-
1
-
-
34547677725
-
Immunodeficiency and immunotherapy in multiple myeloma
-
Pratt G, Goodyear O, Moss P. Immunodeficiency and immunotherapy in multiple myeloma. Br J Haematol 2007; 138: 563-579.
-
(2007)
Br J Haematol
, vol.138
, pp. 563-579
-
-
Pratt, G.1
Goodyear, O.2
Moss, P.3
-
2
-
-
84862291416
-
Novel strategies for immunotherapy in multiple myeloma: Previous experience and future directions
-
Danylesko I, Beider K, Shimoni A, et al. Novel strategies for immunotherapy in multiple myeloma: previous experience and future directions. Clin Dev Immunol 2012; 2012: 753407.
-
(2012)
Clin Dev Immunol
, vol.2012
-
-
Danylesko, I.1
Beider, K.2
Shimoni, A.3
-
3
-
-
84896327564
-
CD38 and bone marrow microenvironment
-
Landmark Ed
-
Chillemi A, Zaccarello G, Quarona V, et al. CD38 and bone marrow microenvironment. Front Biosci (Landmark Ed) 2014; 19: 152-162.
-
(2014)
Front Biosci
, vol.19
, pp. 152-162
-
-
Chillemi, A.1
Zaccarello, G.2
Quarona, V.3
-
4
-
-
84924546237
-
Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma
-
Overdijk MB, Verploegen S, Bögels M, et al. Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma. mAbs 2015; 7: 311-321.
-
(2015)
mAbs
, vol.7
, pp. 311-321
-
-
Overdijk, M.B.1
Verploegen, S.2
Bögels, M.3
-
5
-
-
84942436321
-
Targeting CD38 with daratumumab monotherapy in multiple myeloma
-
Lokhorst HM, Plesner T, Laubach JP, et al. Targeting CD38 with daratumumab monotherapy in multiple myeloma. N Engl J Med 2015; 373: 1207-1219
-
(2015)
N Engl J Med
, vol.373
, pp. 1207-1219
-
-
Lokhorst, H.M.1
Plesner, T.2
Laubach, J.P.3
-
6
-
-
84959354811
-
Phase II study of Daratumumab (DARA) monotherapy in patients with more than 3 lines of prior therapy or double refractory multiple myeloma
-
Lonial S, Weiss BM, Usmani SZ, et al. Phase II study of Daratumumab (DARA) monotherapy in patients with more than 3 lines of prior therapy or double refractory multiple myeloma. J Clin Oncol 2015; 33(Suppl):asbtract LBA8512.
-
(2015)
J Clin Oncol
, vol.33
-
-
Lonial, S.1
Weiss, B.M.2
Usmani, S.Z.3
-
7
-
-
84964255580
-
Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide
-
Nijhof IS, van Bueren JJL, van Kessel B, et al. Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide. Haematologica 2015; 100: 263-268.
-
(2015)
Haematologica
, vol.100
, pp. 263-268
-
-
Nijhof, I.S.1
Van Bueren, J.J.L.2
Van Kessel, B.3
-
8
-
-
84912126930
-
SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38 + hematologic malignancies
-
Deckert J, Wetzel MC, Bartle LM, et al. SAR650984, a novel humanized CD38-targeting antibody, demonstrates potent antitumor activity in models of multiple myeloma and other CD38 + hematologic malignancies. Clin Cancer Res 2014; 20: 4574-4583.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 4574-4583
-
-
Deckert, J.1
Wetzel, M.C.2
Bartle, L.M.3
-
9
-
-
84911112328
-
A phase I trial of SAR650984, a CD38 monoclonal antibody, in relapsed or refractory multiple myeloma
-
Martin TG, Hsu K, Strickland SA, et al. A phase I trial of SAR650984, a CD38 monoclonal antibody, in relapsed or refractory multiple myeloma. J Clin Oncol 2014; 32:8532.
-
(2014)
J Clin Oncol
, vol.32
, pp. 8532
-
-
Martin, T.G.1
Hsu, K.2
Strickland, S.A.3
-
10
-
-
84929080942
-
A Phase Ib Dose Escalation Trial of SAR650984 (Anti-CD-38 mAb) in combination with lenalidomide and dexamethasone in relapsed/refractory multiple myeloma
-
Martin TG, Baz R, Benson DM, et al. A Phase Ib Dose Escalation Trial of SAR650984 (Anti-CD-38 mAb) in combination with lenalidomide and dexamethasone in relapsed/refractory multiple myeloma. Blood 2014; 124(21): Abstract 83.
-
(2014)
Blood
, vol.124
, Issue.21
-
-
Martin, T.G.1
Baz, R.2
Benson, D.M.3
-
11
-
-
84884164729
-
CS1, a SLAM family receptor involved in immune regulation, is a therapeutic target in multiple myeloma
-
Veillette A, Guo H. CS1, a SLAM family receptor involved in immune regulation, is a therapeutic target in multiple myeloma. Crit Rev Oncol Hematol 2013; 88: 168-177.
-
(2013)
Crit Rev Oncol Hematol
, vol.88
, pp. 168-177
-
-
Veillette, A.1
Guo, H.2
-
12
-
-
84890429971
-
Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: Evidence for augmented NK cell function complementing ADCC
-
Collins SM, Bakan CE, Swartzel GD, et al. Elotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: evidence for augmented NK cell function complementing ADCC. Cancer Immunology, Immunotherapy 2013; 62: 1841-1849.
-
(2013)
Cancer Immunology, Immunotherapy
, vol.62
, pp. 1841-1849
-
-
Collins, S.M.1
Bakan, C.E.2
Swartzel, G.D.3
-
13
-
-
84864118302
-
A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced multiple myeloma
-
Zonder JA, Mohrbacher AF, Singhal S, et al. A phase 1, multicenter, open-label, dose escalation study of elotuzumab in patients with advanced multiple myeloma. Blood 2012; 120: 552-559.
-
(2012)
Blood
, vol.120
, pp. 552-559
-
-
Zonder, J.A.1
Mohrbacher, A.F.2
Singhal, S.3
-
14
-
-
84929081501
-
Final results for the 1703 phase 1b/2 study of elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma
-
Richardson PG, et al. Final results for the 1703 phase 1b/2 study of elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma. Blood 2014; 124:(21): 302.
-
(2014)
Blood
, vol.124
, Issue.21
, pp. 302
-
-
Richardson, P.G.1
-
15
-
-
84933569079
-
Elotuzumab therapy for relapsed or refractory multiple myeloma
-
Lonial S, Dimopoulos M, Palumbo A, et al. Elotuzumab therapy for relapsed or refractory multiple myeloma. N Engl J Med 2015; 373: 621-631.
-
(2015)
N Engl J Med
, vol.373
, pp. 621-631
-
-
Lonial, S.1
Dimopoulos, M.2
Palumbo, A.3
-
17
-
-
79952761418
-
Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma
-
Henry DH, Costa L, Goldwasser F, et al. Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. J Clin Oncol 2011; 29: 1125-1132.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1125-1132
-
-
Henry, D.H.1
Costa, L.2
Goldwasser, F.3
-
18
-
-
67650431302
-
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
-
Fulciniti M, Tassone P, Hideshima T, et al. Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood 2009; 114: 371-379.
-
(2009)
Blood
, vol.114
, pp. 371-379
-
-
Fulciniti, M.1
Tassone, P.2
Hideshima, T.3
-
19
-
-
84856744449
-
A phase I/II study of BHQ880, a novel osteoblast activating, anti-DKK1 human monoclonal antibody, in relapsed and refractory multiple myeloma (MM) patients treated with zoledronic acid (Zol) and anti-myeloma therapy (MM Tx)
-
Padmanabhan S, Beck JT, Kelly KR, et al. A phase I/II study of BHQ880, a novel osteoblast activating, anti-DKK1 human monoclonal antibody, in relapsed and refractory multiple myeloma (MM) patients treated with zoledronic acid (Zol) and anti-myeloma therapy (MM Tx). Blood 2009; 114: 312-313.
-
(2009)
Blood
, vol.114
, pp. 312-313
-
-
Padmanabhan, S.1
Beck, J.T.2
Kelly, K.R.3
-
20
-
-
84896491618
-
The IL-6 feed-forward loop: A driver of tumorigenesis
-
Chang Q, Daly L, Bromberg J. The IL-6 feed-forward loop: a driver of tumorigenesis. Semin Immunol 2014; 26: 48-53.
-
(2014)
Semin Immunol
, vol.26
, pp. 48-53
-
-
Chang, Q.1
Daly, L.2
Bromberg, J.3
-
21
-
-
84903879405
-
Siltuximab: First global approval
-
Markham A, Patel T. Siltuximab: first global approval. Drugs 2014; 74: 1147-1152.
-
(2014)
Drugs
, vol.74
, pp. 1147-1152
-
-
Markham, A.1
Patel, T.2
-
22
-
-
84879849025
-
A phase I, open-label study of siltuximab, an anti-IL-6 monoclonal antibody, in patients with B-cell non-Hodgkin lymphoma, multiple myeloma, or Castleman disease
-
Kurzrock R, Voorhees PM, Casper C, et al. A phase I, open-label study of siltuximab, an anti-IL-6 monoclonal antibody, in patients with B-cell non-Hodgkin lymphoma, multiple myeloma, or Castleman disease. Clin Cancer Res 2013; 19: 3659-3670.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3659-3670
-
-
Kurzrock, R.1
Voorhees, P.M.2
Casper, C.3
-
23
-
-
84919683208
-
A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma
-
Orlowski RZ, Gercheva L, Williiams C, et al. A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma. Am J Hematol 2015; 90: 42-49.
-
(2015)
Am J Hematol
, vol.90
, pp. 42-49
-
-
Orlowski, R.Z.1
Gercheva, L.2
Williiams, C.3
-
24
-
-
84903642514
-
Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma
-
San-Miguel J, Bladé J, Shpilberg O, et al. Phase 2 randomized study of bortezomib-melphalan-prednisone with or without siltuximab (anti-IL-6) in multiple myeloma. Blood 2014; 123: 4136-4142.
-
(2014)
Blood
, vol.123
, pp. 4136-4142
-
-
San-Miguel, J.1
Bladé, J.2
Shpilberg, O.3
-
25
-
-
84878156984
-
Monoclonal antibodies: Potential new therapeutic treatment against multiple myeloma
-
Allegra A, Penna G, Alonci A, et al. Monoclonal antibodies: Potential new therapeutic treatment against multiple myeloma. Eur J Haematol 2013; 90: 441-468.
-
(2013)
Eur J Haematol
, vol.90
, pp. 441-468
-
-
Allegra, A.1
Penna, G.2
Alonci, A.3
-
26
-
-
84930946251
-
Randomized, phase III trial of figitumumab in combination with erlotinib versus erlotinib alone in patients with nonadenocarcinoma nonsmall-cell lung cancer
-
Scagliotti GV, Bondarenko I, Blackhall F, et al. Randomized, phase III trial of figitumumab in combination with erlotinib versus erlotinib alone in patients with nonadenocarcinoma nonsmall-cell lung cancer. Ann Oncol 2015; 26: 497-504.
-
(2015)
Ann Oncol
, vol.26
, pp. 497-504
-
-
Scagliotti, G.V.1
Bondarenko, I.2
Blackhall, F.3
-
27
-
-
84941627494
-
The failure of figitumumab: The danger of taking shortcuts in drug development
-
West H. The failure of figitumumab: the danger of taking shortcuts in drug development. Ann Oncol 2015; 26: 447-448.
-
(2015)
Ann Oncol
, vol.26
, pp. 447-448
-
-
West, H.1
-
28
-
-
0018969464
-
A phase I-II study of maytansine utilizing a weekly schedule
-
Franklin R, Samson MK, Fraile RJ, et al. A phase I-II study of maytansine utilizing a weekly schedule. Cancer 1980; 46: 1104-1108.
-
(1980)
Cancer
, vol.46
, pp. 1104-1108
-
-
Franklin, R.1
Samson, M.K.2
Fraile, R.J.3
-
29
-
-
0019157641
-
Neurofibrillary degeneration in cultured adult mouse neurons induced by maytansine
-
Kim SU, Tomonaga M, Ghetti B. Neurofibrillary degeneration in cultured adult mouse neurons induced by maytansine. Acta Neuropathol 1980; 52: 161-164.
-
(1980)
Acta Neuropathol
, vol.52
, pp. 161-164
-
-
Kim, S.U.1
Tomonaga, M.2
Ghetti, B.3
-
30
-
-
67449119398
-
The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo
-
Ikeda H, Hideshima T, Fulciniti M, et al. The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin Cancer Res 2009; 15: 4028-4037.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4028-4037
-
-
Ikeda, H.1
Hideshima, T.2
Fulciniti, M.3
-
31
-
-
84937795971
-
Indatuximab Ravtansine (BT062) in combination with Lenalidomide and low-dose Dexamethasone in patients with relapsed and/or refractory multiple myeloma: Clinical activity in patients already exposed to Lenalidomide and Bortezomib
-
Kelly KR, Chanan-Khan A, Heffner LT, et al. Indatuximab Ravtansine (BT062) in combination with Lenalidomide and low-dose Dexamethasone in patients with relapsed and/or refractory multiple myeloma: clinical activity in patients already exposed to Lenalidomide and Bortezomib. Blood 2014; 124.
-
(2014)
Blood
, vol.124
-
-
Kelly, K.R.1
Chanan-Khan, A.2
Heffner, L.T.3
-
32
-
-
79960272171
-
Efficacy analysis from a Phase I Study of Lorvotuzumab Mertansine (IMGN901), used as Monotherapy, in patients with heavily pre-treated CD56-Positive Multiple Myeloma-A preliminary efficacy analysis
-
819
-
Chanan-Khan A, Wolf J, Garcia J, et al. Efficacy analysis from a Phase I Study of Lorvotuzumab Mertansine (IMGN901), used as Monotherapy, in patients with heavily pre-treated CD56-Positive Multiple Myeloma-A preliminary efficacy analysis. Blood 2010; 116: 819-819.
-
(2010)
Blood
, vol.116
, pp. 819
-
-
Chanan-Khan, A.1
Wolf, J.2
Garcia, J.3
-
33
-
-
84902357463
-
Lorvotuzumab mertansine: Antibody-drug-conjugate for CD56 + multiple myeloma
-
Landmark Ed
-
Berdeja JG. Lorvotuzumab mertansine: antibody-drug-conjugate for CD56 + multiple myeloma. Front Biosci (Landmark Ed) 2014; 19: 163-170.
-
(2014)
Front Biosci
, vol.19
, pp. 163-170
-
-
Berdeja, J.G.1
-
34
-
-
78650607602
-
A phase I study of the anti-appa monoclonal antibody, MDX-1097, in previously treated multiple myeloma patients
-
Spencer A, Walker P, Asvadi P, et al. A phase I study of the anti-appa monoclonal antibody, MDX-1097, in previously treated multiple myeloma patients. J Clin Oncol 2010; 28: 8143.
-
(2010)
J Clin Oncol
, vol.28
, pp. 8143
-
-
Spencer, A.1
Walker, P.2
Asvadi, P.3
-
35
-
-
84901712243
-
A phase II trial of pan-KIR2D blockade with IPH2101 in smoldering multiple myeloma
-
Korde N, Carlsten M, Lee M-J, et al. A phase II trial of pan-KIR2D blockade with IPH2101 in smoldering multiple myeloma. Haematologica 2014; 99: e81-83.
-
(2014)
Haematologica
, vol.99
, pp. e81-e83
-
-
Korde, N.1
Carlsten, M.2
Lee, M.-J.3
-
36
-
-
84969412328
-
Targeting FGFR3 in t(4;14) mutiple myeloma: Pre-clinical studies of PRO-001, a novel anti-FGFR3 neutralizing antibody
-
Trudel S, Wei E, Hua Z, et al. Targeting FGFR3 in t(4;14) mutiple myeloma: pre-clinical studies of PRO-001, a novel anti-FGFR3 neutralizing antibody. Blood 2004; 104: 680A.
-
(2004)
Blood
, vol.104
, pp. 680A
-
-
Trudel, S.1
Wei, E.2
Hua, Z.3
|