메뉴 건너뛰기




Volumn 119, Issue 11, 2016, Pages 1177-1182

Hyperpolarized 13C Metabolic MRI of the Human Heart: Initial Experience

Author keywords

heart failure; magnetic resonance imaging; metabolic imaging; metabolism; mitochondria

Indexed keywords

BICARBONATE; CARBON 13; LACTIC ACID; PYRUVIC ACID; CARBON;

EID: 84991492414     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.309769     Document Type: Article
Times cited : (298)

References (22)
  • 1
    • 0036285606 scopus 로고    scopus 로고
    • Energy metabolism in the normal and failing heart: Potential for therapeutic interventions
    • Stanley WC, Chandler MP. Energy metabolism in the normal and failing heart: potential for therapeutic interventions. Heart Fail Rev. 2002;7:115-130.
    • (2002) Heart Fail Rev. , vol.7 , pp. 115-130
    • Stanley, W.C.1    Chandler, M.P.2
  • 2
    • 34547590901 scopus 로고    scopus 로고
    • Metabolic mechanisms in heart failure
    • Ashrafian H, Frenneaux MP, Opie LH. Metabolic mechanisms in heart failure. Circulation. 2007;116:434-448. doi: 10.1161/ CIRCULATIONAHA.107.702795.
    • (2007) Circulation. , vol.116 , pp. 434-448
    • Ashrafian, H.1    Frenneaux, M.P.2    Opie, L.H.3
  • 4
    • 84883562084 scopus 로고    scopus 로고
    • Cardiac metabolism in heart failure: Implications beyond ATP production
    • Doenst T, Nguyen TD, Abel ED. Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res. 2013;113:709-724. doi: 10.1161/CIRCRESAHA.113.300376.
    • (2013) Circ Res. , vol.113 , pp. 709-724
    • Doenst, T.1    Nguyen, T.D.2    Abel, E.D.3
  • 8
    • 38049103113 scopus 로고    scopus 로고
    • Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR
    • Merritt ME, Harrison C, Storey C, Jeffrey FM, Sherry AD, Malloy CR. Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci U S A. 2007;104:19773-19777. doi: 10.1073/pnas.0706235104.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , pp. 19773-19777
    • Merritt, M.E.1    Harrison, C.2    Storey, C.3    Jeffrey, F.M.4    Sherry, A.D.5    Malloy, C.R.6
  • 10
    • 50149105620 scopus 로고    scopus 로고
    • In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance
    • Schroeder MA, Cochlin LE, Heather LC, Clarke K, Radda GK, Tyler DJ. In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc Natl Acad Sci U S A. 2008;105:12051-12056. doi: 10.1073/pnas.0805953105.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , pp. 12051-12056
    • Schroeder, M.A.1    Cochlin, L.E.2    Heather, L.C.3    Clarke, K.4    Radda, G.K.5    Tyler, D.J.6
  • 11
    • 80053469087 scopus 로고    scopus 로고
    • Hyperpolarized magnetic resonance: A novel technique for the in vivo assessment of cardiovascular disease
    • Schroeder MA, Clarke K, Neubauer S, Tyler DJ. Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease. Circulation. 2011;124:1580-1594. doi: 10.1161/ CIRCULATIONAHA.111.024919.
    • (2011) Circulation. , vol.124 , pp. 1580-1594
    • Schroeder, M.A.1    Clarke, K.2    Neubauer, S.3    Tyler, D.J.4
  • 14
    • 84977838083 scopus 로고    scopus 로고
    • Increasing pyruvate dehydrogenase flux as a treatment for diabetic cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study
    • Le Page LM, Rider OJ, Lewis AJ, Ball V, Clarke K, Johansson E, Carr CA, Heather LC, Tyler DJ. Increasing pyruvate dehydrogenase flux as a treatment for diabetic cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study. Diabetes. 2015;64:2735-2743. doi: 10.2337/db14-1560.
    • (2015) Diabetes. , vol.64 , pp. 2735-2743
    • Le Page, L.M.1    Rider, O.J.2    Lewis, A.J.3    Ball, V.4    Clarke, K.5    Johansson, E.6    Carr, C.A.7    Heather, L.C.8    Tyler, D.J.9
  • 18
    • 79960113705 scopus 로고    scopus 로고
    • Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells
    • Witney TH, Kettunen MI, Brindle KM. Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells. J Biol Chem. 2011;286:24572-24580. doi: 10.1074/jbc.M111.237727.
    • (2011) J Biol Chem. , vol.286 , pp. 24572-24580
    • Witney, T.H.1    Kettunen, M.I.2    Brindle, K.M.3
  • 19
    • 84887618135 scopus 로고    scopus 로고
    • Clinical implications of cardiac hyperpolarized magnetic resonance imaging
    • Rider OJ, Tyler DJ. Clinical implications of cardiac hyperpolarized magnetic resonance imaging. J Cardiovasc Magn Reson. 2013;15:93. doi: 10.1186/1532-429X-15-93.
    • (2013) J Cardiovasc Magn Reson. , vol.15 , pp. 93
    • Rider, O.J.1    Tyler, D.J.2
  • 20
    • 0037046203 scopus 로고    scopus 로고
    • Adaptation and maladaptation of the heart in diabetes: Part I: General concepts
    • Taegtmeyer H, McNulty P, Young ME. Adaptation and maladaptation of the heart in diabetes: Part I: general concepts. Circulation. 2002;105:1727-1733.
    • (2002) Circulation. , vol.105 , pp. 1727-1733
    • Taegtmeyer, H.1    McNulty, P.2    Young, M.E.3
  • 22
    • 84953711992 scopus 로고    scopus 로고
    • Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy
    • Lewis AJ, Neubauer S, Tyler DJ, Rider OJ. Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy. Expert Opin Ther Targets. 2016;20:755-766. doi: 10.1517/14728222.2016.1126248.
    • (2016) Expert Opin Ther Targets. , vol.20 , pp. 755-766
    • Lewis, A.J.1    Neubauer, S.2    Tyler, D.J.3    Rider, O.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.