Glomerular Glucocorticoid Receptors Expression and Clinicopathological Types of Childhood Nephrotic Syndrome

Fetal and Pediatric Pathology

Volumn 36, Issue 1, 2017, Pages 16-26

  Gamal, Yasser ^a   Badawy, Ahlam ^a   Swelam, Salwa ^b   Tawfeek, Mostafa S K ^a   Gad, Eman Fathalla ^a  

^a Assiut University Faculty of Medicine   (Egypt)

^b MINIA UNIVERSITY   (Egypt)

Author keywords

childhood nephrotic syndrome; focal segmental glomerulosclerosis; Glomerular glucocorticoid receptors; glucocorticoid therapy; minimal change disease

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; PREDNISONE; STEROID;

ADOLESCENT; ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL ASSESSMENT; CONTROLLED STUDY; FEMALE; FOCAL GLOMERULOSCLEROSIS; GLOMERULUS; HISTOPATHOLOGY; HUMAN; KIDNEY BIOPSY; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MINIMAL CHANGE GLOMERULONEPHRITIS; MULTICENTER STUDY; NEPHROTIC SYNDROME; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; SCHOOL CHILD; STEROID THERAPY; TREATMENT RESPONSE; BIOPSY; CASE CONTROL STUDY; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; IMMUNOHISTOCHEMISTRY; KIDNEY; METABOLISM; NEPHROSIS, LIPOID;

ADOLESCENT; BIOPSY; CASE-CONTROL STUDIES; CHILD; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; GLUCOCORTICOIDS; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY GLOMERULUS; MALE; NEPHROSIS, LIPOID; NEPHROTIC SYNDROME; PROSPECTIVE STUDIES; RECEPTORS, GLUCOCORTICOID; STEROIDS;

EID: 84989899656     PISSN: 15513815     EISSN: 15513823     Source Type: Journal    
DOI: 10.1080/15513815.2016.1225872     Document Type: Article

References (24)

1. Felicia E. Pediatric nephrology around the World-Africa. In:Text Book of Pediatric Nephrology. Avner D, William AE, eds. 6th ed., Vol. 82; 2009. pp. 1962–1968.
2. Pais P, Avner D. Nephrotic syndrome. In:Nelson Textbook of Pediatrics, 20th ed., Chapter 5; 2016. pp. 1801–1807.
3. Niaudet P, Boyer O. Idiopathic nephrotic syndrome in children:Clinical aspects in:text book of pediatric nephrology. In:Avner D, et al. (eds). 7th ed.; 2016. pp. 839–82.
4. Guess A, Shipra A, Chang Ching A, et al. Dose- and time-dependent glucocorticoid receptor signaling in podocytes. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F845–F853.
5. Wasilewska A, Zoch-Zwierz W, Tomaszewska B, et al. Expression of glucocorticoid receptors in mononuclear cells in NS. Pediatr Nephrol. 2003;18(8):778–782.
6. Muhammed M, Shaheera S, Ali L, et al. The spectrum of histopathological lesions in children presenting with steroid-resistant nephrotic syndrome at a single center in Pakistan. The Scientific World J. 2012;2012; Article ID 681802, doi:10.1100/2012/681802.
7. Davin JC, Rutjes NW. Nephrotic syndrome in children:From bench to treatment. Int J Nephrol. 2011;(2011), Article ID 372304, 6 p., doi:10.4061/2011/372304
8. Asmaa Z, Badawy A, Gamal Y, et al. Glucocorticoid receptors expression and histopathological types in children with nephrotic syndrome. Renal Failure J. (2014);36(7):1067–1072.
9. Müller-Deile J, Schiffer M. Podocyte directed therapy of nephrotic syndrome—can we bring the inside out? Pediatr Nephrol. 2016;31(3):393–405. doi:10.1007/s00467-015-3116-4
10. Ransom RF, Vega-Warner V, Smoyer WE, et al. Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes. Kidney Int. (2005);67:1275–1285.
11. Liu H, Gao X, Xu H, et al. Alpha-actinin-4 is involved in the process by which dexamethasone protects actin cytoskeleton stabilization from Adriamycin induced podocyte injury. Nephrology (Carlton). 2012;17:669–675.
12. He XJ1, Yi ZW, Dang XQ, et al. Effect of glucocorticoid on glucocorticoid-resistant children with primary nephrotic syndrome. Zhonghua Er Ke Za Zhi. 2005 Feb;43(2):109–112.
13. Han SH, Park SY, Li JJ, et al. Glomerular glucocorticoid receptor expression is reduced in late responders to steroids in adult-onset minimal change disease. Nephrol Dial Transplant. 2008;23:169–175.
14. Du J, Li M, Zhang D, Zhu X, et al. Flow cytometry analysis of glucocorticoid receptor expression and binding in steroid-sensitive and steroid-resistant patients with systemic lupus erythematosus. Arthritis Res Ther. 2009;11(4):R108. doi:10.1186/ar2763
15. Bamberger CM, Schulte HM, Chrousos GP. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev. 1996;17:245–61.
16. Jorge Iniguez-Lluhi A. Glucocorticoid receptor function in steroid resistant childhood nephrotic syndrome. National institute of diabetes and digestive and kidney diseases syndrome in Egyptian children. J Nephrol. 2011;25(5):732–737.
17. Hammad A, Yahia S, Gouida MS, et al. Low expression of glucocorticoid receptors in children with steroid resistance nephrotic syndrome. Pediatr Nephrol. 2013;28(5):759–853.
18. Haack D, Scharer K, Asam-Tauscher A, et al. Glucocorticoid receptors in idiopathic nephrotic syndrome. Pediatr Nephrol. 1999;13:653–656.
19. Gulati A, Bagga A, Gulati S, et al. Management of steroid resistant nephrotic syndrome. Indian Pediatr. 2009:46(1):35–47.
20. Kari JA, Halawani M, Mokhtar G, et al. Histopathology of steroid-resistant nephrotic syndrome in children living in the Kingdom of Saudi Arabia. Pediatr Nephrol. 2009;24:1429–1430.
21. Hamasaki Y, Yoshikawa N, Hattori S, et al. Japanese Study Group of Renal Disease. Cyclosporine and steroid therapy in children with steroid-resistant nephrotic syndrome. Pediatr Nephrol. 2009;24(11):2177–2185.
22. Mekahli D, Liutkus A, Ranchin B, et al. Long-term outcome of idiopathic steroid-resistant nephrotic syndrome:a multicenter study. Pediatr Nephrol. 2009;24(8):1525–1532.
23. Xing CY, Saleem MA, Coward RJ, et al. Direct effects of dexamethasone on human podocytes. Kidney Int. 2006;70:1038–10453(1):169–175.
24. Clement LC, Avila-Casado C, Mace C, et al. Podocyte secreted angiopoietin-like 4 mediates proteinuria in glucocorticoid sensitive nephrotic syndrome. Nat Med. 2011;17:117–122.