CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity

Redox Biology

Volumn 9, Issue , 2016, Pages 287-295

  Prior, Kim Kristin ^a,b   Leisegang, Matthias S ^a,b   Josipovic, Ivana ^a,b   Löwe, Oliver ^a,b   Shah, Ajay M ^d   Weissmann, Norbert ^c   Schröder, Katrin ^a,b   Brandes, Ralf P ^a,b  

^a GOETHE UNIVERSITY   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

CRISPR Cas9; CYBA p22phox; NADPH oxidase

Indexed keywords

CELL PROTEIN; CRISPR ASSOCIATED PROTEIN 9; CYTOCHROME B; DUOXA1 PROTEIN; DUOXA2 PROTEIN; GLUTAMINE; HISTIDINE; HYDROGEN PEROXIDE; MEMBRANE PROTEIN; P22PHOX PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 5; SUPEROXIDE; TYROSINE; UNCLASSIFIED DRUG; CYBA PROTEIN, HUMAN; DUOXA2 PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CRISPR CAS SYSTEM; ENZYME ACTIVITY; ENZYME BINDING; ENZYME DEFICIENCY; GENE INACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; GENETICS; METABOLISM; TUMOR CELL LINE;

CELL LINE, TUMOR; CRISPR-CAS SYSTEMS; GENE KNOCKOUT TECHNIQUES; HUMANS; HYDROGEN PEROXIDE; MEMBRANE PROTEINS; NADPH OXIDASE 1; NADPH OXIDASE 4; NADPH OXIDASE 5; NADPH OXIDASES; REACTIVE OXYGEN SPECIES;

EID: 84986277843     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2016.08.013     Document Type: Article

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