Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. J Clin Oncol. 2006;24:3946–3952.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3946-3952
-
-
Heinemann, V.1
Quietzsch, D.2
Gieseler, F.3
-
9
-
-
34250180939
-
Gemcitabine Plus Capecitabine Compared With Gemcitabine Alone in Advanced Pancreatic Cancer: A Randomized, Multicenter, Phase III Trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group
-
Herrmann R, Godsky G, Ruhstaller T, et al. Gemcitabine Plus Capecitabine Compared With Gemcitabine Alone in Advanced Pancreatic Cancer: A Randomized, Multicenter, Phase III Trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J Clin Oncol. 2007;25:2212–2217.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2212-2217
-
-
Herrmann, R.1
Godsky, G.2
Ruhstaller, T.3
-
10
-
-
68949114505
-
Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group
-
Poplin E, Feng Y, Berlin J, et al. Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol. 2009;27:3778–3785.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3778-3785
-
-
Poplin, E.1
Feng, Y.2
Berlin, J.3
-
11
-
-
73949135518
-
Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
-
Cunningham D, Chau I, Stocken DD, et al. Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer. J Clin Oncol. 2009;27:5513–5518.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5513-5518
-
-
Cunningham, D.1
Chau, I.2
Stocken, D.D.3
-
12
-
-
77950498286
-
Gruppo Oncologico Italia Meridionale (GOIM); Gruppo Italiano per lo Studio dei Carcinomi dell'Apparato Digerente (GISCAD); Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC). Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study
-
Colucci G, Labianca R, Di Costanzo F, et al; Gruppo Oncologico Italia Meridionale (GOIM); Gruppo Italiano per lo Studio dei Carcinomi dell'Apparato Digerente (GISCAD); Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC). Randomized phase III trial of gemcitabine plus cisplatin compared with single-agent gemcitabine as first-line treatment of patients with advanced pancreatic cancer: the GIP-1 study. J Clin Oncol. 2010;28:1645–1651.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1645-1651
-
-
Colucci, G.1
Labianca, R.2
Di Costanzo, F.3
-
13
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
Conroy T, Desseigne F, Ychou M, et al; Groupe Tumeurs Digestives of Unicancer; PRODIGE Intergroup. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364:1817–1825.
-
(2011)
N Engl J Med
, vol.364
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
-
14
-
-
83355169753
-
Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial
-
Von Hoff DD, Ramanathan RK, Borad MJ, et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol. 2011;29:4548–4554.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4548-4554
-
-
Von Hoff, D.D.1
Ramanathan, R.K.2
Borad, M.J.3
-
15
-
-
84886741654
-
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
-
Von Hoff DD, Ervin T, Arena FP, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013;369:1691–1703.
-
(2013)
N Engl J Med
, vol.369
, pp. 1691-1703
-
-
Von Hoff, D.D.1
Ervin, T.2
Arena, F.P.3
-
16
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore MJ, Goldstein D, Hamm J, et al; National Cancer Institute of Canada Clinical Trials Group. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25:1960–1966.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
17
-
-
77955914277
-
Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205
-
Philip PA, Benedetti J, Corless CL, et al. Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol. 2010;28:3605–3610.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3605-3610
-
-
Philip, P.A.1
Benedetti, J.2
Corless, C.L.3
-
18
-
-
79952036599
-
Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study
-
Kindler HL, Ioka T, Richel DJ, et al. Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol. 2011;12:256–262.
-
(2011)
Lancet Oncol
, vol.12
, pp. 256-262
-
-
Kindler, H.L.1
Ioka, T.2
Richel, D.J.3
-
19
-
-
77955887676
-
Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303)
-
Kindler HL, Niedzwiecki D, Hollis D, et al. Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol. 2010;28:3617–3622.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3617-3622
-
-
Kindler, H.L.1
Niedzwiecki, D.2
Hollis, D.3
-
20
-
-
84879952361
-
Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer
-
Rougier P, Riess H, Manges R, et al. Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer. Eur J Cancer. 2013;49:2633–2642.
-
(2013)
Eur J Cancer
, vol.49
, pp. 2633-2642
-
-
Rougier, P.1
Riess, H.2
Manges, R.3
-
21
-
-
34247188535
-
Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer
-
Sultana A, Smith CT, Cunningham D, Starling N, Neoptolemos JP, Ghaneh P. Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer. J Clin Oncol. 2007;25:2607–2615.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2607-2615
-
-
Sultana, A.1
Smith, C.T.2
Cunningham, D.3
Starling, N.4
Neoptolemos, J.P.5
Ghaneh, P.6
-
22
-
-
42349093032
-
Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer
-
Heinemann V, Boeck S, Hinke A, Labianca R, Louvet C. Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer. BMC Cancer. 2008;8:82.
-
(2008)
BMC Cancer
, vol.8
, pp. 82
-
-
Heinemann, V.1
Boeck, S.2
Hinke, A.3
Labianca, R.4
Louvet, C.5
-
23
-
-
84871723767
-
Impact of FOLFIRINOX compared with gemcitabine on quality of life in patients with metastatic pancreatic cancer: results from the PRODIGE 4/ACCORD 11 randomized trial
-
Gourgou-Bourgade S, Bascoul-Mollevi C, Desseigne F, et al. Impact of FOLFIRINOX compared with gemcitabine on quality of life in patients with metastatic pancreatic cancer: results from the PRODIGE 4/ACCORD 11 randomized trial. J Clin Oncol. 2013;31:23–29.
-
(2013)
J Clin Oncol
, vol.31
, pp. 23-29
-
-
Gourgou-Bourgade, S.1
Bascoul-Mollevi, C.2
Desseigne, F.3
-
24
-
-
63949084513
-
Irinotecan monotherapy as second-line treatment in advanced pancreatic cancer
-
Yi SY, Park YS, Kim HS, et al. Irinotecan monotherapy as second-line treatment in advanced pancreatic cancer. Cancer Chemother Pharmacol. 2009;63:1141–1145.
-
(2009)
Cancer Chemother Pharmacol
, vol.63
, pp. 1141-1145
-
-
Yi, S.Y.1
Park, Y.S.2
Kim, H.S.3
-
25
-
-
78650253617
-
XELIRI or FOLFIRI as salvage therapy in advanced pancreatic cancer
-
Cereda S, Reni M, Rognone A, et al. XELIRI or FOLFIRI as salvage therapy in advanced pancreatic cancer. Anticancer Res. 2010;30:4785–4790.
-
(2010)
Anticancer Res
, vol.30
, pp. 4785-4790
-
-
Cereda, S.1
Reni, M.2
Rognone, A.3
-
26
-
-
78049421075
-
Irinotecan plus bolus/infusional 5-fluorouracil and leucovorin in patients with pretreated advanced pancreatic carcinoma: a multicenter experience of the Gruppo Oncologico Italia Meridionale
-
Gebbia V, Maiello E, Giuliani F, Borsellino N, Arcara C, Colucci G. Irinotecan plus bolus/infusional 5-fluorouracil and leucovorin in patients with pretreated advanced pancreatic carcinoma: a multicenter experience of the Gruppo Oncologico Italia Meridionale. Am J Clin Oncol. 2010;33:461–464.
-
(2010)
Am J Clin Oncol
, vol.33
, pp. 461-464
-
-
Gebbia, V.1
Maiello, E.2
Giuliani, F.3
Borsellino, N.4
Arcara, C.5
Colucci, G.6
-
27
-
-
84867717109
-
FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts
-
Neuzillet C, Hentic O, Rousseau B, et al. FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts. World J Gastroenterol. 2012;18:4533–4541.
-
(2012)
World J Gastroenterol
, vol.18
, pp. 4533-4541
-
-
Neuzillet, C.1
Hentic, O.2
Rousseau, B.3
-
28
-
-
70449525483
-
A randomised phase II study of modified FOLFIRI.3 vs modified FOLFOX as second-line therapy in patients with gemcitabine-refractory advanced pancreatic cancer
-
Yoo C, Hwang JY, Kim JE, et al. A randomised phase II study of modified FOLFIRI.3 vs modified FOLFOX as second-line therapy in patients with gemcitabine-refractory advanced pancreatic cancer. Br J Cancer. 2009;101:1658–1663.
-
(2009)
Br J Cancer
, vol.101
, pp. 1658-1663
-
-
Yoo, C.1
Hwang, J.Y.2
Kim, J.E.3
-
29
-
-
84863809711
-
FOLFIRI as second-line chemotherapy for advanced pancreatic cancer: a GISCAD multicenter phase II study
-
Zaniboni A, Aitini E, Barni S, et al. FOLFIRI as second-line chemotherapy for advanced pancreatic cancer: a GISCAD multicenter phase II study. Cancer Chemother Pharmacol. 2012;69:1641–1645.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, pp. 1641-1645
-
-
Zaniboni, A.1
Aitini, E.2
Barni, S.3
-
30
-
-
84883169930
-
A multinational phase 2 study of nanoliposomal irinotecan sucrosofate (PEP02, MM-398) for patients with gemcitabine-refractory metastatic pancreatic cancer
-
Ko AH, Tempero MA, Shan YS, et al. A multinational phase 2 study of nanoliposomal irinotecan sucrosofate (PEP02, MM-398) for patients with gemcitabine-refractory metastatic pancreatic cancer. Br J Cancer. 2013;109:920–925.
-
(2013)
Br J Cancer
, vol.109
, pp. 920-925
-
-
Ko, A.H.1
Tempero, M.A.2
Shan, Y.S.3
-
31
-
-
84959459386
-
Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial
-
Wang-Gillam A, Li CP, Bodoky G, et al; NAPOLI-1 Study Group. Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial. Lancet. 2016;387:545–557.
-
(2016)
Lancet
, vol.387
, pp. 545-557
-
-
Wang-Gillam, A.1
Li, C.P.2
Bodoky, G.3
-
32
-
-
0037389850
-
Expression of molecular targets for tyrosine kinase receptor antagonists in malignant endocrine pancreatic tumors
-
Fjallskog ML, Lejonklou MH, Oberg KE, Eriksson BK, Janson ET. Expression of molecular targets for tyrosine kinase receptor antagonists in malignant endocrine pancreatic tumors. Clin Cancer Res. 2003;9:1469–1473.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1469-1473
-
-
Fjallskog, M.L.1
Lejonklou, M.H.2
Oberg, K.E.3
Eriksson, B.K.4
Janson, E.T.5
-
33
-
-
4143128359
-
Epidermal growth factor receptor expression in human pancreatic cancer: significance for liver metastasis
-
Tobita K, Kijima H, Dowaki S, et al. Epidermal growth factor receptor expression in human pancreatic cancer: significance for liver metastasis. Int J Mol Med. 2003;11:305–309.
-
(2003)
Int J Mol Med
, vol.11
, pp. 305-309
-
-
Tobita, K.1
Kijima, H.2
Dowaki, S.3
-
34
-
-
84887272144
-
Modified FOLFIRINOX regimen with improved safety and maintained efficacy in pancreatic adenocarcinoma
-
Mahaseth H, Brutcher E, Kauh J, et al. Modified FOLFIRINOX regimen with improved safety and maintained efficacy in pancreatic adenocarcinoma. Pancreas. 2013;42:1311–1315.
-
(2013)
Pancreas
, vol.42
, pp. 1311-1315
-
-
Mahaseth, H.1
Brutcher, E.2
Kauh, J.3
-
35
-
-
84945436587
-
Safety and efficacy of modified FOLFIRINOX for advanced pancreatic adenocarcinoma: a UK single-centre experience
-
Ghorani E, Wong HH, Hewitt C, Calder J, Corrie P, Basu B. Safety and efficacy of modified FOLFIRINOX for advanced pancreatic adenocarcinoma: a UK single-centre experience. Oncology. 2015;89:281–287.
-
(2015)
Oncology
, vol.89
, pp. 281-287
-
-
Ghorani, E.1
Wong, H.H.2
Hewitt, C.3
Calder, J.4
Corrie, P.5
Basu, B.6
-
36
-
-
84945488556
-
Nab paclitaxel plus gemcitabine for metastatic pancreatic adenocarcinoma after failure of FOLFIRINOX: results of an AGEO multicenter prospective cohort [abstract]
-
Portal A, Pernot S, Arbaud C, et al. Nab paclitaxel plus gemcitabine for metastatic pancreatic adenocarcinoma after failure of FOLFIRINOX: results of an AGEO multicenter prospective cohort [abstract]. J Clin Oncol. 2015;33:Pages. Abstract 4123.
-
(2015)
J Clin Oncol
, vol.33
-
-
Portal, A.1
Pernot, S.2
Arbaud, C.3
-
37
-
-
84909606439
-
Pharmacogenomic modeling of circulating tumor and invasive cells for prediction of chemotherapy response and resistance in pancreatic cancer
-
Yu KH, Ricigliano M, Hidalgo M, et al. Pharmacogenomic modeling of circulating tumor and invasive cells for prediction of chemotherapy response and resistance in pancreatic cancer. Clin Cancer Res. 2014;20:5281–5289.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5281-5289
-
-
Yu, K.H.1
Ricigliano, M.2
Hidalgo, M.3
-
38
-
-
84905817411
-
Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer: outcomes from the CONKO-003 trial
-
Oettle H, Riess H, Stieler JM, et al. Second-line oxaliplatin, folinic acid, and fluorouracil versus folinic acid and fluorouracil alone for gemcitabine-refractory pancreatic cancer: outcomes from the CONKO-003 trial. J Clin Oncol. 2014;32:2423–2429.
-
(2014)
J Clin Oncol
, vol.32
, pp. 2423-2429
-
-
Oettle, H.1
Riess, H.2
Stieler, J.M.3
-
39
-
-
84922004816
-
PANCREOX: a randomized phase 3 study of 5FU/LV with or without oxaliplatin for second-line advanced pancreatic cancer (APC) in patients (pts) who have received gemcitabine (GEM)-based chemotherapy (CT) [abstract]
-
Gill S, Ko Y, Cripps M, et al. PANCREOX: a randomized phase 3 study of 5FU/LV with or without oxaliplatin for second-line advanced pancreatic cancer (APC) in patients (pts) who have received gemcitabine (GEM)-based chemotherapy (CT) [abstract]. J Clin Oncol. 2014;32:Pages. Abstract 4022.
-
(2014)
J Clin Oncol
, vol.32
-
-
Gill, S.1
Ko, Y.2
Cripps, M.3
-
40
-
-
84942988759
-
Nab-paclitaxel plus gemcitabien for metastatic pancreatic adenocarcinoma after FOLFIRINOX failure: an AGEO prospective multicentre cohort
-
Portal A, Pernot S, Tougeron D, et al. Nab-paclitaxel plus gemcitabien for metastatic pancreatic adenocarcinoma after FOLFIRINOX failure: an AGEO prospective multicentre cohort. Br J Cancer. 2015;113:989–995.
-
(2015)
Br J Cancer
, vol.113
, pp. 989-995
-
-
Portal, A.1
Pernot, S.2
Tougeron, D.3
-
41
-
-
84897890425
-
Phase II study of induction therapy with gemcitabine and nab-paclitaxel followed by consolidation with mFOLFIRINOX in patients with metastatic pancreatic cancer
-
(abstr 224)
-
Ramanathan RK, Lee P, Seng JE, et al. Phase II study of induction therapy with gemcitabine and nab-paclitaxel followed by consolidation with mFOLFIRINOX in patients with metastatic pancreatic cancer. J Clin Oncol. 2014;32 (suppl 3; abstr 224).
-
(2014)
J Clin Oncol
, vol.32
-
-
Ramanathan, R.K.1
Lee, P.2
Seng, J.E.3
-
42
-
-
84982187033
-
Outcome of second-line treatment following nab-paclitaxel + gemcitabine or gemcitabine alone for metastatic pancreatic cancer
-
(supple 4S; abstr 333)
-
Goldstein D, Chiorean EG, Tabernero J, et al. Outcome of second-line treatment following nab-paclitaxel + gemcitabine or gemcitabine alone for metastatic pancreatic cancer. J Clin Onc. 2016;34 (supple 4S; abstr 333).
-
J Clin Onc
, vol.2016
, Issue.34
-
-
Goldstein, D.1
Chiorean, E.G.2
Tabernero, J.3
-
43
-
-
84937123903
-
Progress in the treatment of metastatic pancreatic cancer and the search for next opportunities
-
Ko AH. Progress in the treatment of metastatic pancreatic cancer and the search for next opportunities. J Clin Oncol. 2015;33:1779–1786.
-
(2015)
J Clin Oncol
, vol.33
, pp. 1779-1786
-
-
Ko, A.H.1
-
45
-
-
84904010549
-
Cellular and molecular conspirators in pancreas cancer
-
Hingorani SR. Cellular and molecular conspirators in pancreas cancer. Carcinogenesis. 2014;35:1435.
-
(2014)
Carcinogenesis
, vol.35
, pp. 1435
-
-
Hingorani, S.R.1
-
47
-
-
84858602107
-
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
-
Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell. 2012;21:418–429.
-
(2012)
Cancer Cell
, vol.21
, pp. 418-429
-
-
Provenzano, P.P.1
Cuevas, C.2
Chang, A.E.3
Goel, V.K.4
Von Hoff, D.D.5
Hingorani, S.R.6
-
48
-
-
84947248389
-
Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of necuparanib combined with nab-paclitaxel and gemcitabine in patients with metastatic pancreatic cancer: phase 1 results [abstract]
-
O'Reilly E, Mahalingam D, Roach J, et al. Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of necuparanib combined with nab-paclitaxel and gemcitabine in patients with metastatic pancreatic cancer: phase 1 results [abstract]. J Clin Oncol. 2015;33:Pages. Abstract 4114.
-
(2015)
J Clin Oncol
, vol.33
-
-
O'Reilly, E.1
Mahalingam, D.2
Roach, J.3
-
49
-
-
34948852371
-
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
-
Soucek L, Lawlor ER, Soto D, Shchors K, Swigart LB, Evan GI. Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med. 2007;13:1211–1218.
-
(2007)
Nat Med
, vol.13
, pp. 1211-1218
-
-
Soucek, L.1
Lawlor, E.R.2
Soto, D.3
Shchors, K.4
Swigart, L.B.5
Evan, G.I.6
-
50
-
-
84938612287
-
Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma
-
Masso-Valles D, Jauset T, Serrano E, et al. Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma. Cancer Res. 2015;75:1675–1681.
-
(2015)
Cancer Res
, vol.75
, pp. 1675-1681
-
-
Masso-Valles, D.1
Jauset, T.2
Serrano, E.3
-
51
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
Le DT, Uram JN, Wang H, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015;372:2509–2520.
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
-
52
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 2014;371:2189–2199.
-
(2014)
N Engl J Med
, vol.371
, pp. 2189-2199
-
-
Snyder, A.1
Makarov, V.2
Merghoub, T.3
-
53
-
-
67349181841
-
Immunosurveillance of pancreatic adenocarcinoma: insights from genetically engineered mouse models of cancer
-
Clark CE, Beatty GL, Vonderheide RH. Immunosurveillance of pancreatic adenocarcinoma: insights from genetically engineered mouse models of cancer. Cancer Lett. 2009;279:1–7.
-
(2009)
Cancer Lett
, vol.279
, pp. 1-7
-
-
Clark, C.E.1
Beatty, G.L.2
Vonderheide, R.H.3
-
54
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
Postow MA, Chesney J, Pavlick AC, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med. 2015;372:2006–2017.
-
(2015)
N Engl J Med
, vol.372
, pp. 2006-2017
-
-
Postow, M.A.1
Chesney, J.2
Pavlick, A.C.3
-
55
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015;373:1627–1639.
-
(2015)
N Engl J Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
56
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 2015;373:123–135.
-
(2015)
N Engl J Med
, vol.373
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
-
57
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366:2455–2465.
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
58
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363:711–723.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
-
59
-
-
77958050577
-
Phase 2 trial of single agent ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
-
Royal RE, Levy C, Turner K, et al. Phase 2 trial of single agent ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother. 2010;33:828–833.
-
(2010)
J Immunother
, vol.33
, pp. 828-833
-
-
Royal, R.E.1
Levy, C.2
Turner, K.3
-
60
-
-
84960194345
-
Genomic analyses identify molecular subtypes of pancreatic cancer
-
Bailey P, Chang DK, Nones K, et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature. 2016;531:47–52.
-
(2016)
Nature
, vol.531
, pp. 47-52
-
-
Bailey, P.1
Chang, D.K.2
Nones, K.3
-
61
-
-
84987603333
-
PD-1 blockade in mismatch repair deficient non-colorectal gastrointestinal cancers [abstract]
-
Le DT, Uram JN, Wang H, et al. PD-1 blockade in mismatch repair deficient non-colorectal gastrointestinal cancers [abstract]. J Clin Oncol. 2016;34(suppl 4S):Pages. Abstract 195.
-
(2016)
J Clin Oncol
, vol.34
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
-
62
-
-
84890281217
-
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer
-
Feig C, Jones JO, Kraman M, et al. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proc Natl Acad Sci U S A. 2013;110:20212–20217.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 20212-20217
-
-
Feig, C.1
Jones, J.O.2
Kraman, M.3
-
63
-
-
84879850236
-
Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis
-
Sanford DE, Belt BA, Panni RZ, et al. Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis. Clin Cancer Res. 2013;19:3404–3415.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3404-3415
-
-
Sanford, D.E.1
Belt, B.A.2
Panni, R.Z.3
-
64
-
-
85019785966
-
Abstract B24: pharmacokinetic and pharmacodynamic profile of the novel, oral and selective CCR2 inhibitor CCX872-B in a Phase 1B pancreatic cancer trial
-
Hezel A, Eskens F, Sleijfer S, et al. Abstract B24: pharmacokinetic and pharmacodynamic profile of the novel, oral and selective CCR2 inhibitor CCX872-B in a Phase 1B pancreatic cancer trial. Mol Cancer Ther. 2015;14(12 suppl 2):B24.
-
(2015)
Mol Cancer Ther
, vol.14
, Issue.12
, pp. B24
-
-
Hezel, A.1
Eskens, F.2
Sleijfer, S.3
-
65
-
-
84929431322
-
Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer
-
Le DT, Wang-Gillam A, Picozzi V, et al. Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer. J Clin Oncol. 2015;33:1325–1333.
-
(2015)
J Clin Oncol
, vol.33
, pp. 1325-1333
-
-
Le, D.T.1
Wang-Gillam, A.2
Picozzi, V.3
-
67
-
-
84949321701
-
Identification of germline genetic mutations in patients with pancreatic cancer
-
Salo-Mullen EE, O'Reilly EM, Kelsen DP, et al. Identification of germline genetic mutations in patients with pancreatic cancer. Cancer. 2015;121:4382–4388.
-
(2015)
Cancer
, vol.121
, pp. 4382-4388
-
-
Salo-Mullen, E.E.1
O'Reilly, E.M.2
Kelsen, D.P.3
-
68
-
-
84908365902
-
Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers
-
Golan T, Kanji ZS, Epelbaum R, et al. Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers. Br J Cancer. 2014;111:1132–1138.
-
(2014)
Br J Cancer
, vol.111
, pp. 1132-1138
-
-
Golan, T.1
Kanji, Z.S.2
Epelbaum, R.3
-
69
-
-
80054820265
-
An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions
-
Lowery MA, Kelsen DP, Stadler ZK, et al. An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions. Oncologist. 2011;16:1397–1402.
-
(2011)
Oncologist
, vol.16
, pp. 1397-1402
-
-
Lowery, M.A.1
Kelsen, D.P.2
Stadler, Z.K.3
-
70
-
-
84880051282
-
Olaparib monotherapy in patients with advanced cancer and a germ-line BRCA1/2 mutation: an open-label phase II study [abstract]
-
Kaufman B, Shapira-Frommer R, Schmutzler R, et al. Olaparib monotherapy in patients with advanced cancer and a germ-line BRCA1/2 mutation: an open-label phase II study [abstract]. J Clin Oncol. 2013;31:Pages. Abstract 11024.
-
(2013)
J Clin Oncol
, vol.31
-
-
Kaufman, B.1
Shapira-Frommer, R.2
Schmutzler, R.3
-
71
-
-
84905163406
-
Phase IB trial of cisplatin (C), gemcitabine (G), and veliparib (V) in patients with known or potential BRCA or PALB2-mutated pancreas adenocarcinoma (PC) [abstract]
-
O'Reilly E, Lowery M, Segal M, et al. Phase IB trial of cisplatin (C), gemcitabine (G), and veliparib (V) in patients with known or potential BRCA or PALB2-mutated pancreas adenocarcinoma (PC) [abstract]. J Clin Oncol. 2014;32:Pages. Abstract 4023.
-
(2014)
J Clin Oncol
, vol.32
-
-
O'Reilly, E.1
Lowery, M.2
Segal, M.3
-
73
-
-
84962421104
-
Evofosfamide (TH-302) in combination with gemcitabine in previously untreated patients with metastatic or locally advanced unresectable pancreatic ductal adenocarcinoma: primary analysis of the randomized, double-blind phase III MAESTRO study [abstract]
-
Van Cutsem E, Lenz H, Furuse J, et al. Evofosfamide (TH-302) in combination with gemcitabine in previously untreated patients with metastatic or locally advanced unresectable pancreatic ductal adenocarcinoma: primary analysis of the randomized, double-blind phase III MAESTRO study [abstract]. J Clin Oncol. 2016;34(suppl 4S; Abstract 193).
-
(2016)
J Clin Oncol
, vol.34
-
-
Van Cutsem, E.1
Lenz, H.2
Furuse, J.3
|