Human amygdala engagement moderated by early life stress exposure is a biobehavioral target for predicting recovery on antidepressants

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 42, 2016, Pages 11955-11960

  Goldstein Piekarski, Andrea N ^a,b   Korgaonkar, Mayuresh S ^c,d   Green, Erin ^a,e   Suppes, Trisha ^a,e   Schatzberg, Alan F ^a   Hastie, Trevor ^a   Nemeroff, Charles B ^f   Williams, Leanne M ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Amygdala; Antidepressant remission; Early life stress; Human brain imaging; Predictive biomarkers

Indexed keywords

ANTIDEPRESSANT AGENT;

AMYGDALA; AREA UNDER THE CURVE; ARTICLE; BRAIN ACTIVATION; BRAIN FUNCTION; CONTROLLED CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; CONVALESCENCE; DEPRESSION; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; EARLY LIFE STRESS; EMOTION; EXPOSURE; HUMAN; MAJOR CLINICAL STUDY; MEASUREMENT ACCURACY; MEDICAL HISTORY; NEUROIMAGING; PREDICTION; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; REMISSION; REWARD; SENSITIVITY AND SPECIFICITY; THREAT; TREATMENT OUTCOME; BEHAVIOR; DRUG EFFECTS; MAJOR DEPRESSION; MENTAL STRESS; PATHOPHYSIOLOGY; PROGNOSIS; PSYCHOLOGICAL MODEL; REPRODUCIBILITY; STATISTICAL MODEL;

AMYGDALA; ANTIDEPRESSIVE AGENTS; BEHAVIOR; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; HUMANS; MODELS, PSYCHOLOGICAL; MODELS, STATISTICAL; PROGNOSIS; REPRODUCIBILITY OF RESULTS; ROC CURVE; STRESS, PSYCHOLOGICAL; TREATMENT OUTCOME;

EID: 84991694361     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1606671113     Document Type: Article

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