-
1
-
-
67650874081
-
Cancer statistics, 2009
-
PID: 19474385
-
Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin. 2009;59(4):225–49.
-
(2009)
CA Cancer J Clin.
, vol.59
, Issue.4
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
-
2
-
-
84904731034
-
Serum microRNAs: a new diagnostic method for colorectal cancer
-
COI: 1:CAS:528:DC%2BC3sXht1WktLzM, PID: 24648974
-
Yang Y, Gu X, Zhou M, et al. Serum microRNAs: a new diagnostic method for colorectal cancer. Biomed Rep. 2013;1(4):495–8.
-
(2013)
Biomed Rep.
, vol.1
, Issue.4
, pp. 495-498
-
-
Yang, Y.1
Gu, X.2
Zhou, M.3
-
3
-
-
84918815964
-
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012
-
COI: 1:CAS:528:DC%2BC2cXitVyktbzI, PID: 25220842
-
Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86.
-
(2015)
Int J Cancer
, vol.136
, Issue.5
, pp. E359-E386
-
-
Ferlay, J.1
Soerjomataram, I.2
Dikshit, R.3
-
4
-
-
84908573757
-
FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial
-
COI: 1:CAS:528:DC%2BC2cXhtlahs7nK, PID: 25088940
-
Heinemann V, von Weikersthal LF, Decker T, et al. FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol. 2014;15(10):1065–75.
-
(2014)
Lancet Oncol.
, vol.15
, Issue.10
, pp. 1065-1075
-
-
Heinemann, V.1
von Weikersthal, L.F.2
Decker, T.3
-
5
-
-
84908139591
-
Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer
-
PID: 25337750
-
Loupakis F, Cremolini C, Masi G, et al. Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer. N Engl J Med. 2014;371(17):1609–18.
-
(2014)
N Engl J Med
, vol.371
, Issue.17
, pp. 1609-1618
-
-
Loupakis, F.1
Cremolini, C.2
Masi, G.3
-
6
-
-
33646361363
-
Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastastic colorectal cancer
-
COI: 1:CAS:528:DC%2BD28XkvVajtLc%3D, PID: 16622264
-
Meyerhardt JA, Zhu AX, Enzinger PC, et al. Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastastic colorectal cancer. J Clin Oncol. 2006;24(12):1892–7.
-
(2006)
J Clin Oncol
, vol.24
, Issue.12
, pp. 1892-1897
-
-
Meyerhardt, J.A.1
Zhu, A.X.2
Enzinger, P.C.3
-
7
-
-
84862987061
-
Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer
-
COI: 1:CAS:528:DC%2BC38Xptlyrt7k%3D, PID: 22412142
-
Weickhardt AJ, Price TJ, Chong G, et al. Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer. J Clin Oncol. 2012;30(13):1505–12.
-
(2012)
J Clin Oncol
, vol.30
, Issue.13
, pp. 1505-1512
-
-
Weickhardt, A.J.1
Price, T.J.2
Chong, G.3
-
8
-
-
79959571031
-
Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial
-
COI: 1:CAS:528:DC%2BC3MXot1ejtbo%3D, PID: 21641867
-
Adams RA, Meade AM, Seymour MT, et al. Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet Oncol. 2011;12(7):642–53.
-
(2011)
Lancet Oncol.
, vol.12
, Issue.7
, pp. 642-653
-
-
Adams, R.A.1
Meade, A.M.2
Seymour, M.T.3
-
9
-
-
73349089651
-
Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study
-
COI: 1:CAS:528:DC%2BC3cXhtVWisbo%3D, PID: 19786657
-
Chibaudel B, Maindrault-Goebel F, Lledo G, et al. Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study. J Clin Oncol. 2009;27(34):5727–33.
-
(2009)
J Clin Oncol
, vol.27
, Issue.34
, pp. 5727-5733
-
-
Chibaudel, B.1
Maindrault-Goebel, F.2
Lledo, G.3
-
10
-
-
84954026956
-
Maintenance strategies after first-line oxaliplatin plus fluoropyrimidine plus bevacizumab for patients with metastatic colorectal cancer (AIO 0207): a randomised, non-inferiority, open-label, phase 3 trial
-
COI: 1:CAS:528:DC%2BC2MXhsFSit7nE, PID: 26361971
-
Hegewisch-Becker S, Graeven U, Lerchenmuller CA, et al. Maintenance strategies after first-line oxaliplatin plus fluoropyrimidine plus bevacizumab for patients with metastatic colorectal cancer (AIO 0207): a randomised, non-inferiority, open-label, phase 3 trial. Lancet Oncol. 2015;16(13):1355–69.
-
(2015)
Lancet Oncol.
, vol.16
, Issue.13
, pp. 1355-1369
-
-
Hegewisch-Becker, S.1
Graeven, U.2
Lerchenmuller, C.A.3
-
11
-
-
84929514070
-
Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): a phase 3 randomised controlled trial of the Dutch Colorectal Cancer Group
-
COI: 1:CAS:528:DC%2BC2MXmt1Srsr0%3D, PID: 25862517
-
Simkens LH, van Tinteren H, May A, et al. Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): a phase 3 randomised controlled trial of the Dutch Colorectal Cancer Group. Lancet. 2015;385(9980):1843–52.
-
(2015)
Lancet
, vol.385
, Issue.9980
, pp. 1843-1852
-
-
Simkens, L.H.1
van Tinteren, H.2
May, A.3
-
12
-
-
84880918721
-
Maintenance single-agent bevacizumab or observation after first-line chemotherapy in patients with metastatic colorectal cancer: a multicenter retrospective study
-
COI: 1:CAS:528:DC%2BC3sXhtFOksL3N
-
Moscetti L, Nelli F, Fabbri MA, et al. Maintenance single-agent bevacizumab or observation after first-line chemotherapy in patients with metastatic colorectal cancer: a multicenter retrospective study. Invest New Drug. 2013;31(4):1035–43.
-
(2013)
Invest New Drug.
, vol.31
, Issue.4
, pp. 1035-1043
-
-
Moscetti, L.1
Nelli, F.2
Fabbri, M.A.3
-
13
-
-
33644843853
-
OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer: a GERCOR study
-
COI: 1:CAS:528:DC%2BD28XhsFSku7w%3D, PID: 16421419
-
Tournigand C, Cervantes A, Figer A, et al. OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer: a GERCOR study. J Clin Oncol. 2006;24(3):394–400.
-
(2006)
J Clin Oncol
, vol.24
, Issue.3
, pp. 394-400
-
-
Tournigand, C.1
Cervantes, A.2
Figer, A.3
-
14
-
-
84871720057
-
Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial
-
COI: 1:CAS:528:DC%2BC3sXhsV2gug%3D%3D, PID: 23168366
-
Bennouna J, Sastre J, Arnold D, et al. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial. Lancet Oncol. 2013;14(1):29–37.
-
(2013)
Lancet Oncol.
, vol.14
, Issue.1
, pp. 29-37
-
-
Bennouna, J.1
Sastre, J.2
Arnold, D.3
-
15
-
-
84883680951
-
Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
-
COI: 1:CAS:528:DC%2BC3sXhsFGktr3L, PID: 24024839
-
Douillard JY, Oliner KS, Siena S, et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 2013;369(11):1023–34.
-
(2013)
N Engl J Med
, vol.369
, Issue.11
, pp. 1023-1034
-
-
Douillard, J.Y.1
Oliner, K.S.2
Siena, S.3
-
16
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
PID: 19339720
-
Van Cutsem E, Kohne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360(14):1408–17.
-
(2009)
N Engl J Med
, vol.360
, Issue.14
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
-
17
-
-
33646143020
-
Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
-
COI: 1:CAS:528:DC%2BD28XjsFaksrk%3D, PID: 16570047
-
Townsley CA, Major P, Siu LL, et al. Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer. Br J Cancer. 2006;94(8):1136–43.
-
(2006)
Br J Cancer
, vol.94
, Issue.8
, pp. 1136-1143
-
-
Townsley, C.A.1
Major, P.2
Siu, L.L.3
-
18
-
-
84891656497
-
ATLAS: randomized, double-blind, placebo-controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib, after completion of chemotherapy, with bevacizumab for first-line treatment of advanced non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BC3sXhvVGrtrfI, PID: 24101054
-
Johnson BE, Kabbinavar F, Fehrenbacher L, et al. ATLAS: randomized, double-blind, placebo-controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib, after completion of chemotherapy, with bevacizumab for first-line treatment of advanced non-small-cell lung cancer. J Clin Oncol. 2013;31(31):3926–34.
-
(2013)
J Clin Oncol
, vol.31
, Issue.31
, pp. 3926-3934
-
-
Johnson, B.E.1
Kabbinavar, F.2
Fehrenbacher, L.3
-
19
-
-
84928629659
-
Phase II study of bevacizumab, capecitabine, and oxaliplatin followed by bevacizumab plus erlotinib as first-line therapy in metastatic colorectal cancer
-
PID: 24762224
-
Munoz A, Pericay C, Garcia-Giron C, et al. Phase II study of bevacizumab, capecitabine, and oxaliplatin followed by bevacizumab plus erlotinib as first-line therapy in metastatic colorectal cancer. Oncol Res. 2013;21(4):181–91.
-
(2013)
Oncol Res
, vol.21
, Issue.4
, pp. 181-191
-
-
Munoz, A.1
Pericay, C.2
Garcia-Giron, C.3
-
20
-
-
84859001212
-
The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials
-
PID: 22008217
-
Higgins JP, Altman DG, Gotzsche PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.
-
(2011)
BMJ
, vol.343
, pp. d5928
-
-
Higgins, J.P.1
Altman, D.G.2
Gotzsche, P.C.3
-
21
-
-
12744274510
-
Heterogeneity testing in meta-analysis of genome searches
-
PID: 15593093
-
Zintzaras E, Ioannidis JP. Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol. 2005;28(2):123–37.
-
(2005)
Genet Epidemiol
, vol.28
, Issue.2
, pp. 123-137
-
-
Zintzaras, E.1
Ioannidis, J.P.2
-
22
-
-
0028659004
-
Operating characteristics of a rank correlation test for publication bias
-
COI: 1:STN:280:DyaK2Mzgs1GrtQ%3D%3D, PID: 7786990
-
Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–101.
-
(1994)
Biometrics.
, vol.50
, Issue.4
, pp. 1088-1101
-
-
Begg, C.B.1
Mazumdar, M.2
-
23
-
-
0030922816
-
Bias in meta-analysis detected by a simple, graphical test
-
COI: 1:STN:280:DyaK2svls1KjtA%3D%3D, PID: 9310563
-
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34.
-
(1997)
BMJ
, vol.315
, Issue.7109
, pp. 629-634
-
-
Egger, M.1
Davey Smith, G.2
Schneider, M.3
Minder, C.4
-
24
-
-
84883339111
-
A randomized phase III trial on maintenance treatment with bevacizumab alone or in combination with erlotinib after chemotherapy and bevacizumab in metastatic colorectal cancer: the Nordic ACT Trial
-
COI: 1:STN:280:DC%2BC3sjkslKjsQ%3D%3D, PID: 23788755
-
Johnsson A, Hagman H, Frodin JE, et al. A randomized phase III trial on maintenance treatment with bevacizumab alone or in combination with erlotinib after chemotherapy and bevacizumab in metastatic colorectal cancer: the Nordic ACT Trial. Ann Oncol. 2013;24(9):2335–41.
-
(2013)
Ann Oncol
, vol.24
, Issue.9
, pp. 2335-2341
-
-
Johnsson, A.1
Hagman, H.2
Frodin, J.E.3
-
25
-
-
84954029886
-
Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer (GERCOR DREAM; OPTIMOX3): a randomised, open-label, phase 3 trial
-
COI: 1:CAS:528:DC%2BC2MXhs1Kisb3I, PID: 26474518
-
Tournigand C, Chibaudel B, Samson B, et al. Bevacizumab with or without erlotinib as maintenance therapy in patients with metastatic colorectal cancer (GERCOR DREAM; OPTIMOX3): a randomised, open-label, phase 3 trial. Lancet Oncol. 2015;16(15):1493–505.
-
(2015)
Lancet Oncol.
, vol.16
, Issue.15
, pp. 1493-1505
-
-
Tournigand, C.1
Chibaudel, B.2
Samson, B.3
-
26
-
-
84960127748
-
A randomized study of KRAS-guided maintenance therapy with bevacizumab, erlotinib or metronomic capecitabine after first-line induction treatment of metastatic colorectal cancer: the Nordic ACT2 Trial
-
COI: 1:STN:280:DC%2BC28zjtlehtg%3D%3D, PID: 26483047
-
Hagman H, Frodin JE, Berglund A, et al. A randomized study of KRAS-guided maintenance therapy with bevacizumab, erlotinib or metronomic capecitabine after first-line induction treatment of metastatic colorectal cancer: the Nordic ACT2 Trial. Ann Oncol. 2016;27(1):140–7.
-
(2016)
Ann Oncol
, vol.27
, Issue.1
, pp. 140-147
-
-
Hagman, H.1
Frodin, J.E.2
Berglund, A.3
-
27
-
-
66149176908
-
Erlotinib and bevacizumab have synergistic activity against melanoma
-
COI: 1:CAS:528:DC%2BD1MXmtVKlsro%3D, PID: 19447871
-
Schicher N, Paulitschke V, Swoboda A, et al. Erlotinib and bevacizumab have synergistic activity against melanoma. Clin Cancer Res. 2009;15(10):3495–502.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.10
, pp. 3495-3502
-
-
Schicher, N.1
Paulitschke, V.2
Swoboda, A.3
-
28
-
-
80054122779
-
EGFR- and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies
-
COI: 1:CAS:528:DC%2BC3MXhtlSksr3F, PID: 21880790
-
Poindessous V, Ouaret D, El Ouadrani K, et al. EGFR- and VEGF(R)-targeted small molecules show synergistic activity in colorectal cancer models refractory to combinations of monoclonal antibodies. Clin Cancer Res. 2011;17(20):6522–30.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.20
, pp. 6522-6530
-
-
Poindessous, V.1
Ouaret, D.2
El Ouadrani, K.3
-
29
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
COI: 1:CAS:528:DC%2BD1MXjsVCjs74%3D, PID: 19114685
-
Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol. 2009;27(5):672–80.
-
(2009)
J Clin Oncol
, vol.27
, Issue.5
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
-
30
-
-
34547852270
-
Phase II study of FOLFOX, bevacizumab and erlotinib as first-line therapy for patients with metastatic colorectal cancer
-
COI: 1:STN:280:DC%2BD2svls1ChtA%3D%3D, PID: 17483115
-
Meyerhardt JA, Stuart K, Fuchs CS, et al. Phase II study of FOLFOX, bevacizumab and erlotinib as first-line therapy for patients with metastatic colorectal cancer. Ann Oncol. 2007;18(7):1185–9.
-
(2007)
Ann Oncol
, vol.18
, Issue.7
, pp. 1185-1189
-
-
Meyerhardt, J.A.1
Stuart, K.2
Fuchs, C.S.3
-
31
-
-
56749169353
-
Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE)
-
COI: 1:CAS:528:DC%2BD1MXhslCmtw%3D%3D, PID: 18854571
-
Grothey A, Sugrue MM, Purdie DM, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol. 2008;26(33):5326–34.
-
(2008)
J Clin Oncol
, vol.26
, Issue.33
, pp. 5326-5334
-
-
Grothey, A.1
Sugrue, M.M.2
Purdie, D.M.3
-
32
-
-
84906226358
-
Biomarker analyses from a randomized, placebo-controlled, phase IIIb trial comparing bevacizumab with or without erlotinib as maintenance therapy for the treatment of advanced non-small-cell lung cancer (ATLAS)
-
COI: 1:CAS:528:DC%2BC2cXhsVSnt7rM, PID: 25122437
-
Kabbinavar F, Fehrenbacher L, Hainsworth J, et al. Biomarker analyses from a randomized, placebo-controlled, phase IIIb trial comparing bevacizumab with or without erlotinib as maintenance therapy for the treatment of advanced non-small-cell lung cancer (ATLAS). J Thorac Oncol. 2014;9(9):1411–7.
-
(2014)
J Thorac Oncol.
, vol.9
, Issue.9
, pp. 1411-1417
-
-
Kabbinavar, F.1
Fehrenbacher, L.2
Hainsworth, J.3
-
33
-
-
0036570203
-
ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
-
COI: 1:CAS:528:DC%2BD38XjtlGrsbc%3D, PID: 11980649
-
Hirata A, Ogawa S, Kometani T, et al. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res. 2002;62(9):2554–60.
-
(2002)
Cancer Res
, vol.62
, Issue.9
, pp. 2554-2560
-
-
Hirata, A.1
Ogawa, S.2
Kometani, T.3
-
34
-
-
79956205502
-
Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis
-
COI: 1:CAS:528:DC%2BC3MXmsVyltbk%3D, PID: 21439312
-
Larsen AK, Ouaret D, El Ouadrani K, Petitprez A. Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis. Pharmacol Ther. 2011;131(1):80–90.
-
(2011)
Pharmacol Ther
, vol.131
, Issue.1
, pp. 80-90
-
-
Larsen, A.K.1
Ouaret, D.2
El Ouadrani, K.3
Petitprez, A.4
-
35
-
-
25844481618
-
Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy
-
COI: 1:CAS:528:DC%2BD2MXhtFyitbrP, PID: 16113092
-
Bianco R, Troiani T, Tortora G, Ciardiello F. Intrinsic and acquired resistance to EGFR inhibitors in human cancer therapy. Endocr Relat Cancer. 2005;12(Suppl 1):S159–71.
-
(2005)
Endocr Relat Cancer
, vol.12
, pp. S159-S171
-
-
Bianco, R.1
Troiani, T.2
Tortora, G.3
Ciardiello, F.4
-
36
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
COI: 1:CAS:528:DC%2BD1MXhsFyitrw%3D, PID: 19196673
-
Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009;360(6):563–72.
-
(2009)
N Engl J Med
, vol.360
, Issue.6
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
-
37
-
-
84926475781
-
Bevacizumab continuation versus no continuation after first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer: a randomized phase III non-inferiority trial (SAKK 41/06)
-
COI: 1:STN:280:DC%2BC2MvotVCjsw%3D%3D, PID: 25605741
-
Koeberle D, Betticher DC, von Moos R, et al. Bevacizumab continuation versus no continuation after first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer: a randomized phase III non-inferiority trial (SAKK 41/06). Ann Oncol. 2015;26(4):709–14.
-
(2015)
Ann Oncol
, vol.26
, Issue.4
, pp. 709-714
-
-
Koeberle, D.1
Betticher, D.C.2
von Moos, R.3
|