A Pharmacokinetic Model for Protamine Dosing After Cardiopulmonary Bypass

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 30, Issue 5, 2016, Pages 1190-1195

  Meesters, Michael I ^a   Veerhoek, Dennis ^a   de Jong, Jan R ^a   Boer, Christa ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

cardiac surgery; cardiopulmonary bypass; coagulation; hemostasis; heparin; protamine

Indexed keywords

FRESH FROZEN PLASMA; HEMOGLOBIN; HEPARIN; PROTAMINE; HEPARIN ANTAGONIST;

AGED; ARTICLE; BLOOD CLOTTING TEST; BLOOD CLOTTING TIME; BOLUS INJECTION; CARDIOPULMONARY BYPASS; CASE CONTROL STUDY; CLINICAL OUTCOME; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG DOSE TITRATION; DRUG MEGADOSE; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FEMALE; HALF LIFE TIME; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HEMOSTASIS; HEPARINIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PARTIAL THROMBOPLASTIN TIME; PLASMA TRANSFUSION; POSTOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; PROTHROMBIN TIME; RETROSPECTIVE STUDY; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; TITRIMETRY; BLOOD CLOTTING; DOSE RESPONSE; DRUG EFFECTS; HEART SURGERY; PROCEDURES; STATISTICS AND NUMERICAL DATA; THROMBOELASTOGRAPHY;

AGED; BLOOD COAGULATION; BLOOD COAGULATION TESTS; CARDIAC SURGICAL PROCEDURES; CASE-CONTROL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEPARIN ANTAGONISTS; HUMANS; MALE; POSTOPERATIVE CARE; PROTAMINES; RETROSPECTIVE STUDIES; THROMBELASTOGRAPHY;

EID: 84991093555     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2016.04.021     Document Type: Article

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