Neuromuscular Fatigue during Prolonged Exercise in Hypoxia

Medicine and Science in Sports and Exercise

Volumn 49, Issue 3, 2017, Pages 430-439

  Jubeau, Marc ^a,b,c   Rupp, Thomas ^a,b,d   Temesi, John ^d,e   Perrey, Stéphane ^f   Wuyam, Bernard ^a,b   Millet, Guillaume Y ^a,b,d,e   Verges, Samuel ^a,b  

^a UNIV GRENOBLE ALPES   (France)

^b University Grenoble Alpes   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d Univ Lyon University Jean Monnet Saint Etienne   (France)

^e UNIVERSITY OF CALGARY   (Canada)

^f UNIVERSITY OF MONTPELLIER   (France)

Author keywords

BRAIN OXYGENATION; CORTICAL VOLUNTARY ACTIVATION; KNEE EXTENSORS; TRANSCRANIAL MAGNETIC STIMULATION

Indexed keywords

ADULT; CYCLING; ELECTROMYOGRAPHY; ELECTROSTIMULATION; EXERCISE; FEMORAL NERVE; HUMAN; HYPOXIA; KNEE; MALE; MOTOR CORTEX; MOTOR EVOKED POTENTIAL; MUSCLE CONTRACTION; MUSCLE FATIGUE; NEAR INFRARED SPECTROSCOPY; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PHYSIOLOGY; PREFRONTAL CORTEX; TRANSCRANIAL MAGNETIC STIMULATION;

ADULT; BICYCLING; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; EVOKED POTENTIALS, MOTOR; EXERCISE; FEMORAL NERVE; HUMANS; HYPOXIA; KNEE JOINT; MALE; MOTOR CORTEX; MUSCLE CONTRACTION; MUSCLE FATIGUE; OXYGEN CONSUMPTION; PREFRONTAL CORTEX; SPECTROSCOPY, NEAR-INFRARED; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 84991501346     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000001118     Document Type: Article

References (40)

1. Amann M, Blain GM, Proctor LT, Sebranek JJ, Pegelow DF, Dempsey JA. Implications of group III and IV muscle afferents for high-intensity endurance exercise performance in humans. J Physiol. 2011;589(Pt 21):5299-309.
2. Amann M, Calbet JA. Convective oxygen transport and fatigue. J Appl Physiol (1985). 2008;104(3):861-70.
3. Amann M, Kayser B. Nervous system function during exercise in hypoxia. High Alt Med Biol. 2009;10(2):149-64.
4. Amann M, Romer LM, Subudhi AW, Pegelow DF, Dempsey JA. Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans. J Physiol. 2007;581(Pt 1):389-403.
5. Bhambhani Y, Malik R, Mookerjee S. Cerebral oxygenation declines at exercise intensities above the respiratory compensation threshold. Respir Physiol Neurobiol. 2007;156(2):196-202.
6. Cohen J. Statistical Power Analysis for the Behavioral Sciences. Hillsdale (NJ): L. Erlbaum Associates; 1988. pp. 273-406.
7. Fan JL, Bourdillon N, Kayser B. Effect of end-tidal CO2 clamping on cerebrovascular function, oxygenation, and performance during 15-km time trial cycling in severe normobaric hypoxia: the role of cerebral O2 delivery. Physiol Rep. 2013; 1(3):e00066.
8. Froyd C, Millet GY, Noakes TD. The development of peripheral fatigue and short-term recovery during self-paced high-intensity exercise. J Physiol. 2013;591(Pt 5):1339-46.
9. Gandevia SC. Spinal and supraspinal factors in human muscle fatigue. Physiol Rev. 2001;81(4):1725-89.
10. Gandevia SC, Allen GM, Butler JE, Taylor JL. Supraspinal factors in human muscle fatigue: evidence for suboptimal output from the motor cortex. J Physiol. 1996;490(Pt 2):529-36.
11. Goodall S, Gonzalez-Alonso J, Ali L, Ross EZ, Romer LM. Supraspinal fatigue after normoxic and hypoxic exercise in humans. J Physiol. 2012;590(Pt 11):2767-82.
12. Goodall S, Romer LM, Ross EZ. Voluntary activation of human knee extensors measured using transcranial magnetic stimulation. Exp Physiol. 2009;94(9):995-1004.
13. Goodall S, Ross EZ, Romer LM. Effect of graded hypoxia on supraspinal contributions to fatigue with unilateral knee-extensor contractions. J Appl Physiol (1985). 2010;109(6):1842-51.
14. Hermens HJ, Freriks B, Disselhorst-Klug C, Rau G. Development of recommendations for SEMG sensors and sensor placement procedures. J Electromyogr Kinesiol. 2000;10(5):361-74.
15. Jubeau M, Rupp T, Perrey S, et al. Changes in voluntary activation assessed by transcranial magnetic stimulation during prolonged cycling exercise. PLoS One. 2014;9(2):e89157.
16. Millet GY, Lepers R. Alterations of neuromuscular function after prolonged running, cycling and skiing exercises. Sports Med. 2004; 34(2):105-16.
17. Millet GY, Muthalib M, Jubeau M, Laursen PB, Nosaka K. Severe hypoxia affects exercise performance independently of afferent feedback and peripheral fatigue. J Appl Physiol (1985). 2012;112(8): 1335-44.
18. Perrey S. Non-invasive NIR spectroscopy of human brain function during exercise. Methods. 2008;45(4):289-99.
19. Place N, Lepers R, Deley G, Millet GY. Time course of neuromuscular alterations during a prolonged running exercise. Med Sci Sports Exerc. 2004;36(8):1347-56.
20. Robertson CV, Marino FE. A role for the prefrontal cortex in exercise tolerance and termination. J Appl Physiol (1985). 2015;120(4): 464-6.
21. Romer LM, Haverkamp HC, Amann M, Lovering AT, Pegelow DF, Dempsey JA. Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans. Am J Physiol Regul Integr Comp Physiol. 2007;292(1):R598-606.
22. Rooks CR, Thom NJ, McCully KK, Dishman RK. Effects of incremental exercise on cerebral oxygenation measured by nearinfrared spectroscopy: a systematic review. Prog Neurobiol. 2010; 92(2):134-50.
23. Ross EZ, Middleton N, Shave R, George K, Nowicky A. Corticomotor excitability contributes to neuromuscular fatigue following marathon running in man. Exp Physiol. 2007;92(2):417-26.
24. Rupp T, Jubeau M, Millet GY, et al. The effect of hypoxemia and exercise on acute mountain sickness symptoms. J Appl Physiol (1985). 2013;114(2):180-5.
25. Rupp T, Jubeau M, Wuyam B, et al. Time-dependent effect of acute hypoxia on corticospinal excitability in healthy humans. J Neurophysiol. 2012;108(5):1270-7.
26. Rupp T, Mallouf TL, Perrey S, Wuyam B, Millet GY, Verges S. CO2 clamping, peripheral and central fatigue during hypoxic knee extensions in men. Med Sci Sports Exerc. 2015;47(12):2513-24.
27. Saugy J, Place N, Millet GY, Degache F, Schena F, Millet GP. Alterations of neuromuscular function after the worlds most challenging mountain ultra-marathon. PLoS One. 2013;8(6):e65596.
28. Sidhu SK, Bentley DJ, Carroll TJ. Cortical voluntary activation of the human knee extensors can be reliably estimated using transcranial magnetic stimulation. Muscle Nerve. 2009;39(2):186-96.
29. Sidhu SK, Cresswell AG, Carroll TJ. Motor cortex excitability does not increase during sustained cycling exercise to volitional exhaustion. J Appl Physiol (1985). 2012;113(3):401-9.
30. Siebenmann C, SLrensen H, Jacobs RA, Haider T, Rasmussen P, Lundby C. Hypocapnia during hypoxic exercise and its impact on cerebral oxygenation, ventilation and maximal whole body O2 uptake. Respir Physiol Neurobiol. 2013;185(2):461-7.
31. Subudhi AW, Dimmen AC, Roach RC. Effects of acute hypoxia on cerebral and muscle oxygenation during incremental exercise. J Appl Physiol. 2007;103(1):177-83.
32. Subudhi AW, Miramon BR, Granger ME, Roach RC. Frontal and motor cortex oxygenation during maximal exercise in normoxia and hypoxia. J Appl Physiol (1985). 2009;106(4):1153-8.
33. Szubski C, Burtscher M, Löscher WN. Neuromuscular fatigue during sustained contractions performed in short-term hypoxia. Med Sci Sports Exerc. 2007;39(6):948-54.
34. Taylor JL, Butler JE, Allen GM, Gandevia SC. Changes in motor cortical excitability during human muscle fatigue. J Physiol. 1996; 490(Pt 2):519-28.
35. Temesi J, Arnal PJ, Davranche K, et al. Does central fatigue explain reduced cycling after complete sleep deprivation? Med Sci Sports Exerc. 2013;45(12):2243-53.
36. Todd G, Taylor JL, Gandevia SC. Measurement of voluntary activation of fresh and fatigued human muscles using transcranial magnetic stimulation. J Physiol. 2003;551(Pt 2):661-71.
37. Ueda T, Nabetani T, Teramoto K. Differential perceived exertion measured using a new visual analogue scale during pedaling and running. J Physiol Anthropol. 2006;25(2):171-7.
38. Verges S,Maffiuletti NA, Kerherve H, Decorte N,Wuyam B, Millet GY. Comparison of electrical and magnetic stimulations to assess quadricepsmuscle function. J Appl Physiol (1985). 2009;106(2):701-10.
39. Verges S, Rupp T, Jubeau M, et al. Cerebral perturbations during exercise in hypoxia. Am J Physiol Regul Integr Comp Physiol. 2012;302(8):R903-16.
40. Vogiatzis I, Louvaris Z, Habazettl H, et al. Frontal cerebral cortex blood flow, oxygen delivery and oxygenation during normoxic and hypoxic exercise in athletes. J Physiol. 2011;589(Pt 16):4027-39.