NFB inhibition attenuates LPS-induced TLR4 activation in monocyte cells

Molecular Medicine Reports

Volumn 14, Issue 5, 2016, Pages 4505-4510

  Wan, Jian ^a,b   Shan, Yi ^a   Fan, Yibo ^b   Fan, Conghui ^b   Chen, Song ^b   Sun, Jie ^b   Zhu, Lili ^b   Qin, Long ^b   Yu, Mengjin ^b   Lin, Zhaofen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY OF MEDICINE AND HEALTH SCIENCES   (China)

Author keywords

Lipopolysaccharide; Nuclear factorB; THP1 cells; Toll like receptor 4

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; MESSENGER RNA; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; DNA BINDING PROTEIN; TLR4 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CELL MEMBRANE; CHEMICAL STRUCTURE; CHROMATIN; CONTROLLED STUDY; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MONOCYTE; POSITIVE FEEDBACK; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; UPREGULATION; WESTERN BLOTTING; CELL DIFFERENTIATION; CELL LINE; CELL MOTION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; NF-KAPPA B; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRANSCRIPTIONAL ACTIVATION;

EID: 84992337513     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.5825     Document Type: Article

References (17)

1. Bellanti JA: Immunology. In: Proceedings of the Annual Meeting of the Medical Section of the American Life Insurance Association. American Life Insurance Association, Washington, D. C., pp16-30, 1975.
2. Takeda K, Kaisho T and Akira S: Toll-like receptors. Annu Rev Immunol 21: 335-376, 2003.
3. Lien E, Sellati TJ, Yoshimura A, Flo TH, Rawadi G, Finberg RW, Carroll JD, Espevik T, Ingalls RR, Radolf JD, et al: Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 274: 33419-33425, 1999.
4. Zeromski J, Mozer-Lisewska I and Kaczmarek M: Significance of toll-like receptors expression in tumor growth and spreading: a short review. Cancer Microenviron 1: 37-42, 2008.
5. West AP, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P, Walsh MC, Choi Y, Shadel GS and Ghosh S: TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472: 476-480, 2011.
6. Flo TH, Ryan L, Latz E, Takeuchi O, Monks BG, Lien E, Halaas Ø, Akira S, Skjåk-Braek G, Golenbock DT, et al: Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. J Biol Chem 277: 35489-35495, 2002.
7. Tsuboi N, Yoshikai Y, Matsuo S, Kikuchi T, Iwami K, Nagai Y, Takeuchi O, Akira S and Matsuguchi T: Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells. J Immunol 169: 2026-2033, 2002.
8. Medzhitov R, Preston-Hurlburt P and Janeway CA Jr: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397, 1997.
9. Pfarr KM, Fischer K and Hoerauf A: Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontis. Med Microbiol Immunol 192: 53-56, 2003.
10. Lien E, Means TK, Heine H, Yoshimura A, Kusumoto S, Fukase K, Fenton MJ, Oikawa M, Qureshi N, Monks B, et al: Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest 105: 497-504, 2000.
11. Barton GM and Medzhitov R: Toll-like receptor signaling pathways. Science 300: 1524-1525, 2003.
12. Zhang G and Ghosh S: Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest 107: 13-19, 2001.
13. Anders HJ, Banas B and Schlöndorff D: Signaling danger: toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 15: 854-867, 2004.
14. Territo MC and Cline MJ: Mononuclear phagocyte proliferation, maturation and function. Clin Haematol 4: 685-703, 1975.
15. Suzuki Y, Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V and Egido J: Inflammation and angiotensin II. Int J Biochem Cell Biol 35: 881-900, 2003.
16. Wolf G, Wenzel U, Burns KD, Harris RC, Stahl RA and Thaiss F: Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors. Kidney Int 61: 1986-1995, 2002.
17. Leendertse M, Willems RJ, Giebelen IA, van den Pangaart PS, Wiersinga WJ, de Vos AF, Florquin S, Bonten MJ and van der Poll T: TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis. J Immunol 180: 4865-4874, 2008.