Efficacy of the Hydroalcoholic Extract of Tribulus terrestris on the Serum Glucose and Lipid Profile of Women With Diabetes Mellitus: A Double-Blind Randomized Placebo-Controlled Clinical Trial

Journal of Evidence-Based Complementary and Alternative Medicine

Volumn 21, Issue 4, 2016, Pages NP91-NP97

  Samani, Nasrin Babadaei ^a   Jokar, Azam ^b   Soveid, Mahmood ^c   Heydari, Mojtaba ^d   Mosavat, Seyed Hamdollah ^e  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

diabetes mellitus; herbal medicine; traditional medicine; Tribulus terrestris

Indexed keywords

ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; LIPID; PLANT EXTRACT;

ADULT; BLOOD; CHEMISTRY; CONTROLLED STUDY; DRUG EFFECTS; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL; TRIBULUS;

ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; LIPIDS; MIDDLE AGED; PLANT EXTRACTS; TRIBULUS;

EID: 84989225632     PISSN: 21565872     EISSN: None     Source Type: Journal    
DOI: 10.1177/2156587216650775     Document Type: Article

References (36)

1. Esteghamati A, Meysamie A, Khalilzadeh O. Third national Surveillance of Risk Factors of Non-Communicable Diseases (SuRFNCD-2007) in Iran: methods and results on prevalence of diabetes, hypertension, obesity, central obesity, and dyslipidemia. BMC Public Health. 2009;9:167.
2. Monterrosa-Castro A, Blümel J, Portela-Buelvas K. Type II diabetes mellitus and menopause: a multinational study. Climacteric. 2013;16:663–672.
3. Doubova Dubova VS, Flores-Hernández S, Rodriguez-Aguilar L, Pérez-Cuevas R. Quality of care and health-related quality of life of climacteric stage women cared for in family medicine clinics in Mexico. Health Qual Life Outcomes. 2010;8:1–12.
4. Arastoo A, Ghassemzadeh R, Nasseh H. Factors affecting quality of life in elderly diabetic residents of the Kahrizak Geriatric Nursing Home of Tehran. Iran J Endocrinol Metab. 2012;14:18–24.
5. Schroeder EB, Hanratty R, Beaty BL, Bayliss EA, Havranek EP, Steiner JF. Simultaneous control of diabetes mellitus, hypertension, and hyperlipidemia in 2 health systems. Circ Cardiovasc Qual Outcomes. 2012;5:645–653.
6. Borrelli F, Ernst E. Alternative and complementary therapies for the menopause. Maturitas. 2010;66:333–343.
7. Gold EB, Bair Y, Zhang G. Cross-sectional analysis of specific complementary and alternative medicine (CAM) use by racial/ethnic group and menopausal status: the Study of Women’s Health Across the Nation (SWAN). Menopause. 2007;14:612–623.
8. Hashempur MH, Heydari M, Mosavat SH, Heydari ST, Shams M. Complementary and alternative medicine use in Iranian patients with diabetes mellitus. J Integr Med. 2015;13:319–325.
9. Heydari M, Homayouni K, Hashempur MH, Shams M. Topical Citrullus colocynthis (bitter apple) extract oil in painful diabetic neuropathy: a double-blind randomized placebo-controlled clinical trial. J Diabetes. 2016;8:246–252. doi:10.1111/1753-0407.12287.
10. Hosseini S, Jamshidi L, Mehrzadi S. Effects of Juglans regia L. leaf extract on hyperglycemia and lipid profiles in type two diabetic patients: a randomized double-blind, placebo-controlled clinical trial. J Ethnopharmacol. 2014;152:451–456.
11. Ayyanar M, Ignacimuthu S. Ethnobotanical survey of medicinal plants commonly used by Kani tribals in Tirunelveli hills of Western Ghats, India. J Ethnopharmacol. 2011;134:851–864.
12. Hussain AA, Mohammed AA, Ibrahim HH, Abbas AH. Study the biological activities of tribulus terrestris extracts. World Acad Sci Eng Technol. 2009;57:433–435.
13. Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction—an evaluation using primates, rabbit and rat. Phytomedicine. 2008;15:44–54.
14. Shudi C, Weijing Q, Mu L, Qunhua C. Research advance on chemical component and pharmacological action of Tribulus terrestris [J]. Chin Wild Plant Resour. 2003;4:001.
15. Mosavat SH, Ghahramani L, Rahmanian-Haghighi E, Rostami-Chaijan M, Hashempur MH, Heydari M. Anorectal diseases in “Avicenna Canon of Medicine.” Acta Med Hist Adriat. 2015;13(suppl 2):103–114.
16. Hashempur MH, Lari ZN, Ghoreishi PS. A pilot randomized double-blind placebo-controlled trial on topical chamomile (Matricaria chamomilla L.) oil for severe carpal tunnel syndrome. Complement Ther Clin Pract. 2015;21:223–228.
17. Gandhi S, Srinivasan B, Akarte AS. Potential nephrotoxic effects produced by steroidal saponins from hydro alcoholic extract of Tribulus terrestris in STZ-induced diabetic rats. Toxicol Mech Methods. 2013;23:548–557.
18. Bashir A, Tahir M, Samee W, Munir B. Effects of Tribulus terrestris on testicular development of immature albino rats. Biomedica. 2009;25:63–68.
19. Guo Y, Shi D-Z, Yin H-J, Chen K-J. Effects of Tribuli saponins on ventricular remodeling after myocardial infarction in hyperlipidemic rats. Am J Chin Med. 2007;35:309–316.
20. El-Tantawy W, Hassanin L. Hypoglycemic and hypolipidemic effects of alcoholic extract of Tribulus alatus in streptozotocin-induced diabetic rats: a comparative study with T. terrestris (Caltrop). Indian J Exp Biol. 2007;45:778.
21. Li M, Qu W, Chu S, Wang H, Tian C, Tu M. Effect of the decoction of Tribulus terrestris on mice gluconeogenesis [in Chinese]. Zhong Yao Cai. 2001;24:586–588.
22. Zhang S, Qu W, Zhong S. Inhibitory effects of saponins from Tribulus terrestris on α-glucosidase in small intestines of rats [in Chinese]. Zhongguo Zhong Yao Za Zhi. 2006;31:910–913.
23. Sengupta G, Hazra A, Kundu A, Ghosh A. Comparison of Murraya koenigii– and Tribulus terrestris–based oral formulation versus tamsulosin in the treatment of benign prostatic hyperplasia in men aged> 50 years: a double-blind, double-dummy, randomized controlled trial. Clin Ther. 2011;33:1943–1952.
24. Rogerson S, Riches CJ, Jennings C, Weatherby RP, Meir RA, Marshall-Gradisnik SM. The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players. J Strength Cond Res. 2007;21:348–353.
25. Brown GA, Vukovich MD, Martini ER. Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30- to 58-year-old men. J Am Coll Nutr. 2001;20:520–528.
26. Roghani M, Baluchnejadmojarad T, Andalibi N, Ansari F, Sharayeli M. Effect of Consumption of Tribulus terrestris on serum glucose and lipid levels in diabetic rats. J Shahid Sadoughi Univ Med Sci Health Serv. 2010;18:17–23.
27. Mali F, Yupeng W. Hypoglycemic effect of puncture vine caltrap (Tribulus terrestris). Zhong Yao Cai. 1998;2:016.
28. Tuncer MA, Yaymaci B, Sati L. Influence of Tribulus terrestris extract on lipid profile and endothelial structure in developing atherosclerotic lesions in the aorta of rabbits on a high-cholesterol diet. Acta Histochem. 2009;111:488–500.
29. Chang-jie S, Wei-jing Q, Jie-si W, Ting-ting D. Effect of tribu saponin from Tribulus terrestris on the formation of atherosclerosis in rats. Nat Prod Res Dev. 2009;21:53.
30. Nimrouzi M, Sadeghpour O, Imanieh MH. Remedies for children constipation in medieval Persia. J Evid Based Complementary Altern Med. 2014;19:137–143.
31. Mosavat SH, Ghahramani L, Sobhani Z, Haghighi ER, Heydari M. Topical Allium ampeloprasum subsp Iranicum (Leek) extract cream in patients with symptomatic hemorrhoids: a pilot randomized and controlled clinical trial. J Evid Based Complementary Altern Med. 2015;20:132–136.
32. Sharifi H, Minaie MB, Qasemzadeh MJ, Ataei N, Gharehbeglou M, Heydari M. Topical use of Matricaria recutita L (chamomile) oil in the treatment of monosymptomatic enuresis in children: a double-blind randomized controlled trial [published online September 30, 2015]. J Evid Based Complementary Altern Med. doi:10.1177/2156587215608989.
33. Qasemzadeh MJ, Sharifi H, Hamedanian M. The effect of Viola odorata flower syrup on the cough of children with asthma: a double-blind, randomized controlled trial. J Evid Based Complementary Altern Med. 2015;20:287–291.
34. Khorasani MA. Makhzan al Advieh. Tehran, Iran: Bavardaran Press Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences; 2001.
35. Brown GA, Vukovich MD, Martini ER. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam Nutr Res. 2001;71:293–301.
36. Antonio J, Uelmen J, Rodriguez R, Earnest C. The effects of Tribulus terrestris on body composition and exercise performance in resistance-trained males. Int J Sport Nutr Exerc Metab. 2000;10:208–215.