Stimulation of cytotoxic immune response in breast cancer patients culture of mononuclear cells with dendritic cells loaded by tumor antigens lysates

Immunologiya

Volumn 34, Issue 6, 2013, Pages 327-330

  Shevchenko, J A ^a   Khantakova, J N ^a   Kurilin, V V ^a   Lopatnikova, J A ^a   Sidorov, S V ^b   Kozlov, V A ^a   Sennikov, S V ^a  

^a INSTITUTE OF CLINICAL IMMUNOLOGY   (Russian Federation)

^b State Budgetary Organization of Healthcare Municipal Clinical Hospital No1   (Russian Federation)

Author keywords

Cytotoxity; Dendritic cells; Perforin; Tumor lysate

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 4; TUMOR ANTIGEN;

ARTICLE; BREAST CANCER; CANCER PATIENT; CELL STIMULATION; CYTOKINE PRODUCTION; CYTOTOXICITY; DENDRITIC CELL; IMMUNE RESPONSE; LYMPHOCYTE COUNT; MONONUCLEAR CELL;

EID: 84990818496     PISSN: 02064952     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Chissov V. I., Starinskij V. V., Petrova G. V., eds. Condition cancer care in Russia in 2011. M.: FGBU «MNIOI im. P. A. Gercena» Minzdravsocrazvitija Rossii; 2012 (in Russian).
2. Palucka K., Ueno H., Fay J., Banchereau J. Dendritic cells and immunity against cancer. J. Intern. Med. 2011;269(1):64-73.
3. Mohamadzadeh M., Luftig R. Dendritic cells: In the forefront of immunopathogenesis and vaccine development. A review. J. Immune Based Ther. Vaccines. 2004;2(1):1.
4. O'Neill D. W., Adams S., Bhardwaj N. Manipulating dendritic cell biology for the active immunotherapy of cancer. Blood. 2004;104(8):2235-46.
5. Ridgway D. The first 1000 dendritic cell vaccines. Cancer Invest. 2003;21(6):873-8.
6. Bohnenkamp H. R., Coleman J., Burchell J. M., Taylor-Papadimitriou J., Noll T. Breast carcinoma cell lysate-pulsed dendritic cells cross-prime MUC 1-specific CD8+ T cells identified by peptide-MHC-class-I tetramers. Cell. Immunol. 2004;231(1-2):112-25.
7. Chiang C. L., Maier D. A., Kandalaft L. E., Brennan A. L., Lanitis E., Ye Q. et al. Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate. J. Transl. Med. 2011;9:198. doi: 10.1186/1479-5876-9-198.
8. Delirezh N., Moazzeni S. M., Shokri F., Shokrgozar M. A., Atri M., Kokhaei P. Autologous dendritic cells loaded with apoptotic tumor cells induce T cell-mediated immune responses against breast cancer in vitro. Cell. Immunol. 2009;257(1-2):23-31.
9. Kass R., Bellone S., Palmieri M., Canè S., Bignotti E., Henry-Tillman R. et al. Restoration of tumor-specific HLA class I restricted cytotoxicity in tumor infiltrating lymphocytes of advanced breast cancer patients by in vitro stimulation with tumor antigen-pulsed autologous dendritic cells. Breast Cancer Res. Treat. 2003;80(3):275-85.
10. Pandolfi F., Cianci R., Pagliari D., Casciano F., Bagala C., Astone A. et al. The immune response to tumors as a tool toward immunotherapy. Clin. Dev. Immunol. 2011;2011:894704. doi: 10.1155/2011/894704.
11. Jeras M., Bergant M., Repnik U. In vitro preparation and functional assessment of human monocyte-derived dendritic cells-potential antigen-specific modulators of in vivo immune responses. Transplant. Immunol. 2005;14(3-4):231-44.
12. Boudreau J. E., Bonehill A., Thielemans K., Wan Y. Engineering dendritic cells to enhance cancer immunotherapy. Mol. Ther. 2011;19(5):841-53.
13. Colomb M. P., Trinchieri G. Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev. 2002;13(2):155-68.
14. Yang Y., Huang C. T., Huang X., Pardoll D. M. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nature Immunol. 2004;5(5):508-15.
15. Jakushenko E. V., Lopatnikova Ju. A., Sennikov S. V. Interleukin-18 and its role in the immune response. Medicinskaja immunologija. 2005;7(4):355-64 (in Russian).
16. Iinuma H., Okinaga K., Fukushima R., Inaba T., Iwasaki K., Okinaga A. et al. Superior protective and therapeutic effects of IL-12 and IL-18 gene-transduced dendritic neuroblastoma fusion cells on liver metastasis of murine neuroblastoma. J. Immunol. 2006;176(6):3461-9.
17. Voskoboinik I., Dunstone M. A., Baran K., Whisstock J. C., Trapani J. A. Perforin: structure, function, and role in human immunopathology. Immunol. Rev. 2010;235(1):35-54.
18. Zhou F. Perforin: more than just a pore-forming protein. Int. Rev. Immunol. 2010;29(1):56-76.