LncRNA-UCA1 enhances cell proliferation through functioning as a ceRNA of Sox4 in esophageal cancer

Oncology Reports

Volumn 36, Issue 5, 2016, Pages 2960-2966

  Jiao, Changjie ^a   Song, Zhiming ^a   Chen, Jianming ^a   Zhong, Jing ^a   Cai, Weibin ^a   Tian, Suke ^a   Chen, Songlin ^a   Yi, Yunfeng ^a   Xiao, Yun ^b  

^a 909th Hospital of Joint Logistics Support Force   (China)

^b ZHONGSHAN HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

CeRNA; Esophageal cancer; LncRNA; MiR 204; Proliferation; UCA1

Indexed keywords

LONG UNTRANSLATED RNA; MESSENGER RNA; MICRORNA; MICRORNA 204; TRANSCRIPTION FACTOR SOX4; UNCLASSIFIED DRUG; MIRN204 MICRORNA, HUMAN; SOX4 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX; TUMOR MARKER; UCA1 RNA, HUMAN;

3' UNTRANSLATED REGION; ADULT; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER PROGNOSIS; CANCER TISSUE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ESOPHAGUS CANCER; FEMALE; GENE CONTROL; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RNA BINDING; RETROSPECTIVE STUDY; RNA DEGRADATION; UPREGULATION; UROTHELIAL CARCINOMA ASSOCIATED 1 GENE; APOPTOSIS; BIOSYNTHESIS; CELL TRANSFORMATION; ESOPHAGUS TUMOR; GENE EXPRESSION REGULATION; GENETICS; PATHOLOGY; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

APOPTOSIS; BIOMARKERS, TUMOR; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; ESOPHAGEAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; RNA, LONG NONCODING; SOXC TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84989809264     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2016.5121     Document Type: Article

References (38)

1. Sun X, Chen W, Chen Z, Wen D, Zhao D and He Y: Populationbased case-control study on risk factors for esophageal cancer in five high-risk areas in China. Asian Pac J Cancer Prev 11: 1631-1636, 2010.
2. Hongo M, Nagasaki Y and Shoji T: Epidemiology of esophageal cancer: Orient to Occident. Effects of chronology, geography and ethnicity. J Gastroenterol Hepatol 24: 729-735, 2009.
3. Song Q, Liu H, Wang J, Jia Y, Liu Y, Wang N, Tan B, Guan S, An D and Cheng Y: Dinner-to-bed time and post-dinner walk: New potential independent factors in esophageal cancer development. J Cancer Res Clin Oncol 140: 817-821, 2014.
4. J emal A, Center MM, DeSantis C and Ward EM: Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev 19: 1893-1907, 2010.
5. Tang WR, Fang JY, Wu KS, Shi XJ, Luo JY and Lin K: Epidemiological characteristics and prediction of esophageal cancer mortality in China from 1991 to 2012. Asian Pac J Cancer Prev 15: 6929-6934, 2014.
6. Louro R, Smirnova AS and Verjovski-Almeida S: Long intronic noncoding RNA transcription: Expression noise or expression choice? Genomics 93: 291-298, 2009.
7. Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM and Morrisey EE: Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes Dev 28: 1363-1379, 2014.
8. Hu X, Feng Y, Zhang D, Zhao SD, Hu Z, Greshock J, Zhang Y, Yang L, Zhong X, Wang LP, et al: A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell 26: 344-357, 2014.
9. Yuan JH, Yang F, Wang F, Ma JZ, Guo YJ, Tao QF, Liu F, Pan W, Wang TT, Zhou CC, et al: A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell 25: 666-681, 2014.
10. Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L and Zhang X: Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway. Cancer Res 75: 846-857, 2015.
11. Rühle F and Stoll M: Long non-coding RNA databases in cardiovascular research. Genomics Proteomics Bioinformatics 14: 191-199, 2016.
12. Yang C, Wu D, Gao L, Liu X, Jin Y, Wang D, Wang T and Li X: Competing endogenous RNA networks in human cancer: Hypothesis, validation, and perspectives. Oncotarget 7: 13479-13490, 2016.
13. Liu X, Xiao ZD, Han L, Zhang J, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, et al: LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol 18: 431-442, 2016.
14. Liu F, Yuan JH, Huang JF, Yang F, Wang TT, Ma JZ, Zhang L, Zhou CC, Wang F, Yu J, et al: Long noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a. Oncogene: Apr 11, 2016. doi: 10.1038/onc.2016.80
15. Chen M, Zhuang C, Liu Y, Li J, Dai F, Xia M, Zhan Y, Lin J, Chen Z, He A, et al: Tetracycline-inducible shRNA targeting antisense long non-coding RNA HIF1A-AS2 represses the malignant phenotypes of bladder cancer. Cancer Lett 376: 155-164, 2016.
16. B ian Z, Jin L, Zhang J, Yin Y, Quan C, Hu Y, Feng Y, Liu H, Fei B, Mao Y, et al: LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p. Sci Rep 6: 23892, 2016.
17. Hu JJ, Song W, Zhang SD, Shen XH, Qiu XM, Wu HZ, Gong PH, Lu S, Zhao ZJ, He ML, et al: HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling. Sci Rep 6: 23521, 2016.
18. Gu W, Gao T, Sun Y, Zheng X, Wang J, Ma J, Hu X, Li J and Hu M: LncRNA expression profile reveals the potential role of lncRNAs in gastric carcinogenesis. Cancer Biomark 15: 249-258, 2015.
19. Wu W, Zhang S, Li X, Xue M, Cao S and Chen W: Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells. PLoS One 8: e73920, 2013.
20. Fan Y, Shen B, Tan M, Mu X, Qin Y, Zhang F and Liu Y: Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. FEBS J 281: 1750-1758, 2014.
21. Li Z, Li X, Wu S, Xue M and Chen W: Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway. Cancer Sci 105: 951-955, 2014.
22. Du Z, Sun T, Hacisuleyman E, Fei T, Wang X, Brown M, Rinn JL, Lee MG, Chen Y, Kantoff PW, et al: Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer. Nat Commun 7: 10982, 2016.
23. Yu CC, Chen PN, Peng CY, Yu CH and Chou MY: Suppression of miR-204 enables oral squamous cell carcinomas to promote cancer stemness, EMT traits, and lymph node metastasis. Oncotarget 7: 20180-20192, 2016.
24. Ying Z, Li Y, Wu J, Zhu X, Yang Y, Tian H, Li W, Hu B, Cheng SY and Li M: Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype. Cancer Res 73: 990-999, 2013.
25. Liu J, Sun X, Zhu H, Qin Q, Yang X and Sun X: Long noncoding RNA POU6F2-AS2 is associated with esophageal squamous cell carcinoma. J Biochem: Mar 31, 2016 (Epub ahead of print) pii: mvw025.
26. Li W, Zheng J, Deng J, You Y, Wu H, Li N, Lu J and Zhou Y: Increased levels of the long intergenic non-protein coding RNA POU3F3 promote DNA methylation in esophageal squamous cell carcinoma cells. Gastroenterology 146: 1714-1726.e5, 2014.
27. Liu Z, Long J, Du R, Ge C, Guo K and Xu Y: miR-204 regulates the EMT by targeting snai1 to suppress the invasion and migration of gastric cancer. Tumour Biol 37: 8327-8335, 2016.
28. Wu ZY, Wang SM, Chen ZH, Huv SX, Huang K, Huang BJ, Du JL, Huang CM, Peng L, Jian ZX, et al: MiR-204 regulates HMGA2 expression and inhibits cell proliferation in human thyroid cancer. Cancer Biomark 15: 535-542, 2015.
29. Ding M, Lin B, Li T, Liu Y, Li Y, Zhou X, Miao M, Gu J, Pan H, Yang F, et al: A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells. Oncotarget 6: 7686-7700, 2015.
30. Yang Y, Jiang Y, Wan Y, Zhang L, Qiu J, Zhou S and Cheng W: UCA1 functions as a competing endogenous RNA to suppress epithelial ovarian cancer metastasis. Tumour Biol: Feb 11, 2016 (Epub ahead of print).
31. Nie W, Ge HJ, Yang XQ, Sun X, Huang H, Tao X, Chen WS and Li B: LncRNA-UCA1 exerts oncogenic functions in non-small cell lung cancer by targeting miR-193a-3p. Cancer Lett 371: 99-106, 2016.
32. Xue M, Pang H, Li X, Li H, Pan J and Chen W: Long non-coding RNA urothelial cancer-associated 1 promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2- FSCN1 pathway. Cancer Sci 107: 18-27, 2016.
33. Ye X and Weinberg RA: Epithelial-mesenchymal plasticity: A central regulator of cancer progression. Trends Cell Biol 25: 675-686, 2015.
34. B ilir B, Osunkoya AO, Wiles WG IV, Sannigrahi S, Lefebvre V, Metzger D, Spyropoulos DD, Martin WD and Moreno CS: SOX4 is essential for prostate tumorigenesis initiated by PTEN ablation. Cancer Res 76: 1112-1121, 2016.
35. Sun R, Jiang B, Qi H, Zhang X, Yang J, Duan J, Li Y and Li G: SOX4 contributes to the progression of cervical cancer and the resistance to the chemotherapeutic drug through ABCG2. Cell Death Dis 6: e1990, 2015.
36. K oumangoye RB, Andl T, Taubenslag KJ, Zilberman ST, Taylor CJ, Loomans HA and Andl CD: SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells. Mol Cancer 14: 24, 2015.
37. Hu F, Min J, Cao X, Liu L, Ge Z, Hu J and Li X: MiR-363-3p inhibits the epithelial-to-mesenchymal transition and suppresses metastasis in colorectal cancer by targeting Sox4. Biochem Biophys Res Commun 474: 35-42, 2016.
38. Zhang F, Luo Y, Shao Z, Xu L, Liu X, Niu Y, Shi J, Sun X, Liu Y, Ding Y, et al: MicroRNA-187, a downstream effector of TGFβ pathway, suppresses Smad-mediated epithelial-mesenchymal transition in colorectal cancer. Cancer Lett 373: 203-213, 2016.