Pregnancy-related relapse risk factors in women with anti-AQP4 antibody positivity and neuromyelitis optica spectrum disorder

Multiple Sclerosis

Volumn 22, Issue 11, 2016, Pages 1413-1420

  Shimizu, Yuko ^a   Fujihara, Kazuo ^b   Ohashi, Takashi ^a   Nakashima, Ichiro ^b   Yokoyama, Kazumasa ^c   Ikeguch, Ryotaro ^a   Takahashi, Toshiyuki ^b   Misu, Tatsuro ^b   Shimizu, Satoru ^a   Aoki, Masashi ^b   Kitagawa, Kazuo ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

Anti aquaporin 4 antibody; immunosuppression; immunosuppressive drugs; neonates; neuromyelitis optica; neuromyelitis optica spectrum disorders; pregnancy; recurrence; relapse rate; risk factors

Indexed keywords

AQUAPORIN 4 ANTIBODY; AZATHIOPRINE; METHYLPREDNISOLONE; PREDNISOLONE; TACROLIMUS; AQP4 PROTEIN, HUMAN; AQUAPORIN 4; AUTOANTIBODY;

ADULT; ARTICLE; FEMALE; HOSPITALIZATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; MYELOOPTIC NEUROPATHY; NEUROMYELITIS OPTICA SPECTRUM DISORDER; NEWBORN; ONSET AGE; PREGNANCY DISORDER; PUERPERIUM; RECURRENCE RISK; RETROSPECTIVE STUDY; RISK ASSESSMENT; TREATMENT WITHDRAWAL; YOUNG ADULT; ADOLESCENT; ANTIBODY TITER; CESAREAN SECTION; DRUG MEGADOSE; LOW BIRTH WEIGHT; LOW DRUG DOSE; MULTIPLE SCLEROSIS; MYELITIS; NATURAL CHILDBIRTH; OBSTETRIC DELIVERY; OPTIC NEURITIS; PLASMAPHERESIS; PREECLAMPSIA; PREGNANCY OUTCOME; PREMATURITY; RISK FACTOR; UTERUS MYOMA; VACUUM EXTRACTION; IMMUNOLOGY; JAPAN; PREGNANCY; PREGNANCY COMPLICATION; RECURRENT DISEASE;

ADULT; AQUAPORIN 4; AUTOANTIBODIES; FEMALE; HUMANS; JAPAN; NEUROMYELITIS OPTICA; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY COMPLICATIONS; RECURRENCE; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84989823903     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458515583376     Document Type: Article

References (28)

1. Carroll WM, Fujihara K,. Neuromyelitis optica. Curr Treat Options Neurol 2010; 12: 244-255.
2. Wingerchuk DM, Lennon VA, Pittock SJ, et al. Revised diagnostic criteria for neuromyelitis optica. Neurology 2006; 66: 1485-1489.
3. Wingerchuk DM, Lennon VA, Lucchinetti CF, et al. The spectrum of neuromyelitis optica. Lancet Neurol 2007; 6: 805-815.
4. Fujihara K, Misu T, Nakashima I, et al. Neuromyelitis optica should be classified as an astrocytopathic disease rather than a demyelinating disease. Clin Exp Neuroimmunol 2012; 3: 58-73.
5. Confavreux C, Hutchinson M, Houres MM, et al. Rate of pregnancy-related relapse in multiple sclerosis. New Engl J Med 1998; 229: 285-291.
6. Vukusic S, Hutchinson M, Hours M, et al. Pregnancy and multiple sclerosis (the PRIMS study): Clinical predictors of post-partum relapse. Brain 2004; 127: 1353-1360.
7. Bonnet F, Mercie P, Morlat P, et al. Devic's neuromyelitis optica during pregnancy in a patient with systemic lupus erythematosus. Lupus 1999; 8: 244-247.
8. Bencherifa F, Bourissa A, Mellal Z, et al. Devic's neuro-optic myelitis and pregnancy. J Fr Ophthalmol 2007; 30: 737-743.
9. Cornelio DB, Braga RP, Rosa MW, et al. Devic's neuromyelitis optica and pregnancy: Distinction from multiple sclerosis is essential. Arch Gynecol Obstet 2009; 280: 475-477.
10. Shang W, Liu J,. Neuromyelitis optica during pregnancy. Int J Gynecol Obstet 2011; 115: 66-67.
11. Bourre B, Marignier R, Zephir H, et al. Neuromyelitis optica and pregnancy. Neurology 2012; 78: 875-879.
12. Kim W, Kim SH, Nakashima I, et al. Influence of pregnancy on neuromyelitis optic spectrum disorder. Neurology 2012; 78: 1264-1267.
13. Fragoso YD, Adoni T, Bichuetti DB, et al. Neuromyelitis optica and pregnancy. J Neurol 2013; 260: 2614-2619.
14. Takahashi T, Fujihara K, Nakashima I, et al. Establishment of a new sensitive assay for anti-human aquaporin-4 antibody in neuromyelitis optica. Tohoku J Exp Med 2006; 210: 307-313.
15. Watanabe S, Misu T, Miyazawa I, et al. Low-dose corticosteroids reduce relapses in neuromyelitis optica: A retrospective analysis. Mult Scler 2007; 13: 968-974.
16. Nagaishi A, Takagi M, Umemura A, et al. Clinical features of neuromyelitis optica in a large Japanese cohort: Comparison between phenotypes. J Neurol Neurosurg Psychiatry 2011; 82: 1360-1364.
17. Ostensen M, Forger F,. How safe are anti-rheumatic drugs during pregnancy? Curr Op Pharmacol 2013; 13: 470-475.
18. Akbari M, Shah S, Velayos FS, et al. Systemic review and meta-analysis on the effects of thiopurines on birth outcomes from female and male patients with inflammatory bowel disease. Inflamm Bowel Dis 2013; 19: 15-22.
19. Ringelstein M, Harmel J, Distelmaier F, et al. Neuromyelitis optica and pregnancy during therapeutic B-cell depletion: Infant exposure to anti-AQP4 antibody and prevention of rebound relapses with low-dose rituximab postpartum. Mult Scler 2013; 19: 1544-1547.
20. Bordhers AT, Naguwa SM, Keen CL, et al. The implications of autoimmunity and pregnancy. J Autoimm 2010; 34: J287-299.
21. Kinoshita M, Nakatsuji Y, Kimura T, et al. Passive transfer to rats by human immunoglobulin. Biochem Biophys Res Commun 2009; 386: 623-637.
22. Bradl M, Misu T, Takahashi T, et al. Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo. Ann Neurol 2009; 66: 630-643.
23. Kinoshita M, Nakatsuji Y, Moriya M, et al. Astrocytic necrosis is induced by anti-aquaporin-4 antibody-positive serum. Neuroreport 2009; 20: 508-512.
24. Zifman E, Litmanovitz I, Segal G, et al. Marked hypotonia in an infant of a mother with Devic's disease. J Child Neurol 2010; 25: 746-747.
25. Robinson DP, Klein SL,. Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis. Horm Behav 2012; 62: 263-271.
26. Wegemann TG, Lin H, Guilbert L, et al. Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 14: 353-356.
27. Quick AM, Cipolla MJ,. Pregnancy-induced up-regulation of aquaporin-4 protein in brain and its role in eclampsia. FASEB J 2005; 19: 170-175.
28. Orsi NM, Tribe RM,. Cytokine networks and the regulation of uterine function in pregnancy and parturition. J Neuroendocrinol 2008; 20: 462-469.