Chronic infusion of epigallocatechin-3-O-gallate into the hypothalamic paraventricular nucleus attenuates hypertension and sympathoexcitation by restoring neurotransmitters and cytokines

Toxicology Letters

Volumn 262, Issue , 2016, Pages 105-113

  Yi, Qiu Yue ^a,b   Li, Hong Bao ^a   Qi, Jie ^a   Yu, Xiao Jing ^a   Huo, Chan Juan ^a   Li, Xiang ^a   Bai, Juan ^a   Gao, Hong Li ^a   Kou, Bo ^b   Liu, Kai Li ^a   Zhang, Dong Dong ^a   Chen, Wen Sheng ^c   Cui, Wei ^b   Zhu, Guo Qing ^d   Shi, Xiao Lian ^a   Kang, Yu Ming ^a  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Cytokines; Epigallocatechin 3 O gallate; Hypertension; Neurotransmitters; Oxidative stress; Paraventricular nucleus

Indexed keywords

CYTOKINE; EPIGALLOCATECHIN GALLATE; GLUTAMATE DECARBOXYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; NEUROTRANSMITTER; NORADRENALIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TYROSINE 3 MONOOXYGENASE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANTIOXIDANT; CATECHIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DRUG INFUSION; EXCITATION; HYPERTENSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; OSMOTIC MINIPUMP; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SYMPATHETIC TONE; UPREGULATION; ADRENERGIC SYSTEM; ANALOGS AND DERIVATIVES; ANIMAL; ARTERIAL PRESSURE; BLOOD; DRUG EFFECTS; INJECTION; METABOLISM; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

ANIMALS; ANTIOXIDANTS; ARTERIAL PRESSURE; CATECHIN; CYTOKINES; HYPERTENSION; INJECTIONS; MALE; NEUROTRANSMITTER AGENTS; NOREPINEPHRINE; OXIDATIVE STRESS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; REACTIVE OXYGEN SPECIES; SYMPATHETIC NERVOUS SYSTEM;

EID: 84989848373     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2016.09.010     Document Type: Article

References (33)

1. Agarwal, D., Haque, M., Sriramula, S., Mariappan, N., Pariaut, R., Francis, J., Role of proinflammatory cytokines and redox homeostasis in exercise-induced delayed progression of hypertension in spontaneously hypertensive rats. Hypertension 54 (2009), 1393–1400.
2. Agarwal, D., Welsch, M.A., Keller, J.N., Francis, J., Chronic exercise modulates RAS components and improves balance between pro-and anti-inflammatory cytokines in the brain of SHR. Basic Res. Cardiol. 106 (2011), 1069–1085.
3. Barber, M., Kasturi, B.S., Austin, M.E., Patel, K.P., MohanKumar, S.M., MohanKumar, P.S., Diabetes-induced neuroendocrine changes in rats: role of brain monoamines, insulin and leptin. Brain Res. 964 (2003), 128–135.
4. Byun, E.B., Mi, S., Kim, J.H., Song, D.S., Lee, B.S., Park, J.N., Park, S.H., Park, C., Jung, P.M., Sung, N.Y., Byun, E.H., Epigallocatechin-3-gallate-mediated Tollip induction through the 67 kDa laminin receptor negatively regulating TLR4 signaling in endothelial cells. Immunobiology 219 (2014), 866–872.
5. Cabrera, C., Artacho, R., Gimenez, R., Beneficial effects of green tea–a review. J. Am. Coll. Nutr. 25 (2006), 79–99.
6. Cardinale, J.P., Sriramula, S., Mariappan, N., Agarwal, D., Francis, J., Angiotensin II-induced hypertension is modulated by nuclear factor-kappaB in the paraventricular nucleus. Hypertension 59 (2012), 113–121.
7. Chalmers, J., Volhard lecture. Brain, blood pressure and stroke. J. Hypertens. 16 (1998), 1849–1858.
8. Dange, R.B., Agarwal, D., Teruyama, R., Francis, J., Toll-like receptor 4 inhibition within the paraventricular nucleus attenuates blood pressure and inflammatory response in a genetic model of hypertension. J. Neuroinflammation, 12, 2015, 31.
9. Davisson, R.L., Oliverio, M.I., Coffman, T.M., Sigmund, C.D., Divergent functions of angiotensin II receptor isoforms in the brain. J. Clin. Invest. 106 (2000), 103–106.
10. Granger, J.P., An emerging role for inflammatory cytokines in hypertension. Am. J. Physiol. Heart Circ. Physiol. 290 (2006), H923–924.
11. Hao, J., Kim, C.H., Ha, T.S., Ahn, H.Y., Epigallocatechin-3 gallate prevents cardiac hypertrophy induced by pressure overload in rats. J. Vet. Sci. 8 (2007), 121–129.
12. Jeong, W.S., Kim, I.W., Hu, R., Kong, A.N., Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. Pharm. Res. 21 (2004), 661–670.
13. Jin, J., Ying, H., Huang, M., Du, Q., Bioactive compounds in green tea leaves attenuate the injury of retinal ganglion RGC-5 cells induced by H2O2 and ultraviolet radiation. Pak. J. Pharm. Sci. 28 (2015), 2267–2272.
14. Kang, Y.M., Ma, Y., Elks, C., Zheng, J.P., Yang, Z.M., Francis, J., Cross-talk between cytokines and renin-angiotensin in hypothalamic paraventricular nucleus in heart failure: role of nuclear factor-kappaB. Cardiovasc. Res. 79 (2008), 671–678.
15. Kang, Y.M., He, R.L., Yang, L.M., Qin, D.N., Guggilam, A., Elks, C., Yan, N., Guo, Z., Francis, J., Brain tumour necrosis factor-alpha modulates neurotransmitters in hypothalamic paraventricular nucleus in heart failure. Cardiovasc. Res. 83 (2009), 737–746.
16. Kang, Y.M., Ma, Y., Zheng, J.P., Elks, C., Sriramula, S., Yang, Z.M., Francis, J., Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovasc. Res. 82 (2009), 503–512.
17. Kang, Y.M., Gao, F., Li, H.H., Cardinale, J.P., Elks, C., Zang, W.J., Yu, X.J., Xu, Y.Y., Qi, J., Yang, Q., Francis, J., NF-kappaB in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in heart failure. Basic Res. Cardiol. 106 (2011), 1087–1097.
18. Kang, Y.M., Zhang, D.M., Yu, X.J., Yang, Q., Qi, J., Su, Q., Suo, Y.P., Yue, L.Y., Zhu, G.Q., Qin, D.N., Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. Toxicol. Appl. Pharmacol. 274 (2014), 436–444.
19. Li, H.B., Qin, D.N., Ma, L., Miao, Y.W., Zhang, D.M., Lu, Y., Song, X.A., Zhu, G.Q., Kang, Y.M., Chronic infusion of lisinopril into hypothalamic paraventricular nucleus modulates cytokines and attenuates oxidative stress in rostral ventrolateral medulla in hypertension. Toxicol. Appl. Pharmacol. 279 (2014), 141–149.
20. Li, H.B., Qin, D.N., Cheng, K., Su, Q., Miao, Y.W., Guo, J., Zhang, M., Zhu, G.Q., Kang, Y.M., Central blockade of salusin beta attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats. Sci. Rep., 5, 2015, 11162.
21. Li, H.B., Qin, D.N., Suo, Y.P., Guo, J., Su, Q., Miao, Y.W., Sun, W.Y., Yi, Q.Y., Cui, W., Cheng, K., Zhu, G.Q., Kang, Y.M., Blockade of salusin-beta in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy in salt-induced hypertensive rats. J. Cardiovasc. Pharmacol. 66 (2015), 323–331.
22. Liu, Y., Zhao, B., Mao, G., Fang, X., Huang, Y., Wang, N., Epigallocatechin-3-O-gallate, a green tea polyphenol, induces expression of pim-1 kinase via PPARgamma in human vascular endothelial cells. Cardiovasc. Toxicol. 13 (2013), 391–395.
23. MohanKumar, S.M., MohanKumar, P.S., Quadri, S.K., Specificity of interleukin-1beta-induced changes in monoamine concentrations in hypothalamic nuclei: blockade by interleukin-1 receptor antagonist. Brain Res. Bull. 47 (1998), 29–34.
24. Shi, P., Diez-Freire, C., Jun, J.Y., Qi, Y., Katovich, M.J., Li, Q., Sriramula, S., Francis, J., Sumners, C., Raizada, M.K., Brain microglial cytokines in neurogenic hypertension. Hypertension 56 (2010), 297–303.
25. Shi, P., Raizada, M.K., Sumners, C., Brain cytokines as neuromodulators in cardiovascular control. Clin. Exp. Pharmacol. Physiol. 37 (2010), e52–57.
26. Sriramula, S., Francis, J., Tumor necrosis factor-alpha is essential for angiotensin II-induced ventricular remodeling: role for oxidative stress. PLoS One, 10, 2015, e0138372.
27. Sriramula, S., Haque, M., Majid, D.S., Francis, J., Involvement of tumor necrosis factor-alpha in angiotensin II-mediated effects on salt appetite, hypertension, and cardiac hypertrophy. Hypertension 51 (2008), 1345–1351.
28. Su, Q., Qin, D.N., Wang, F.X., Ren, J., Li, H.B., Zhang, M., Yang, Q., Miao, Y.W., Yu, X.J., Qi, J., Zhu, Z., Zhu, G.Q., Kang, Y.M., Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin-angiotensin system and proinflammatory cytokines in hypertension. Toxicol. Appl. Pharmacol. 276 (2014), 115–120.
29. Su, Q., Liu, J.J., Cui, W., Shi, X.L., Guo, J., Li, H.B., Huo, C.J., Miao, Y.W., Zhang, M., Yang, Q., Kang, Y.M., Alpha lipoic acid supplementation attenuates reactive oxygen species in hypothalamic paraventricular nucleus and sympathoexcitation in high salt-induced hypertension. Toxicol. Lett. 241 (2016), 152–158.
30. Wolfram, S., Effects of green tea and EGCG on cardiovascular and metabolic health. J. Am. Coll. Nutr. 26 (2007), 373S–388S.
31. Yi, Q.Y., Qi, J., Yu, X.J., Li, H.B., Zhang, Y., Su, Q., Shi, T., Zhang, D.M., Guo, J., Feng, Z.P., Wang, M.L., Zhu, G.Q., Liu, J.J., Shi, X.L., Kang, Y.M., Paraventricular nucleus infusion of epigallocatechin-3-o-gallate improves renovascular hypertension. Cardiovas. Toxicol. 16:3 (2016), 276–285.
32. Yue, T.L., Gu, J.L., Wang, C., Reith, A.D., Lee, J.C., Mirabile, R.C., Kreutz, R., Wang, Y., Maleeff, B., Parsons, A.A., Ohlstein, E.H., Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy. J. Biol. Chem. 275 (2000), 37895–37901.
33. de Wardener, H.E., The hypothalamus and hypertension. Physiol. Rev. 81 (2001), 1599–1658.