GBT440 inhibits sickling of sickle cell trait blood under in vitro conditions mimicking strenuous exercise

Hematology Reports

Volumn 8, Issue 3, 2016, Pages 37-41

  Dufu, Kobina ^a   Lehrer Graiwer, Josh ^a   Ramos, Eleanor ^a   Oksenberg, Donna ^a  

^a Global Blood Therapeutics Inc ^*  (United States)

Author keywords

Exertional sickling; Hemoglobin oxygen affinity; Rhabdomylosis; Sickle cell disease; Sickle cell trait

Indexed keywords

ANTISICKLING AGENT; GBT 440; HEMOGLOBIN A; HEMOGLOBIN S; UNCLASSIFIED DRUG;

ACIDOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEHYDRATION; DRUG MECHANISM; ERYTHROCYTE; EXERCISE; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; OXYGEN AFFINITY; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); POLYMERIZATION; SICKLE CELL TRAIT;

EID: 84990852355     PISSN: 20388322     EISSN: 20388330     Source Type: Journal    
DOI: 10.4081/hr.2016.6637     Document Type: Article

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