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Volumn 7, Issue 9, 2016, Pages 819-821

The Added Value of Assessing Ligand-Receptor Binding Kinetics in Drug Discovery

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITY; BINDING KINETICS; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG RESEARCH; DRUG SCREENING; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; RECEPTOR BINDING ASSAY; REVIEW; TRANSLATIONAL RESEARCH;

EID: 84986277612     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.6b00273     Document Type: Review
Times cited : (27)

References (13)
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  • 2
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    • Guo, D.; Hillger, J. M.; IJzerman, A. P.; Heitman, L. H. Drug-target residence time-a case for G protein-coupled receptors Med. Res. Rev. 2014, 34 (4) 856-892 10.1002/med.21307
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  • 3
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    • Drug-target residence time and its implications for lead optimization
    • Copeland, R. A.; Pompliano, D. L.; Meek, T. D. Drug-target residence time and its implications for lead optimization Nat. Rev. Drug Discovery 2006, 5 (9) 730-9 10.1038/nrd2082
    • (2006) Nat. Rev. Drug Discovery , vol.5 , Issue.9 , pp. 730-739
    • Copeland, R.A.1    Pompliano, D.L.2    Meek, T.D.3
  • 4
    • 84957845231 scopus 로고    scopus 로고
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    • Copeland, R. A. The drug-target residence time model: a 10-year retrospective Nat. Rev. Drug Discovery 2016, 15 (2) 87-95 10.1038/nrd.2015.18
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    • Copeland, R.A.1
  • 5
    • 84881171375 scopus 로고    scopus 로고
    • Pharmacokinetics and the drug-target residence time concept
    • Dahl, G.; Akerud, T. Pharmacokinetics and the drug-target residence time concept Drug Discovery Today 2013, 18 (15-16) 697-707 10.1016/j.drudis.2013.02.010
    • (2013) Drug Discovery Today , vol.18 , Issue.1516 , pp. 697-707
    • Dahl, G.1    Akerud, T.2
  • 6
    • 77956309074 scopus 로고    scopus 로고
    • Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action
    • Vauquelin, G.; Charlton, S. J. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action Br. J. Pharmacol. 2010, 161 (3) 488-508 10.1111/j.1476-5381.2010.00936.x
    • (2010) Br. J. Pharmacol. , vol.161 , Issue.3 , pp. 488-508
    • Vauquelin, G.1    Charlton, S.J.2
  • 9
    • 84975225039 scopus 로고    scopus 로고
    • Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type i CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9
    • Ayaz, P.; Andres, D.; Kwiatkowski, D. A.; Kolbe, C. C.; Lienau, P.; Siemeister, G.; Lucking, U.; Stegmann, C. M. Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9 ACS Chem. Biol. 2016, 11 (6) 1710-9 10.1021/acschembio.6b00074
    • (2016) ACS Chem. Biol. , vol.11 , Issue.6 , pp. 1710-1719
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    • Hothersall, J. D.; Brown, A. J.; Dale, I.; Rawlins, P. Can. residence time offer a useful strategy to target agonist drugs for sustained GPCR responses? Drug Discovery Today 2016, 21 (1) 90-6 10.1016/j.drudis.2015.07.015
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.