Transmissible Degenerative Encephalopathies: Inactivation of the Unconventional Causal Agents

Russell, Hugo and Ayliffe's Principles and Practice of Disinfection, Preservation and Sterilization: Fourth Edition

Volumn , Issue , 2008, Pages 324-342

  Taylor, David M ^a  

^a SEDECON 2000   (United Kingdom)

Author keywords

Alkylating agents; Chaotropes; Detergents; Encephalopathies; Sheep

Indexed keywords

EID: 84986917594     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470755884.ch10     Document Type: Chapter

References (139)

1. ACDP (1994) Precautions for Work with Human and Animal Transmissible Spongiform Encephalopathies. London: HMSO.
2. Adams, D.H., Field, E.J. & Joyce, G. (1972) Periodate -an inhibitor of the scrapie agent? Research in Veterinary Science, 13, 195-198.
3. Alper, T. (1987) Radio-and photobiological techniques in the investigation of prions. In Prions: Novel Infectious Pathogens Causing Scrapie and Creutzfeldt-Jakob Disease (eds Prusiner, S.B. & McKinlay, M.P.), pp. 113-146. London: Academic Press.
4. Alpers, M. (1987) Epidemiology and clinical aspects of kuru. In Prions: Novel Infectious Pathogens Causing Scrapie and Creutzfeldt-Jakob Disease (eds Prusiner, S.B. & McKinlay, M.P.), pp. 451-465. London: Academic Press.
5. Amyx, H.L., Gibbs, C.J., Kingsbury, D.T. & Gajdusek, D.C. (1981) Some physical and chemical characteristics of a strain of Creutzfeldt-Jakob disease in mice. In Abstracts of the Twelfth World Congress of Neurology, Kyoto, 20-25 September, p. 255.
6. Appel, T.R., Groschup, M.H. & Riesner, D. (1999) Acid inactivation of hamster scrapie prion rods. Abstracts of a Symposium on Characterization and Diagnosis of Prion Diseases in Animals and Man, Tübingen, 23-25 September, p. 169.
7. Asher, D.M., Gibbs, C.J., Diwan, A.R., Kingsbury, D.T, Sulima, M.P. & Gajdusek, D.C. (1981) Effects of several disinfectants and gas sterilisation on the infectivity of scrapie and Creutzfeldt-Jakob disease. In Abstracts of the Twelfth World Congress of Neurology, Kyoto, 20-25 September, p. 225.
8. Asher, D.M., Pomeroy, K.L., Murphy, L., Gibbs, C.J. & Gajdusek, D.C. (1987) Attempts to disinfect surfaces contaminated with etiological agents of the spongiform encephalopathies. In Abstracts of the VIIth International Congress of Virology, Edmonton, 9-14 August, p. 147.
9. Ayliffe, G.A.J. (1993) Surgical instruments and disease transmission. Lancet 341, 1098.
10. Berger, J.R. & David, N.J. (1993) Creutzfeldt-Jakob disease in a physician: a review of the disorder in health care workers. Neurology, 43, 205-206.
11. Bernoulli, C., Siegfried, J., Baumgartner, G. et al. (1977) Danger of accidental person-to-person transmission of Creutzfeldt-Jakob disease by surgery. Lancet, i, 478-479.
12. Bessen, R.A., Kocisko, D.A., Raymond, G.J., Nandan, S., Lansbury, P.T. & Caughey, B. (1995) Non-genetic propagation of strain-specific properties of scrapie prion protein. Nature, 375, 698-700.
13. Brown, K., Stewart, K., Ritchie, D.L. et al. (1999) Scrapie replication in lymphoid tissues depends on prion proteinexpressing follicular dendritic cells. Nature Medicine 5, 1308-1312.
14. Brown P. & Gajdusek, D.C. (1991) Survival of scrapie virus after 3 years' interment. Lancet, 337, 269-270.
15. Brown, P., Gibbs, C.J., Amyx, H.L. et al. (1982a) Chemical disinfection of Creutzfeldt-Jakob disease virus. New England Journal of Medicine, 306, 1279-1282.
16. Brown, P., Rohwer, R.G., Green, E.M. & Gajdusek, D.C. (1982b) Effects of chemicals, heat and histopathological processing on high-infectivity hamster-adapted scrapie virus. Journal of Infectious Diseases, 145, 683-687.
17. Brown, P., Gibbs, C.J., Gajdusek, D.C., Cathala, F. & LaBauge, R. (1986a) Transmission of Creutzfeldt-Jakob disease from formalin-fixed, paraffin-embedded human brain tissue. New England Journal of Medicine, 315, 1614-1615.
18. Brown, P., Rohwer, R.G. & Gajdusek, D.C. (1986b) Newer data on the inactivation of scrapie virus or Creutzfeldt-Jakob disease virus in brain tissue. Journal of Infectious Diseases, 153, 1145-1148.
19. Brown, P., Liberski, P.P., Wolff, A. & Gajdusek, D.C. (1990a) Resistance of scrapie agent to steam autoclaving after formaldehyde fixation and limited survival after ashing at 360°C: practical and theoretical implications. Journal of Infectious Diseases, 161, 467-472.
20. Brown, P., Wolff, A. & Gajdusek, D.C. (1990b) A simple and effective method for inactivating virus infectivity in formalin-fixed tissue samples from patients with Creutzfeldt-Jakob disease. Neurology, 40, 887-890.
21. Brown, P., Preece, M.A. & Will, R.G. (1992) 'Friendly fire' in medicine: hormones, homografts, and Creutzfeldt-Jakob disease. Lancet, ii, 24-27.
22. Brown, P., Rau, E.H., Johnson, B.J., Bacote, E.A., Gibbs, C.J. & Gajdusek (2000) New studies on the heat resistance of hamster-adapted scrapie agent; threshold survival after ashing at 600 °C suggests an inorganic template of replication. Proceedings of the the National Academy of Sciences of the U S A, 97, 3418-3421.
23. Brown, P., Cervenakova, L. & Diringer, H. (2001) Blood infectivity and the prospects for a diagnostic screening test in Creutzfeldt-Jakob diseas. Journal of Laboratory and Clinical Medicine 137, 5-13.
24. Bruce, M.E. (1993) Scrapie strain variation and mutation. British Medical Bulletin, 49, 822-838.
25. Bruce, M.E., McBride, P.A. & Farquhar, C.F. (1989) Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie. Neuroscience Letters, 102, 1-6.
26. Bruce, M.E., Chree, A., McConnell, I., Foster, J.D., Pearson, G. & Fraser, H. (1994) Transmission of bovine spongiform encephalopathy and scrapie to mice; strain variation and the species barrier. Philosophical Transactions of the Royal Society B, 343, 405-411.
27. Bruce, M.E., Will, R.G., Ironside, J.W. et al. (1997) Transmissions in mice indicate that 'new variant' CJD is caused by the BSE agent. Nature, 389, 498-501.
28. Bruce, M.E., McConnel, I., Will, R.G. & Ironside, J.W. (2001)) Detection of variant Creutzfeldt-Jakob disease infectivity in extraneural tissues. Lancet, 358, 208-209.
29. Brumback, R.A. (1988) Routine use of phenolised formalin in fixation of autopsy brain tissue to reduce risk of inadvertent transmission of Creutzfeldt-Jakob disease. New England Journal of Medicine, 319, 654.
30. Bueler, H., Aguzzi, A., Sailer, A. et al. (1993) Mice devoid of PrP are resistant to scrapie. Cell, 73, 1339-1347.
31. Burger, D. & Gorham, J.R. (1977) Observation on the remarkable stability of transmissible mink encephalopathy virus. Research in Veterinary Science, 22, 131-132.
32. Caramelli, M., Ru, G., Casalone, C. et al. (2001) Evidence for the transmission of scrapie to sheep and goats from a vaccine against Mycoplasma agalactiae. Veterinary Record, 148, 531-536.
33. Carp, R.I., Merz, P.A., Kascsak, R.J., Merz, G. & Wisniewski, H.M. (1985) Nature of the scrapie agent: current status of facts and hypotheses. Journal of General Virology, 66, 1357-1368.
34. Chesebro, B. (1998) BSE and prions; uncertainties about the agent. Science, 279, 42-43.
35. Coates, D. (1985) A comparison of sodium hypochlorite and sodium dichloroisocyanurate products. Journal of Hospital Infection, 6, 31-40.
36. Commission Decision (1994) On the approval of alternative heat treatment systems for processing animal waste of ruminant origin with a view to the inactivation of spongiform encephalopathy agents, Commission Decision 94/382/EC. Official Journal of the European Communities, L172, 25-27.
37. Commission Decision (1996) On the approval of alternative heat treatment systems for processing animal waste with a view to the inactivation of spongiform encephalopathy agents, Commission Decision 96/449/EC. Official Journal of the European Communities, L184, 43-46.
38. Culkin, F. & Fung, D.Y.C. (1975) Destruction of Escherichia coli and Salmonella typhimurium in microwavecooked soups. Journal of Milk and Food Technology, 38, 8-15.
39. DHSS (1984) Management of Patients with Spongiform Encephalopathy, Creutzfeldt-Jakob disease (CJD). DHSS Circular DA (84) 16. London: HMSO.
40. Dickinson, A.G. (1976) Scrapie in sheep and goats. In Slow Virus Diseases of Animals and Man (ed. Kimberlin, R.H.), pp. 209-241. Amsterdam: North-Holland.
41. Dickinson, A.G. & Fraser, H. (1969) Modification of the pathogenesis of scrapie in mice by treatment of the agent. Nature, London, 222, 892-893.
42. Dickinson, A.G. & Outram, G.W. (1979) The scrapie replication-site hypothesis and its implications for pathogenesis. In The scrapie replication-site hypothesis and its implications for pathogenesis (Slow Transmissible Diseases of the Nervous System), eds Prusiner, S.B. & Hadlow, W.J., pp. Vol. 2-13. 21.
43. Dickinson, A.G. & Taylor, D.M. (1978) Resistance of scrapie agent to decontamination. New England Journal of Medicine, 229, 1413-1414.
44. Dickinson, A.G. & Taylor, D.M. (1988). Options for the control of scrapie in sheep and its counterpart in cattle. In Proceedings of the Third World Congress on Sheep and Beef Cattle Breeding, Vol. 1, 19-23 June, Paris, pp. 553-564.
45. Dickinson, A.G., Outram, G.W., Taylor, D.M. & Foster, J.D. (1989) Further evidence that scrapie agent has an independent genome. In Unconventional Virus Diseases of the Central Nervous System (eds Court, LA., Dormont, D., Brown, P. & Kingsbury, D.T), pp. 446-460. Moisdon la Rivière: Abbaye de Melleray.
46. Diprose, M.F. & Benson, F.A. (1984) The effect of externally applied electrostatic fields, microwave radiation and electric currents on plants, with special reference to weed control. Botanical Reviews, 50, 171-223.
47. Diringer, H. & Braig, H.R. (1989) Infectivity of unconventional viruses in dura mater. Lancet, i, 439-440.
48. Eckroade, R.J., ZuRhein, G.M. & Hanson, R.P. (1979) Experimental transmissible mink encephalopathy: brain lesions and their sequential development in mink. In Experimental transmissible mink encephalopathy: brain lesions and their sequential development in mink (Slow Transmissible Diseases of the Nervous System), eds Prusiner, S.B. & Hadlow, W.J., pp. Vol. 1-409. 449.
49. Endo, T., Groth, D., Prusiner, S.B. & Kobata, A. (1989) Diversity of oligosaccharide structures linked to asparagines of the scrapie prion protein. Biochemistry, 28, 8380-8388.
50. Ernst, D.R. & Race, R.E. (1993) Comparative analysis of scrapie agent inactivation. Journal of Virological Methods, 41, 193-202.
51. Esiri, M.M. (1989) Diagnostic Neuropathology, Oxford: Blackwell.
52. Evatt, B.L. (1998) Prions and haemophilia; assessment of risk. Haemophilia, 4, 628-633,.
53. Farquhar, C.F., Somerville, R.A. & Bruce, M.E. (1998) Straining the prion hypothesis. Nature, 391, 345-346.
54. Foncin, J.F. Gaches, J., Cathala, F., El Sherif, E. & Le Beau (1980) Transmission iatrogène interhumaine possible de maladie de Creutzfeldt-Jakob avec atteinte des grains du cervelet. Revue Neurologique, 136, 280.
55. Fraser, H., McConnell, L., Wells, G.A.H. & Dawson, M. (1989) Transmission of bovine spongiform encephalopathy to mice. Veterinary Record, 123, 472.
56. Fraser, H., Bruce, M.E., Chree, A., McConnell, I. & Wells, G.A.H. (1992) Transmission of bovine spongiform encephalopathy and scrapie to mice. Journal of General Virology, 173, 1891-1897.
57. Gajdusek, D.C. & Gibbs, C.J. (1968) Slow, latent and temperature virus infections of the central nervous system. In Infections of the Nervous System (ed. Zimmerman, H.M.), pp. 254-280. Baltimore, MD: Williams & Wilkins.
58. Gard, S. & Maaloe, O. (1959) Inactivation of viruses. In The Viruses, Vol. 1 (eds Burnet, F.M. & Stanley, W.M.), pp. 359-427. New York: Academic Press.
59. Gibbs, C.J., Asher, D.M. & Kobrine, A. (1994) Transmission of Creutzfeldt-Jakob disease to a chimpanzee by electrodes contaminated during neurosurgery. Journal of Neurology, Neurosurgery and Psychiatry, 57, 757-758.
60. Greig, J.R. (1950) Scrapie in sheep. Journal of Comparative Pathology, 60, 263-266.
61. Haig, D.A. & Clarke, M.C. (1968). The effect of bpropiolactone on the scrapie agent. Journal of General Virology, 3, 281-283.
62. Hecker, R., Taraboulos, A., Scott, M. et al. (1992) Replication of distinct scrapie prion isolates is region-specific in brains of transgenic mice and hamsters. Genes and Development, 6, 1213-1228.
63. Heye, N., Hensen, S. & Muller, N. (1994) Creutzfeldt-Jakob disease and blood transfusion. Lancet, 343, 298-299.
64. Hill, A.F., Antoniou, M. & Collinge, J. (1999) Proteaseresistant prion protein produced in vitro lacks detectable infectivity. Journal of General Virology, 80, 11-14.
65. Hill, A.F., Butterworth, R.J., Joiner, S. et al. (1999) Investigation of variant Creutzfeldt-Jakob disease and other prion diseases with tonsil biopsy samples. Lancet, 353, 183-189.
66. Horaud, F. (1993) Safety of medicinal products: summary. Developments in Biological Standardization, 80, 207-208.
67. Hunter, G.D. & Millson, G.C. (1964) Further experiments on the comparative potency of tissue extracts from mice infected with scrapie. Research in Veterinary Science, 5, 149-153.
68. Hunter, G.D. & Millson, G.C. (1967) Attempts to release the scrapie agent from tissue debris. Journal of Comparative Pathology, 77, 301-307.
69. Hunter, G.D., Gibbons, R.A., Kimberlin, R.H. & Millson, G.C. (1969) Further studies of the infectivity and stability of extracts and homogenates derived from scrapie affected mouse brains. Journal of Comparative Pathology, 79, 101-108.
70. Hunter, G.D., Millson, G.C. & Heitzman, R.J. (1972) The nature and biochemical properties of the scrapie agent. Annales de Microbiologie, Institut Pasteur, 123, 571-583.
71. Kimberlin, R.H. (1977) Biochemical approaches to scrapie research. Trends in Biochemical Sciences, 2, 220-223.
72. Kimberlin, R.H., Walker, C.A., Millson, G.C. et al. (1983) Disinfection studies with two strains of mouse-passaged scrapie agent. Journal of the Neurological Sciences, 59, 355-369.
73. Kleinman, G.M. (1980) Case records of the Massachusetts General Hospital (case 45-1980). New England Journal of Medicine, 303, 1162-1171.
74. Latarjet, R. (1979) Inactivation of the agents of scrapie, Creutzfeldt-Jakob disease, and kuru by radiations. In Slow Transmissible Disease of the Nervous System, Vol. 2 (eds Prusiner, S.B. & Hadlow, W.J.), pp. 387-407. London: Academic Press.
75. Latimer, J.M. & Matsen, J.M. (1977) Microwave oven irradiation as a method for bacterial decontamination in a clinical microbiology laboratory. Journal of Clinical Microbiology, 6, 340-342.
76. Lax, A.J., Millson, G.C. & Manning, E.J. (1983) Can scrapie titres be calculated accurately from incubation periods? Journal of General Virology, 64, 971-973.
77. McBride, P.A., Eikelenboom, P., Kraal, G., Fraser, H. & Bruce, M.E. (1992) PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice. Journal of Pathology, 168, 413-418.
78. Mackenzie, J.M. & Fellowes, W (1990) Phenolized formalin may obscure early histological changes of Creutzfeldt-Jakob disease. Neuropathology and Applied Neurobiology, 16, 255.
79. Manuelidis, L. (1997) Decontamination of Creutzfeldt-Jakob disease and other transmissible agents. Journal of Neurovirology, 3, 62-65.
80. Manuelidis, L. (1998) Cleaning CJD-contaminated instruments. Science, 281, 1961.
81. Marsh, R.F. & Hanson, R.P. (1969) Physical and chemical properties of the transmissible mink encephalopathy agent. Journal of Virology, 3, 176-180.
82. Marsh, R.F., Bessen, R.A., Lehmann, S. & Hartsough, G.R. (1991) Epidemiological and experimental studies on a new incident of transmissible mink encephalopathy. Journal of General Virology, 72, 589-594.
83. Masters, C.L., Jacobsen, P.F. & Kakulas, B.A. (1985a) Letter to the editor. Neuropathology and Applied Neurobiology, 44, 304-307.
84. Masters, C.L., Jacobsen, P.F. & Kakulas, B.A. (1985b) Letter to the editor. Neuropathology and Applied Neurobiology, 45, 760-761.
85. Millson, G.C., Hunter, G.D. & Kimberlin, R.H. (1976) The physico-chemical nature of the scrapie agent. In Slow Virus Diseases of Animals and Man (ed. Kimberlin, R.H.), pp. 243-266. Amsterdam: North-Holland.
86. Mould, D.L., Dawson, A.McL. & Smith, W. (1965) Scrapie in mice: the stability of the agent to various suspending media, pH and solvent extraction. Research in Veterinary Science, 6, 151-154.
87. Outram, G.W. (1976) The pathogenesis of scrapie in mice. In Slow Virus Diseases of Animals and Man (ed. Kimberlin, R.H.), pp. 325-357. Amsterdam: North-Holland.
88. Palsson, P.A. (1979) Rida (scrapie) in Iceland and its epidemiology. In Slow Transmissible Disease of the Nervous System, Vol. 1 (eds Prusiner, S.B. & Hadlow, WJ.), pp. 357-366. London: Academic Press.
89. Pocchiari, M., Peano, S. & Conz (1991) Combination filtration and 6m urea treatment of human growth hormone effectively minimizes risk from potential Creutzfeldt-Jakob disease virus. Hormone Research, 35, 161-166.
90. Prusiner, S.B. (1982) Novel proteinaceous infectious particles cause scrapie. Science, 216, 136-144.
91. Prusiner, S.B., McKinley, M.P., Groth, D.F. et al. (1981) Scrapie agent contains a hydrophobic protein. Proceedings of the National Academy of Sciences of the USA, 78, 6675-6679.
92. Prusiner, S.B., McKinlay, M.P., Bolton, D.C. et al. (1984) Prions: methods for assay, purification, and characterisation. In Methods in Virology, Vol. VIII (eds Maramorosch, K. & Koprowski, H.), pp. 293-345 New York: Academic Press.
93. Regalado, A. (2002) Growing plague of 'mad deer' baffles scientists. Wall Street Journal, 24 May.
94. Rohwer, R.G. (1983) Scrapie inactivation kinetics-an explanation scrapie's apparent resistance to inactivation-a re-evaluation of estimates of its small size. In Virus Non Conventionnels et Affections du Système Nerveux Central (eds Court, L.A. & Cathala, E.), pp. 84-113. Paris: Masson.
95. Rohwer, R.G. & Gajdusek, D.C. (1980) Scrapie, virus or viroid: the case for a virus. In Search of the Cause of Multiple Sclerosis and other Chronic Diseases of the CNS (Proceedings of the 1st International Symposium of the Hertie Foundation, Frankfurt, September 1979), pp. 335-355. Weinheim: Verlag Chemie.
96. Rosaspina, S., Salvatorelli, G. & Anzane, D. (1994) The bactericidal effect of microwaves on Mycobacterium bovis dried on scalpel blades. Journal of Hospital Infection, 26, 45-50.
97. Rosenberg, R.N., White, C.L., Brown, P. et al. (1986) Precautions in handling tissues, fluids, and other contaminated materials from patients with documented or suspected Creutzfeldt-Jakob disease. Annals of Neurology, 19, 75-77.
98. Salk, J.E. & Gori, J.B. (1960) A review of theoretical, experimental, and practical considerations in the use of formaldehyde for the inactivation of poliovirus. Annals of the New York Academy of Sciences, 83, 609-637.
99. Schreuder, B.E.C., Geerstma, R.E., van Keulen, L.J.M. et al.(1998) Studies on the efficacy of hyperbaric rendering procedures in inactivating bovine spongiform encephalopathy (BSE) and scrapie agents. Veterinary Record, 142, 474-480.
100. Somerville, R.A. & Carp, R.I. (1983) Altered scrapie infectivity estimates by titration and incubation period in the presence of detergents. Journal of General Virology, 64, 2045-2050.
101. Somerville, R.A., Oberthur, R.C., Havekost, U., MacDonald, F., Taylor, D.M. & Dickinson, A.G. (2002) Characterization of thermodynamic diversity between transmissible spongiform encephalopathy agent strains and its theoretical implications. Journal of Biological Chemistry, 277, 11084-11089.
102. Stamp, J.T., Brotherston, J.C., Zlotnik, L, McKay, J.M.K. & Smith, W. (1959) Further studies on scrapie. Journal of Comparative Pathology, 69, 268-280.
103. Steele, P.J., Taylor, D.M. & Fernie, K. (1999) Survival of BSE and scrapie agents at 200 °C. Abstracts of a Meeting of the Association of Veterinary Teachers and Research Workers. Scarborough, 29-31 March, p. 21.
104. Taguchi, E., Tamai, Y., Uchida, K. et al. (1991) Proposal for a procedure for complete inactivation of the Creutzfeldt-Jakob disease agent. Archives of Virology, 119, 297-301.
105. Tamai, Y., Taguchi, F. & Miura, S. (1988) Inactivation of the Creutzfeldt-Jakob disease agent. Annals of Neurology, 24, 466.
106. Tateishi, J., Koga, M., Sato, Y. & Mori, R. (1980) Properties of the transmissible agent derived from chronic spongiform encephalopathy. Annals of Neurology, 7, 390-391.
107. Tateishi, J., Hikita, K., Kitamoto, T. & Nagara, H. (1987) Experimental Creutzfeldt-Jakob disease: inducation of amyloid plaques in rodents. In Prions: Novel Infectious Pathogens Causing Scrapie and Creutzfeldt-Jakob Disease (eds Prusiner, S.B. & McKinlay, M.P.), pp. 415-426. New York: Academic Press.
108. Tateishi, J., Tashima, T. & Kitamoto, T. (1988) Inactivation of the Creutzfeldt-Jakob disease agent. Annals of Neurology, 24, 466.
109. Tateishi, J. Tashima, T. & Kitamoto, T. (1991) Practical methods for for chemical inactivation of Creudtzfeldt-Jajob disease pathogen. Microbiology and Immunology, 35, 163-166.
110. Taylor, D.M. (1986) Decontamination of Creutzfeldt-Jakob disease agent. Annals of Neurology, 20, 749.
111. Taylor, D.M. (1989a) Phenolized formalin may not inactivate Creutzfeldt-Jakob disease infectivity. Neuropathology and Applied Neurology, 15, 585-586.
112. Taylor, D.M. (1989b) Bovine spongiform encephalopathy and human health. Veterinary Record, 125, 413-415.
113. Taylor, D.M. (1991) Resistance of the ME7 scrapie agent to peracetic acid. Veterinary Microbiology, 27, 19-24.
114. Taylor, D.M. (1993) Inactivation of SE agents. British Medical Bulletin, 49, 810-821.
115. Taylor, D.M. (1994) Survival of mouse-passaged bovine spongiform encephalopathy agent after exposure to paraformaldehyde-lysine-periodate and formic acid. Veterinary Microbiology, 44, 111-112.
116. Taylor, D.M. (1996) Transmissible subacute spongiform encephalopathies: practical aspects of agent inactivation. In Transmissible Subacute Spongiform Encephalopathies: Prion Disease. IIIrd International Symposium on Subacute Spongiform Encephalopathies: Prion Diseases, Paris, 18-20 March (eds. Court L. & Dodet, D.), pp.479-482.
117. Taylor, D.M. (1997) Research on the safety of meat and bone meal with regard to bovine spongiform encephalopathy and scrapie agents. Transcripts of an International Conference on Meat and Bone Meal, Brussels, 1-2 July, pp. 37-40, 42-44, 63.
118. Taylor, D.M. (2000) Inactivation of transmissible degenerative encephalopathy agents; a review. Veterinary Journal, 159, 10-17.
119. Taylor, D.M. & Bell, J.E. (1993) Prevention of iatrogenic transmission of Creutzfeldt-Jakob disease. Lancet, 341, 1543-1544.
120. Taylor, D.M. & Diprose, M.F. (1996) The response of the 22A strain of scrapie agent to microwave irradiation compared with boiling. Neuropathology and Applied Neurobiology, 22, 256-258.
121. Taylor, D.M. & Fernie, K. (1996) Exposure to autoclaving or sodium hydroxide extends the dose-response curve of the 263K strain of scrapie agent in hamsters. Journal of General Virology, 77, 811-813.
122. Taylor, D.M. & McBride, P.A. (1987) Autoclaved, formolfixed scrapie brain is suitable for histopathological examination but may still be infective. Acta Neuropathologica, 74, 194-196.
123. Taylor, D.M. & McConnell, I. (1988) Autoclaving does not decontaminate formol-fixed scrapie tissues. Lancet, i, 1463-1464.
124. Taylor, D.M., Fraser, H., McConnell, I. et al. (1994) Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie. Archives of Virology, 139, 313-326.
125. Taylor, D.M., Woodgate, S.L. & Atkinson, M.J. (1995) Inactivation of the bovine spongiform encephalopathy agent by rendering procedures. Veterinary Record, 137, 605-610.
126. Taylor, D.M., McConnell, I. & Fraser, H. (1996a) Scrapie infection can be established readily through skin scarification in immunocompetent but not immunodeficient mice. Journal of General Virology, 77, 1595-1599.
127. Taylor, D.M., Woodgate, S.L. & Fleetwood, A.J. (1996b) Scrapie agent survives rendering procedures. In Abstracts of the Jubilee Meeting of the Association of Veterinary Teachers and Research Workers, Scarborough, p. 33.
128. Taylor, D.M., McConnell, I. & Fernie, K. (1996c) The effect of dry heat on the ME7 strain of scrapie agent. Journal of General Virology, 77, 3161-3164.
129. Taylor, D.M., Fernie, K. & McConnell, I. (1997) Inactivation of the 22A strain of scrapie agent by autoclaving in sodium hydroxide. Veterinary Microbiology, 58, 87-91.
130. Taylor, D.M., Fernie, K., McConnell, I., Ferguson, C.E. & Steele, P.J. (1998) Solvent extraction as an adjunct to rendering: the effect on BSE and scrapie agents of hot solvents, followed by dry heat and steam. Veterinary Record, 143, 6-9.
131. Taylor, D.M., Fernie, K., McConnell, I. & Steele, P.J. (1999) Survival of scrapie agent after exposure to sodium dodecyl sulphate and heat. Veterinary Microbiology, 67, 13-16.
132. Taylor, D.M., McConnell, I. & Ferguson, C.E. (2000) Closely similar values obtained when the ME7 strain of scrapie agent was titrated in parallel by two different individuals in separate laboratories using two sublines of C57BL mice. Journal of Virological Methods, 86, 35-40.
133. Taylor, D.M., Fernie, K., Steele, P.J., McConnell, I. & Somerville, R.A. (2002) Thermostability of mouse-passaged BSE and scrapie is independent of host PrP genotype: implications for the nature of the causal agents. Journal of General Virology, 83, 3199-3204.
134. Titford, M. & Bastian, F.L. (1989) Handling Creutzfeldt-Jakob disease tissues in the laboratory. Journal of Histotechnology, 12, 214-217.
135. Walker, A.S., Inderlied, C.B. & Kingsbury, D.T. (1983) Conditions for the chemical and physical inactivation of the K.Fu. strain of the agent of Creutzfeldt-Jakob disease. American Journal of Public Health, 73, 661-665.
136. Wilesmith, J.W., Wells, G.A.J., Cranwell, M.P. & Ryan, J.B.M. (1988) Bovine spongiform encephalopathy: epidemiological studies. Veterinary Record, 123, 638-644.
137. Will, R.G., Ironside, J.W, Zeidler, M. et al. (1996) A new variant form of Creutzfeldt-Jakob disease in the UK. Lancet, 347, 921-925.
138. Williams, E.S. & Young, S. (1980) Chronic wasting disease of captive mule deer: a spongiform encephalopathy. Journal of Wildlife Diseases, 16, 89-98.
139. Wilson, D.R., Anderson, R.D. & Smith, W. (1950) Studies in scrapie. Journal of Comparative Pathology, 60, 267-282.