Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity

BMC Genomics

Volumn 17, Issue 1, 2016, Pages

  Petros, Zelalem ^a,b   Lee, Ming Ta Michael ^a   Takahashi, Atsushi ^a   Zhang, Yanfei ^a   Yimer, Getnet ^b   Habtewold, Abiy ^b   Amogne, Wondwossen ^b   Aderaye, Getachew ^b   Schuppe Koistinen, Ina ^c   Mushiroda, Taisei ^a   Makonnen, Eyasu ^b   Kubo, Michiaki ^a   Aklillu, Eleni ^d  

^a Institute of Physical and Chemical Research   (Japan)

^b ADDIS ABABA UNIVERSITY   (Ethiopia)

^c SCIENCE FOR LIFE LABORATORY   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Africa; AGBL4; Anti tuberculosis; C6ORF32; Drug induced liver injury; Ethiopian; FAM65B; GWAS; Hepatotoxicity; Tuberculosis

Indexed keywords

ABC TRANSPORTER; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; ETHAMBUTOL PLUS ISONIAZID PLUS PYRAZINAMIDE PLUS RIFAMPICIN; GUANINE NUCLEOTIDE BINDING PROTEIN; ISONIAZID PLUS RIFAMPICIN;

ADULT; AGBL4 GENE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CHROMOSOME 6; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG TOLERANCE; ETHIOPIAN; FAM65B GENE; FEMALE; GENE; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; INTRON; LIVER CELL DAMAGE; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; SHORT COURSE THERAPY; SIDE EFFECT; SINGLE NUCLEOTIDE POLYMORPHISM; TUBERCULOSIS;

EID: 84992128554     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/s12864-016-3078-3     Document Type: Article

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