First report of safety and efficacy of daratumumab in 2 cases of advanced immunoglobulin light chain amyloidosis

Blood

Volumn 128, Issue 15, 2016, Pages 1987-1989

  Sher, Taimur ^a   Fenton, Brooke ^a   Akhtar, Adnan ^b   Gertz, Morie A ^a,c  

^a MAYO CLINIC   (United States)

^b FLORIDA HOSPITAL   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BORTEZOMIB; CARFILZOMIB; CYCLOPHOSPHAMIDE; DARATUMUMAB; DEXAMETHASONE; IMMUNOGLOBULIN KAPPA CHAIN; MELPHALAN; TROPONIN T; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY;

ADULT; ALBUMINURIA; AMYLOIDOSIS; ANEMIA; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BURNING SENSATION; CASE REPORT; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; HEART AMYLOIDOSIS; HEMORRHOID; HEPATIC AMYLOIDOSIS; HUMAN; HUMAN TISSUE; LETTER; LIVER BIOPSY; MALE; MIDDLE AGED; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; NUCLEAR MAGNETIC RESONANCE IMAGING; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; QUALITY OF LIFE; RECTUM HEMORRHAGE; TREATMENT RESPONSE; TREATMENT WITHDRAWAL; AL AMYLOIDOSIS; BLOOD; DISEASE EXACERBATION; PATHOLOGY; TREATMENT OUTCOME;

ANTIBODIES, MONOCLONAL; DISEASE PROGRESSION; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN LIGHT-CHAIN AMYLOIDOSIS; MALE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 84991646684     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-06-722496     Document Type: Letter

References (5)

1. Kumar S, Dispenzieri A, Katzmann JA, et al. Serum immunoglobulin free light-chain measurement in primary amyloidosis: prognostic value and correlations with clinical features. Blood. 2010;116(24):5126-5129.
2. Lebovic D, Hoffman J, Levine BM, et al. Predictors of survival in patients with systemic light-chain amyloidosis and cardiac involvement initially ineligible for stem cell transplantation and treated with oral melphalan and dexamethasone. Br J Haematol. 2008;143(3):369-373.
3. Sher T, Dispenzieri A, Gertz MA. Evolution of hematopoietic cell transplantation for immunoglobulin light chain amyloidosis. Biol Blood Marrow Transplant. 2016;22(5):796-801.
4. Sanchorawala V, Seldin DC, Berk JL, Sloan JM, Doros G, Skinner M. Oral cyclic melphalan and dexamethasone for patients with AL amyloidosis. Clin Lymphoma Myeloma Leuk. 2010;10(6):469-472.
5. Sher T, Gertz MA. Antibody based immunotherapy for multiple myeloma: it's about time. Leuk Lymphoma. 2016;57(2):269-275.