Development of human-like advanced coronary plaques in low-density lipoprotein receptor knockout pigs and justification for statin treatment before formation of atherosclerotic plaques

Journal of the American Heart Association

Volumn 5, Issue 4, 2016, Pages

  Li, Yuxin ^a   Fuchimoto, Daiichiro ^b   Sudo, Mitsumasa ^a   Haruta, Hironori ^a   Lin, Qing Fei ^a   Takayama, Tadateru ^a   Morita, Shotaro ^c   Nochi, Tomonori ^c   Suzuki, Shunichi ^b   Sembon, Shoichiro ^b   Nakai, Michiko ^b   Kojima, Misaki ^b   Iwamoto, Masaki ^d   Hashimoto, Michiko ^d   Yoda, Shunichi ^a   Kunimoto, Satoshi ^a   Hiro, Takafumi ^a   Matsumoto, Taro ^a   Mitsumata, Masako ^a   Sugitani, Masahiko ^a   Saito, Satoshi ^a   Hirayama, Atsushi ^a   Onishi, Akira ^b,e   more..

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d Prime Tech Ltd   (Japan)

^e NIHON UNIVERSITY   (Japan)

Author keywords

Atherosclerosis; Cholesterol; Coronary disease; Plaque; Statins

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PITAVASTATIN; PROTEIN; VERY LOW DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROMA; ATHEROSCLEROTIC PLAQUE; BLEEDING; CALCIFICATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FIBROATHEROMA; INTRAPLAQUE HEMORRHAGE; INTRAVASCULAR ULTRASOUND; KNOCKOUT PIG; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; PATHOLOGY; PIG; PRIORITY JOURNAL; PROPHYLAXIS; PROTEIN BLOOD LEVEL; ADVERSE EFFECTS; ANIMAL; ATHEROGENIC DIET; CORONARY ARTERY DISEASE; DISEASE MODEL; GENE INACTIVATION; GENETICS; PHYSIOLOGY; PLAQUE, ATHEROSCLEROTIC; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CORONARY ARTERY DISEASE; DIET, ATHEROGENIC; DISEASE MODELS, ANIMAL; FEMALE; GENE KNOCKOUT TECHNIQUES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; PLAQUE, ATHEROSCLEROTIC; RECEPTORS, LDL; SWINE;

EID: 84992435989     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.115.002779     Document Type: Article

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