Overdiagnosis and overtreatment of malaria in children in a secondary healthcare centre in Sekondi-Takoradi, Ghana

Tropical Doctor

Volumn 46, Issue 4, 2016, Pages 191-198

  Orish, Verner N ^a   Ansong, Joseph Y ^a   Onyeabor, Onyekachi S ^b   Sanyaolu, Adekunle O ^c,d   Oyibo, Wellington A ^d   Iriemenam, Nnaemeka C ^d  

^a Effia Nkwanta Regional Hospital Sekondi Takoradi   (Ghana)

^b MOREHOUSE SCHOOL OF MEDICINE   (United States)

^c SAINT JAMES SCHOOL OF MEDICINE   (Anguilla)

^d UNIVERSITY OF LAGOS   (Nigeria)

Author keywords

children; healthcare; malaria; Overdiagnosis; overtreatment

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER; BENFLUMETOL;

ARTICLE; CHILD; CONTROLLED STUDY; CONVULSION; COUGHING; FEMALE; FEVER; GHANA; HUMAN; MALARIA; MALE; PREVALENCE; RETROSPECTIVE STUDY; SECONDARY HEALTH CARE; VOMITING; HEALTH SERVICE; HOSPITALIZATION; INAPPROPRIATE PRESCRIBING; INFANT; NEWBORN; PRESCHOOL CHILD; SECONDARY CARE CENTER; SEX RATIO; STATISTICS AND NUMERICAL DATA;

ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; FEMALE; FEVER; GHANA; HOSPITALIZATION; HUMANS; INAPPROPRIATE PRESCRIBING; INFANT; INFANT, NEWBORN; MALARIA; MALE; MEDICAL OVERUSE; PREVALENCE; RETROSPECTIVE STUDIES; SECONDARY CARE CENTERS; SEX DISTRIBUTION;

EID: 84989306822     PISSN: 00494755     EISSN: 17581133     Source Type: Journal    
DOI: 10.1177/0049475515622861     Document Type: Article

References (35)

1. World Health Organization. World Malaria Report 2014, Geneva: WHO, 2014. Available at: http://appswhoint/iris/bitstream/10665/144852/2/9789241564830_engpdf.
2. World Health Organization. World Malaria Report 2012, Geneva: WHO, 2012. Available at: http://wwwwhoint/malaria/publications/world_malaria_report_2012/en/.
3. Reyburn H, Mbatia R, Drakeley C. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. BMJ 2004; 329: 1212–1212.
4. Whitty CJ, Chandler C, Ansah E, Leslie T, Staedke SG. Deployment of ACT antimalarials for treatment of malaria: challenges and opportunities. Malar J 2008; 7(Suppl. 1): S7–S7.
5. Bisoffi Z, Gobbi F, Angheben A, Van den Ende J. The role of rapid diagnostic tests in managing malaria. PLoS Med 2009; 6: e1000063–e1000063.
6. Nankabirwa J, Zurovac D, Njogu JN. Malaria misdiagnosis in Uganda–implications for policy change. Malar J 2009; 8: 66–66.
7. Oladosu OO, Oyibo WA. Overdiagnosis and overtreatment of malaria in children that presented with fever in Lagos, Nigeria. ISRN Infectious Diseases 2013; 2013: 914675–914675.
8. Baiden F, Malm K, Bart-Plange C. Shifting from presumptive to test-based management of malaria - technical basis and implications for malaria control in Ghana. Ghana Med J 2014; 48: 112–122.
9. World Health Organization. Technical Updates of the Guidelines on the Integrated Management of Childhood Illness (IMCI), Geneva: WHO, 2005. Available at http://whqlibdocwhoint/publications/2005/9241593482pdf.
10. Reyburn H, Mbakilwa H, Mwangi R. Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial. BMJ 2007; 334: 403–403.
11. World Health Organization. World Malaria Report 2008, Geneva: WHO, 2008. Available at: http://wwwsearowhoint/LinkFiles/Reports_WMR_2008_Finalpdf.
12. Chandramohan D, Jaffar S, Greenwood B. Use of clinical algorithms for diagnosing malaria. Trop Med Int Health 2002; 7: 45–52.
13. A-Elgayoum SM, El-Feki Ael K, Mahgoub BA, El-Rayah el A, Giha HA. Malaria overdiagnosis and burden of malaria misdiagnosis in the suburbs of central Sudan: special emphasis on artemisinin-based combination therapy era. Diagn Microbiol Infect Dis 2009; 64: 20–26.
14. GhanaWeb. Free nets cause decline in malaria. 2013. Available at: http://wwwghanawebcom/GhanaHomePage/health/artikelphp?ID=269341
15. Ghana Health Service. National Malaria Control Programme Ghana Malaria Report 2010. 2010. Available at: http://wwwghanahealthserviceorg/malaria_controlphp
16. Abreha T, Alemayehu B, Tadesse Y. Malaria diagnostic capacity in health facilities in Ethiopia. Malar J 2014; 13: 292–292.
17. English M, Reyburn H, Goodman C, Snow RW. Abandoning presumptive antimalarial treatment for febrile children aged less than five years–a case of running before we can walk? PLoS Med 2009; 6: e1000015–e1000015.
18. D’Acremont V, Lengeler C, Mshinda H, Mtasiwa D, Tanner M, Genton B. Time to move from presumptive malaria treatment to laboratory-confirmed diagnosis and treatment in African children with fever. PLoS Med 2009; 6: e252–e252.
19. Polage CR, Bedu-Addo G, Owusu-Ofori A. Laboratory use in Ghana: physician perception and practice. Am J Trop Med Hyg 2006; 75: 526–531.
20. Chandler CI, Jones C, Boniface G, Juma K, Reyburn H, Whitty CJ. Guidelines and mindlines: why do clinical staff over-diagnose malaria in Tanzania? A qualitative study. Malar J 2008; 7: 53–53.
21. Derua YA, Ishengoma DR, Rwegoshora RT. Users’ and health service providers’ perception on quality of laboratory malaria diagnosis in Tanzania. Malar J 2011; 10: 78–78.
22. Fonjungo PN, Kebede Y, Messele T. Laboratory equipment maintenance: a critical bottleneck for strengthening health systems in sub-Saharan Africa? J Public Health Policy 2012; 33: 34–45.
23. Gove S. Integrated management of childhood illness by outpatient health workers: technical basis and overview. The WHO Working Group on Guidelines for Integrated Management of the Sick Child. Bull World Health Organ 1997; 75(Suppl. 1): 7–24.
24. World Health Organization. Guidelines for the treatment of malaria, 2nd ed. Geneva: WHO, 2010. Available at: http://whqlibdocwhoint/publications/2010/9789241547925_engpdf.
25. Ndyomugyenyi R, Magnussen P, Clarke S. Diagnosis and treatment of malaria in peripheral health facilities in Uganda: findings from an area of low transmission in south-western Uganda. Malar J 2007; 6: 39–39.
26. Redd SC, Bloland PB, Kazembe PN, Patrick E, Tembenu R, Campbell CC. Usefulness of clinical case-definitions in guiding therapy for African children with malaria or pneumonia. Lancet 1992; 340: 1140–1143.
27. Hogh B, Marbiah NT, Burghaus PA, Andersen PK. Relationship between maternally derived anti-Plasmodium falciparum antibodies and risk of infection and disease in infants living in an area of Liberia, west Africa, in which malaria is highly endemic. Infect Immun 1995; 63: 4034–4038.
28. Runsewe-Abiodun IT, Ogunfowora OB, Fetuga BM. Neonatal malaria in Nigeria–a 2 year review. BMC Pediatrics 2006; 6: 19–19.
29. Olaleye BO, Williams LA, D’Alessandro U. Clinical predictors of malaria in Gambian children with fever or a history of fever. Trans R Soc Trop Med Hyg 1998; 92: 300–304.
30. Muller O, Traore C, Becher H, Kouyate B. Malaria morbidity, treatment-seeking behaviour, and mortality in a cohort of young children in rural Burkina Faso. Trop Med Int Health 2003; 8: 290–296.
31. Clarke SE, Brooker S, Njagi JK. Malaria morbidity among school children living in two areas of contrasting transmission in western Kenya. Am J Trop Med Hyg 2004; 71: 732–738.
32. Afoakwah R, Boampong JN, Egyir-Yawson A, Nwaefuna EK, Verner ON, Asare KK. High prevalence of PfCRT K76T mutation in Plasmodium falciparum isolates in Ghana. Acta Trop 2014; 136: 32–36.
33. Gbotosho GO, Happi CT, Ganiyu A, Ogundahunsi OA, Sowunmi A, Oduola AM. Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin combination therapy. Malar J 2009; 8: 313–313.
34. Yeung S, Socheat D, Moorthy VS, Mills AJ. Artemisinin resistance on the Thai-Cambodian border. Lancet 2009; 374: 1418–1419.
35. Jonkman A, Chibwe RA, Khoromana CO. Cost-saving through microscopy-based versus presumptive diagnosis of malaria in adult outpatients in Malawi. Bull World Health Organ 1995; 73: 223–227.