Islet neogenesis from the constitutively nestin expressing human umbilical cord matrix derived mesenchymal stem cells

Islets

Volumn 2, Issue 2, 2010, Pages 112-120

  Kadam, Sachin S ^a   Bhonde, Ramesh R ^a  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Diabetes reversal; Human umbilical cord; Islet neogenesis; Mesenchymal stem cells; Wharton's jelly

Indexed keywords

5' NUCLEOTIDASE; BETA1 INTEGRIN; C PEPTIDE; FAT; GLUCAGON; HERMES ANTIGEN; INSULIN; KI 67 ANTIGEN; NESTIN; NEUROGENIN 3; OCTAMER TRANSCRIPTION FACTOR 4; SMOOTH MUSCLE ACTIN; SOMATOSTATIN; STAGE SPECIFIC EMBRYO ANTIGEN 4; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN; TRANSCRIPTION FACTOR PDX 1; VIMENTIN; INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE; CARTILAGE; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; CELL REGENERATION; CELL TRANSPLANTATION; DIABETES MELLITUS; EXTRACELLULAR MATRIX; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MOUSE; NERVE CELL; NONHUMAN; PANCREAS ISLET; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL CORD; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL SEPARATION; CHEMICALLY INDUCED DISORDER; CYTOLOGY; EVALUATION; EXPERIMENTAL DIABETES MELLITUS; MALE; METABOLISM; METHODOLOGY; ORGANOGENESIS; PANCREAS ISLET TRANSPLANTATION; PHYSIOLOGY; PRENATAL DEVELOPMENT; XENOGRAFT;

ANIMALS; CELL DIFFERENTIATION; CELL SEPARATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; INTERMEDIATE FILAMENT PROTEINS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED BALB C; NERVE TISSUE PROTEINS; ORGANOGENESIS; STREPTOZOCIN; TRANSPLANTATION, HETEROLOGOUS; UMBILICAL CORD;

EID: 84988324897     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.2.2.11280     Document Type: Article

References (35)

1. Weiss ML, Anderson C, Medicetty S, Seshareddy KB, Weiss RJ, Vanderwerff I, et al. Immune Properties of Human Umbilical Cord Wharton's Jelly-Derived Cells. Stem Cells 2008; 26:2865-74.
2. Park KS, Lee YS, Kang KS. In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood. J Vet Sci 2006; 7:343-8.
3. Klingemann H. Discarded stem cells with a future? Expert Opin Biol Ther 2006; 6:1251-4.
4. Sanchez-Ramos J. Stem cells from umbilical cord blood. Semin Reprod Med 2006; 24:358-69.
5. Di Gioacchino G, Di Campli C, Zocco MA, Piscaglia AC, Novi M, Santoro M, et al. Transdifferentiation of stem cells in pancreatic cells: state of the art. Transplant Proc 2005; 37:2662-3.
6. Koblas T, Harman SM, Saudek F. The application of umbilical cord blood cells in the treatment of diabetes mellitus. Rev Diabet Stud 2005; 2:228-34.
7. Sun B, Roh KH, Lee SR, Lee YS, Kang KS. Induction of human umbilical cord blood-derived stem cells with embryonic stem cell phenotypes into insulin producing islet-like structure. Biochem Biophys Res Commun 2007; 354:919-23.
8. Yoshida S, Ishikawa F, Kawano N, Shimoda K, Nagafuchi S, Shimoda S, et al. Human cord blood-derived cells generate insulin-producing cells in vivo. Stem Cells 2005; 23:1409-16.
9. Secco M, Zucconi E, Vieira NM, Fogaca LL, Cerqueira A, Carvalho MD, et al. Multipotent stem cells from umbilical cord: cord is richer than blood! Stem Cells 2008; 26:146-50.
10. Fu YS, Cheng YC, Lin MY, Cheng H, Chu PM, Chou SC, et al. Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism. Stem Cells 2006; 24:115-24.
11. Sarugaser R, Lickorish D, Baksh D, Hosseini M, Davies J. Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors. Stem Cells 2005; 23:220-9.
12. Troyer DL, Weiss ML. Wharton's jelly-derived cells are a primitive stromal cell population. Stem Cells 2008; 26:591-9.
13. Weiss ML, Medicetty S, Bledsoe AR, Rachakatla RS, Choi M, Merchav S, et al. Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells 2006; 24:781-92.
14. Fong CY, Richards M, Manasi N, Biswas A, Bongso A. Comparative growth behavior and characterization of stem cells from human Wharton's jelly. Reprod Biomed Online 2007; 15:708-18.
15. Conconi MT, Burra P, Di Liddo R, Calore C, Turetta M, Bellini S, et al. CD105(+) cells from Wharton's jelly show in vitro and in vivo myogenic differentiative potential. Int J Mol Med 2006; 18:1089-96.
16. Karahuseyinoglu S, Cinar O, Kilic E, Kara F, Akay GG, Demiralp DO, et al. Biology of stem cells in human umbilical cord stroma: in situ and in vitro surveys. Stem Cells 2007; 25:319-31.
17. Nishiyama N, Miyoshi S, Hida N, Uyama T, Okamoto K, Ikegami Y, et al. The significant cardiomyogenic potential of human umbilical cord blood-derived mesenchymal stem cells in vitro. Stem Cells 2007; 25:2017-24.
18. Chen L, Jiang X, Yang L. Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta cells. World J Gastroenterol 2004; 10:3016-20.
19. Ma L, Feng XY, Cui BL, Law F, Jiang X, Yang L, et al. Human umbilical cord Wharton's Jelly-derived mesenchymal stem cells differentiation into nerve-like cells. Chin Med J (Engl) 2005; 118:1987-93.
20. Zulewski H, Abraham EJ, Gerlach MJ, Daniel PB, Moritz W, Muller B, et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine and hepatic phenotypes. Diabetes 2001; 50:521-33.
21. Joanette EA, Reusens B, Arany E, Thyssen S, Remacle RC, Hill DJ. Low-protein diet during early life causes a reduction in the frequency of cells immunopositive for nestin and CD34 in both pancreatic ducts and islets in the rat. Endocrinology 2004; 145:3004-13.
22. Chao KC, Chao KF, Fu YS, Liu SH. Islet-like clusters derived from mesenchymal stem cells in Wharton's Jelly of the human umbilical cord for transplantation to control type 1 diabetes. PLoS ONE 2008; 3:1451.
23. Kadam SS, Tiwari S, Bhonde RR. Simultaneous isolation of vascular endothelial cells and mesenchymal stem cells from the human umbilical cord. In Vitro Cell Dev Biol Anim 2009; 45:23-7.
24. Phadnis SM, Joglekar MV, Venkateshan V, Ghaskadbi SM, Hardikar AA, Bhonde RR. Human umbilical cord blood serum promotes growth, proliferation, as well as differentiation of human bone marrow-derived progenitor cells. In Vitro Cell Dev Biol Anim 2006;
25. Shetty P, Bharucha K, Tanavde V. Human umbilical cord blood serum can replace fetal bovine serum in the culture of mesenchymal stem cells. Cell Biol Int 2007; 31:293-8.
26. Nanaev AK, Kohnen G, Milovanov AP, Domogatsky SP, Kaufmann P. Stromal differentiation and architecture of the human umbilical cord. Placenta 1997; 18:53-64.
27. Takechi K, Kuwabara Y, Mizuno M. Ultrastructural and immunohistochemical studies of Wharton's jelly umbilical cord cells. Placenta 1993; 14:235-45.
28. Yarygin KN, Suzdal'tseva YG, Burunova VV, Voronov AV, Petrakova NV, Cheglakov IB, et al. Comparative study of adult human skin fibroblasts and umbilical fibroblast-like cells. Bull Exp Biol Med 2006; 141:161-6.
29. Gang EJ, Bosnakovski D, Figueiredo CA, Visser JW, Perlingeiro RC. SSEA-4 identifies mesenchymal stem cells from bone marrow. Blood 2007; 109:1743-51.
30. Carlin R, Davis D, Weiss M, Schultz B, Troyer D. Expression of early transcription factors Oct-4, Sox-2 and Nanog by porcine umbilical cord (PUC) matrix cells. Reprod Biol Endocrinol 2006; 4:8.
31. Hodges H, Pollock K, Stroemer P, Patel S, Stevanato L, Reuter I, Sinden J. Making stem cell lines suitable for transplantation. Cell Transplant 2007; 16:101-15.
32. Keyser KA, Beagles KE, Kiem HP. Comparison of mesenchymal stem cells from different tissues to suppress T-cell activation. Cell Transplant 2007; 16:555-62.
33. Chandra V, Swetha G, Phadnis S, Nair PD, Bhonde RR. Generation of Pancreatic Hormone Expressing Islet like Cell Aggregates from Murine Adipose Tissue-derived Stem Cells. Stem Cells 2009; 27:1941-53.
34. Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, Raaka BM. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 2004; 306:2261-4.
35. Samual AC, Kermit MB, Sandra SD, Thelma CR, William LL. Staining and in vitro toxicity of dithiozone with canine porcine and bovine islets. Cell Transplant 1994; 3:299-306.