GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease

British Journal of Haematology

Volumn 174, Issue 4, 2016, Pages 499-500

  Ferrone, Frank A ^a  

^a DREXEL UNIVERSITY   (United States)

Author keywords

GBT440; hemoglobin polymerization; sickle cell disease

Indexed keywords

ANTISICKLING AGENT; GBT 440; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN BETA CHAIN; HEMOGLOBIN F; HEMOGLOBIN S; HYDROXYUREA; UNCLASSIFIED DRUG;

CELL COUNT; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; EDITORIAL; ERYTHROCYTE LIFESPAN; MURINE MODEL; NONHUMAN; OXYGEN AFFINITY; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; PROTEIN QUATERNARY STRUCTURE; SICKLE CELL ANEMIA;

EID: 84982893749     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.14212     Document Type: Editorial

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