Ventilator-related causes of lung injury: the mechanical power

Intensive Care Medicine

Volumn 42, Issue 10, 2016, Pages 1567-1575

  Gattinoni, L ^a   Tonetti, T ^a   Cressoni, M ^b   Cadringher, P ^c   Herrmann, P ^a   Moerer, O ^a   Protti, A ^c   Gotti, M ^b   Chiurazzi, C ^b   Carlesso, E ^b   Chiumello, D ^b   Quintel, M ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF MILAN   (Italy)

^c FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

ARDS; Mechanical ventilation; Respiratory mechanics; VILI

Indexed keywords

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AIRWAY RESISTANCE; ARTICLE; ARTIFICIAL VENTILATION; BREATHING RATE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; POSITIVE END EXPIRATORY PRESSURE; PRESSURE VOLUME CURVE; RESPIRATORY TRACT PARAMETERS; TIDAL VOLUME; VENTILATOR INDUCED LUNG INJURY; ADVERSE EFFECTS; AGED; BREATHING MECHANICS; CASE CONTROL STUDY; LUNG; MECHANICAL VENTILATOR; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RESPIRATORY DISTRESS SYNDROME, ADULT; STATISTICAL MODEL; VENTILATOR-INDUCED LUNG INJURY;

ADULT; AGED; AIRWAY RESISTANCE; CASE-CONTROL STUDIES; FEMALE; HUMANS; LOGISTIC MODELS; LUNG; MALE; MIDDLE AGED; POSITIVE-PRESSURE RESPIRATION; RESPIRATORY DISTRESS SYNDROME, ADULT; RESPIRATORY MECHANICS; TIDAL VOLUME; VENTILATOR-INDUCED LUNG INJURY; VENTILATORS, MECHANICAL;

EID: 84987624066     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-016-4505-2     Document Type: Article

References (24)

1. Kumar A et al (1973) Pulmonary barotrauma during mechanical ventilation. Crit Care Med 1(4):181–186
2. Dreyfuss D et al (1988) High inflation pressure pulmonary edema. Respective effects of high airway pressure, high tidal volume, and positive end-expiratory pressure. Am Rev Respir Dis 137(5):1159–1164
3. Protti A et al. (2016) Role of strain rate in the pathogenesis of ventilator-induced lung edema. Crit Care Med 44(9):e838–e845. doi:10.1097/CCM.0000000000001718
4. Hotchkiss JR Jr et al (2000) Effects of decreased respiratory frequency on ventilator-induced lung injury. Am J Respir Crit Care Med 161(2 Pt 1):463–468
5. Cressoni M et al (2016) Mechanical power and development of ventilator-induced lung injury. Anesthesiology 124(5):1100–1108. doi:10.1097/ALN.0000000000001056
6. Gattinoni L et al (1987) Pressure-volume curve of total respiratory system in acute respiratory failure. Computed tomographic scan study. Am Rev Respir Dis 136(3):730–736
7. Cressoni M et al (2014) Lung inhomogeneity in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 189(2):149–158
8. Gattinoni L et al (1995) Effects of positive end-expiratory pressure on regional distribution of tidal volume and recruitment in adult respiratory distress syndrome. Am J Respir Crit Care Med 151(6):1807–1814
9. Tremblay L et al (1997) Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. J Clin Investig 99(5):944–952
10. Otis AB, Fenn WO, Rahn H (1950) Mechanics of breathing in man. J Appl Physiol 2(11):592–607
11. Marini JJ, Crooke PS 3rd (1993) A general mathematical model for respiratory dynamics relevant to the clinical setting. Am Rev Respir Dis 147(1):14–24
12. Chiumello D et al (2008) Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. Am J Respir Crit Care Med 178(4):346–355
13. Valenza F et al (2003) Positive end-expiratory pressure delays the progression of lung injury during ventilator strategies involving high airway pressure and lung overdistention. Crit Care Med 31(7):1993–1998
14. Brunner JX, Wysocki M (2009) Is there an optimal breath pattern to minimize stress and strain during mechanical ventilation? Intensive Care Med 35(8):1479–1483
15. Caironi P et al (2011) Time to generate ventilator-induced lung injury among mammals with healthy lungs: a unifying hypothesis. Intensive Care Med 37(12):1913–1920
16. Rodarte JR, Rehder K (1986) Dynamics of respiration. In: Macklem PT, Mead J (eds) Handbook of Physiology. Williams & Wilkins, Baltimore, pp 131–144
17. Pelosi P et al (1995) Alterations of lung and chest wall mechanics in patients with acute lung injury: effects of positive end-expiratory pressure. Am J Respir Crit Care Med 152(2):531–537
18. Guerin C, Fournier G, Milic-Emili J (2001) Effects of PEEP on inspiratory resistance in mechanically ventilated COPD patients. Eur Respir J 18(3):491–498
19. Protti A et al (2015) Lung anatomy, energy load, and ventilator-induced lung injury. Intensive Care Med Exp 3(1):34
20. Gattinoni L, Pesenti A (2005) The concept of “baby lung”. Intensive Care Med 31(6):776–784
21. Bachofen H, Hildebrandt J (1971) Area analysis of pressure-volume hysteresis in mammalian lungs. J Appl Physiol 30(4):493–497
22. Fredberg JJ, Stamenovic D (1989) On the imperfect elasticity of lung tissue. J Appl Physiol 67(6):2408–2419
23. Gattinoni L et al (2016) The “baby lung” became an adult. Intensive Care Med 42(5):663–673
24. Amato MBP et al (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The acute respiratory distress syndrome network. N Engl J Med 342(18):301–308