High inbreeding in the Faroe Islands does not appear to constitute a risk factor for multiple sclerosis

Multiple Sclerosis

Volumn 21, Issue 8, 2015, Pages 996-1002

  Binzer, S ^a   Imrell, K ^d   Binzer, M ^a,b,c   Kyvik, K O ^a,e   Hillert, J ^d   Stenager, E ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b MS Clinic of Southern Jutland   (Denmark)

^c Department of Medicine   (Faroe Islands)

^d KAROLINSKA INSTITUTE   (Sweden)

^e ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Faroe Islands; genetics; inbreeding; Multiple sclerosis; risk factors; runs of homozygosity

Indexed keywords

ADULT; ARTICLE; BASE PAIRING; CASE CONTROL STUDY; CLINICAL ARTICLE; CONSANGUINITY; CONTROLLED STUDY; FAROE ISLANDS; FEMALE; GENOTYPE; HOMOZYGOSITY; HUMAN; INBREEDING; MALE; MULTIPLE SCLEROSIS; RISK ASSESSMENT; RISK FACTOR; AGED; SINGLE NUCLEOTIDE POLYMORPHISM; DENMARK; GENETICS; HETEROZYGOTE; HOMOZYGOTE; HUMAN GENOME; MIDDLE AGED; REGISTER; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

DNA;

ADULT; AGED; CONSANGUINITY; DENMARK; DNA; FEMALE; GENOME, HUMAN; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; INBREEDING; MALE; MIDDLE AGED; MODELS, STATISTICAL; MULTIPLE SCLEROSIS; REGISTRIES; RISK FACTORS;

EID: 84985993418     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458514557305     Document Type: Article

References (23)

1. Compston A, Coles A,. Multiple sclerosis. Lancet 2008; 372: 1502-1517.
2. Patsopoulos NA, Bayer Pharma MS Genetics Working Group; Steering Committees of Studies Evaluating IFNβ-1b and a CCR1-Antagonist, et al. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol 2011; 70: 897-912.
3. International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA,. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet 2013; 45: 1353-1360.
4. Watson CT, Disanto G, Breden F,. Estimating the proportion of variation in susceptibility to multiple sclerosis captured by common SNPs. Sci Rep 2012; 2: 770.
5. Jakkula E, Leppä V, Sulonen AM,. Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am J Hum Genet 2010; 86: 285-291.
6. Dessa Sadovnick A, Yee IM, Ebers GC,. Recurrence risks to sibs of MS index cases: Impact of consanguineous matings. Neurology 2001; 56: 784-785.
7. Al Jumah M, Kojan S, Al Khathaami A,. Familial multiple sclerosis: Does consanguinity have a role? Mult Scler 2011; 17: 487-489.
8. Roberts DF,. Consanguinity and multiple sclerosis in Orkney. Genet Epidemiol 1991; 8: 147-151.
9. Hoppenbrouwers IA, Cortes LM, Aulchenko YS,. Familial clustering of multiple sclerosis in a Dutch genetic isolate. Mult Scler 2007; 13: 17-24.
10. Binzer M, Forsgren L, Holmgren G,. Familial clustering of multiple sclerosis in a northern Swedish rural district. J Neurol Neurosurg Psychiatry 1994; 57: 497-499.
11. Callander M, Landtblom AM,. A cluster of multiple sclerosis cases in Lysvik in the Swedish county of Värmland. Acta Neurol Scand 2004; 110: 14-22.
12. Cocco E, Sardu C, Massa R,. Epidemiology of multiple sclerosis in south-western Sardinia. Mult Scler 2011; 17: 1282-1289.
13. Roberts DF, Roberts MJ, Poskanzer DC,. Genetic analysis of multiple sclerosis in Shetland. J Epidemiol Community Health 1983; 37: 281-285.
14. Jorgensen TH, Buttenschön HN, Wang AG,. The origin of the isolated population of the Faroe Islands investigated using Y chromosomal markers. Hum Genet 2004; 115: 19-28.
15. Als TD, Jorgensen TH, Børglum AD,. Highly discrepant proportions of female and male Scandinavian and British Isles ancestry within the isolated population of the Faroe Islands. Eur J Hum Genet 2006; 14: 497-504.
16. Kurtzke JF, Hyllested K,. Multiple sclerosis in the Faroe Islands: I. Clinical and epidemiological features. Ann Neurol 1979; 5: 6-21.
17. Binzer S, Imrell K, Binzer M,. Multiple sclerosis in a family on the Faroe Islands. Acta Neurol Scand 2010; 121: 16-19.
18. Purcell S, Neale B, Todd-Brown K,. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575.
19. McWhirter RE, McQuillan R, Visser E,. Genome-wide homozygosity and multiple sclerosis in Orkney and Shetland Islanders. Eur J Hum Genet 2012; 20: 198-202.
20. McQuillan R, Leutenegger AL, Abdel-Rahman R,. Runs of homozygosity in European populations. Am J Hum Genet 2008; 83: 359-372.
21. Joensen P,. Incidence of amyotrophic lateral sclerosis in the Faroe Islands. Acta Neurol Scand 2012; 126: 62-66.
22. Lund AM, Joensen F, Hougaard DM,. Carnitine transporter and holocarboxylase synthetase deficiencies in The Faroe Islands. J Inherit Metab Dis 2007; 30: 341-349.
23. Poulsen SD, Lund AM, Christensen E,. Carnitine transporter deficiency is a hereditary disease with a high incidence in the Faroe Islands [article in Danish]. Ugeskr Laeger 2012; 174: 1217-1219.