The ethics of expanding access to cheaper, less effective treatments

The Lancet

Volumn 388, Issue 10047, 2016, Pages 932-934

  Persad, Govind C ^a   Emanuel, Ezekiel J ^b,c  

^a GEORGETOWN UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ANTIBIOTIC AGENT; PHENOBARBITAL; STAVUDINE; TENOFOVIR; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL THERAPY; BACTERIAL MENINGITIS; COST EFFECTIVENESS ANALYSIS; DRUG COST; DRUG SAFETY; EPILEPSY; ETHICS; FOOD AND DRUG ADMINISTRATION; GROSS NATIONAL PRODUCT; HEALTH CARE ACCESS; HEALTH CARE QUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN PAPILLOMAVIRUS DNA TEST; LIPODYSTROPHY; LOWEST INCOME GROUP; MEDICAL CARE; MEDICAL DEVICE; MIDDLE INCOME COUNTRY; NOTE; PRIORITY JOURNAL; SOUTH AFRICA; UTERINE CERVIX DYSPLASIA; WORLD HEALTH ORGANIZATION; DEVELOPED COUNTRY; DEVELOPING COUNTRY; DRUG ADMINISTRATION; ECONOMICS; ETHICAL THEORY; HEALTH; HEALTH CARE DELIVERY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV INFECTIONS; STANDARDS; TREATMENT OUTCOME; TRENDS; UNITED STATES;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DEVELOPED COUNTRIES; DEVELOPING COUNTRIES; DRUG ADMINISTRATION SCHEDULE; ETHICAL THEORY; GLOBAL HEALTH; HEALTH SERVICES ACCESSIBILITY; HIV INFECTIONS; HUMANS; SOUTH AFRICA; STAVUDINE; TENOFOVIR; TREATMENT OUTCOME; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION; WORLD HEALTH ORGANIZATION; ZIDOVUDINE;

EID: 84988493363     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(15)01025-9     Document Type: Note

References (15)

1. 1 Wood, R, The role of stavudine in the South African public sector antiretroviral programme: should the perfect be the enemy of the good?. South Afr J HIV Med 7 (2006), 5–8.
2. 2 Andrieux-Meyer, I, Clayden, P, Collins, S, et al. Why it's time to say goodbye to stavudine… everywhere. South Afr J HIV Med 13 (2012), 17–19.
3. 3 WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: what's new, 2015, World Health Organization, Geneva.
4. 4 Venter, WDF, Innes, S, Cotton, M, Low-dose stavudine trials: a public health priority for developing countries. South Afr J HIV Med 13 (2012), 20–21.
5. 5 UNAIDS. How AIDS changed everything factsheet. http://www.unaids.org/en/resources/campaigns/HowAIDSchangedeverything/factsheet, 2015 (accessed Oct 1, 2015).
6. 6 WHO. Number of people eligible for antiretroviral therapy in low-income and middle-income countries based on the epidemic and response status at the end of 2012. http://www.who.int/hiv/data/ARTeligibility2013.png (accessed Aug 4, 2014).
7. 7 UNITAID. UNITAID to provide USD 77 million for better HIV medicines. http:www.unitaid.eu/en/resources/press-centre/releases/1226-unaitaid-to-provide-usd77-million-for-better-hiv-medicines, 2013 (accessed Aug 2, 2014).
8. 8 WHO. Epilepsy in the WHO African region: bridging the gap. Initiatives to address epilepsy in Africa: WHO regional strategy for mental health. AFR/MNH/04·1, 2004, World Health Organization, Geneva, 15.
9. 9 WHO. Antimicrobial and support therapy for bacterial meningitis in children: report of the meeting of 18–20 June 1997 Geneva, Switzerland. HO/CHD/98·6; WHO/EMC/BAC/98·2. http://www.who.int/csr/resources/publications/meningitis/WHO_EMC_BAC_98_2/en/ (accessed March 10, 2016).
10. 10 WHO. Medical device regulations: global overview and guiding principles, 2003, World Health Organization, Geneva.
11. 11 Farmer, P, Gastineau, N, Rethinking health and human rights: time for a paradigm shift. J Law Med Ethics 30 (2002), 655–666.
12. 12 WHO. World Health Report 1999: making a difference. Message from the Director-General: vii. http://www.who.int/whr/1999/en/whr99_dgmessage_en.pdf (accessed April 11, 2016).
13. 13 WHO, Global Network of People Living with HIV. PLHIV input into the revision of the WHO ART guidelines. http://www.who.int/hiv/topics/treatment/final_report_gnphiv.pdf, 2009 (accessed March 10, 2016).
14. 14 Gostin, LO, Meeting the survival needs of the world's least healthy people: a proposed model for global health governance. JAMA, 298, 2007, 225.
15. 15 Garrett L. The challenge of global health. Foreign Affairs (Tampa, FL, USA), Nov 30, 2015.