The prokineticin receptor agonist Bv8 decreases IL-10 and IL-4 production in mice splenocytes by activating prokineticin receptor-1

BMC Immunology

Volumn 9, Issue , 2008, Pages

  Franchi, Silvia ^a   Giannini, Elisa ^b   Lattuada, Donatella ^a   Lattanzi, Roberta ^b   Tian, Hui ^c   Melchiorri, Pietro ^b   Negri, Lucia ^b   Panerai, Alberto E ^a   Sacerdote, Paola ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOCRINE GLAND DERIVED VASCULAR ENDOTHELIAL GROWTH FACTOR; ENDOCRINE GLAND DERIVED VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR; GAMMA INTERFERON; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; PROKINETICIN 2; UNCLASSIFIED DRUG; CONCANAVALIN A; G PROTEIN COUPLED RECEPTOR; HEMOCYANIN; INTERLEUKIN 1; KEYHOLE LIMPET HEMOCYANIN; KEYHOLE-LIMPET HEMOCYANIN; PKR1 PROTEIN, MOUSE; PKR2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL FUNCTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE AMPLIFICATION; GENE SEQUENCE; HELPER CELL; IMMUNIZATION; IMMUNOMODULATION; LYMPHOCYTOPOIESIS; LYMPHOID CELL; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN TARGETING; SPLEEN CELL; T LYMPHOCYTE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHYSIOLOGY; SPLEEN;

ANIMALS; CONCANAVALIN A; HEMOCYANIN; INTERFERON-GAMMA; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; RECEPTORS, G-PROTEIN-COUPLED; SPLEEN; VASCULAR ENDOTHELIAL GROWTH FACTOR, ENDOCRINE-GLAND-DERIVED;

EID: 56649100301     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-9-60     Document Type: Article

References (36)

1. Mollay C Wechselberger C Mignogna G Negri L Melchiorri P Barra D Keil G: Bv8, a small protein from frog skin and its homologue from snake venom induce hyperalgesia in rats. Eur J Pharmacol 1999, 374:189-196. 10.1016/ S0014-2999(99)00229-0 10422759
2. Wechselberger C Puglisi R Engel E Lepperdinger G Boitani C Kreil G: The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes. Febs Lett 1999, 462:177-181. 10.1016/S0014-5793(99)01473-8 10580115
3. LeCouter J Kowalski J Foster J Hass P Zhang Z Dillard-Telm L Frantz G Rangell L DeGuzman L Keller GA Peale F Gurney A Hillan KJ Ferrara N: Identification of an angiogenic mitogen selective for endocrine gland endothelium. Nature 2001, 412:876-884. 10.1038/35091000
4. Li M Bullock CM Knauer DJ Ehlert FJ Zhou QY: Identification of two prokineticin cDNAs: Recombinant proteins potently contract gastrointestinal smooth muscle. Mol Pharmacol 2001, 59:692-698. 11259612
5. Shojaei F Wu X Zhong C Yu L Liang XH Yao J Blanchard D Bais C Peale FV van Bruggen N Ho C Ross J Tan M Carano RA Meng YG Ferrara N: Bv8 regulates myeloid-cell-dependent tumor angiogenesis. Nature 2007, 450:825-831. 10.1038/nature06348 18064003
6. Melchiorri D Bruno V Besong G Ngomba RT Cuomo L De Blasi A Copani A Moschella C Storto M Nicoletti F Lepperdinger G Passarelli F: The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the Map Kinase/Pi-3-kinase pathways. Eur J Neurosci 2001, 13:1694-1702. 10.1046/ j.1460-9568.2001.01549.x 11359521
7. LeCouter J Zlot C Tejada M Peale F Ferrara N: Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization. Proc Natl Acad Sci 2004, 101:16813-16818. 528996 15548611 10.1073/pnas.0407697101
8. Masuda Y Takatsu Y Terao Y Kumano S Ishibashi Y Suenaga M Abe M Fukusumi S Watanabe T Shintani Y Yamada T Hinuma S Inatomi N Ohtaki T Onda H Fujino M: Isolation and identification of eg-vegf/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Biochem Biophys Res Commun 2002, 293:396-402. 10.1016/S0006-291X(02)00239-5 12054613
9. Lin DCH Bullock CM Ehlert FJ Chen JL Thian H Zhou QY: Identification and molecular characterization of two closely related g-protein coupled receptors activated by prokineticins/eg-vegf. J Biol Chem 2002, 277:19276-19280. 10.1074/jbc.M202139200 11886876
10. Negri L Lattanzi R Giannini E Metere A Colucci MA Barra D Kreil G Melchiorri P: Nociceptive sensitization by the secretory protein Bv8. Br J Pharmacol 2002, 137:1147-1154. 1573618 12466223 10.1038/sj.bjp.0704995
11. Negri L Lattanzi R Giannini E Colucci MA Margheriti F Melchiorri P Vellani V Tian H De Felice M Porreca F: Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: Focus on interaction between PKR1 and the capsaicin receptor TRPV in pain behavior. J Neurosci 2006, 26:6716-6727. 10.1523/ JNEUROSCI.5403-05.2006 16793879
12. LeCouter J Aerrara N: EG-VEGF and Bv8: a novel family of tissue-selective mediators of angiogenesis, endothelial phenotype and function. Trends Cardiovasc Med 2003, 13:276-282. 10.1016/ S1050-1738(03)00110-5 14522467
13. Negri L Lattanzi R Giannini E De Felice M Colucci MA Melchiorri P: Bv8, the amphibian homologue of the mammalian prokineticins, modulates ingestive behavior in rats. Br J Pharmacol 2004, 142:181-191. 1574913 15066905 10.1038/sj.bjp.0705686
14. Cheng MJ Bullock CM Li C Lee AG Bermak JC Belluzzi J Weaver DR Leslie FM Zhou QY: Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 2002, 417:405-410. 10.1038/417405a 12024206
15. Li JD Hu WP Boehmer L Cheng MY Lee AG Jilek A Siegel JM Zhou QY: Attenuated circadian rhythms in mice lacking the prokineticin 2 gene. J Neurosci 2006, 26:11615-11623. 10.1523/JNEUROSCI.3679-06.2006 17093083
16. Kisliouk T Podlovni H Spaneel Borowsky K Ovadia O Zhou QY Meidan R: Prokineticins (endocrine gland-derived vascular endothelial growth factor and BV8) in the bovine ovary: Expression and role as mitogens and survival factors for corpus luteum-derived endothelial cells. Endocrinol 2005, 146:3950-3958. 10.1210/en.2005-0297
17. Vellani V Colucci MA Lattanzi R Negri L Melchiorri P McNaughton PA: Sensitization of Transient Receptor Potential Vanilloid 1 by the prokineticin receptor agonist Bv8. J Neurosci 2006, 26:5109-5116. 10.1523/JNEUROSCI.3870-05.2006 16687502
18. Dorsch M Qiu Y Soler D Frank N Duong T Goodearl A O'Neil S Lora J Fraser CC: Pk/1/EgVEGF induces monocyte differentiation and activation. J Leukoc Biol 2005, 78:426-434. 10.1189/jlb.0205061 15908459
19. Martucci C Franchi S Giannini E Tian H Melchiorri P Negri L Sacerdote P: Bv8, the amphibian homologue of the mammalian prokineticins, induced a proinflammatory phenotype of mouse macrophages. Br J Pharmacol 2006, 147:225-234. 1615858 16299550 10.1038/sj.bjp.0706467
20. Hoebe K Janssen E Beutler B: The interface between innate and adaptive immunity. Nat Immunol 2004, 5:917-974. 10.1038/ni1004-971
21. Moore KW O'Garra A De Waal Malefyt R Vieira P Mosman TR: Interleukin-10. Annu Rev Immunol 1993, 11:165-190. 10.1146/annurev.iy.11.040193.001121 8386517
22. Mosman TR Sad S: The expanding universe of T-cell subsets; Th1, Th2 and more. Immunol Today 1996, 17:138-146. 10.1016/0167-5699(96)80606-2 8820272
23. Trincheri G; Interleukin-12: A pro-inflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995, 13:251-276. 7612223
24. Umetsu DT DeKruyff RH: The regulation of allergy and asthma. Immunol Rev 2006, 212:238-255. 10.1111/j.0105-2896.2006.00413.x 16903918
25. Leary O: T-ceAl activation: a new pathway to curb inflammation. Nat Rev Immunol 2008, 7:921-922.
26. Roncarolo MG Gregari S Battaglia M Bacchetta R Fleischhauer K Levings MK: Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev 2006, 212:28-50. 10.1111/j.0105-2896.2006.00420.x 16903904
27. Sacerdote P Manfredi B Gaspani L Panerai AE: The opioid antagonist naloxone induces a shift from type 1 cytokine pattern to type 2 cytokine pattern in BALB/CJ mice. Blood 2000, 95:2031-2036. 10706871
28. Martucci C Franchi S Lattuada D Panerai AE Sacerdote P: Differential involvement of relb in morphine-induced modulation of chemotaxis, NO and cytokine production in murine macrophages and lymphocytes. J Leukoc Biol 2007, 81:344-354. 10.1189/jlb.0406237 17023558
29. Negri L Lattanzi R Giannini E Melchiorri P: Bv8/prokineticin proteins and their receptors. Life Sci 2007, 81:1103-1116. 10.1016/ j.lfs.2007.08.011 17881008
30. Anastasi E Campese AF Bellavia D Bulotta A Balestri A Pascucci M Checquolo S Gradini R Lendahl U Frati L Gulino A Di Mario U Screpanti I: Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol 2003, 171:4504-4511. 14568923
31. Maroder M Bellavia D Meco D Napolitano M Stigliano A Alesse E Vacca A Giannini G Frati L Gulino A Screpanti I: Expression of TrêB neurotrophin receptor during T cell development. Role of brain derived neurotrophic factor in immature thymocyte survival. J Immunol 1996, 157:2864-2872. 8816391
32. Monnier J Samson M: Cytokine properties of prokineticins. FEBS Journal 2008, 275:4014-4021. 10.1111/j.1742-4658.2008.06559.x 18647349
33. Romagnani S: Lymphokine production by human T cell in disease states Annu Rev Immunol 1994, 12:227-257. 10.1146/annurev.iy.12.040194.001303 8011282
34. Charlton B Lafferty KJ: The Th1/Th2 balance in autoimmunity. Curr Op Immunol 1995, 7:793-798. 10.1016/0952-7915(95)80050-6
35. Bullock CM Li JD Zhou QY: Structural determinants required for the bioactivities of prokineticins and identification of prokineticin receptor antagonists. Mol Pharmac 2004, 65:582-588. 10.1124/mol.65.3.582
36. Negri L Lattanzi R Giannini E Colucci MA Mignogna G Barra D Grohovaz F Codazzi F Kaiser A Kreil G Melchiorri P: Biological activities of Bv8 analogues. Br J Pharmacol 2005, 146:625-632. 1751197 16113687 10.1038/ sj.bjp.0706376