Prokineticin 2 antagonist, PKRA7 suppresses arthritis in mice with collagen-induced arthritis

BMC Musculoskeletal Disorders

Volumn 17, Issue 1, 2016, Pages

  Ito, Haruyasu ^a   Noda, Kentaro ^a   Yoshida, Ken ^a   Otani, Kazuhiro ^a   Yoshiga, Masayuki ^a   Oto, Yohsuke ^a   Saito, Saburo ^a   Kurosaka, Daitaro ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Collagen induced arthritis; PKRA7; Prokineticin 2; Prokineticin antagonist; Prokineticin receptor 1; Prokineticin receptor 2

Indexed keywords

ANTIRHEUMATIC AGENT; COLIPASE; G PROTEIN COUPLED RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; PKRA7; PROKINETICIN 2; PROKINETICIN RECEPTOR 1; PROKINETICIN RECEPTOR 2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; 1-(4-FLUORO-3-METHOXYBENZYL)-N-(9-CHLORO-3,4-DIHYDRO-2H-1,5-BENZODIOXEPIN-7-YLMETHYL)-N-ISOBUTYLPYRROLIDINE-3-CARBOXAMIDE; ANGIOGENESIS INHIBITOR; COLLAGEN TYPE 2; CYTOKINE; GASTROINTESTINAL HORMONE; NEUROPEPTIDE; OXEPINE DERIVATIVE; PROK2 PROTEIN, MOUSE; PYRROLIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLLAGEN-INDUCED ARTHRITIS; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION; MONONUCLEAR CELL; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN LOCALIZATION; SYNOVIUM; ANIMAL; ANTAGONISTS AND INHIBITORS; DBA MOUSE; EXPERIMENTAL ARTHRITIS; GENE EXPRESSION PROFILING; HUMAN; IMMUNOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS;

ANGIOGENESIS INHIBITORS; ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; COLLAGEN TYPE II; CYTOKINES; GASTROINTESTINAL HORMONES; GENE EXPRESSION PROFILING; HUMANS; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED DBA; NEUROPEPTIDES; OXEPINS; PYRROLIDINES; REAL-TIME POLYMERASE CHAIN REACTION; SYNOVIAL MEMBRANE;

EID: 84986208123     PISSN: None     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/s12891-016-1243-0     Document Type: Article

References (21)

1. Negri L, Lattanzi R, Giannini E, Melchiorri P. Bv8/Prokineticin proteins and their receptors. Life Sci. 2007;14:1103-16.
2. Martucci C, Franchi S, Giannini E, Tian H, Melchiorri P, Negri L, Sacerdote P. Bv8, the amphibian homologue of the mammalian prokineticins, induces a proinflammatory phenotype of mouse macrophages. Br J Pharmacol. 2006;147:225-34.
3. Franchi S, Giannini E, Lattuada D, Lattanzi R, Tian H, Melchiorri P, Negri L, Panerai AE, Sacerdot P. The prokineticin receptor agonist Bv8 decreases IL-10 and IL-4 production in mice splenocytes by activating prokineticin receptor-1. BMC Immunol. 2008;9:60.
4. Soga T, Matsumoto SI, Oda T, Saito T, Hiyama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H, Furuichi K. Molecular cloning and characterization of prokineticin receptors. Biochim Biophys Acta. 2002;1579:173-9.
5. Zhong C, Qu X, Tan M, Meng YG, Ferrara N. Characterization and Regulation of Bv8 in Human Blood Cells. Clin Cancer Res. 2009;15:2675-84.
6. Shojaei F, Wu X, Zhong C, et al. Bv8 regulates myeloidcell-dependent tumour angiogenesis. Nature. 2007;450:825-31.
7. Monnier J, Samson M. Prokineticins in angiogenesis and cancer. Cancer Lett. 2010;296:144-9.
8. De Felice M, Melchiorri P, Ossipov MH, Vanderah TW, Porreca F, Negri L. Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression. Neurosci Lett. 2012;521:40-5.
9. Cheng MY, Bullock CM, Li C. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature. 2002;417:405-10.
10. Duncan WC, Nio-Kobayashi J. Targeting angiogenesis in the pathological ovary. Reprod Fertil Dev. 2013;25:362-71.
11. Urayama K, Guilini C, Messaddeg N, Hu K, Steenman M, Kurose H, Ert G, Nebigil CG. The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival and angiogenesis. FASEB J. 2007;11:2980-93.
12. Matsumoto S, Yamazaki C, Masumoto KH, Nagano M, Naito M, Soga T, Hiyama H, Matsumoto M, Takasaki J, Kamohara M, Matsuo A, Kobori M, Katoh M, Matsushime H, Furuichi K, Shigeyoshi Y. Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2. Proc Natl Acad Sci U S A. 2006;103:4140-5.
13. Kurosaka D, Hirai K, Nishioka M, Miyamoto Y, Yoshida K, Takahashi E, Ukichi T, Noda K, Yanagimachi M, Furuya K, Fukuda K, Yamada A. Correlation between synovial blood flow signals and serum vascular endothelial growth factor levels in patients with refractory rheumatoid arthritis. Mod Rheumatol. 2009;19:187-91.
14. Kurosaka D, Hirai K, Nishioka M, Miyamoto Y, Yoshida K, Noda K, Ukichi T, Yanagimachi M, Furuya K, Takahashi E, Kingetsu I, Fukuda K, Yamada A. Clinical significance of serum levels of vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in patients with rheumatoid arthritis. J Rheumatol. 2010;37:1121-8.
15. Kurosaka D, Noda K, Yoshida K, Furuya K, Ukichi T, Takahashi E, Yanagimachi M, Kingetsu I, Saito S, Yamada A. Elevation of Bombina variegata peptide 8 in mice with collagen-induced arthritis. BMC Musculoskelet Disord. 2009;10:45.
16. Chen B, Yu L, Wang J, Li C, Zhao K, Zhang H. Involvement of Prokineticin 2 and Prokineticn Receptor 1 in Lipopolysaccharide-Induced Testis in Rats. Inflammation. 2016;39:534-42.
17. Watson RP, Lilleyv E, Panesar M, Bhalay G, Langridge S, Tian SS, McClenagham C, Ropenga A, Zeng F, Nash MS. Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport. Neurogastroenterol Motil. 2012;24:65-75.
18. Abou-Hamdan M, Costanza M, Fontana E, Di Dario M, Musio S, Congiu C, Onnis V, Lattanzi R, Radaelli M, Salvadori S, Negri L, Poliani PL, Farina C, Balboni G, Steinman L, Pedotti L. Critical role for prokineticin 2 in CNS autoimmunity. Neurol Neuroimmunol Neuroinflamm. 2015;2:e95.
19. Curtis VF, Wang H, Yang P, McLendon RE, Li X, Zhou QY, Wang XF. A PK2/Bv8/PROK2 Antagonist Suppresses Tumorigenic Processes by Inhibiting Angiogenesis in Glioma and Blocking Myeloid Cell Infiltration in Pancreatic Cancer. PLoS One. 2013;8:e54916.
20. Wright HL, Moots RJ, Edwards SW. The multifactorial role of neutrophils in rheumatoid arthritis. Nat Rev Rheumatol. 2014;10:593-601.
21. Mclnnes IB, Schett G. The Pathogenesis of Rheumatoid Arthritis. N Engl J Med. 2011;365:2205-19.