The ratio of CD8+/FOXP3 T lymphocytes infiltrating breast tissues predicts the relapse of ductal carcinoma in situ

OncoImmunology

Volumn 5, Issue 10, 2016, Pages

  Semeraro, Michaela ^a,b,c,d,e   Adam, Julien ^a   Stoll, Gautier ^a,b,c,d,e   Louvet, Emilie ^a   Chaba, Kariman ^a,b,c,d,e   Poirier Colame, Vichnou ^a,f,g   Sauvat, Allan ^a,b,c,d,e   Senovilla, Laura ^a,b,c,d,e   Vacchelli, Erika ^a,b,c,d,e   Bloy, Norma ^a,b,c,d,e,f   Humeau, Juliette ^a,b,c,d,e,f   Buque, Aitziber ^a,b,c,d,e   Kepp, Oliver ^a,b,c,d,e   Zitvogel, Laurence ^a,b,f,g   André, Fabrice ^a,b   Mathieu, Marie Christine ^a   Delaloge, Suzette ^a   Kroemer, Guido ^{a,b,c,d,e,h,i}  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b INSERM   (France)

^c CENTRE DE RECHERCHE DES CORDELIERS   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e SORBONNE UNIVERSITÉ   (France)

^f UNIVERSITÉ PARIS SACLAY   (France)

^g Center of Clinical Investigations in Biotherapies of Cancer CICBT 507   (France)

^h HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

ⁱ KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cytotoxic T cells; hyperploidy; immunogenic cell death; immunosuppressive regulatory T cells; intraductal carcinoma

Indexed keywords

CALRETICULIN; INITIATION FACTOR 2ALPHA; TRANSCRIPTION FACTOR FOXP3;

ADULT; AGED; ARTICLE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; DISEASE FREE SURVIVAL; GENE SEQUENCE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMAGE GUIDED BIOPSY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOSURVEILLANCE; INTRADUCTAL CARCINOMA; MAJOR CLINICAL STUDY; MIDDLE AGED; NUCLEAR SIZE; PLOIDY; TISSUE MICROARRAY;

EID: 84990895537     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2016.1218106     Document Type: Article

References (33)

1. C.Denkert, S.Loibl, A.Noske, M.Roller, B.M.Muller, M.Komor, J.Budczies, S.Darb-Esfahani, R.Kronenwett, C.Hanusch et al. Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol 2010; 28:105-13; PMID:19917869; http://dx.doi.org/10.1200/JCO.2009.23.7370
2. C.Denkert, G.von Minckwitz, J.C.Brase, B.V.Sinn, S.Gade, R.Kronenwett, B.M.Pfitzner, C.Salat, S.Loi, W.D.Schmitt et al. Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers. J Clin Oncol 2015; 33:983-91; PMID:25534375; http://dx.doi.org/10.1200/JCO.2014.58.1967
3. M.V.Dieci, M.C.Mathieu, V.Guarneri, P.Conte, S.Delaloge, F.Andre, A.Goubar. Prognostic and predictive value of tumor-infiltrating lymphocytes in two phase III randomized adjuvant breast cancer trials. Ann Oncol 2015; 26:1698-704; PMID:25995301; http://dx.doi.org/10.1093/annonc/mdv239
4. M.V.Dieci, C.Criscitiello, A.Goubar, G.Viale, P.Conte, V.Guarneri, G.Ficarra, M.C.Mathieu, S.Delaloge, G.Curigliano et al. Prognostic value of tumor-infiltrating lymphocytes on residual disease after primary chemotherapy for triple-negative breast cancer:a retrospective multicenter study. Ann Oncol 2015; 26:1518; PMID:26109735; http://dx.doi.org/10.1093/annonc/mdv239
5. G.Kroemer, L.Senovilla, L.Galluzzi, F.Andre, L.Zitvogel. Natural and therapy-induced immunosurveillance in breast cancer. Nat Med 2015; 21:1128-38; PMID:26444637; http://dx.doi.org/10.1038/nm.3944
6. B.Ingold Heppner, M.Untch, C.Denkert, B.M.Pfitzner, B.Lederer, W.D.Schmitt, H.Eidtmann, P.A.Fasching, H.Tesch, C.Solbach et al. Tumor-infiltrating lymphocytes:a predictive and prognostic biomarker in neoadjuvant treated HER2-positive breast cancer. Clin Cancer Res 2016; PMID:27189162; http://dx.doi.org/10.1158/1078-0432.CCR-15-2338
7. B.Ingold Heppner, S.Loibl, C.Denkert. Tumor-Infiltrating Lymphocytes:A Promising Biomarker in Breast Cancer. Breast Care (Basel) 2016; 11:96-100; PMID:27239170; http://dx.doi.org/10.1159/000444357
8. G.Stoll, D.Enot, B.Mlecnik, J.Galon, L.Zitvogel, G.Kroemer. Immune-related gene signatures predict the outcome of neoadjuvant chemotherapy. Oncoimmunol 2014; 3:e27884; PMID:24790795; http://dx.doi.org/10.4161/onci.27884
9. S.Ladoire, D.Enot, L.Senovilla, F.Ghiringhelli, V.Poirier-Colame, K.Chaba, M.Semeraro, M.Chaix, F.Penault-Llorca, L.Arnould et al. The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer. Autophagy 2016; 12:864-75; PMID:26979828; http://dx.doi.org/10.1080/15548627.2016.1154244
10. L.Senovilla, I.Vitale, I.Martins, M.Tailler, C.Pailleret, M.Michaud, L.Galluzzi, S.Adjemian, O.Kepp, M.Niso-Santano et al. An immunosurveillance mechanism controls cancer cell ploidy. Science 2012; 337:1678-84; PMID:23019653; http://dx.doi.org/10.1126/science.1224922
11. R.D.Schreiber, L.J.Old, M.J.Smyth. Cancer immunoediting:integrating immunity's roles in cancer suppression and promotion. Science 2011; 331:1565-70; PMID:21436444; http://dx.doi.org/10.1126/science.1203486
12. A.K.Palucka, L.M.Coussens. The Basis of Oncoimmunology. Cell 2016; 164:1233-47; PMID:26967289; http://dx.doi.org/10.1016/j.cell.2016.01.049
13. L.Zitvogel, M.Ayyoub, B.Routy, G.Kroemer. Microbiome and Anticancer Immunosurveillance. Cell 2016; 165:276-87; PMID:27058662; http://dx.doi.org/10.1016/j.cell.2016.03.001
14. T.Fujiwara, M.Bandi, M.Nitta, E.V.Ivanova, R.T.Bronson, D.Pellman. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 2005; 437:1043-7; PMID:16222300; http://dx.doi.org/10.1038/nature04217
15. T.I.Zack, S.E.Schumacher, S.L.Carter, A.D.Cherniack, G.Saksena, B.Tabak, M.S.Lawrence, C.Z.Zhsng, J.Wala, C.H.Mermel et al. Pan-cancer patterns of somatic copy number alteration. Nat Genet 2013; 45:1134-40; PMID:24071852; http://dx.doi.org/10.1038/ng.2760
16. I.Vitale, L.Galluzzi, L.Senovilla, A.Criollo, M.Jemaa, M.Castedo, G.Kroemer. Illicit survival of cancer cells during polyploidization and depolyploidization. Cell Death Differ 2011; 18:1403-13; PMID:21072053; http://dx.doi.org/10.1038/cdd.2010.145
17. O.Kepp, M.Semeraro, J.M.Bravo-San Pedro, N.Bloy, A.Buque, X.Huang, H.Zhou, L.Senovilla, G.Kroemer, L.Galluzzi et al. eIF2alpha phosphorylation as a biomarker of immunogenic cell death. Semin Cancer Biol 2015; 33:86-92; PMID:25749194; http://dx.doi.org/10.1016/j.semcancer.2015.02.004
18. T.Panaretakis, O.Kepp, U.Brockmeier, A.Tesniere, A.C.Bjorklund, D.C.Chapman, M.Durchschlag, N.Joza, G.Pierron, P.van Endert et al. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J 2009; 28:578-90; PMID:19165151; http://dx.doi.org/10.1038/emboj.2009.1
19. A.Boileve, L.Senovilla, I.Vitale, D.Lissa, I.Martins, D.Metivier, S.van den Brink, H.Clevers, L.Galluzzi, M.Castedo et al. Immunosurveillance against tetraploidization-induced colon tumorigenesis. Cell Cycle 2013; 12:473-9; PMID:23324343; http://dx.doi.org/10.4161/cc.23369
20. L.Senovilla, I.Vitale, I.Martins, O.Kepp, L.Galluzzi, L.Zitvogel, M.Castedo, G.Kroemer. An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells. Oncoimmunol 2013; 2:e22409; PMID:23482968; http://dx.doi.org/10.4161/onci.22409
21. O.Kepp, L.Menger, E.Vacchelli, C.Locher, S.Adjemian, T.Yamazaki, I.Martins, A.Q.Sukkurwala, M.Michaud, L.Senovilla et al. Crosstalk between ER stress and immunogenic cell death. Cytokine Growth Factor Rev 2013; 24:311-8; PMID:23787159; http://dx.doi.org/10.1016/j.cytogfr.2013.05.001
22. N.Bloy, A.Sauvat, K.Chaba, A.Buque, J.Humeau, J.M.Bravo-San Pedro, J.Bui, O.Kepp, G.Kroemer, L.Senovilla et al. Morphometric analysis of immunoselection against hyperploid cancer cells. Oncotarget 2015; 6:41204-15; PMID:26517677; http://dx.doi.org/10.18632/oncotarget.5400
23. C.Shah, J.Wobb, B.Manyam, N.Kundu, D.Arthur, D.Wazer, E.Fernandez, F.Vicini. Management of Ductal Carcinoma in Situ of the Breast:A Review. JAMA Oncol 2016; PMID:27253401; http://dx.doi.org/10.1001/jamaoncol.2016.0525
24. M.R.Decker, A.Trentham-Dietz, N.K.Loconte, H.B.Neuman, M.A.Smith, R.S.Punglia, C.C.Greenberg, L.G.Wilke. The Role of Intraoperative Pathologic Assessment in the Surgical Management of Ductal Carcinoma In Situ. Ann Surg Oncol 2016; PMID:27026436; http://dx.doi.org/10.1245/s10434-016-5192-5
25. M.Morita, R.Yamaguchi, M.Tanaka, G.M.Tse, M.Yamaguchi, N.Kanomata, Y.Naito, J.Akiba, S.Hattori, S.Minami et al. CD8 tumor-infiltrating lymphocytes contribute to spontaneous “healing” in HER2-positive ductal carcinoma in situ. Cancer Med 2016; 5:1607-18; PMID:27061242; http://dx.doi.org/10.1002/cam4.715
26. E.Thompson, J.M.Taube, H.Elwood, R.Sharma, A.Meeker, H.N.Warzecha, P.Argani, A.Cimino-Mathews, L.A.Emens. The immune microenvironment of breast ductal carcinoma in situ. Mod Pathol 2016; 29:249-58; PMID:26769139; http://dx.doi.org/10.1038/modpathol.2015.158
27. J.Fucikova, E.Becht, K.Iribarren, J.Goc, R.Remark, D.Damotte, M.Alifano, P.Devi, J.Biton, C.Germain et al. Calreticulin Expression in Human Non-Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis. Cancer Res 2016; 76:1746-56; PMID:26842877; http://dx.doi.org/10.1158/0008-5472.CAN-15-1142
28. S.Shen, M.Niso-Santano, S.Adjemian, T.Takehara, S.A.Malik, H.Minoux, S.Souquere, G.Mariño, S.Lachkar, L.Senovilla et al. Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell 2012; 48:667-80; PMID:23084476; http://dx.doi.org/10.1016/j.molcel.2012.09.013
29. M.Wemeau, O.Kepp, A.Tesniere, T.Panaretakis, C.Flament, S.De Botton, L.Zitvogel, G.Kroemer, N.Chaput. Calreticulin exposure on malignant blasts predicts a cellular anticancer immune response in patients with acute myeloid leukemia. Cell Death Dis 2010; 1:e104; PMID:21368877; http://dx.doi.org/10.1038/cddis.2010.82
30. J.A.van Der Laak, M.M.Pahlplatz, A.G.Hanselaar, P.C.de Wilde. Hue-saturation-density (HSD) model for stain recognition in digital images from transmitted light microscopy. Cytometry 2000; 39:275-84; PMID:10738280; http://dx.doi.org/10.1002/(SICI)1097-0320(20000401)39:4%3c275::AID-CYTO5%3e3.0.CO;2-8
31. S.Rusakiewicz, M.Semeraro, M.Sarabi, M.Desbois, C.Locher, R.Mendez, N.Vimond, A.Concha, F.Garrido, N.Isambert et al. Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors. Cancer Res 2013; 73:3499-510; PMID:23592754; http://dx.doi.org/10.1158/0008-5472.CAN-13-0371
32. E.Vacchelli, M.Semeraro, D.P.Enot, K.Chaba, V.Poirier Colame, P.Dartigues, A.Perier, I.Villa, S.Rusakiewicz, C.Gronnier et al. Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy. Oncotarget 2015; 6:20840-50; PMID:26369701; http://dx.doi.org/10.18632/oncotarget.4428
33. E.Vacchelli, M.Semeraro, J.Adam, P.Dartigues, L.Zitvogel, G.Kroemer. Immunosurveillance in esophageal carcinoma:The decisive impact of regulatory T cells. Oncoimmunol 2016; 5:e1064581; PMID:27057430; http://dx.doi.org/10.1080/2162402X.2015.1064581