The involvement of miR-100 in bladder urothelial carcinogenesis changing the expression levels of mRNA and proteins of genes related to cell proliferation, survival, apoptosis and chromosomal stability

Cancer Cell International

Volumn 14, Issue 1, 2014, Pages

  Morais, Denis R ^a   Reis, Sabrina T ^a   Viana, Nayara ^a   Piantino, Camila Berfort ^a   Massoco, Cristina ^a   Moura, Caio ^a   Dip, Nelson ^a   Silva, Iran A ^a   Srougi, Miguel ^a   Leite, Katia R M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bladder cancer; Gene expression; MicroRNA; MiR 100; PCR; Protein expression; Western blotting

Indexed keywords

BAZ2A PROTEIN; DNA; DNA BINDING PROTEIN; FIBROBLAST GROWTH FACTOR RECEPTOR 3; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MICRORNA 100; RNA ANTIBODY; SMARCA5 PROTEIN; THANATOS ASSOCIATED PROTEIN 2; TRANSCRIPTION FACTOR SNF; TUMOR MARKER; TUMOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BAZ2A GENE; BLADDER CANCER CELL LINE; BLADDER CARCINOGENESIS; CANCER GRADING; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DOWN REGULATION; FGFR3 GENE; FLOW CYTOMETRY; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE TARGETING; GENETIC ASSOCIATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MTOR GENE; PLOIDY; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RT4 CELL LINE; SMARCA5 GENE; T24 CELL LINE; THAP2 GENE; TRANSITIONAL CELL CARCINOMA; WESTERN BLOTTING;

EID: 84988643350     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/s12935-014-0119-3     Document Type: Article

References (32)

1. Bartel DP: MicroRNAs: Target Recognition and Regulatory Functions. Cell 2009, 136(2):215-233.
2. Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ: miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res 2006, 34:D140-D144.
3. Friedman RC, Farh KKH, Burge CB, Bartel DP: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009, 19(1):92-105.
4. Esteller M: Non-coding RNAs in human disease. Nat Rev Genet 2011, 12(12):861-874.
5. Nelson Dip STR, Timoszczuk LS, Daniel Kanda A, Marcos D'O, Miguel S, Katia RM L: Under-expression of miR-100 may be a new Carcinogenic pathway for low-grade pTa Bladder Urothelial Carcinomas. J Mol Biomarkers Diagnosis 2012, 3(1):1-3.
6. Wong TS, Liu XB, Wong BYH, Ng RWM, Yuen APW, Wei WI: Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res 2008, 14(9):2588-2592.
7. Henson BJ, Bhattacharjee S, O'Dee DM, Feingold E, Gollin SM: Decreased Expression of miR-125b and miR-100 in Oral Cancer Cells Contributes to Malignancy. Genes Chromosomes & Cancer 2009, 48(7):569-582.
8. Shi W, Alajez NM, Bastianutto C, Hui ABY,Mocanu JD, Ito E, Busson P, Lo KW, Ng R, Waldron J, O'Sullivan B, Liu FF: Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer. Int J Cancer 2010, 126(9):2036-2048.
9. Petrelli A, Perra A, Schernhuber K, Cargnelutti M, Salvi A, Migliore C, Ghiso E, Benetti A, Barlati S, Ledda-Columbano GM, Portolani N, De Petro G, Columbano A, Giordano S: Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression. Oncogene 2012, 31(42):4517-4526.
10. Cairo S, Wang YP, de Reynies A, Duroure K, Dahan J, Redon MJ, Fabre M, McClelland M, Wang XW, Croce CM, Buendia MA: Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer. P Natl Acad Sci USA 2010, 107(47):20471-20476.
11. Nam EJ, Yoon HJ, Kim SW, Kim HG, Kim YT, Kim JH, Kim JW, Kim SH: MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res 2008, 14(9):2690-2695.
12. Liu W, Gong YH, Chao TF, Peng XZ, Yuan JG, Ma ZY, Jia G, Zhao JZ: Identiflcation of differentially expressed microRNAs by microarray: a possible role for microRNAs gene in medulloblastomas. Chin Med J 2009, 122(20):2405-2411.
13. Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, Alder H, Liu CG, Oue N, Yasui W, Yoshida K, Sasaki H, Nomura S, Seto Y, Kaminishi M, Calin GA, Croce CM: Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol 2010, 11(2):136-146.
14. Lee EJ, Gusev Y, Jiang JM, Nuovo GJ, Lerner MR, Frankel WL, Morgan DL, Postier RG, Brackett DJ, Schmittgen TD: Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer 2007, 120(5):1046-1054.
15. Leite KR, Tomiyama A, Reis ST, Sousa-Canavez JM, Sanudo A, Dall'Oglio MF, Camara-Lopes LH, Srougi M: MicroRNA-100 expression is independently related to biochemical recurrence of prostate cancer. J Urol 2011, 185(3):1118-1122.
16. Dip N, Reis ST, Timoszczuk LS, Viana NI, Piantino CB, Morais DR, Moura CM, Abe DK, Silva IA, Srougi M, Dall'Oglio MF, Leite KR: Stage, grade and behavior of bladder urothelial carcinoma defined by the microRNA expression profile. J Urol 2012, 188(5):1951-1956.
17. Song T, Xia W, Shao N, Zhang X, Wang C, Wu Y, Dong J, Cai W, Li H: Differential miRNA expression profiles in bladder urothelial carcinomas. APJCP 2010, 11(4):905-911.
18. Catto JW, Miah S, Owen HC, Bryant H, Myers K, Dudziec E, Larre S, Milo M, Rehman I, Rosario DJ, Di Martino E, Knowles MA, Meuth M, Harris AL, Hamdy FC: Distinct microRNA alterations characterize high-and low-grade bladder cancer. Cancer Res 2009, 69(21):8472-8481.
19. Rieger-Christ KM, Mourtzinos A, Lee PJ, Zagha RM, Cain J, Silverman M, Libertino JA, Summerhayes IC: Identification of fibroblast growth factor receptor 3 mutations in urine sediment DNA samples complements cytology in bladder tumor detection. Cancer 2003, 98(4):737-744.
20. Neuzillet Y, Paoletti X, Ouerhani S, Mongiat-Artus P, Soliman H, de The H, Sibony M, Denoux Y, Molinie V, Herault A, Lepage ML, Maille P, Renou A, Vordos D, Abbou CC, Bakkar A, Asselain B, Kourda N, El Gaaied A, Leroy K, Laplanche A, Benhamou S, Lebret T, Allory Y, Radvanyi F: A Meta-Analysis of the Relationship between FGFR3 and TP53 Mutations in Bladder Cancer. Plos One 2012, 7(12):e48993.
21. Garcia JA, Danielpour D: Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies. Mol Cancer Ther 2008, 7(6):1347-1354.
22. Park SJ, Lee TJ, Chang IH: Role of the mTOR Pathway in the Progression and Recurrence of Bladder Cancer: An Immunohistochemical Tissue Microarray Study. Korean journal of urology 2011, 52(7):466-473.
23. Xu C, Zeng Q, Xu W, Jiao L, Chen Y, Zhang Z, Wu C, Jin T, Pan A, Wei R, Yang B, Sun Y: miRNA-100 Inhibits Human Bladder Urothelial Carcinogenesis by Directly Targeting mTOR. Mol Cancer Ther 2013, 12(2):207-219.
24. Lan L, Ui A, Nakajima S, Hatakeyama K, Hoshi M, Watanabe R, Janicki SM, Ogiwara H, Kohno T, Kanno S, Yasui UMA: The ACF1 complex is required for DNA double-strand break repair in human cells. Mol Cell 2010, 40(6):976-987.
25. Havas K, Whitehouse I, Owen-Hughes T: ATP-dependent chromatin remodeling activities. Cell Mol Life Sci 2001, 58(5-6):673-682.
26. Mueller AC, Sun D, Dutta A: The miR-99 family regulates the DNA damage response through its target SNF2H. Oncogene 2013, 32(9):1164-1172.
27. Bessiere D, Lacroix C, Campagne S, Ecochard V, Guillet V, Mourey L, Lopez F, Czaplicki J, Demange P, Milon A, Girard JP, Gervais V: Structure-function analysis of the THAP zinc finger of THAP1, a large C2CH DNA-binding module linked to Rb/E2F pathways. J Biol Chem 2008, 283(7):4352-4363.
28. Macfarlan T, Kutney S, Altman B, Montross R, Yu J, Chakravarti D: Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor. The Journal of biological chemistry 2005, 280(8):7346-7358.
29. Roussigne M, Cayrol C, Clouaire T, Amalric F, Girard JP: THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies. Oncogene 2003, 22(16):2432-2442.
30. Cayrol C, Lacroix C, Mathe C, Ecochard V, Ceribelli M, Loreau E, Lazar V, Dessen P, Mantovani R, Aguilar L, Girardi JP: The THAP-zinc finger protein THAP1 regulates endothelial cell proliferation through modulation of pRB/E2F cell-cycle target genes. Blood 2007, 109(2):584-594.
31. Knowles MA: Molecular pathogenesis of bladder cancer. Int J Clin Oncol 2008, 13(4):287-297.
32. Zhou Y, Santoro R, Grummt I: The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription. The EMBO journal 2002, 21(17):4632-4640.