-
1
-
-
84861591910
-
The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
-
Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012;142:1592–1609.
-
(2012)
Gastroenterology
, vol.142
, pp. 1592-1609
-
-
Chalasani, N.1
Younossi, Z.2
Lavine, J.E.3
Diehl, A.M.4
Brunt, E.M.5
Cusi, K.6
-
2
-
-
0032695030
-
Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
-
Angulo P, Keach JC, Batts KP, Lindor KD. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 1999;30:1356–1362.
-
(1999)
Hepatology
, vol.30
, pp. 1356-1362
-
-
Angulo, P.1
Keach, J.C.2
Batts, K.P.3
Lindor, K.D.4
-
3
-
-
33750606061
-
Long-term follow-up of patients with NAFLD and elevated liver enzymes
-
Ekstedt M, Franzen LE, Mathiesen UL, Thorelius L, Holmqvist M, Bodemar G, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006;44:865–873.
-
(2006)
Hepatology
, vol.44
, pp. 865-873
-
-
Ekstedt, M.1
Franzen, L.E.2
Mathiesen, U.L.3
Thorelius, L.4
Holmqvist, M.5
Bodemar, G.6
-
4
-
-
84865545850
-
Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis
-
Loomba R, Abraham M, Unalp A, Wilson L, Lavine J, Doo E, et al. Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology 2012;56:943–951.
-
(2012)
Hepatology
, vol.56
, pp. 943-951
-
-
Loomba, R.1
Abraham, M.2
Unalp, A.3
Wilson, L.4
Lavine, J.5
Doo, E.6
-
5
-
-
84938057875
-
Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease
-
Angulo P, Kleiner DE, Dam-Larsen S, Adams LA, Bjornsson ES, Charatcharoenwitthaya P, et al. Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology 2015;149:389–397.
-
(2015)
Gastroenterology
, vol.149
, pp. 389-397
-
-
Angulo, P.1
Kleiner, D.E.2
Dam-Larsen, S.3
Adams, L.A.4
Bjornsson, E.S.5
Charatcharoenwitthaya, P.6
-
6
-
-
10644220306
-
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
-
Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004;40:1387–1395.
-
(2004)
Hepatology
, vol.40
, pp. 1387-1395
-
-
Browning, J.D.1
Szczepaniak, L.S.2
Dobbins, R.3
Nuremberg, P.4
Horton, J.D.5
Cohen, J.C.6
-
7
-
-
78650486196
-
Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study
-
Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 2011;140:124–131.
-
(2011)
Gastroenterology
, vol.140
, pp. 124-131
-
-
Williams, C.D.1
Stengel, J.2
Asike, M.I.3
Torres, D.M.4
Shaw, J.5
Contreras, M.6
-
9
-
-
84949959656
-
Heritability of hepatic fibrosis and steatosis based on a prospective twin study
-
Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, et al. Heritability of hepatic fibrosis and steatosis based on a prospective twin study. Gastroenterology 2015;149:1784–1793.
-
(2015)
Gastroenterology
, vol.149
, pp. 1784-1793
-
-
Loomba, R.1
Schork, N.2
Chen, C.H.3
Bettencourt, R.4
Bhatt, A.5
Ang, B.6
-
10
-
-
56749096610
-
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
-
Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008;40:1461–1465.
-
(2008)
Nat Genet
, vol.40
, pp. 1461-1465
-
-
Romeo, S.1
Kozlitina, J.2
Xing, C.3
Pertsemlidis, A.4
Cox, D.5
Pennacchio, L.A.6
-
11
-
-
78049457761
-
Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease
-
Chalasani N, Guo X, Loomba R, Goodarzi MO, Haritunians T, Kwon S, et al. Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease. Gastroenterology 2010;139:1567–1576.
-
(2010)
Gastroenterology
, vol.139
, pp. 1567-1576
-
-
Chalasani, N.1
Guo, X.2
Loomba, R.3
Goodarzi, M.O.4
Haritunians, T.5
Kwon, S.6
-
12
-
-
79953745343
-
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
-
Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet 2011;7:e1001324.
-
(2011)
PLoS Genet
, vol.7
-
-
Speliotes, E.K.1
Yerges-Armstrong, L.M.2
Wu, J.3
Hernaez, R.4
Kim, L.J.5
Palmer, C.D.6
-
13
-
-
84898058711
-
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
-
Kozlitina J, Smagris E, Stender S, Nordestgaard BG, Zhou HH, Tybjaerg-Hansen A, et al. Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2014;46:352–356.
-
(2014)
Nat Genet
, vol.46
, pp. 352-356
-
-
Kozlitina, J.1
Smagris, E.2
Stender, S.3
Nordestgaard, B.G.4
Zhou, H.H.5
Tybjaerg-Hansen, A.6
-
14
-
-
84941885943
-
The genetics of nonalcoholic fatty liver disease: spotlight on PNPLA3 and TM6SF2
-
Anstee QM, Day CP. The genetics of nonalcoholic fatty liver disease: spotlight on PNPLA3 and TM6SF2. Semin Liver Dis 2015;35:270–290.
-
(2015)
Semin Liver Dis
, vol.35
, pp. 270-290
-
-
Anstee, Q.M.1
Day, C.P.2
-
15
-
-
84931321456
-
Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study
-
Zarrinpar A, Gupta S, Maurya MR, Subramaniam S, Loomba R. Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study. Gut 2015; doi: 10.1136/gutjnl-2015-309456.
-
(2015)
Gut
-
-
Zarrinpar, A.1
Gupta, S.2
Maurya, M.R.3
Subramaniam, S.4
Loomba, R.5
-
16
-
-
84938150863
-
The hierarchical model of NAFLD: prognostic significance of histologic features in NASH
-
Loomba R, Chalasani N. The hierarchical model of NAFLD: prognostic significance of histologic features in NASH. Gastroenterology 2015;149:278–281.
-
(2015)
Gastroenterology
, vol.149
, pp. 278-281
-
-
Loomba, R.1
Chalasani, N.2
-
17
-
-
4043132498
-
Portal fibrosis and hepatic steatosis in morbidly obese subjects: a spectrum of nonalcoholic fatty liver disease
-
Abrams GA, Kunde SS, Lazenby AJ, Clements RH. Portal fibrosis and hepatic steatosis in morbidly obese subjects: a spectrum of nonalcoholic fatty liver disease. Hepatology 2004;40:475–483.
-
(2004)
Hepatology
, vol.40
, pp. 475-483
-
-
Abrams, G.A.1
Kunde, S.S.2
Lazenby, A.J.3
Clements, R.H.4
-
18
-
-
33748110788
-
Hepatic histology in obese patients undergoing bariatric surgery
-
Machado M, Marques-Vidal P, Cortez-Pinto H. Hepatic histology in obese patients undergoing bariatric surgery. J Hepatol 2006;45:600–606.
-
(2006)
J Hepatol
, vol.45
, pp. 600-606
-
-
Machado, M.1
Marques-Vidal, P.2
Cortez-Pinto, H.3
-
19
-
-
57749183469
-
Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus
-
Leite NC, Salles GF, Araujo AL, Villela-Nogueira CA, Cardoso CR. Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus. Liver Int 2009;29:113–119.
-
(2009)
Liver Int
, vol.29
, pp. 113-119
-
-
Leite, N.C.1
Salles, G.F.2
Araujo, A.L.3
Villela-Nogueira, C.A.4
Cardoso, C.R.5
-
20
-
-
79960029926
-
Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
-
Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011;34:274–285.
-
(2011)
Aliment Pharmacol Ther
, vol.34
, pp. 274-285
-
-
Vernon, G.1
Baranova, A.2
Younossi, Z.M.3
-
22
-
-
84865569519
-
Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial
-
Le TA, Chen J, Changchien C, Peterson MR, Kono Y, Patton H, et al. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology 2012;56:922–932.
-
(2012)
Hepatology
, vol.56
, pp. 922-932
-
-
Le, T.A.1
Chen, J.2
Changchien, C.3
Peterson, M.R.4
Kono, Y.5
Patton, H.6
-
23
-
-
84925339397
-
Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial)
-
Loomba R, Sirlin CB, Ang B, Bettencourt R, Jain R, Salotti J, et al. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology 2015;61:1239–1250.
-
(2015)
Hepatology
, vol.61
, pp. 1239-1250
-
-
Loomba, R.1
Sirlin, C.B.2
Ang, B.3
Bettencourt, R.4
Jain, R.5
Salotti, J.6
-
24
-
-
0037136543
-
Heritability of mammographic density, a risk factor for breast cancer
-
Boyd NF, Dite GS, Stone J, Gunasekara A, English DR, McCredie MR, et al. Heritability of mammographic density, a risk factor for breast cancer. N Engl J Med 2002;347:886–894.
-
(2002)
N Engl J Med
, vol.347
, pp. 886-894
-
-
Boyd, N.F.1
Dite, G.S.2
Stone, J.3
Gunasekara, A.4
English, D.R.5
McCredie, M.R.6
-
25
-
-
84888298670
-
Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials
-
Noureddin M, Lam J, Peterson MR, Middleton M, Hamilton G, Le TA, et al. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology 2013;58:1930–1940.
-
(2013)
Hepatology
, vol.58
, pp. 1930-1940
-
-
Noureddin, M.1
Lam, J.2
Peterson, M.R.3
Middleton, M.4
Hamilton, G.5
Le, T.A.6
-
26
-
-
84888290605
-
Emerging quantitative magnetic resonance imaging biomarkers of hepatic steatosis
-
Reeder SB. Emerging quantitative magnetic resonance imaging biomarkers of hepatic steatosis. Hepatology 2013;58:1877–1880.
-
(2013)
Hepatology
, vol.58
, pp. 1877-1880
-
-
Reeder, S.B.1
-
27
-
-
80052996528
-
Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy
-
Reeder SB, Cruite I, Hamilton G, Sirlin CB. Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging 2011;34:729–749.
-
(2011)
J Magn Reson Imaging
, vol.34
, pp. 729-749
-
-
Reeder, S.B.1
Cruite, I.2
Hamilton, G.3
Sirlin, C.B.4
-
28
-
-
77953809119
-
Assessment of liver fat quantification in the presence of iron
-
Bydder M, Shiehmorteza M, Yokoo T, Sugay S, Middleton MS, Girard O, et al. Assessment of liver fat quantification in the presence of iron. Magn Reson Imaging 2010;28:767–776.
-
(2010)
Magn Reson Imaging
, vol.28
, pp. 767-776
-
-
Bydder, M.1
Shiehmorteza, M.2
Yokoo, T.3
Sugay, S.4
Middleton, M.S.5
Girard, O.6
-
29
-
-
85027925485
-
Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease—MRI accurately quantifies hepatic steatosis in NAFLD
-
Permutt Z, Le TA, Peterson MR, Seki E, Brenner DA, Sirlin C, et al. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease—MRI accurately quantifies hepatic steatosis in NAFLD. Aliment Pharmacol Ther 2012;36:22–29.
-
(2012)
Aliment Pharmacol Ther
, vol.36
, pp. 22-29
-
-
Permutt, Z.1
Le, T.A.2
Peterson, M.R.3
Seki, E.4
Brenner, D.A.5
Sirlin, C.6
-
30
-
-
84876907610
-
Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis
-
Tang A, Tan J, Sun M, Hamilton G, Bydder M, Wolfson T, et al. Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis. Radiology 2013;267:422–431.
-
(2013)
Radiology
, vol.267
, pp. 422-431
-
-
Tang, A.1
Tan, J.2
Sun, M.3
Hamilton, G.4
Bydder, M.5
Wolfson, T.6
-
31
-
-
84911948591
-
Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study
-
Loomba R, Wolfson T, Ang B, Hooker J, Behling C, Peterson M, et al. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Hepatology 2014;60:1920–1928.
-
(2014)
Hepatology
, vol.60
, pp. 1920-1928
-
-
Loomba, R.1
Wolfson, T.2
Ang, B.3
Hooker, J.4
Behling, C.5
Peterson, M.6
-
32
-
-
84929289615
-
Comparative diagnostic accuracy of magnetic resonance elastography versus eight clinical prediction rules for non-invasive diagnosis of advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease: a prospective study
-
Cui J, Ang B, Haufe W, Hernandez C, Verna EC, Sirlin CB, et al. Comparative diagnostic accuracy of magnetic resonance elastography versus eight clinical prediction rules for non-invasive diagnosis of advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease: a prospective study. Aliment Pharmacol Ther 2015;41:1271–1280.
-
(2015)
Aliment Pharmacol Ther
, vol.41
, pp. 1271-1280
-
-
Cui, J.1
Ang, B.2
Haufe, W.3
Hernandez, C.4
Verna, E.C.5
Sirlin, C.B.6
-
33
-
-
84956713473
-
Magnetic resonance elastography is superior to acoustic radiation force impulse for the diagnosis of fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease: a prospective study
-
Cui J, Heba E, Hernandez C, Haufe W, Hooker J, Andre MP, et al. Magnetic resonance elastography is superior to acoustic radiation force impulse for the diagnosis of fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease: a prospective study. Hepatology 2016;63:453–461.
-
(2016)
Hepatology
, vol.63
, pp. 453-461
-
-
Cui, J.1
Heba, E.2
Hernandez, C.3
Haufe, W.4
Hooker, J.5
Andre, M.P.6
-
35
-
-
33845567067
-
Heritability and genetic loci of fatty liver in familial combined hyperlipidemia
-
Brouwers MC, Cantor RM, Kono N, Yoon JL, van der Kallen CJ, Bilderbeek-Beckers MA, et al. Heritability and genetic loci of fatty liver in familial combined hyperlipidemia. J Lipid Res 2006;47:2799–2807.
-
(2006)
J Lipid Res
, vol.47
, pp. 2799-2807
-
-
Brouwers, M.C.1
Cantor, R.M.2
Kono, N.3
Yoon, J.L.4
van der Kallen, C.J.5
Bilderbeek-Beckers, M.A.6
-
36
-
-
65249188812
-
Heritability of nonalcoholic fatty liver disease
-
Schwimmer JB, Celedon MA, Lavine JE, Salem R, Campbell N, Schork NJ, et al. Heritability of nonalcoholic fatty liver disease. Gastroenterology 2009;136:1585–1592.
-
(2009)
Gastroenterology
, vol.136
, pp. 1585-1592
-
-
Schwimmer, J.B.1
Celedon, M.A.2
Lavine, J.E.3
Salem, R.4
Campbell, N.5
Schork, N.J.6
-
37
-
-
6344269191
-
Power of the classical twin design revisited
-
Visscher PM. Power of the classical twin design revisited. Twin Res 2004;7:505–512.
-
(2004)
Twin Res
, vol.7
, pp. 505-512
-
-
Visscher, P.M.1
-
38
-
-
33751545838
-
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
-
Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006;355:2297–2307.
-
(2006)
N Engl J Med
, vol.355
, pp. 2297-2307
-
-
Belfort, R.1
Harrison, S.A.2
Brown, K.3
Darland, C.4
Finch, J.5
Hardies, J.6
-
39
-
-
46349088361
-
Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) trial
-
Ratziu V, Giral P, Jacqueminet S, Charlotte F, Hartemann-Heurtier A, Serfaty L, et al. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) trial. Gastroenterology 2008;135:100–110.
-
(2008)
Gastroenterology
, vol.135
, pp. 100-110
-
-
Ratziu, V.1
Giral, P.2
Jacqueminet, S.3
Charlotte, F.4
Hartemann-Heurtier, A.5
Serfaty, L.6
-
40
-
-
77951874018
-
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
-
Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010;362:1675–1685.
-
(2010)
N Engl J Med
, vol.362
, pp. 1675-1685
-
-
Sanyal, A.J.1
Chalasani, N.2
Kowdley, K.V.3
McCullough, A.4
Diehl, A.M.5
Bass, N.M.6
-
41
-
-
77956636268
-
The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
-
Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology 2010;52:894–903.
-
(2010)
Hepatology
, vol.52
, pp. 894-903
-
-
Rotman, Y.1
Koh, C.2
Zmuda, J.M.3
Kleiner, D.E.4
Liang, T.J.5
-
42
-
-
84903708160
-
TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
-
Liu YL, Reeves HL, Burt AD, Tiniakos D, McPherson S, Leathart JB, et al. TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease. Nat Commun 2014;5:4309.
-
(2014)
Nat Commun
, vol.5
, pp. 4309
-
-
Liu, Y.L.1
Reeves, H.L.2
Burt, A.D.3
Tiniakos, D.4
McPherson, S.5
Leathart, J.B.6
-
43
-
-
84921487729
-
Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
-
Dongiovanni P, Petta S, Maglio C, Fracanzani AL, Pipitone R, Mozzi E, et al. Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease. Hepatology 2015;61:506–514.
-
(2015)
Hepatology
, vol.61
, pp. 506-514
-
-
Dongiovanni, P.1
Petta, S.2
Maglio, C.3
Fracanzani, A.L.4
Pipitone, R.5
Mozzi, E.6
-
44
-
-
84992459206
-
-
Presented at ESGAR, June 9-12,, Paris, France.
-
Hooker JC, Liao S, Le TA, Chen J, Wolfson T, Middleton MS, et al. Inter-reader reproducibility of MRI hepatic proton density fat fraction (PDFF) estimation in adults with biopsy-proven NASH. Presented at: ESGAR, June 9-12, 2015, Paris, France. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485664/
-
(2015)
Inter-reader reproducibility of MRI hepatic proton density fat fraction (PDFF) estimation in adults with biopsy-proven NASH
-
-
Hooker, J.C.1
Liao, S.2
Le, T.A.3
Chen, J.4
Wolfson, T.5
Middleton, M.S.6
|