3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection

Protein and Cell

Volumn 7, Issue 11, 2016, Pages 839-843

  Wang, Song ^a   Luo, Xiaoqin ^a   Yan, Ruoxiang ^a   Wang, Quanxin ^b   Qi, Qiuyue ^b   Chi, Xiaojuan ^a   Zhang, Lanlan ^a   Yu, Ziding ^a   Cai, Binxiang ^a   Chen, Ji Long ^a,b   Liu, Hongwei ^b  

^a FUJIAN AGRICULTURE AND FORESTRY UNIVERSITY   (China)

^b INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 ANHYDRO 6 HYDROXY OPHIOBOLIN A; ANTIVIRUS AGENT; GEMCITABINE; INTERFERON; OBATOCLAX; SESTERTERPENE; UNCLASSIFIED DRUG; ZANAMIVIR; OPHIOBOLIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; GENE EXPRESSION; GENETIC DRIFT; HUMAN; HUMAN CELL; INFLUENZA A; INFLUENZA A VIRUS; LETTER; MICROARRAY ANALYSIS; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; VIRAL PLAQUE ASSAY; VIRUS LOAD; VIRUS REPLICATION; VIRUS STRAIN; A-549 CELL LINE; ANIMAL; ANTIVIRAL RESISTANCE; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECTS; METABOLISM; ORTHOMYXOVIRUS INFECTION; PRECLINICAL STUDY;

A549 CELLS; ANIMALS; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, VIRAL; HUMANS; INFLUENZA A VIRUS; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; SESTERTERPENES;

EID: 84991087014     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-016-0325-y     Document Type: Letter

References (15)

1. Au TK, Chick WS, Leung PC (2000) The biology of ophiobolins. Life Sci 67:733–742
2. Cheng PK, Leung TW, Ho EC, Leung PC, Ng AY, Lai MY, Lim WW (2009) Oseltamivir-and amantadine-resistant influenza viruses A (H1N1). Emerg Infect Dis 15:966
3. Denisova OV, Kakkola L, Feng L, Stenman J, Nagaraj A, Lampe J, Yadav B, Aittokallio T, Kaukinen P, Ahola T (2012) Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection. J Biol Chem 287:35324–35332
4. Droebner K, Pleschka S, Ludwig S, Planz O (2011) Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res 92:195–203
5. Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K et al (2013) Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 368:1888–1897
6. Haasbach E, Reiling SJ, Ehrhardt C, Droebner K, Ruckle A, Hrincius ER, Leban J, Strobl S, Vitt D, Ludwig S et al (2013) The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus. Antiviral Res 99:336–344
7. Hurt AC, Holien JK, Parker M, Kelso A, Barr IG (2009) Zanamivir-resistant influenza viruses with a novel neuraminidase mutation. J Virol 83:10366–10373
8. Karlas A, Machuy N, Shin Y, Pleissner KP, Artarini A, Heuer D, Becker D, Khalil H, Ogilvie LA, Hess S (2010) Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature. 463:818–822
9. Moscona A (2009) Global transmission of oseltamivir-resistant influenza. N Engl J Med 360:953–956
10. Phuwapraisirisan P, Sawang K, Siripong P, Tip-Pyang S (2007) Anhydrocochlioquinone A, a new antitumor compound from Bipolaris oryzae. Tetrahedron Lett. 48:5193–5195
11. Planz O (2013) Development of cellular signaling pathway inhibitors as new antivirals against influenza. Antiviral Res 98:457–468
12. Regoes RR, Bonhoeffer S (2006) Emergence of drug-resistant influenza virus: population dynamical considerations. Science 312:389–391
13. Wang QX, Yang JL, Qi QY, Bao L, Yang XL, Liu MM, Huang P, Zhang LX, Chen JL, Cai L et al (2013) 3-Anhydro-6-hydroxy-ophiobolin A, a new sesterterpene inhibiting the growth of methicillin-resistant Staphylococcus aureus and inducing the cell death by apoptosis on K562, from the phytopathogenic fungus Bipolaris oryzae. Bioorg Med Chem Lett 23:3547–3550
14. Watanabe T, Watanabe S, Kawaoka Y (2010) Cellular networks involved in the influenza virus life cycle. Cell Host Microbe 7:427–439
15. Yang T, Lu Z, Meng L, Wei S, Hong K, Zhu W, Huang C (2012) The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways. Bioorg Med Chem Lett 22:579–585