Intrarenal and urinary oxygenation during norepinephrine resuscitation in ovine septic acute kidney injury

Kidney International

Volumn 90, Issue 1, 2016, Pages 100-108

  Lankadeva, Yugeesh R ^a   Kosaka, Junko ^a   Evans, Roger G ^b   Bailey, Simon R ^a   Bellomo, Rinaldo ^c   May, Clive N ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c AUSTIN HEALTH   (Australia)

Author keywords

cortical and medullary tissue oxygenation; cortical and medullary tissue perfusion; hypoxia; norepinephrine; renal blood flow; sepsis

Indexed keywords

NORADRENALIN; SODIUM CHLORIDE; OXYGEN; VASOCONSTRICTOR AGENT;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; EWE; KIDNEY ARTERY; KIDNEY CORTEX; KIDNEY MEDULLA; MEAN ARTERIAL PRESSURE; NONHUMAN; OLIGURIA; OVINE MODEL; PRIORITY JOURNAL; RESUSCITATION; SEPSIS; SHEEP; TISSUE OXYGENATION; URINARY CATHETER; ACUTE KIDNEY INJURY; ADVERSE EFFECTS; ANIMAL; BLOOD PRESSURE; CHEMICALLY INDUCED; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; FEMALE; HUMAN; HYPOXIA; KIDNEY CIRCULATION; METABOLISM; OXYGEN CONSUMPTION; PATHOLOGY; URINARY TRACT;

ACUTE KIDNEY INJURY; ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPOXIA; KIDNEY CORTEX; KIDNEY MEDULLA; NOREPINEPHRINE; OLIGURIA; OXYGEN; OXYGEN CONSUMPTION; RENAL ARTERY; RENAL CIRCULATION; RESUSCITATION; SEPSIS; SHEEP; URINARY TRACT; VASOCONSTRICTOR AGENTS;

EID: 84986605789     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2016.02.017     Document Type: Article

References (47)

1. 1 Bagshaw, S.M., Uchino, S., Bellomo, R., Morimatsu, H., et al. Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin J Am Soc Nephrol 2 (2007), 431–439.
2. 2 Bagshaw, S.M., George, C., Bellomo, R., ANZICS Database Management Committee. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care, 12, 2008, R47.
3. 3 Di Giantomasso, D., May, C., Bellomo, R., Norepinephrine and vital organ blood flow during experimental hyperdynamic sepsis. Intensive Care Med 29 (2003), 1774–1781.
4. 4 Langenberg, C., Wan, L., Egi, M., May, C.N., et al. Renal blood flow in experimental septic acute renal failure. Kidney Int 69 (2006), 1996–2002.
5. 5 Weber, A., Schwieger, I.M., Poinsot, O., Klohn, M., et al. Sequential changes in renal oxygen consumption and sodium transport during hyperdynamic sepsis in sheep. Am J Physiol 262 (1992), F965–F971.
6. 6 Brenner, M., Schaer, G.L., Mallory, D.L., Suffredini, A.F., et al. Detection of renal blood flow abnormalities in septic and critically ill patients using a newly designed indwelling thermodilution renal vein catheter. Chest 98 (1990), 170–179.
7. 7 Rector, F., Goyal, S., Rosenberg, I.K., Lucas, C.E., Sepsis: a mechanism for vasodilation in the kidney. Ann Surg 178 (1973), 222–226.
8. 8 Chvojka, J., Sykora, R., Krouzecky, A., Radej, J., et al. Renal haemodynamic, microcirculatory, metabolic and histopathological responses to peritonitis-induced septic shock in pigs. Crit Care, 12, 2008, R164.
9. 9 Kanoore Edul, V., Dubin, A., Ince, C., The microcirculation as a therapeutic target in the treatment of sepsis and shock. Semin Respir Crit Care Med 32 (2011), 558–568.
10. 10 De Backer, D., Donadello, K., Sakr, Y., Ospina-Tascon, G., et al. Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Crit Care Med 41 (2013), 791–799.
11. 11 Dubin, A., Pozo, M.O., Casabella, C.A., Palizas, F. Jr., et al. Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care, 13, 2009, R92.
12. 12 Brezis, M., Rosen, S., Hypoxia of the renal medulla—its implications for disease. N Engl J Med 332 (1995), 647–655.
13. 13 Evans, R.G., Ince, C., Joles, J.A., Smith, D.W., et al. Haemodynamic influences on kidney oxygenation: clinical implications of integrative physiology. Clin Exp Pharmacol Physiol 40 (2013), 106–122.
14. 14 Eckardt, K.-U., Bernhardt, W.M., Weidemann, A., Warnecke, C., et al. Role of hypoxia in the pathogenesis of renal disease. Kidney Int 68 (2005), S46–S51.
15. 15 Dellinger, R.P., Levy, M., Rhodes, A., Annane, D., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 39 (2013), 165–228.
16. 16 Calzavacca, P., Evans, R.G., Bailey, M., Lankadeva, Y.R., et al. Long-term measurement of renal cortical and medullary tissue oxygenation and perfusion in unanesthetized sheep. Am J Physiol Regul Integr Comp Physiol 308 (2015), R832–R839.
17. 17 Calzavacca, P., Evans, R., Bailey, M., Bellomo, R., et al. Variable responses of regional renal oxygenation and perfusion to vasoactive agents in awake sheep. Am J Physiol Regul Integr Comp Physiol 309 (2015), R1226–R1233.
18. 18 Evans, R.G., Smith, J.A., Wright, C., Gardiner, B.S., et al. Urinary oxygen tension: a clinical window on the health of the renal medulla?. Am J Physiol Regul Integr Comp Physiol 306 (2014), R45–R50.
19. 19 Calzavacca, P., Evans, R.G., Bailey, M., Bellomo, R., et al. Cortical and medullary tissue perfusion and oxygenation in experimental septic acute kidney injury. Crit Care Med 43 (2015), e431–e439.
20. 20 Brezis, M., Agmon, Y., Epstein, F.H., Determinants of intrarenal oxygenation. I. Effects of diuretics. Am J Physiol Renal Physiol 267 (1994), F1059–F1062.
21. 21 Brezis, M., Heyman, S.N., Epstein, F.H., Determinants of intrarenal oxygenation. II. Hemodynamic effects. Am J Physiol Renal Physiol 267 (1994), F1063–F1068.
22. 22 Evans, R.G., Gardiner, B.S., Smith, D.W., O'Connor, P.M., Methods for studying the physiology of kidney oxygenation. Clin Exp Pharmacol Physiol 35 (2008), 1405–1412.
23. 23 Evans, R.G., Eppel, G.A., Anderson, W.P., Denton, K.M., Mechanisms underlying the differential control of blood flow in the renal medulla and cortex. J Hypertens 22 (2004), 1439–1451.
24. 24 Legrand, M., Bezemer, R., Kandil, A., Dimirci, C., et al. The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats. Intensive Care Med 37 (2011), 1534–1542.
25. 25 Dyson, A., Bezemer, R., Legrand, M., Balestra, G., et al. Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-H rat model of LPS-induced endotoxemia. Shock 36 (2011), 83–89.
26. 26 Zafrani, L., Payen, D., Azoulay, E., Ince, C., The microcirculation of the septic kidney. Semin Nephrol 35 (2015), 75–84.
27. 27 Calzavacca, P., Lankadeva, Y., Bailey, S.R., Bailey, M., et al. Effects of selective beta1-adrenoceptor blockade on cardiovascular and renal function and circulating cytokines in ovine hyperdynamic sepsis. Crit Care, 18, 2014, 610.
28. 28 Holmqvist, B., Olsson, C., Svensson, M.-L., Svanborg, C., et al. Expression of nitric oxide synthase isoforms in the mouse kidney: cellular localization and influence by lipopolysaccharide and Toll-like receptor 4. J Mol Histol 36 (2005), 499–516.
29. 29 Langenberg, C., Gobe, G., Hood, S., May, C.N., et al. Renal histopathology during experimental septic acute kidney injury and recovery. Crit Care Med 42 (2014), e58–e67.
30. 30 Langenberg, C., Wan, L., Egi, M., May, C.N., et al. Renal blood flow and function during recovery from experimental septic acute kidney injury. Intensive Care Med 33 (2007), 1614–1618.
31. 31 Takasu, O., Gaut, J.P., Watanabe, E., To, K., et al. Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med 187 (2013), 509–517.
32. 32 Lerolle, N., Nochy, D., Guérot, E., Bruneval, P., et al. Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration. Intensive Care Med 36 (2010), 471–478.
33. 33 Bellomo, R., Wan, L., May, C., Vasoactive drugs and acute kidney injury. Crit Care Med 36 (2008), S179–S186.
34. 34 Hollenberg, S.M., Vasopressor support in septic shock. Chest 132 (2007), 1678–1687.
35. 35 Albanèse, J., Leone, M., Garnier, F., Bourgoin, A., et al. Renal effects of norepinephrine in septic and nonseptic patients. Chest 126 (2004), 534–539.
36. 36 Martin, C., Papazian, L., Perrin, G., Saux, P., et al. Norepinephrine or dopamine for the treatment of hyperdynamic septic shock?. Chest 103 (1993), 1826–1831.
37. 37 Martin, C., Eon, B., Saux, P., Aknin, P., et al. Renal effects of norepinephrine used to treat septic shock patients. Crit Care Med 18 (1990), 282–285.
38. 38 Jhanji, S., Stirling, S., Patel, N., Hinds, C.J., et al. The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock. Crit Care Med 37 (2009), 1961–1966.
39. 39 Evans, R.G., Gardiner, B.S., Smith, D.W., O'Connor, P.M., Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis. Am J Physiol Renal Physiol 295 (2008), F1259–F1270.
40. 40 Aksu, U., Demirci, C., Ince, C., The pathogenesis of acute kidney injury and the toxic triangle of oxygen, reactive oxygen species and nitric oxide. Contrib Nephrol 174 (2011), 119–128.
41. 41 Haase, M., Bellomo, R., Haase-Fielitz, A., Novel biomarkers, oxidative stress, and the role of labile iron toxicity in cardiopulmonary bypass-associated acute kidney injury. J Am Coll Cardiol 55 (2010), 2024–2033.
42. 42 Valente, A., Sorrentino, L., La Torre, G., Draisci, G., Post-transfusional variation in urinary oxygen tension in surgical patients. Clin Exp Pharmacol Physiol 35 (2008), 1109–1112.
43. 43 Morelli, A., Rocco, M., Conti, G., Orecchioni, A., et al. Monitoring renal oxygen supply in critically-ill patients using urinary oxygen tension. Anesth Analg 97 (2003), 1764–1768.
44. 44 Kainuma, M., Yamada, M., Miyake, T., Continuous urine oxygen tension monitoring in patients undergoing cardiac surgery. J Cardiothoracic Vasc Anesth 10 (1996), 603–608.
45. 45 Leonhardt, K.O., Landes, R.R., Oxygen tension of the urine and renal structures. Preliminary report of clinical findings. N Engl J Med 269 (1963), 115–121.
46. 46 Ludbrook, J., Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc Res 28 (1994), 303–311.
47. 47 Ludbrook, J., A primer for biomedical scientists on how to execute model II linear regression analysis. Clin Exp Pharmacol Physiol 39 (2012), 329–335.