Nonenzymatic glycation/enzymatic deglycation: A novel hypothesis on the etiology of diabetic complications

International Congress Series

Volumn 1245, Issue C, 2002, Pages 143-152

  Szwergold, Benjamin S ^a   Howell, Scott K ^a   Beisswenger, Paul J ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Enzymatic deglycation; FN3K; Fructosamine 3 kinase; Fructoselysine; Glucoselysine

Indexed keywords

EID: 84985872421     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0531-5131(02)01020-8     Document Type: Article

References (35)

1. Diabetes in America, 2nd ed., 1995 NIH Publication No. 95-1468, Bethesda, MD.
2. Krolewski, A.S., Warram, J.H., Freire, M.B., Epidemiology of late diabetic complications. A basis for the development and evaluation of preventive programs. Endocrinol. Metab. Clin. N. Am. 25 (1996), 217–242.
3. DCCT research group. The effect of intensive diabetes treatment on the development and progression of long-complications in insulin-dependent diabetes mellitus: the diabetes control and complications trial. N. Engl. J. Med. 329 (1993), 977–986.
4. Anonymous, Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes [UKPDS 33]. UK Prospective Diabetes Study [UKPDS] Group. Lancet 352 (1998), 837–853.
5. Lyons, T.J., Jenkins, A.J., Glycation, oxidation and lipoxidation in the development of the complications of diabetes: a carbonyl stress hypothesis. Diabetes Rev. 5 (1997), 365–391.
6. King, G.L., Brownlee, M., The cellular and molecular mechanisms of diabetic complications. Endocrinol. Metab. Clin. N. Am. 25 (1996), 255–270.
7. Baynes, J.W., Thorpe, S.R., Role of oxidative stress in diabetic complications—a new perspective on an old paradigm. Diabetes 48 (1998), 1–9.
8. Bucala, R., Cerami, A., Advanced glycosylation: chemistry, biology, and implications for diabetes and aging. Adv. Pharmacol. 23 (1992), 1–34.
9. Brownlee, M, Glycation and diabetic complications. Diabetes 43 (1994), 836–841.
10. Monnier, V.M., The maillard reaction in aging, diabetes and nutrition. Prog. Clin. Biol. Res. 304 (1989), 1–22.
11. Bunn, H.F., Higgins, P.J., Reaction of monosaccharides with proteins. Possible evolutionary significance. Science 213 (1981), 222–224.
12. Baynes, J.W., Thorpe, S.R., Murtiashaw, M.H., Nonenzymatic glucosylation of lysine residues in albumin. Methods Enzymol. 106 (1984), 88–98.
13. Lendl, F., Schleicher, E., New aspects of the Maillard reaction in foods and in the human body. Angew. Chem. 29 (1990), 565–706.
14. Meng, J., Sakata, N., Takebayashi, S., Asano, T., Futata, T., Araki, N., Horiuchi, S., Advanced glycation end products of the Maillard reaction in aortic pepsin-insoluble and pepsin-soluble collagen from diabetic rats. Diabetes 45 (1996), 1037–1043.
15. Van Boekel, M.A., Hoenders, H.J., In vivo glycation of bovine lens crystallins. Biochim. Biophys. Acta 1159 (1992), 99–102.
16. Gugliucci, A., Bendayan, M., Histones from diabetic rats contain increased levels of advanced glycation end products. Biochem. Biophys. Res. Commun. 212 (1995), 56–62.
17. Beisswenger, P.J., Makita, Z., Curphey, T.J., Moore, L.L., Jean, S., Brinck-Johnsen, T., Bucala, R., Vlassara, H., Formation of immunochemical advanced glycosylation end products precedes and correlates with early manifestations of renal and retinal disease in diabetes. Diabetes 44 (1995), 824–829.
18. Sun, M., Yokoyama, M., Ishiwata, T., Asano, G., Deposition of advanced glycation end products [AGE] and expression of the receptor for AGE in cardiovascular tissue of the diabetic rat. Int. J. Exp. Pathol. 79 (1998), 207–222.
19. Hirata, C., Nakano, K., Nakamura, N., Kitagawa, Y., Shigeta, H., Hasegawa, G., Ogata, M., Ikeda, T., Sawa, H., Nakamura, K., Ienaga, K., Obayashi, H., Kondo, M., Advanced glycation end products induce expression of vascular endothelial growth factor by retinal Muller cells. Biochem. Biophys. Res. Commun. 236 (1997), 712–715.
20. McVerry, B.A., Fisher, C., Hopp, A., Huens, E.R., Production of pseudodiabetic renal glomerular changes in mice after repeated injections of glucosylated proteins. Lancet, 1980, 738–740.
21. Szwergold, B.S., Taylor, K., Lal, S., Su, B., Kappler, F., Brown, T.R., Identification of a novel protein kinase activity specific for Amadori adducts on glycated proteins. Diabetes, 46(Suppl. 1), 1997, 108A.
22. Kappler, F., Djafroudi, S., Kayser, H., Su, B., Lal, S., Randall, W.C., Walker, M.A., Taylor, A., Szwergold, B.S., Erbersdobler, H., Brown, T., Metabolism of fructoselysine in the kidney. Proc. Sixth Intern. Maillard Symposium, 1997, Royal Society of Chemistry, Cambridge, UK, 415.
23. Szwergold, B.S., Howell, S.K., Beisswenger, P.J., Human fructosamine-3-kinase (FN3K): purification, sequencing, substrate specificity and evidence of activity in-vivo. Diabetes 50 (2001), 2139–2147.
24. Delpierre, G., Rider, M.H., Collard, F., Stroobant, V., Santos, H., Van Schaftingen, E., Identification, cloning and heterologous expression of a mammalian fructosamine-3-kinase. Diabetes 49 (2000), 1627–1634.
25. Abraham, E.C., Perry, R.E., Satllings, M., Application of affinity chromatography for separation and quantitation of glycosylated hemoglobins. J. Lab. Clin. Med. 102 (1983), 187–197.
26. Acharya, A.S., Sussman, L.G., The reversibility of the ketoamine linkages of aldoses with proteins. J. Biol. Chem. 259 (1984), 4372–4378.
27. Lal, S., Szwergold, B.S., Taylor, A.H., Randall, W.C., Kappler, F., Wells-Knecht, K., Baynes, J., Brown, T.R., Metabolism of fructose-3-phosphate in the diabetic rat lens. Arch. Biochem. Biophys. 318 (1995), 191–199.
28. Mortensen, H.B., Marshall, M.O., Effects of saline incubation on red cell content of glucosylated hemoglobins studied by iso-electric focusing. Clin. Chim. Acta 132 (1983), 213–217.
29. Porta, M., La Selva, M., Bertagna, A., Molinatti, G.M., High glucose concentrations inhibit DNA synthesis and replication without causing death or impairing injury repair in cultured human endothelial cells. Diabetes Res. 7 (1988), 59–63.
30. Lorenzi, M., Nordberg, J.A., Toledo, S., High glucose prolongs cell-cycle traversal of cultured human endothelial cells. Diabetes 36 (1987), 1261–1267.
31. Baumgartner-Parzer, S.M., Wagner, L., Pettermann, M., Grillari, J., Gessl, A., Waldhausl, W., High-glucose-triggered apoptosis in cultured endothelial cells. Diabetes 44 (1995), 1323–1327.
32. Naruse, K., Nakamura, J., Hamada, Y., Nakayama, M., Chaya, S., Komori, T., Kato, K., Kasuya, Y., Miwa, K., Hotta, N., Aldose reductase inhibition prevents glucose-induced apoptosis in cultured bovine retinal microvascular pericytes. Exp. Eye Res. 71 (2000), 309–315.
33. Yao, J., Li, L.S., Role of transforming growth factor-beta in the growth inhibition of cultured rat mesangial cells in high glucose media. Chin. Med. J. 107 (1994), 455–459.
34. Kato, H., van Chuyen, N., Shinoda, T., Sekiya, F., Hayase, F., Metabolism of 3-deoxyglucosone, an intermediate compound in the Maillard reaction, administered orally or intravenously to rats. Biochim. Biophys. Acta 1035 (1990), 71–76.
35. Fujii, E., Iwase, H., Ishii-Karakasa, I., Yajima, Y., Hotta, K., The presence of 2-keto-3 deoxygluconic acid and oxoaldehyde dehydrogenase activity in human erythrocytes. Biochem. Biophys. Res. Commun. 210 (1995), 852–857.