Serum interleukin 6 and 10 levels in Takotsubo cardiomyopathy: Increased admission levels may predict adverse events at follow-up

Atherosclerosis

Volumn 254, Issue , 2016, Pages 28-34

  Santoro, Francesco ^a,b   Tarantino, Nicola ^a   Ferraretti, Armando ^a   Ieva, Riccardo ^c   Musaico, Francesco ^a   Guastafierro, Francesca ^a   Di Martino, Luigi ^a   Di Biase, Matteo ^a   Brunetti, Natale Daniele ^a  

^a UNIVERSITY OF FOGGIA   (Italy)

^b Asklepios Klinik Sankt Georg   (Germany)

^c University Hospital Ospedali Riuniti Foggia   (Italy)

Author keywords

Interleukin 10; Interleukin 6; Prognosis; Takotsubo cardiomyopathy

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; TROPONIN I; IL10 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN;

AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; CORONARY ANGIOGRAPHY; DIABETES MELLITUS; DYSLIPIDEMIA; FEMALE; FOLLOW UP; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HOSPITAL ADMISSION; HOSPITAL READMISSION; HUMAN; HYPERTENSION; LUNG EDEMA; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECURRENT DISEASE; TAKOTSUBO CARDIOMYOPATHY; ACUTE DISEASE; BLOOD; DOPPLER ECHOCARDIOGRAPHY; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; INFLAMMATION; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY;

ACUTE DISEASE; AGED; CORONARY ANGIOGRAPHY; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-6; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PATIENT ADMISSION; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RECURRENCE; TAKOTSUBO CARDIOMYOPATHY; VENTRICULAR FUNCTION, LEFT;

EID: 84988720854     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2016.09.012     Document Type: Article

References (46)

1. [1] Lyon, A.R., Bossone, E., Schneider, B., Sechtem, U., Citro, R., et al. Current state of knowledge on takotsubo syndrome: a position statement from the taskforce on takotsubo syndrome of the heart failure association of the European society of Cardiology. Eur. J. Heart Fail. 18 (2016), 8–27.
2. [2] WittsteinIS, Thiemann DR., Lima, J.A., Baughman, K.L., Schulman, S.P., et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N. Engl. J. Med. 352 (2005), 539–548.
3. [3] Madias, J.E., Could myocardial inflammation in Takotsubo syndrome be secondary to the mechanical disruption, rather than a primary feature, of the illness?. Int. J. Cardiol., 189, 2015, 196.
4. [4] Brunetti, N.D., Correale, M., Pellegrino, P.L., Munno, I., Cuculo, A., et al. Early inflammatory cytokine response: a direct comparison between spontaneous coronary plaque destabilization vs angioplasty induced. Atherosclerosis 236 (2014), 456–460.
5. [5] Brunetti, N.D., Troccoli, R., Correale, M., Pellegrino, P.L., Di Biase, M., C-reactive protein in patients with acute coronary syndrome: correlation with diagnosis, myocardial damage, ejection fraction and angiographic findings. Int. J. Cardiol. 109 (2006), 248–256.
6. [6] Pellegrino, P.L., Brunetti, N.D., De Gennaro, L., Ziccardi, L., Grimaldi, M., Biase, M.D., Inflammatory activation in an unselected population of subjects with atrial fibrillation: links with structural heart disease, atrial remodeling and recent onset. Intern Emerg. Med. 8 (2013), 123–128.
7. [7] De Gennaro, L., Brunetti, N.D., Montrone, D., De Rosa, F., Cuculo, A., Di Biase, M., Subacute inflammatory activation in subjects with acute coronary syndrome and left ventricular dysfunction. Inflammation 35 (2012), 363–370.
8. [8] Eitel, I., von Knobelsdorff-Brenkenhoff, F., Bernhardt, P., Carbone, I., Muellerleile, K., et al. Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy. JAMA 306 (2011), 277–286.
9. [9] Sachdeva, J., Dai, W., Kloner, R.A., Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy. J. Am. Heart Assoc., 3, 2014, e000921.
10. [10] Brunetti, N.D., Munno, I., Pellegrino, P.L., Ruggero, V., Correale, M., et al. Inflammatory cytokines imbalance in the very early phase of acute coronary syndrome: correlations with angiographic findings and in-hospital events. Inflammation 34 (2011), 58–66.
11. [11] Miyao, Y., Yasue, H., Ogawa, H., Misumi, I., Masuda, T., et al. Elevated plasma interleukin-6 levels in patients with acute myocardial infarction. Am. Heart J. 126 (1993), 1299–1304.
12. [12] Ridker, P.M., Rifai, N., Stampfer, M.J., Hennekens, C.H., Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101 (2000), 1767–1772.
13. [13] Falcao, R.A., Christopher, S., Oddi, C., Reznikov, L., Grizzard, J.D., et al. Interleukin-10 in patients with ST-segment elevation myocardial infarction. Int. J. Cardiol. 172 (2014), e6–8.
14. [14] Yip, H.K., Youssef, A.A., Chang, L.T., Yang, C.H., Sheu, J.J., et al. Association of interleukin-10 level with increased 30-day mortality in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention. Circ. J. 71 (2007), 1086–1091.
15. [15] Ammirati, E., Cannistraci, C.V., Cristell, N.A., Vecchio, V., Palini, A.G., et al. Identification and predictive value of interleukin-6+ interleukin-10+ and interleukin-6- interleukin-10+ cytokine patterns in ST-elevation acute myocardial infarction. Circ. Res. 111 (2012), 1336–1348.
16. [16] Prasad, A., Lerman, A., Rihal, C.S., Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am. Heart J. 155 (2008), 408–417.
17. [17] World Health organization Classification of disease. ICD-10 2016 http://www.who.int/classifications/icd/.
18. [18] Templin, C., Ghadri, J.R., Diekmann, J., Napp, L.C., Bataiosu, D.R., et al. Clinical features and outcomes of takotsubo (stress) cardiomyopathy. N. Engl. J. Med. 373 (2015), 929–938.
19. [19] Morel, O., Sauer, F., Imperiale, A., Cimarelli, S., Blondet, C., et al. Importance of inflammation and neurohumoral activation in Takotsubo cardiomyopathy. J. Card. Fail. 15 (2009), 206–213.
20. [20] Pirzer, R., Elmas, E., Haghi, D., Lippert, C., Kralev, S., et al. Platelet and monocyte activity markers and mediators of inflammation in Takotsubo cardiomyopathy. Heart Vessels 27 (2012), 186–192.
21. [21] Eitel, I., Lücke, C., Grothoff, M., Sareban, M., Schuler, G., et al. Inflammation in takotsubo cardiomyopathy: insights from cardiovascular magnetic resonance imaging. Eur. Radiol. 20 (2010), 422–431.
22. [22] Seta, Y., Shan, K., Bozkurt, B., Oral, H., Mann, D.L., Basic mechanisms in heart failure: the cytokine hypothesis. J. Card. Fail. 2 (1996), 243–249.
23. [23] Mann, D.L., Innate immunity and the failing heart: the cytokine hypothesis revisited. Circ. Res. 116 (2015), 1254–1268.
24. [24] Oikonomou, E., Tousoulis, D., Siasos, G., Zaromitidou, M., Papavassiliou, A.G., Stefanadis, C., The role of inflammation in heart failure: new therapeutic approaches. Hell. J. Cardiol. 52 (2011), 30–40.
25. [25] Brunetti, N.D., Munno, I., Pellegrino, P.L., Ruggero, V., Correale, M., et al. Inflammatory cytokines imbalance in the very early phase of acute coronary syndrome: correlations with angiographic findings and in-hospital events. Inflammation 34 (2011), 58–66.
26. [26] Nymo, S.H., Hulthe, J., Ueland, T., McMurray, J., Wikstrand, J., et al. Inflammatory cytokines in chronic heart failure: interleukin-8 is associated with adverse outcome. Results from CORONA. Eur. J. Heart Fail. 16 (2014), 68–75.
27. [27] Finkel, M.S., Oddis, C.V., Jacob, T.D., Watkins, S.C., Hattler, B.G., Simmons, R.L., Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257 (1992), 387–389.
28. [28] Tsutamoto, T., Hisanaga, T., Wada, A., Maeda, K., Ohnishi, M., et al. Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. J. Am. Coll. Cardiol. 31 (1998), 391–398.
29. [29] Yamauchi-Takihara, K., Ihara, Y., Ogata, A., Yoshizaki, K., Azuma, J., Kishimoto, T., Hypoxic stress induces cardiac myocyte-derived interleukin-6. Circulation 91 (1995), 1520–1524.
30. [30] Ohtsuka, T., Hamada, M., Inoue, K., Ohshima, K., Sujzuki, J., et al. Relation of circulating interleukin-6 to left ventricular remodeling in patients with reperfused anterior myocardial infarction. Clin. Cardiol. 27 (2004), 417–420.
31. [31] Erzen, B., Sabovic, M., Sebestjen, M., Keber, I., Poredos, P., Interleukin-6 correlates with endothelial dysfunction in young post-myocardial infarction patients. Cardiology 107 (2007), 111–116.
32. [32] De Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C.G., De Vries, J.E., Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174 (1991), 1209–1220.
33. [33] Parissis, J.T., Farmakis, D., Nikolaou, M., Birmpa, D., Bistola, V., et al. Plasma B-type natriuretic peptide and anti-inflammatory cytokine interleukin-10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1-year follow-up study. Eur. J. Heart Fail. 11 (2009), 967–972.
34. [34] Ohtsuka, T., Hamada, M., Hiasa, G., Sasaki, O., Suzuki, M., et al. Effect of beta-blockers on circulating levels of inflammatory and anti-inflammatory cytokines in patients with dilated cardiomyopathy. J. Am. Coll. Cardiol. 37 (2001), 412–417.
35. [35] Trifunović, J., Miller, L., Debeljak, Z., Horvat, V., Pathologic patterns of interleukin 10 expression–A review. Biochem. Med. 25 (2015), 36–48.
36. [36] Nef, H.M., Möllmann, H., Troidl, C., Kostin, S., Voss, S., et al. Abnormalities in intracellular Ca2+ regulation contribute to the pathomechanism of Tako-Tsubo cardiomyopathy. Eur. Heart J. 30 (2009), 2155–2164.
37. [37] Nef, H.M., Möllmann, H., Hilpert, P., Troidl, C., Voss, S., et al. Activated cell survival cascade protects cardiomyocytes from cell death in Tako-Tsubo cardiomyopathy. Eur. J. Heart Fail. 11 (2009), 758–764.
38. [38] Kan, H., Finkel, M.S., Interactions between cytokines and neurohormonal systems in the failing heart. Heart Fail Rev. 6 (2001), 119–127.
39. [39] Finkel, M.S., Oddis, C.V., Jacob, T.D., Watkins, S.C., Hattler, B.G., Simmons, R.L., Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 257 (1992), 387–389.
40. [40] Damodaran, S., Mrozek, E., Liebner, D., Kendra, K., Focal takotsubo cardiomyopathy with high-dose interleukin-2 therapy for malignant melanoma. J. Natl. Compr. Canc Netw. 12 (2014), 1666–1670.
41. [41] Santoro, F., Ferraretti, A., Ieva, R., Musaico, F., Fanelli, M., et al. Renal impairment and outcome in patients with takotsubo cardiomyopathy. Am. J. Emerg. Med. 34 (2016), 548–552.
42. [42] Santoro, F., Ferraretti, A., Musaico, F., Di Martino, L., Tarantino, N., et al. Carbohydrate-antigen-125 levels predict hospital stay duration and adverse events at long-term follow-up in Takotsubo cardiomyopathy. Intern Emerg. Med. 11 (2016), 687–694.
43. [43] Miettinen, K.H., Lassus, J., Harjola, V.P., Siirilä-Waris, K., Melin, J., et al. Prognostic role of pro- and anti-inflammatory cytokines and their polymorphisms in acute decompensated heart failure. Eur. J. Heart Fail. 10 (2008), 396–403.
44. [44] Ferrario, C.M., Strawn, W.B., Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease. Am. J. Cardiol. 98 (2006), 121–128.
45. [45] Santoro, F., Ieva, R., Musaico, F., Ferraretti, A., Triggiani, G., et al. Lack of efficacy of drug therapy in preventing takotsubo cardiomyopathy recurrence: a meta-analysis. Clin. Cardiol. 37 (2014), 434–439.
46. [46] Brunetti, N.D., Santoro, F., De Gennaro, L., Correale, M., Gaglione, A., Di Biase, M., Drug treatment rates with beta-blockers and ACE-inhibitors/angiotensin receptor blockers and recurrences in takotsubo cardiomyopathy: a meta-regression analysis. Int. J. Cardiol. 214 (2016), 340–342.