Analysis of Diagnostic Findings from the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015

Journal of Infectious Diseases

Volumn 214, Issue , 2016, Pages S250-S257

  Kerber, Romy ^a,b,d   Krumkamp, Ralf ^a,d   DIallo, Boubacar ⁱ   Jaeger, Anna ^a,d   Rudolf, Martin ^a,b,d   Lanini, Simone ^b,m   Bore, Joseph Akoi ^b,j   Koundouno, Fara Raymond ^b,j   Becker Ziaja, Beate ^a,b,d   Fleischmann, Erna ^b,d,e   Stoecker, Kilian ^b,d,e   Meschi, Silvia ^b,m   Mély, Stéphane ^b,n,o   Newman, Edmund N C ^b,q   Carletti, Fabrizio ^b,m   Portmann, Jasmine ^b,s   Korva, Misa ^b,u   Wolff, Svenja ^b,d,f   Molkenthin, Peter ^b,d,e   Kis, Zoltan ^b,v   Kelterbaum, Anne ^b,d,f   Bocquin, Anne ^b,n,o   Strecker, Thomas ^b,d,f   Fizet, Alexandra ^b,n,p   Castilletti, Concetta ^b,m   Schudt, Gordian ^b,d,f   Ottowell, Lisa ^b,q   Kurth, Andreas ^b,g   Atkinson, Barry ^b,q   Badusche, Marlis ^a,b,d   Cannas, Angela ^b,m   Pallasch, Elisa ^a,b,d   Bosworth, Andrew ^b,q   Yue, Constanze ^b,g   Pályi, Bernadett ^b,v   Ellerbrok, Heinz ^b,g   Kohl, Claudia ^b,g   Oestereich, Lisa ^a,b,d   Logue, Christopher H ^b,q   Lüdtke, Anja ^b,c,d   Richter, Martin ^b,g   Ngabo, DIdier ^b,q   Borremans, Benny ^b,w   Becker, DIrk ^b,d,f   Gryseels, Sophie ^b,w   Abdellati, Saïd ^b,x   Vermoesen, Tine ^b,x   Kuisma, Eeva ^b,q   Kraus, Annette ^b,aa   Liedigk, Britta ^a,b,d   Maes, Piet ^b,y   Thom, Ruth ^b,q   Duraffour, Sophie ^b,y   DIederich, Sandra ^b,d,h   Hinzmann, Julia ^b,g   Afrough, Babak ^b,q   Repits, Johanna ^b,ab   Mertens, Marc ^b,d,h   Vitoriano, Inês ^b,q   Bah, Amadou ^b,t   Sachse, Andreas ^b,g   Boettcher, Jan Peter ^b,g   Wurr, Stephanie ^a,b,d   Bockholt, Sabrina ^a,b,d   Nitsche, Andreas ^b,g   Aupanc, Tatjana Avšič ^b,u   Strasser, Marc ^b,s   Ippolito, Giuseppe ^b,m   Becker, Stephan ^b,d,f   Raoul, Herve ^b,o   Carroll, Miles W ^b,q,r   De Clerck, Hilde ^z   Van Herp, Michel ^z   Sprecher, Armand ^z   Koivogui, Lamine ^k   Magassouba, N'Faly ^l   Keïta, Sakoba ^j   Drury, Patrick ⁱ   Gurry, Cèline ⁱ   Formenty, Pierre ⁱ   May, Jürgen ^a,d   Gabriel, Martin ^a,b,d   Wölfel, Roman ^b,d,e   Günther, Stephan ^a,b,d   DI Caro, Antonino ^b,m   more..

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^b European Mobile Laboratory Consortium   (Germany)

^c LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^d German Center for Infection Research   (Germany)

^e BUNDESWEHR INSTITUTE OF MICROBIOLOGY   (Germany)

^f PHILIPPS UNIVERSITY MARBURG   (Germany)

^g ROBERT KOCH INSTITUTE   (Germany)

^h FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

ⁱ WORLD HEALTH ORGANIZATION   (Switzerland)

^j National Coordination Cell in the Fight against Ebola   (Guinea)

^k INSTITUT NATIONAL DE SANTÉ PUBLIQUE   (Guinea)

^l Université Gamal Abdel Nasser de Conakry   (Guinea)

^m NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

ⁿ National Reference Center for Viral Hemorrhagic Fevers   (France)

^o INSERM   (France)

^p INSTITUT PASTEUR   (France)

^q PUBLIC HEALTH ENGLAND   (United Kingdom)

^r UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^s SPIEZ LABORATORY   (Switzerland)

^t SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^u UNIVERSITY OF LJUBLJANA   (Slovenia)

^v NATIONAL CENTER FOR EPIDEMIOLOGY   (Hungary)

^w UNIVERSITY OF ANTWERP   (Belgium)

^x INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^y REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^z MÉDECINS SANS FRONTIÈRES   (Belgium)

^aa SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^ab Janssen Cilag   (Sweden)

more..

Author keywords

Ebola virus disease; Epidemic; Filovirus; Guinea; Malaria; Mobile laboratory

Indexed keywords

VIRUS RNA;

ADOLESCENT; ADULT; AGE; AGED; ANALYTICAL PARAMETERS; ARTICLE; BLOOD ANALYSIS; CASE FATALITY RATE; CHILD; CONTROLLED STUDY; CYCLE THRESHOLD; DATA BASE; DIAGNOSTIC TEST; EBOLA HEMORRHAGIC FEVER; GUINEA; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MIXED INFECTION; NONHUMAN; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION SYSTEM; PREVALENCE; PRIORITY JOURNAL; RAPID TEST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVOR; THROAT CULTURE; VIRUS LOAD; BLOOD; CLINICAL LABORATORY SERVICE; COMPLICATION; EBOLAVIRUS; EPIDEMIC; FEMALE; FILOVIRIDAE; FILOVIRIDAE INFECTIONS; GENETICS; HEMORRHAGIC FEVER, EBOLA; INFANT; ISOLATION AND PURIFICATION; MALE; MIDDLE AGED; PARASITOLOGY; PRESCHOOL CHILD; PREVENTIVE HEALTH SERVICE; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; CLINICAL LABORATORY SERVICES; EBOLAVIRUS; EPIDEMICS; FEMALE; FILOVIRIDAE; FILOVIRIDAE INFECTIONS; GUINEA; HEMORRHAGIC FEVER, EBOLA; HUMANS; INFANT; MALARIA; MALE; MIDDLE AGED; MOBILE HEALTH UNITS; RNA, VIRAL; VIRAL LOAD; YOUNG ADULT;

EID: 84991013851     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiw269     Document Type: Article

References (27)

1. Feldmann H, Geisbert TW. Ebola haemorrhagic fever. Lancet 2011; 377:849-62.
2. Baize S, Pannetier D, Oestereich L, et al. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med 2014; 371:1418-25.
3. World Health Organization. Ebola situation report-16 March 2016. http://apps. who.int/ebola/current-situation/ebola-situation-report-16-march-2016. Accessed 30 March 2016.
4. Lever RA, Whitty CJ. Ebola virus disease: emergence, outbreak and future directions. Br Med Bull 2016; 117:95-106.
5. Wolfel R, Stoecker K, Fleischmann E, et al. Mobile diagnostics in outbreak response, not only for Ebola: a blueprint for a modular and robust field laboratory. Euro Surveill 2015; 20:pii:30055.
6. World Health Organization. Interim guideline: case definition recommendations for Ebola or Marburg virus diseases, 9 August 2014. http://apps.who.int/iris/bitstream/10665/146397/1/WHO-EVD-CaseDef-14.1-eng.pdf?ua=1&ua=1. Accessed 25 June 2016.
7. Rieger T, Kerber R, El Halas H, et al. Evaluation of RealStar RT-PCR kits for filovirus detection in the laboratory and field. J Infect Dis 2016; 214(suppl 3):S243-9.
8. Alere. Test kit product instructions-BinaxNOW malaria test kit. IN665000 Rev. 6, 2015/04. http://www.alere.com/en/home/product-details/binaxnow-malaria. html. Accessed 25 June 2016.
9. World Health Organization (WHO). Guinea. In: World malaria report. Geneva, Switzerland: WHO, 2015:121. http://www.who.int/entity/malaria/publications/country-profiles/profile-gin-en.pdf?ua=1. Accessed 25 June 2016.
10. Mwangi TW, Ross A, Snow RW, Marsh K. Case definitions of clinical malaria under different transmission conditions in Kilifi District, Kenya. J Infect Dis 2005; 191:1932-9.
11. Bejon P, Berkley JA, Mwangi T, et al. Defining childhood severe falciparum malaria for intervention studies. PLoS Med 2007; 4:e251.
12. World Health Organization. Ebola situation report-25 March 2015. http://apps. who.int/ebola/current-situation/ebola-situation-report-25-march-2015. Accessed 13 March 2016.
13. Sissoko D, Laouenan C, Folkesson E, et al. Experimental treatment with favipiravir for Ebola virus disease (the JIKI Trial): a historically controlled, single-arm proofof-concept trial in Guinea. PLoS Med 2016; 13:e1001967.
14. Fitzpatrick G, Vogt F, Moi Gbabai OB, et al. The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Medecins Sans Frontieres Ebola case management centre, Kailahun, Sierra Leone, June-October 2014. J Infect Dis 2015; 212:1752-8.
15. Towner JS, Rollin PE, Bausch DG, et al. Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome. J Virol 2004; 78:4330-41.
16. Schieffelin JS, Shaffer JG, Goba A, et al. Clinical illness and outcomes in patients with Ebola in Sierra Leone. N Engl J Med 2014; 371:2092-100.
17. Yan T, Mu J, Qin E, et al. Clinical characteristics of 154 patients suspected of having Ebola virus disease in the Ebola holding center of Jui Government Hospital in Sierra Leone during the 2014 Ebola outbreak. Eur J Clin Microbiol Infect Dis 2015; 34:2089-95.
18. Hunt L, Gupta-Wright A, Simms V, et al. Clinical presentation, biochemical, and haematological parameters and their association with outcome in patients with Ebola virus disease: an observational cohort study. Lancet Infect Dis 2015; 15:1292-9.
19. Lanini S, Portella G, Vairo F, et al. Blood kinetics of Ebola virus in survivors and nonsurvivors. J Clin Invest 2015; 125:4692-8.
20. Faye O, Andronico A, Faye O, et al. Use of viremia to evaluate the baseline case fatality ratio of Ebola virus disease and inform treatment studies: a retrospective cohort study. PLoS Med 2015; 12:e1001908.
21. Bah EI, Lamah MC, Fletcher T, et al. Clinical presentation of patients with Ebola virus disease in Conakry, Guinea. N Engl J Med 2015; 372:40-7.
22. Zhang X, Rong Y, Sun L, et al. Prognostic analysis of patients with Ebola virus disease. PLoS Negl Trop Dis 2015; 9:e0004113.
23. Lu HJ, Qian J, Kargbo D, et al. Ebola virus outbreak investigation, Sierra Leone, September 28-November 11, 2014. Emerg Infect Dis 2015; 21:1921-7.
24. Crowe SJ, Maenner MJ, Kuah S, et al. Prognostic indicators for Ebola patient survival. Emerg Infect Dis 2016; 22:217-23.
25. de Wit E, Falzarano D, Onyango C, et al. The merits of malaria diagnostics during an Ebola virus disease outbreak. Emerg Infect Dis 2016; 22:323-6.
26. Agua-Agum J, Ariyarajah A, Blake IM, et al. Ebola virus disease among children in West Africa. N Engl J Med 2015; 372:1274-7.
27. Taubenberger JK, Morens DM. 1918 Influenza: the mother of all pandemics. Emerg Infect Dis 2006; 12:15-22.