No convincing association between post-operative delirium and post-operative cognitive dysfunction: a secondary analysis

Acta Anaesthesiologica Scandinavica

Volumn 60, Issue 10, 2016, Pages 1404-1414

  Franck, M ^a   Nerlich, K ^a   Neuner, B ^a   Schlattmann, P ^b   Brockhaus, W R ^a   Spies, C D ^a   Radtke, F M ^a,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c NAESTVED HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL SURGERY; ADULT; AGED; ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE ASSOCIATION; DSM-IV; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; OUTCOME ASSESSMENT; POSTOPERATIVE COGNITIVE DYSFUNCTION; POSTOPERATIVE DELIRIUM; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECOVERY ROOM; RISK; SECONDARY ANALYSIS; THORAX SURGERY;

EID: 84989909880     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/aas.12779     Document Type: Article

References (34)

1. Inouye SK, Charpentier PA. Precipitating factors for delirium in hospitalized elderly persons. Predictive model and interrelationship with baseline vulnerability. JAMA 1996; 275: 852–7.
2. Maldonado JR. Neuropathogenesis of delirium: review of current etiologic theories and common pathways. Am J Geriatr Psychiatry 2013; 21: 1190–222.
3. Deiner S, Silverstein JH. Postoperative delirium and cognitive dysfunction. Br J Anaesth 2009; 103(Suppl 1): i41–6.
4. Krenk L, Rasmussen LS. Postoperative delirium and postoperative cognitive dysfunction in the elderly - what are the differences? Minerva Anestesiol 2011; 77: 742–9.
5. Inouye SK. Delirium in hospitalized older patients. Clin Geriatr Med 1998; 14: 745–64.
6. Thomason JW, Shintani A, Peterson JF, Pun BT, Jackson JC, Ely EW. Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care 2005; 9: R375–81.
7. Raats JW, van Eijsden WA, Crolla RM, Steyerberg EW, van der Laan L. Risk factors and outcomes for postoperative delirium after major surgery in elderly patients. PLoS ONE 2015; 10: e0136071.
8. McCusker J, Cole M, Abrahamowicz M, Primeau F, Belzile E. Delirium predicts 12-month mortality. Arch Intern Med 2002; 162: 457–63.
9. van den Boogaard M, Peters SA, van der Hoeven JG, Dagnelie PC, Leffers P, Pickkers P, Schoonhoven L. The impact of delirium on the prediction of in-hospital mortality in intensive care patients. Crit Care 2010; 14: R146.
10. Klein Klouwenberg PM, Zaal IJ, Spitoni C, Ong DS, van der Kooi AW, Bonten MJ, Slooter AJ, Cremer OL. The attributable mortality of delirium in critically ill patients: prospective cohort study. BMJ 2014; 349: g6652.
11. Kat MG, Vreeswijk R, de Jonghe JF, van der Ploeg T, van Gool WA, Eikelenboom P, Kalisvaart KJ. Long-term cognitive outcome of delirium in elderly hip surgery patients. A prospective matched controlled study over two and a half years. Dement Geriatr Cogn Disord 2008;26:1–8.
12. Wacker P, Nunes PV, Cabrita H, Forlenza OV. Post-operative delirium is associated with poor cognitive outcome and dementia. Dement Geriatr Cogn Disord 2006; 21: 221–7.
13. Berger M, Nadler JW, Browndyke J, Terrando N, Ponnusamy V, Cohen HJ, Whitson HE, Mathew JP. Postoperative cognitive dysfunction: minding the gaps in our knowledge of a common postoperative complication in the elderly. Anesthesiol Clin 2015; 33: 517–50.
14. Rasmussen LS, Larsen K, Houx P, Skovgaard LT, Hanning CD, Moller JT. The assessment of postoperative cognitive function. Acta Anaesthesiol Scand 2001; 45: 275–89.
15. Rasmussen LS. Postoperative cognitive dysfunction: incidence and prevention. Best Pract Res Clin Anaesthesiol 2006; 20: 315–30.
16. Lezak MD, Howieson DB, Loring DW. Neuropsychological assessment. 4 ed. New York: Oxford University Press, 2004.
17. Radtke FM, Franck M, Lendner J, Kruger S, Wernecke KD, Spies CD. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction. Br J Anaesth 2013; 110(Suppl 1): i98–105.
18. Murkin JM, Newman SP, Stump DA, Blumenthal JA. Statement of consensus on assessment of neurobehavioral outcomes after cardiac surgery. Ann Thorac Surg 1995; 59: 1289–95.
19. Rasmussen LS, Johnson T, Kuipers HM, Kristensen D, Siersma VD, Vila P, Jolles J, Papaioannou A, Abildstrom H, Silverstein JH, Bonal JA, Raeder J, Nielsen IK, Korttila K, Munoz L, Dodds C, Hanning CD, Moller JT. Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand 2003; 47: 260–6.
20. Canet J, Raeder J, Rasmussen LS, Enlund M, Kuipers HM, Hanning CD, Jolles J, Korttila K, Siersma VD, Dodds C, Abildstrom H, Sneyd JR, Vila P, Johnson T, Munoz CL, Silverstein JH, Nielsen IK, Moller JT. Cognitive dysfunction after minor surgery in the elderly. Acta Anaesthesiol Scand 2003; 47: 1204–10.
21. Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, Canet J, Rabbitt P, Jolles J, Larsen K, Hanning CD, Langeron O, Johnson T, Lauven PM, Kristensen PA, Biedler A, van BH, Fraidakis O, Silverstein JH, Beneken JE, Gravenstein JS. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study ISPOCD investigators. International study of post-operative cognitive dysfunction. Lancet 1998;351:857–61.
22. Monk TG, Weldon BC, Garvan CW, Dede DE, van der Aa MT, Heilman KM, Gravenstein JS. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology 2008; 108: 18–30.
23. Rudolph JL, Marcantonio ER, Culley DJ, Silverstein JH, Rasmussen LS, Crosby GJ, Inouye SK. Delirium is associated with early postoperative cognitive dysfunction. Anaesthesia 2008; 63: 941–7.
24. Neufeld KJ, Leoutsakos JM, Sieber FE, Wanamaker BL, Gibson Chambers JJ, Rao V, Schretlen DJ, Needham DM. Outcomes of early delirium diagnosis after general anesthesia in the elderly. Anesth Analg 2013;117:471–8.
25. Krogseth M, Watne LO, Juliebo V, Skovlund E, Engedal K, Frihagen F, Wyller TB. Delirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patients. Arch Gerontol Geriatr 2016; 64: 38–44.
26. Radtke FM, Franck M, Lendner J, Krüger S, Wernecke KD, Spies CD. Monitoring depth of anaesthesia in a randomized trial decreases the rate of postoperative delirium but not postoperative cognitive dysfunction. Br J Anaesth 2013; 110(Suppl): 1.
27. Rubin DB, Schenker N. Multiple imputation in health-care databases: an overview and some applications. Stat Med 1991; 10: 585–98.
28. Statistical Package for the Social Sciences (SPSS). Statistical Package for the Social Sciences (SPSS) [computer program]. Version 22.0. Armonk, New York, USA: IBM Corporation, 2014.
29. SAS (Statistical Analysis System). SAS (Statistical Analysis System) [computer program] Version 9.4. Cary, North Carolina, USA: SAS Institute, 2013.
30. Quinlan N, Marcantonio ER, Inouye SK, Gill TM, Kamholz B, Rudolph JL. Vulnerability: the crossroads of frailty and delirium. J Am Geriatr Soc 2011; 59(Suppl 2): S262–8.
31. Rappold T, Laflam A, Hori D, Brown C, Brandt J, Mintz CD, Sieber F, Gottschalk A, Yenokyan G, Everett A, Hogue CW. Evidence of an association between brain cellular injury and cognitive decline after non-cardiac surgery. Br J Anaesth 2016; 116: 83–9.
32. Svenningsen H, Tonnesen EK, Videbech P, Frydenberg M, Christensen D, Egerod I. Intensive care delirium - effect on memories and health-related quality of life - a follow-up study. J Clin Nurs 2014; 23: 634–44.
33. Jackson JC, Ely EW. Cognitive impairment after critical illness: etiologies, risk factors, and future directions. Semin Respir Crit Care Med 2013; 34: 216–22.
34. Inouye SK, Marcantonio ER, Kosar CM, Tommet D, Schmitt EM, Travison TG, Saczynski JS, Ngo LH, Alsop DC, Jones RN. The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients. Alzheimers Dement 2016; 12: 766–75.