Enhanced mucosal antibody production and protection against respiratory infections following an orally administered bacterial extract

Frontiers in Medicine

Volumn 1, Issue OCT, 2014, Pages 1-1

  Pasquali, Christian ^a   Salami, Olawale ^b   Taneja, Manisha ^b   Gollwitzer, Eva S ^b   Trompette, Aurelien ^b   Pattaroni, Céline ^b   Yadava, Koshika ^b   Bauer, Jacques ^a   Marsland, Benjamin J ^b  

^a Vifor (International) Inc   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Influenza; Lung; Super infection

Indexed keywords

EID: 84992462683     PISSN: None     EISSN: 2296858X     Source Type: Journal    
DOI: 10.3389/fmed.2014.00041     Document Type: Article

References (28)

1. Guthrie R. Community-acquired lower respiratory tract infections: etiology and treatment. Chest (2001) 120(6):2021-34. doi: 10.1378/chest.120.6.2021
2. Hussell T, Godlee A, Salek-Ardakani S, Snelgrove RJ. Respiratory viral infections: knowledge based therapeutics. Curr Opin Immunol (2012) 24(4):438-43. doi:10.1016/j.coi.2012.06.001
3. Levy O. Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol (2007) 7(5):379-90. doi:10.1038/nri2075
4. Smith K, McCoy KD, Macpherson AJ. Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin Immunol (2007) 19(2):59-69. doi:10.1016/j.smim.2006.10.002
5. Klaenhammer TR, Kleerebezem M, Kopp MV, Rescigno M. The impact of probiotics and prebiotics on the immune system. Nat Rev Immunol (2012) 12(10):728-34. doi:10.1038/nri3312
6. Cazzola M, Capuano A, Rogliani P, Matera MG. Bacterial lysates as a potentially effective approach in preventing acute exacerbation of COPD. Curr Opin Pharmacol (2012) 12(3):300-8. doi:10.1016/j.coph.2012.01.019
7. Masihi KN. Immunomodulatory agents for prophylaxis and therapy of infections. Int J Antimicrob Agents (2000) 14(3):181-91. doi:10.1016/S0924-8579(99)00161-2
8. Han L, Zheng CP, Sun YQ, Xu G, Wen W, Fu QL. A bacterial extract of OM-85 Broncho-Vaxom prevents allergic rhinitis in mice. Am J Rhinol Allergy (2014) 28(2):110-6. doi:10.2500/ajra.2013.27.4021
9. Fu R, Li J, Zhong H, Yu D, Zeng X, Deng M, et al. Broncho-Vaxom attenuates allergic airway inflammation by restoring GSK3beta-related T regulatory cell insufficiency. PLoS One (2014) 9(3):e92912. doi:10.1371/journal.pone.0092912
10. Navarro S, Cossalter G, Chiavaroli C, Kanda A, Fleury S, Lazzari A, et al. The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways. Mucosal Immunol (2011) 4(1):53-65. doi:10.1038/mi.2010.51
11. Huber M, Krauter K, Winkelmann G, Bauer HW, Rahlfs VW, Lauener PA, et al. Immunostimulation by bacterial components: II. Efficacy studies and meta-analysis of the bacterial extract OM-89. Int J Immunopharmacol (2000) 22(12):1103-11. doi:10.1016/S0192-0561(00)00070-9
12. Evans SE, Scott BL, Clement CG, Larson DT, Kontoyiannis D, Lewis RE, et al. Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol (2010) 42(1):40-50. doi:10.1165/rcmb.2008-0260OC
13. Tuvim MJ, Evans SE, Clement CG, Dickey BF, Gilbert BE. Augmented lung inflammation protects against influenza A pneumonia. PLoS One (2009) 4(1):e4176. doi:10.1371/journal.pone.0004176
14. Orcel B, Delclaux B, Baud M, Derenne JP. Oral immunization with bacterial extracts for protection against acute bronchitis in elderly institutionalized patients with chronic bronchitis. Eur Respir J (1994) 7(3):446-52. doi:10.1183/09031936.94.07030446
15. Collet JP, Shapiro P, Ernst P, Renzi T, Ducruet T, Robinson A. Effects of an immunostimulating agent on acute exacerbations and hospitalizations in patients with chronic obstructive pulmonary disease. The PARI-IS study steering committee and research group. Prevention of acute respiratory infection by an immunostimulant. Am J Respir Crit Care Med (1997) 156(6):1719-24
16. Soler M, Mutterlein R, Cozma G, Swiss-German OMSG. Double-blind study of OM-85 in patients with chronic bronchitis or mild chronic obstructive pulmonary disease. Respiration (2007) 74(1):26-32. doi:10.1159/000093933
17. Schaad UB. OM-85 BV, an immunostimulant in pediatric recurrent respiratory tract infections: a systematic review. World J Pediatr (2010) 6(1):5-12. doi:10.1007/s12519-010-0001-x
18. Esposito S, Marchisio P, Prada E, Daleno C, Porretti L, Carsetti R, et al. Impact of a mixed bacterial lysate (OM-85 BV) on the immunogenicity, safety and tolerability of inactivated influenza vaccine in children with recurrent respiratory tract infection. Vaccine (2014) 32(22):2546-52. doi:10.1016/j.vaccine.2014.03.055
19. Razi CH, Harmanci K, Abaci A, Ozdemir O, Hizli S, Renda R, et al. The immunostimulant OM-85 BV prevents wheezing attacks in preschool children. J Allergy Clin Immunol (2010) 126(4):763-9. doi:10.1016/j.jaci.2010.07.038
20. Luan H, Zhang Q, Wang L, Wang C, Zhang M, Xu X, et al. OM85-BV induced the productions of IL-1beta, IL-6, and TNF-alpha via TLR4-and TLR2-mediated ERK1/2/NF-kappaB pathway in RAW264.7 cells. J Interferon Cytokine Res (2014) 34(7):526-36. doi:10.1089/jir.2013.0077
21. Strickland DH, Judd S, Thomas JA, Larcombe AN, Sly PD, Holt PG. Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control. Mucosal Immunol (2011) 4(1):43-52. doi:10.1038/mi.2010.43
22. Sun K, Ye J, Perez DR, Metzger DW. Seasonal FluMist vaccination induces cross-reactive T cell immunity against H1N1 (2009) influenza and secondary bacterial infections. J Immunol (2011) 186(2):987-93. doi:10.4049/jimmunol.1002664
23. Haynes L, Szaba FM, Eaton SM, Kummer LW, Lanthier PA, Petell AH, et al. Immunity to the conserved influenza nucleoprotein reduces susceptibility to secondary bacterial infections. J Immunol (2012) 189(10):4921-9. doi:10.4049/jimmunol.1201916
24. Yadava K, Sichelstiel A, Luescher IF, Nicod LP, Harris NL, Marsland BJ. TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function. Mucosal Immunol (2013) 6(1):83-92. doi:10.1038/mi.2012.50
25. Yoo JK, Kim TS, Hufford MM, Braciale TJ. Viral infection of the lung: host response and sequelae. J Allergy Clin Immunol (2013) 132(6):1263-76. doi:10.1016/j.jaci.2013.06.006
26. Parola C, Salogni L, Vaira X, Scutera S, Somma P, Salvi V, et al. Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway. PLoS One (2013) 8(12):e82867. doi:10.1371/journal.pone.0082867
27. Metzger DW, Sun K. Immune dysfunction and bacterial coinfections following influenza. J Immunol (2013) 191(5):2047-52. doi:10.4049/jimmunol.1301152
28. Huber M, Mossmann H, Bessler WG. Th1-orientated immunological properties of the bacterial extract OM-85-BV. Eur J Med Res (2005) 10(5):209-17