Galectin-3 binds highly galactosylated IgG1 and is crucial for the IgG1 complex mediated inhibition of C5aReceptor induced immune responses

Biochemical and Biophysical Research Communications

Volumn 479, Issue 1, 2016, Pages 86-90

  Heyl, Kerstin A ^a   Karsten, Christian M ^b   Slevogt, Hortense ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Fc Fc RIIB Dectin 1 receptor complex; Galectin 3; IgG1 immune complexes; Neutrophil chemotaxis

Indexed keywords

COMPLEMENT COMPONENT C5A RECEPTOR; DECTIN 1; FC RECEPTOR IIB; GALECTIN 3; GLYCAN; IMMUNOGLOBULIN G1; ANTIGEN ANTIBODY COMPLEX; FC RECEPTOR; FCGR2B PROTEIN, MOUSE; GALACTOSE; IMMUNOGLOBULIN G; LECTIN; MEDIATOR COMPLEX; PROTEIN BINDING;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNOREGULATION; IN VITRO STUDY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL MOTION; CYTOLOGY; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; NEUTROPHIL; WESTERN BLOTTING;

ANIMALS; ANTIGEN-ANTIBODY COMPLEX; BLOTTING, WESTERN; CELL MOVEMENT; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; GALACTOSE; GALECTIN 3; IMMUNOGLOBULIN G; INFLAMMATION; LECTINS, C-TYPE; MEDIATOR COMPLEX; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PROTEIN BINDING; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, IGG; SIGNAL TRANSDUCTION;

EID: 84988442735     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.09.038     Document Type: Article

References (29)

1. [1] Ricklin, D., Hajishengallis, G., Yang, K., Lambris, J.D., Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11 (2010), 785–797.
2. [2] Klos, A., Tenner, A.J., Johswich, K.O., Ager, R.R., Reis, E.S., Kohl, J., The role of the anaphylatoxins in health and disease. Mol. Immunol. 46 (2009), 2753–2766.
3. [3] Guo, R.F., Ward, P.A., Role of C5a in inflammatory responses. Annu. Rev. Immunol. 23 (2005), 821–852.
4. [4] Kohl, J., Anaphylatoxins and infectious and non-infectious inflammatory diseases. Mol. Immunol. 38 (2001), 175–187.
5. [5] Karsten, C.M., Pandey, M.K., Figge, J., Kilchenstein, R., Taylor, P.R., Rosas, M., McDonald, J.U., Orr, S.J., Berger, M., Petzold, D., Blanchard, V., Winkler, A., Hess, C., Reid, D.M., Majoul, I.V., Strait, R.T., Harris, N.L., Kohl, G., Wex, E., Ludwig, R., Zillikens, D., Nimmerjahn, F., Finkelman, F.D., Brown, G.D., Ehlers, M., Kohl, J., Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcgammaRIIB and dectin-1. Nat. Med. 18 (2012), 1401–1406.
6. [6] Henderson, N.C., Sethi, T., The regulation of inflammation by galectin-3. Immunol. Rev. 230 (2009), 160–171.
7. [7] Sato, S., St-Pierre, C., Bhaumik, P., Nieminen, J., Galectins in innate immunity: dual functions of host soluble beta-galactoside-binding lectins as damage-associated molecular patterns (DAMPs) and as receptors for pathogen-associated molecular patterns (PAMPs). Immunol. Rev. 230 (2009), 172–187.
8. [8] Ahmad, N., Gabius, H.J., Andre, S., Kaltner, H., Sabesan, S., Roy, R., Liu, B., Macaluso, F., Brewer, C.F., Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes. J. Biol. Chem. 279 (2004), 10841–10847.
9. [9] Shan, M., Gentile, M., Yeiser, J.R., Walland, A.C., Bornstein, V.U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., Comerma, L., Huang, B., Blander, J.M., Xiong, H., Mayer, L., Berin, C., Augenlicht, L.H., Velcich, A., Cerutti, A., Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342 (2013), 447–453 New York, N.Y.
10. [10] Strait, R.T., Morris, S.C., Finkelman, F.D., IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. J. Clin. Investigation 116 (2006), 833–841.
11. [11] Massa, S.M., Cooper, D.N., Leffler, H., Barondes, S.H., L-29, an endogenous lectin, binds to glycoconjugate ligands with positive cooperativity. Biochemistry 32 (1993), 260–267.
12. [12] Cumpstey, I., Salomonsson, E., Sundin, A., Leffler, H., Nilsson, U.J., Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters. Chembiochem. Eur. J. Chem. Biol. 8 (2007), 1389–1398.
13. [13] Colnot, C., Fowlis, D., Ripoche, M.A., Bouchaert, I., Poirier, F., Embryonic implantation in galectin 1/galectin 3 double mutant mice. Dev. Dyn. Of. Publ. Am. Assoc. Anat. 211 (1998), 306–313.
14. [14] Karsten, C.M., Laumonnier, Y., Kohl, J., Functional analysis of C5a effector responses in vitro and in vivo. Methods Mol. Biol. 1100 (2014), 291–304 Clifton, N.J.
15. [15] Marth, J.D., Grewal, P.K., Mammalian glycosylation in immunity, Nature reviews. Immunology 8 (2008), 874–887.
16. [16] van Kooyk, Y., Rabinovich, G.A., Protein-glycan interactions in the control of innate and adaptive immune responses. Nat. Immunol. 9 (2008), 593–601.
17. [17] Arnold, J.N., Wormald, M.R., Sim, R.B., Rudd, P.M., Dwek, R.A., The impact of glycosylation on the biological function and structure of human immunoglobulins. Annu. Rev. Immunol. 25 (2007), 21–50.
18. [18] Nimmerjahn, F., Anthony, R.M., Ravetch, J.V., Agalactosylated IgG antibodies depend on cellular Fc receptors for in vivo activity. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 8433–8437.
19. [19] Raju, T.S., Terminal sugars of Fc glycans influence antibody effector functions of IgGs. Curr. Opin. Immunol. 20 (2008), 471–478.
20. [20] Bernardes, E.S., Silva, N.M., Ruas, L.P., Mineo, J.R., Loyola, A.M., Hsu, D.K., Liu, F.T., Chammas, R., Roque-Barreira, M.C., Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity. Am. J. Pathol. 168 (2006), 1910–1920.
21. [21] Farnworth, S.L., Henderson, N.C., Mackinnon, A.C., Atkinson, K.M., Wilkinson, T., Dhaliwal, K., Hayashi, K., Simpson, A.J., Rossi, A.G., Haslett, C., Sethi, T., Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function. Am. J. Pathol. 172 (2008), 395–405.
22. [22] Linden, J.R., Kunkel, D., Laforce-Nesbitt, S.S., Bliss, J.M., The role of galectin-3 in phagocytosis of Candida albicans and Candida parapsilosis by human neutrophils. Cell. Microbiol. 15 (2013), 1127–1142.
23. [23] Park, A.M., Hagiwara, S., Hsu, D.K., Liu, F.T., Yoshie, O., Galectin-3 plays an important role in innate immunity to gastric infection by Helicobacter pylori. Infect. Immun. 84 (2016), 1184–1193.
24. [24] Chung, A.W., Sieling, P.A., Schenk, M., Teles, R.M., Krutzik, S.R., Hsu, D.K., Liu, F.T., Sarno, E.N., Rea, T.H., Stenger, S., Modlin, R.L., Lee, D.J., Galectin-3 regulates the innate immune response of human monocytes. J. Infect. Dis. 207 (2013), 947–956.
25. [25] Quattroni, P., Li, Y., Lucchesi, D., Lucas, S., Hood, D.W., Herrmann, M., Gabius, H.J., Tang, C.M., Exley, R.M., Galectin-3 binds Neisseria meningitidis and increases interaction with phagocytic cells. Cell. Microbiol. 14 (2012), 1657–1675.
26. [26] Sato, S., Ouellet, N., Pelletier, I., Simard, M., Rancourt, A., Bergeron, M.G., Role of galectin-3 as an adhesion molecule for neutrophil extravasation during streptococcal pneumonia. J. Immunol. 168 (2002), 1813–1822 Baltimore, Md.: 1950.
27. [27] Nieminen, J., St-Pierre, C., Sato, S., Galectin-3 interacts with naive and primed neutrophils, inducing innate immune responses. J. Leukoc. Biol. 78 (2005), 1127–1135.
28. [28] Baseras, B., Gaida, M.M., Kahle, N., Schuppel, A.K., Kathrey, D., Prior, B., Wente, M., Hansch, G.M., Galectin-3 inhibits the chemotaxis of human polymorphonuclear neutrophils in vitro. Immunobiology 217 (2012), 83–90.
29. [29] Cherayil, B.J., Weiner, S.J., Pillai, S., The Mac-2 antigen is a galactose-specific lectin that binds IgE. J. Exp. Med. 170 (1989), 1959–1972.