Elevated erk/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in Fragile X mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 41, 2016, Pages E6290-E6297

  Sawicka, Kirsty ^a,b   Pyronneau, Alexander ^a   Chao, Miranda ^a   Bennett, Michael V L ^a   Zukin, R Suzanne ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Autism; FMRP; Intellectual disability; MTOR; RSK

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P90; S6 KINASE; DNA BINDING PROTEIN; ELF4 PROTEIN, MOUSE; FMR1 PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3 KINASE; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDIOGENIC SEIZURE; BRAIN CELL; BRAIN REGION; CELL ACTIVATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; FRAGILE X SYNDROME; HIPPOCAMPUS; MOUSE; NEOCORTEX; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPTOSOME; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN CORTEX; COMPLICATION; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHOSPHORYLATION; REFLEX EPILEPSY; SEIZURE;

ANIMALS; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; EPILEPSY, REFLEX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; MICE; MICE, KNOCKOUT; NEURONS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SEIZURES; SIGNAL TRANSDUCTION; SYNAPSES; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84991435169     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1610812113     Document Type: Article

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