Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Teeguarden, Justin G ^a   Mikheev, Vladimir B ^b   Minard, Kevin R ^a   Forsythe, William C ^b   Wang, Wei ^c   Sharma, Gaurav ^b   Karin, Norman ^d   Tilton, Susan C ^a   Waters, Katrina M ^a   Asgharian, Bahman ^e   Price, Owen R ^e   Pounds, Joel G ^a   Thrall, Brian D ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

^d ROSWELL PARK CANCER INSTITUTE   (United States)

^e APPLIED RESEARCH ASSOCIATES   (United States)

Author keywords

Dosimetry; Extrapolation; In vivo testing; Lung deposition; Magnetic particle detection; Nano aerosol; Nanoparticle

Indexed keywords

CCL9 CHEMOKINE; CHEMOKINE; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CXCL3 CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; THYMUS AND ACTIVATION REGULATED CHEMOKINE; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG; AEROSOL; AUTACOID; CYTOKINE; MAGNETITE NANOPARTICLE; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; CCL3 GENE; CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; CXCL1 GENE; CXCL2 GENE; CXCL3 GENE; DOSIMETRY; EPITHELIUM CELL; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTOLOGY; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INHALATION; LIQUID CELL CULTURE; LUNG ALVEOLUS EPITHELIUM; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS; ADVERSE EFFECTS; AEROSOL; ANIMAL; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; EXPOSURE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; LUNG; MALE; METABOLISM; PARTICLE SIZE; PATHOLOGY; PNEUMONIA; RISK ASSESSMENT; TIME FACTOR;

AEROSOLS; ANIMALS; CELL LINE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; INHALATION EXPOSURE; LUNG; MACROPHAGES; MAGNETITE NANOPARTICLES; MALE; MICE, INBRED BALB C; MICE, INBRED C57BL; PARTICLE SIZE; PNEUMONIA; RISK ASSESSMENT; RNA, MESSENGER; TIME FACTORS;

EID: 84988614903     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/s12989-014-0046-4     Document Type: Article

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