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Volumn 35, Issue 11, 2016, Pages 2647-2656

Implications of fluoroquinolone contamination for the aquatic environment—A review

Author keywords

Antibiotics; Ecotoxicity; Freshwater ecology; Residues

Indexed keywords

ANIMALS; ANTIBIOTICS; AQUATIC ORGANISMS; ECOLOGY; ECOSYSTEMS; ENVIRONMENTAL IMPACT; MICROORGANISMS; TOXICITY; WATER;

EID: 84992391329     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.3552     Document Type: Review
Times cited : (177)

References (66)
  • 1
    • 2142782525 scopus 로고    scopus 로고
    • Bacteria versus Antibacterial Agents, American Society of Microbiology, Washington, DC. [cited 2016 February 27]. Available from
    • Mascaretti OA. 2003. Bacteria versus Antibacterial Agents. American Society of Microbiology, Washington, DC. [cited 2016 February 27]. Available from: http://www.asmscience.org/content/book/10.1128/9781555817794
    • (2003)
    • Mascaretti, O.A.1
  • 2
    • 0344328778 scopus 로고    scopus 로고
    • Mechanisms of quinolone resistance. In Rubinstein E, Hooper DC, eds,, Quinolone Antimicrobiol Agents, 3rd ed. American Society of Microbiology, [cited 2016 April 7]. Available from
    • Hooper DC. 2003. Mechanisms of quinolone resistance. In Rubinstein E, Hooper DC, eds, Quinolone Antimicrobiol Agents, 3rd ed. American Society of Microbiology, pp 41–67. [cited 2016 April 7]. Available from: http://www.asmscience.org/content/book/10.1128/9781555817817.chap3
    • (2003) , pp. 41-67
    • Hooper, D.C.1
  • 3
    • 81155125070 scopus 로고    scopus 로고
    • Toxicity of the fluoroquinolone antibiotics enrofloxacin and ciprofloxacin to photoautotrophic aquatic organisms
    • Ebert I, Bachmann J, Kühnen U, Küster A, Kussatz C, Maletzki D, Schlüter C. 2011. Toxicity of the fluoroquinolone antibiotics enrofloxacin and ciprofloxacin to photoautotrophic aquatic organisms. Environ Toxicol Chem 30:2786–2792.
    • (2011) Environ Toxicol Chem , vol.30 , pp. 2786-2792
    • Ebert, I.1    Bachmann, J.2    Kühnen, U.3    Küster, A.4    Kussatz, C.5    Maletzki, D.6    Schlüter, C.7
  • 4
    • 12344291679 scopus 로고    scopus 로고
    • Toxicity of fluoroquinolone antibiotics to aquatic organisms
    • Robinson AA, Belden JB, Lydy MJ. 2005. Toxicity of fluoroquinolone antibiotics to aquatic organisms. Environ Toxicol Chem 24:423–430.
    • (2005) Environ Toxicol Chem , vol.24 , pp. 423-430
    • Robinson, A.A.1    Belden, J.B.2    Lydy, M.J.3
  • 5
    • 33747876745 scopus 로고    scopus 로고
    • A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment
    • Sarmah AK, Meyer MT, Boxall ABA. 2006. A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere 65:725–759.
    • (2006) Chemosphere , vol.65 , pp. 725-759
    • Sarmah, A.K.1    Meyer, M.T.2    Boxall, A.B.A.3
  • 7
    • 84992373920 scopus 로고    scopus 로고
    • European Medicines Agency., Sales of veterinary antimicrobial agents in 26 EU/EEA countries in 2012 Fourth ESVAC report. European Medicines Agency, London, UK. [cited 2016 April 7]. Available from
    • European Medicines Agency. 2014. Sales of veterinary antimicrobial agents in 26 EU/EEA countries in 2012: Fourth ESVAC report. European Medicines Agency, London, UK. [cited 2016 April 7]. Available from: zotero://attachment/58/.
    • (2014)
  • 8
    • 84992320290 scopus 로고    scopus 로고
    • Government of Canada., Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) annual report. Chapter 2 Antimicrobial resistance., Public Health Agency of Canada, Guelph, Canada
    • Government of Canada. 2014. Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) annual report. Chapter 2: Antimicrobial resistance. Public Health Agency of Canada, Guelph, Canada.
    • (2014)
  • 9
    • 84992370559 scopus 로고    scopus 로고
    • American Association of Swine Veterinarians., News archive Baytril FDA approved for control of E. coli in swine. [cited 2016 April 7]. Available from
    • American Association of Swine Veterinarians. 2015. News archive: Baytril FDA approved for control of E. coli in swine. [cited 2016 April 7]. Available from: https://www.aasv.org/news/story.php?id=7798
    • (2015)
  • 10
    • 84992320286 scopus 로고    scopus 로고
    • US Food and Drug Administration., 2012 Summary report on antimicrobials sold or distributed for use in food-producing animals., Department of Health and Human Services, Washington, DC
    • US Food and Drug Administration. 2014. 2012 Summary report on antimicrobials sold or distributed for use in food-producing animals. Department of Health and Human Services, Washington, DC.
    • (2014)
  • 11
    • 84992360644 scopus 로고    scopus 로고
    • US Food and Drug Administration., 2013 summary report on antimicrobials sold or distributed for use in food-producing animals., Department of Health and Human Services, Washington, DC
    • US Food and Drug Administration. 2015. 2013 summary report on antimicrobials sold or distributed for use in food-producing animals. Department of Health and Human Services, Washington, DC.
    • (2015)
  • 12
    • 79960106682 scopus 로고    scopus 로고
    • Antibiotic contaminants in coastal wetlands from Vietnamese shrimp farming
    • Thuy HTT, Nga LP, Loan TTC. 2011. Antibiotic contaminants in coastal wetlands from Vietnamese shrimp farming. Environ Sci Pollut Res 18:835–841.
    • (2011) Environ Sci Pollut Res , vol.18 , pp. 835-841
    • Thuy, H.T.T.1    Nga, L.P.2    Loan, T.T.C.3
  • 13
    • 84992373780 scopus 로고    scopus 로고
    • European Centre for Disease Prevention and Control, European Food Safety Authority, European Medicines Agency., Surveillance of antimicrobial consumption in Europe 2012., Stockholm, Sweden
    • European Centre for Disease Prevention and Control, European Food Safety Authority, European Medicines Agency. 2014. Surveillance of antimicrobial consumption in Europe 2012. Stockholm, Sweden.
    • (2014)
  • 14
    • 84992370552 scopus 로고    scopus 로고
    • Government of Canada., Human antimicrobial drug use report 2012/2013., Public Health Agency of Canada, Toronto, Canada
    • Government of Canada. 2014. Human antimicrobial drug use report 2012/2013. Public Health Agency of Canada, Toronto, Canada.
    • (2014)
  • 15
    • 84874991232 scopus 로고    scopus 로고
    • Accelerated biodegradation of veterinary antibiotics in agricultural soil following long-term exposure, and isolation of a sulfamethazine-degrading sp
    • Topp E, Chapman R, Devers-Lamrani M, Hartmann A, Marti R, Martin-Laurent F, Sabourin L, Scott A, Sumarah M. 2013. Accelerated biodegradation of veterinary antibiotics in agricultural soil following long-term exposure, and isolation of a sulfamethazine-degrading sp. J Environ Qual 42:173.
    • (2013) J Environ Qual , vol.42 , pp. 173
    • Topp, E.1    Chapman, R.2    Devers-Lamrani, M.3    Hartmann, A.4    Marti, R.5    Martin-Laurent, F.6    Sabourin, L.7    Scott, A.8    Sumarah, M.9
  • 16
    • 63449084512 scopus 로고    scopus 로고
    • Antibiotics in the aquatic environment-A review-Part I
    • Kümmerer K. 2009. Antibiotics in the aquatic environment-A review-Part I. Chemosphere 75:417–434.
    • (2009) Chemosphere , vol.75 , pp. 417-434
    • Kümmerer, K.1
  • 17
    • 0004138186 scopus 로고    scopus 로고
    • Pharmaceuticals in the Environment—A Brief Summary, Springer, New York, NY, USA. [cited 2016 January 8]. Available from
    • Kümmerer K. 2008. Pharmaceuticals in the Environment—A Brief Summary. Springer, New York, NY, USA. [cited 2016 January 8]. Available from: http://link.springer.com/chapter/10.1007/978-3-540-74664-5_1
    • (2008)
    • Kümmerer, K.1
  • 18
    • 0030721747 scopus 로고    scopus 로고
    • Degradation of the fluoroquinolone enrofloxacin by the brown rot fungus Gloeophyllum striatum: Identification of metabolites
    • Wetzstein H-G, Schmeer N, Karl W. 1997. Degradation of the fluoroquinolone enrofloxacin by the brown rot fungus Gloeophyllum striatum: Identification of metabolites. Appl Environ Microbiol 63:4272–4281.
    • (1997) Appl Environ Microbiol , vol.63 , pp. 4272-4281
    • Wetzstein, H.-G.1    Schmeer, N.2    Karl, W.3
  • 20
    • 84870056998 scopus 로고    scopus 로고
    • Direct photochemistry of three fluoroquinolone antibacterials: Norfloxacin, ofloxacin, and enrofloxacin
    • Wammer KH, Korte AR, Lundeen RA, Sundberg JE, McNeill K, Arnold WA. 2013. Direct photochemistry of three fluoroquinolone antibacterials: Norfloxacin, ofloxacin, and enrofloxacin. Water Res 47:439–448.
    • (2013) Water Res , vol.47 , pp. 439-448
    • Wammer, K.H.1    Korte, A.R.2    Lundeen, R.A.3    Sundberg, J.E.4    McNeill, K.5    Arnold, W.A.6
  • 21
    • 0036828688 scopus 로고    scopus 로고
    • Determination of fluoroquinolone antibacterial agents in sewage sludge and sludge-treated soil using accelerated solvent extraction followed by solid-phase extraction
    • Golet EM, Strehler A, Alder AC, Giger W. 2002. Determination of fluoroquinolone antibacterial agents in sewage sludge and sludge-treated soil using accelerated solvent extraction followed by solid-phase extraction. Anal Chem 74:5455–5462.
    • (2002) Anal Chem , vol.74 , pp. 5455-5462
    • Golet, E.M.1    Strehler, A.2    Alder, A.C.3    Giger, W.4
  • 24
    • 77950400095 scopus 로고    scopus 로고
    • Aquatic photochemistry of fluoroquinolone antibiotics: Kinetics, pathways, and multivariate effects of main water constituents
    • Ge L, Chen J, Wei X, Zhang S, Qiao X, Cai X, Xie Q. 2010. Aquatic photochemistry of fluoroquinolone antibiotics: Kinetics, pathways, and multivariate effects of main water constituents. Environ Sci Technol 44:2400–2405.
    • (2010) Environ Sci Technol , vol.44 , pp. 2400-2405
    • Ge, L.1    Chen, J.2    Wei, X.3    Zhang, S.4    Qiao, X.5    Cai, X.6    Xie, Q.7
  • 25
    • 84940490426 scopus 로고    scopus 로고
    • Mass flow of antibiotics in a wastewater treatment plant focusing on removal variations due to operational parameters
    • Marx C, Günther N, Schubert S, Oertel R, Ahnert M, Krebs P, Kuehn V. 2015. Mass flow of antibiotics in a wastewater treatment plant focusing on removal variations due to operational parameters. Sci Total Environ 538:779–788.
    • (2015) Sci Total Environ , vol.538 , pp. 779-788
    • Marx, C.1    Günther, N.2    Schubert, S.3    Oertel, R.4    Ahnert, M.5    Krebs, P.6    Kuehn, V.7
  • 26
    • 84917706463 scopus 로고    scopus 로고
    • Ciprofloxacin residues in municipal biosolid compost do not selectively enrich populations of resistant bacteria
    • Youngquist CP, Liu J, Orfe LH, Jones SS, Call DR. 2014. Ciprofloxacin residues in municipal biosolid compost do not selectively enrich populations of resistant bacteria. Appl Environ Microbiol 80:7521–7526.
    • (2014) Appl Environ Microbiol , vol.80 , pp. 7521-7526
    • Youngquist, C.P.1    Liu, J.2    Orfe, L.H.3    Jones, S.S.4    Call, D.R.5
  • 27
    • 84877344351 scopus 로고    scopus 로고
    • Occurrence and partitioning of antibiotic compounds found in the water column and bottom sediments from a stream receiving two wastewater treatment plant effluents in Northern New Jersey, 2008
    • Gibs J, Heckathorn HA, Meyer MT, Klapinski FR, Alebus M, Lippincott RL. 2013. Occurrence and partitioning of antibiotic compounds found in the water column and bottom sediments from a stream receiving two wastewater treatment plant effluents in Northern New Jersey, 2008. Sci Total Environ 458–460:107–116.
    • (2013) Sci Total Environ , vol.458-460 , pp. 107-116
    • Gibs, J.1    Heckathorn, H.A.2    Meyer, M.T.3    Klapinski, F.R.4    Alebus, M.5    Lippincott, R.L.6
  • 28
    • 33646239812 scopus 로고    scopus 로고
    • Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA
    • Karthikeyan KG, Meyer MT. 2006. Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA. Sci Total Environ 361:196–207.
    • (2006) Sci Total Environ , vol.361 , pp. 196-207
    • Karthikeyan, K.G.1    Meyer, M.T.2
  • 31
    • 84904367804 scopus 로고    scopus 로고
    • Development of sensitive and reliable LC-MS/MS methods for the determination of three fluoroquinolones in water and fish tissue samples and preliminary environmental risk assessment of their presence in two rivers in northern Poland
    • Wagil M, Kumirska J, Stolte S, Puckowski A, Maszkowska J, Stepnowski P, Białk-Bielińska A. 2014. Development of sensitive and reliable LC-MS/MS methods for the determination of three fluoroquinolones in water and fish tissue samples and preliminary environmental risk assessment of their presence in two rivers in northern Poland. Sci Total Environ 493:1006–1013.
    • (2014) Sci Total Environ , vol.493 , pp. 1006-1013
    • Wagil, M.1    Kumirska, J.2    Stolte, S.3    Puckowski, A.4    Maszkowska, J.5    Stepnowski, P.6    Białk-Bielińska, A.7
  • 32
    • 0036711595 scopus 로고    scopus 로고
    • Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley watershed, Switzerland
    • Golet EM, Alder AC, Giger W. 2002. Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley watershed, Switzerland. Environ Sci Technol 36:3645–3651.
    • (2002) Environ Sci Technol , vol.36 , pp. 3645-3651
    • Golet, E.M.1    Alder, A.C.2    Giger, W.3
  • 33
    • 11144341431 scopus 로고    scopus 로고
    • Determination of fluoroquinolone antibiotics in wastewater effluents by liquid chromatography–mass spectrometry and fluorescence detection
    • Nakata H, Kannan K, Jones PD, Giesy JP. 2005. Determination of fluoroquinolone antibiotics in wastewater effluents by liquid chromatography–mass spectrometry and fluorescence detection. Chemosphere 58:759–766.
    • (2005) Chemosphere , vol.58 , pp. 759-766
    • Nakata, H.1    Kannan, K.2    Jones, P.D.3    Giesy, J.P.4
  • 36
    • 84879254436 scopus 로고    scopus 로고
    • Role of hospital effluents in the contribution of antibiotics and antibiotic resistant bacteria to the aquatic environment
    • Ahmad M, Khan A, Wahid A, Butt Z, Farhan M, Ahmad F. 2012. Role of hospital effluents in the contribution of antibiotics and antibiotic resistant bacteria to the aquatic environment. Pak J Nutr 11:1177–1182.
    • (2012) Pak J Nutr , vol.11 , pp. 1177-1182
    • Ahmad, M.1    Khan, A.2    Wahid, A.3    Butt, Z.4    Farhan, M.5    Ahmad, F.6
  • 37
    • 84856048573 scopus 로고    scopus 로고
    • Occurrence of antibiotics in eight sewage treatment plants in Beijing, China
    • Gao L, Shi Y, Li W, Niu H, Liu J, Cai Y. 2012. Occurrence of antibiotics in eight sewage treatment plants in Beijing, China. Chemosphere 86:665–671.
    • (2012) Chemosphere , vol.86 , pp. 665-671
    • Gao, L.1    Shi, Y.2    Li, W.3    Niu, H.4    Liu, J.5    Cai, Y.6
  • 38
    • 84871997055 scopus 로고    scopus 로고
    • Occurrence of fluoroquinolones and fluoroquinolone-resistance genes in the aquatic environment
    • Adachi F, Yamamoto A, Takakura K-I, Kawahara R. 2013. Occurrence of fluoroquinolones and fluoroquinolone-resistance genes in the aquatic environment. Sci Total Environ 444:508–514.
    • (2013) Sci Total Environ , vol.444 , pp. 508-514
    • Adachi, F.1    Yamamoto, A.2    Takakura, K.-I.3    Kawahara, R.4
  • 39
    • 84862986117 scopus 로고    scopus 로고
    • Occurrence and sorption of fluoroquinolones in poultry litters and soils from São Paulo State, Brazil
    • Leal RMP, Figueira RF, Tornisielo VL, Regitano JB. 2012. Occurrence and sorption of fluoroquinolones in poultry litters and soils from São Paulo State, Brazil. Sci Total Environ 432:344–349.
    • (2012) Sci Total Environ , vol.432 , pp. 344-349
    • Leal, R.M.P.1    Figueira, R.F.2    Tornisielo, V.L.3    Regitano, J.B.4
  • 40
    • 3042828263 scopus 로고    scopus 로고
    • Occurrence of antimicrobials in the final effluents of wastewater treatment plants in Canada
    • Miao X-S, Bishay F, Chen M, Metcalfe CD. 2004. Occurrence of antimicrobials in the final effluents of wastewater treatment plants in Canada. Environ Sci Technol 38:3533–3541.
    • (2004) Environ Sci Technol , vol.38 , pp. 3533-3541
    • Miao, X.-S.1    Bishay, F.2    Chen, M.3    Metcalfe, C.D.4
  • 41
    • 0037085574 scopus 로고    scopus 로고
    • Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999−2000: A national reconnaissance
    • Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT. 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999−2000: A national reconnaissance. Environ Sci Technol 36:1202–1211.
    • (2002) Environ Sci Technol , vol.36 , pp. 1202-1211
    • Kolpin, D.W.1    Furlong, E.T.2    Meyer, M.T.3    Thurman, E.M.4    Zaugg, S.D.5    Barber, L.B.6    Buxton, H.T.7
  • 42
    • 8844244723 scopus 로고    scopus 로고
    • Residues of selected antibiotics in water and mud from shrimp ponds in mangrove areas in Viet Nam
    • Le TX, Munekage Y. 2004. Residues of selected antibiotics in water and mud from shrimp ponds in mangrove areas in Viet Nam. Mar Pollut Bull 49:922–929.
    • (2004) Mar Pollut Bull , vol.49 , pp. 922-929
    • Le, T.X.1    Munekage, Y.2
  • 43
    • 84919777134 scopus 로고    scopus 로고
    • Ecological risk assessment of the antibiotic enrofloxacin applied to Pangasius catfish farms in the Mekong Delta, Vietnam
    • Andrieu M, Rico A, Phu TM, Huong DTT, Phuong NT, Van den Brink PJ. 2015. Ecological risk assessment of the antibiotic enrofloxacin applied to Pangasius catfish farms in the Mekong Delta, Vietnam. Chemosphere 119:407–414.
    • (2015) Chemosphere , vol.119 , pp. 407-414
    • Andrieu, M.1    Rico, A.2    Phu, T.M.3    Huong, D.T.T.4    Phuong, N.T.5    Van den Brink, P.J.6
  • 44
    • 77949396811 scopus 로고    scopus 로고
    • Fluoroquinolone antibiotics determination in piggeries environmental waters
    • Pena A, Pina J, Silva LJG, Meisel L, Lino CM. 2010. Fluoroquinolone antibiotics determination in piggeries environmental waters. J Environ Monit 12:642–646.
    • (2010) J Environ Monit , vol.12 , pp. 642-646
    • Pena, A.1    Pina, J.2    Silva, L.J.G.3    Meisel, L.4    Lino, C.M.5
  • 45
    • 61649087633 scopus 로고    scopus 로고
    • The occurrence of antibiotics in an urban watershed: From wastewater to drinking water
    • Watkinson AJ, Murby EJ, Kolpin DW, Costanzo SD. 2009. The occurrence of antibiotics in an urban watershed: From wastewater to drinking water. Sci Total Environ 407:2711–2723.
    • (2009) Sci Total Environ , vol.407 , pp. 2711-2723
    • Watkinson, A.J.1    Murby, E.J.2    Kolpin, D.W.3    Costanzo, S.D.4
  • 46
    • 84861332141 scopus 로고    scopus 로고
    • Hospital effluent: Investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment
    • Verlicchi P, Al Aukidy M, Galletti A, Petrovic M, Barceló D. 2012. Hospital effluent: Investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment. Sci Total Environ 430:109–118.
    • (2012) Sci Total Environ , vol.430 , pp. 109-118
    • Verlicchi, P.1    Al Aukidy, M.2    Galletti, A.3    Petrovic, M.4    Barceló, D.5
  • 47
    • 0031935383 scopus 로고    scopus 로고
    • Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater
    • Hartmann A, Alder AC, Koller T, Widmer RM. 1998. Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater. Environ Toxicol Chem 17:377–382.
    • (1998) Environ Toxicol Chem , vol.17 , pp. 377-382
    • Hartmann, A.1    Alder, A.C.2    Koller, T.3    Widmer, R.M.4
  • 49
    • 32444449124 scopus 로고    scopus 로고
    • Behavior of fluoroquinolones and trimethoprim during mechanical, chemical, and active sludge treatment of sewage water and digestion of sludge
    • Lindberg RH, Olofsson U, Rendahl P, Johansson MI, Tysklind M, Andersson BA. 2006. Behavior of fluoroquinolones and trimethoprim during mechanical, chemical, and active sludge treatment of sewage water and digestion of sludge. Environ Sci Technol 40:1042–1048.
    • (2006) Environ Sci Technol , vol.40 , pp. 1042-1048
    • Lindberg, R.H.1    Olofsson, U.2    Rendahl, P.3    Johansson, M.I.4    Tysklind, M.5    Andersson, B.A.6
  • 50
    • 77954997263 scopus 로고    scopus 로고
    • Determination of fluoroquinolone antibiotics in wastewater using ultra high-performance liquid chromatography with mass spectrometry and fluorescence detection
    • Seifrtová M, Aufartová J, Vytlačilová J, Pena A, Solich P, Nováková L. 2010. Determination of fluoroquinolone antibiotics in wastewater using ultra high-performance liquid chromatography with mass spectrometry and fluorescence detection. J Sep Sci 33:2094–2108.
    • (2010) J Sep Sci , vol.33 , pp. 2094-2108
    • Seifrtová, M.1    Aufartová, J.2    Vytlačilová, J.3    Pena, A.4    Solich, P.5    Nováková, L.6
  • 51
    • 84903585487 scopus 로고    scopus 로고
    • Seasonal changes in antibiotics, antidepressants/psychiatric drugs, antihistamines and lipid regulators in a wastewater treatment plant
    • Golovko O, Kumar V, Fedorova G, Randak T, Grabic R. 2014. Seasonal changes in antibiotics, antidepressants/psychiatric drugs, antihistamines and lipid regulators in a wastewater treatment plant. Chemosphere 111:418–426.
    • (2014) Chemosphere , vol.111 , pp. 418-426
    • Golovko, O.1    Kumar, V.2    Fedorova, G.3    Randak, T.4    Grabic, R.5
  • 52
    • 84893392939 scopus 로고    scopus 로고
    • A multi-biomarker assessment of single and combined effects of norfloxacin and sulfamethoxazole on male goldfish (Carassius auratus)
    • Liu J, Lu G, Wu D, Yan Z. 2014. A multi-biomarker assessment of single and combined effects of norfloxacin and sulfamethoxazole on male goldfish (Carassius auratus). Ecotoxicol Environ Saf 102:12–17.
    • (2014) Ecotoxicol Environ Saf , vol.102 , pp. 12-17
    • Liu, J.1    Lu, G.2    Wu, D.3    Yan, Z.4
  • 53
    • 84959121835 scopus 로고    scopus 로고
    • Do antibiotics have environmental side-effects? Impact of synthetic antibiotics on biogeochemical processes
    • Roose-Amsaleg C, Laverman AM. 2016. Do antibiotics have environmental side-effects? Impact of synthetic antibiotics on biogeochemical processes. Environ Sci Pollut Res 23:4000–4012.
    • (2016) Environ Sci Pollut Res , vol.23 , pp. 4000-4012
    • Roose-Amsaleg, C.1    Laverman, A.M.2
  • 54
    • 84868480601 scopus 로고    scopus 로고
    • Toxicity of 15 veterinary pharmaceuticals in zebrafish (Danio rerio) embryos
    • Carlsson G, Patring J, Kreuger J, Norrgren L, Oskarsson A. 2013. Toxicity of 15 veterinary pharmaceuticals in zebrafish (Danio rerio) embryos. Aquat Toxicol 126:30–41.
    • (2013) Aquat Toxicol , vol.126 , pp. 30-41
    • Carlsson, G.1    Patring, J.2    Kreuger, J.3    Norrgren, L.4    Oskarsson, A.5
  • 55
    • 67651087170 scopus 로고    scopus 로고
    • Effects of norfloxacin and butylated hydroxyanisole on the freshwater microalga Scenedesmus obliquus
    • Nie X, Gu J, Lu J, Pan W, Yang Y. 2009. Effects of norfloxacin and butylated hydroxyanisole on the freshwater microalga Scenedesmus obliquus. Ecotoxicology 18:677–684.
    • (2009) Ecotoxicology , vol.18 , pp. 677-684
    • Nie, X.1    Gu, J.2    Lu, J.3    Pan, W.4    Yang, Y.5
  • 58
    • 84916232796 scopus 로고    scopus 로고
    • The sensitivity of Daphnia magna and Daphnia curvirostris to 10 veterinary antibacterials and to some of their binary mixtures
    • Dalla Bona M, Di Leva V, De Liguoro M. 2014. The sensitivity of Daphnia magna and Daphnia curvirostris to 10 veterinary antibacterials and to some of their binary mixtures. Chemosphere 115:67–74.
    • (2014) Chemosphere , vol.115 , pp. 67-74
    • Dalla Bona, M.1    Di Leva, V.2    De Liguoro, M.3
  • 59
    • 38049027760 scopus 로고    scopus 로고
    • Response of the freshwater alga Chlorella vulgaris to trichloroisocyanuric acid and ciprofloxacin
    • Nie X, Wang X, Chen J, Zitko V, An T. 2008. Response of the freshwater alga Chlorella vulgaris to trichloroisocyanuric acid and ciprofloxacin. Environ Toxicol Chem 27:168–173.
    • (2008) Environ Toxicol Chem , vol.27 , pp. 168-173
    • Nie, X.1    Wang, X.2    Chen, J.3    Zitko, V.4    An, T.5
  • 62
    • 84866078622 scopus 로고    scopus 로고
    • Toxic effects of erythromycin, ciprofloxacin and sulfamethoxazole exposure to the antioxidant system in Pseudokirchneriella subcapitata
    • Nie X-P, Liu B-Y, Yu H-J, Liu W-Q, Yang Y-F. 2013. Toxic effects of erythromycin, ciprofloxacin and sulfamethoxazole exposure to the antioxidant system in Pseudokirchneriella subcapitata. Environ Pollut 172:23–32.
    • (2013) Environ Pollut , vol.172 , pp. 23-32
    • Nie, X.-P.1    Liu, B.-Y.2    Yu, H.-J.3    Liu, W.-Q.4    Yang, Y.-F.5
  • 65
    • 73449123747 scopus 로고    scopus 로고
    • Effluent from bulk drug production is toxic to aquatic vertebrates
    • Carlsson G, Örn S, Larsson DG. 2009. Effluent from bulk drug production is toxic to aquatic vertebrates. Environ Toxicol Chem 28:2656–2662.
    • (2009) Environ Toxicol Chem , vol.28 , pp. 2656-2662
    • Carlsson, G.1    Örn, S.2    Larsson, D.G.3
  • 66
    • 34548354864 scopus 로고    scopus 로고
    • Effluent from drug manufactures contains extremely high levels of pharmaceuticals
    • Larsson DGJ, de Pedro C, Paxeus N. 2007. Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater 148:751–755.
    • (2007) J Hazard Mater , vol.148 , pp. 751-755
    • Larsson, D.G.J.1    de Pedro, C.2    Paxeus, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.