L718Q mutation as new mechanism of acquired resistance to AZD9291 in EGFR-mutated NSCLC

Journal of Thoracic Oncology

Volumn 11, Issue 10, 2016, Pages e121-e123

  Bersanelli, Melissa ^a   Minari, Roberta ^a   Bordi, Paola ^a   Gnetti, Letizia ^a   Bozzetti, Cecilia ^a   Squadrilli, Anna ^a   Lagrasta, Costanza Anna Maria ^a,b   Bottarelli, Lorena ^a   Osipova, Ganna ^a   Capelletto, Enrica ^c   Mor, Marco ^b   Tiseo, Marcello ^a  

^a UNIVERSITY HOSPITAL OF PARMA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; GEFITINIB; OSIMERTINIB; PEMETREXED; ACRYLAMIDE DERIVATIVE; ANILINE DERIVATIVE; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR;

AGED; ARTICLE; CANCER RESISTANCE; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; GENE AMPLIFICATION; GENE MUTATION; HUMAN; HUMAN TISSUE; LUNG BIOPSY; MULTIPLE CYCLE TREATMENT; NEXT GENERATION SEQUENCING; NON SMALL CELL LUNG CANCER; PHASE 1 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; TREATMENT RESPONSE; TUMOR BIOPSY; ANTAGONISTS AND INHIBITORS; DRUG RESISTANCE; GENETICS; LUNG TUMOR; MUTATION; PATHOLOGY;

ACRYLAMIDES; AGED; ANILINE COMPOUNDS; CARCINOMA, NON-SMALL-CELL LUNG; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; LUNG NEOPLASMS; MUTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84991065603     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1016/j.jtho.2016.05.019     Document Type: Article

References (5)

1. Jänne PA, Yang JC, Planchard D, et al. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N Engl J Med. 2015;372:1689-1699.
2. Thress KS, Pawelets CP, Felip E, et al. Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small-cell lung cancer harboring EGFR T790M. Nat Med. 2015;21:560-562.
3. Kim TM, Song A, Kim DW, et al. Mechanisms of acquired resistance to AZD9291. J Thorac Oncol. 2015;10: 1736-1744.
4. Ercan D, Choi HG, Yun CH, et al. EGFR mutations and resistance to irreversible pyrimidine based EGFR inhibitors. Clin Can Res. 2015;21:3913-3923.
5. Yosaatmadja Y, Silva S, Dickson JM, et al. Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed. J Struct Biol. 2015;192: 539-544.